ZIP kinase


Gene Symbol: ZIP kinase
Description: death-associated protein kinase 3
Alias: ZIPK, dlk, death-associated protein kinase 3, DAP kinase 3, DAP-like kinase, MYPT1 kinase, ZIP-kinase, death-associated kinase 3
Species: mouse
Products:     ZIP kinase

Top Publications

  1. Kawai T, Matsumoto M, Takeda K, Sanjo H, Akira S. ZIP kinase, a novel serine/threonine kinase which mediates apoptosis. Mol Cell Biol. 1998;18:1642-51 pubmed
    We have identified a novel serine/threonine kinase, designated ZIP kinase, which mediates apoptosis. ZIP kinase contains a leucine zipper structure at its C terminus, in addition to a kinase domain at its N terminus...
  2. Kawai T, Akira S, Reed J. ZIP kinase triggers apoptosis from nuclear PML oncogenic domains. Mol Cell Biol. 2003;23:6174-86 pubmed
    ..b>ZIP kinase (ZIPK) is a proapoptotic protein kinase with homology to DAP kinase, a protein kinase implicated in apoptosis...
  3. Cai Z, Cao R, Zhang K, Xue Y, Zhang C, Zhou Y, et al. Oncogenic miR-17/20a Forms a Positive Feed-forward Loop with the p53 Kinase DAPK3 to Promote Tumorigenesis. J Biol Chem. 2015;290:19967-75 pubmed publisher
    ..This newly identified tumorigenic pathway may thus contribute to miR-17/20a amplification and tumor growth in diverse human cancers. ..
  4. Levy Strumpf N, Kimchi A. Death associated proteins (DAPs): from gene identification to the analysis of their apoptotic and tumor suppressive functions. Oncogene. 1998;17:3331-40 pubmed
  5. Komatsu S, Ikebe M. ZIP kinase is responsible for the phosphorylation of myosin II and necessary for cell motility in mammalian fibroblasts. J Cell Biol. 2004;165:243-54 pubmed
    ..The kinase responsible for the phosphorylation was ZIP kinase because (a) the kinase in the cell extracts phosphorylated Ser19 and Thr18 of MLC20 with similar potency; (b) ..
  6. Sato N, Kawai T, Sugiyama K, Muromoto R, Imoto S, Sekine Y, et al. Physical and functional interactions between STAT3 and ZIP kinase. Int Immunol. 2005;17:1543-52 pubmed
    ..In this study, we provide evidence that zipper-interacting protein kinase (ZIPK) interacts physically with STAT3...
  7. Shoval Y, Pietrokovski S, Kimchi A. ZIPK: a unique case of murine-specific divergence of a conserved vertebrate gene. PLoS Genet. 2007;3:1884-93 pubmed
    Zipper interacting protein kinase (ZIPK, also known as death-associated protein kinase 3 [DAPK3]) is a Ser/Thr kinase that functions in programmed cell death...
  8. Wooldridge A, Fortner C, Lontay B, Akimoto T, Neppl R, Facemire C, et al. Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle. J Biol Chem. 2008;283:11850-9 pubmed publisher
    ..Our findings suggest roles for SMTNL1 in cGMP/cAMP-mediated adaptations to exercise through mechanisms involving direct modulation of contractile activity. ..
  9. Ohbayashi N, Okada K, Kawakami S, Togi S, Sato N, Ikeda O, et al. Physical and functional interactions between ZIP kinase and UbcH5. Biochem Biophys Res Commun. 2008;372:708-12 pubmed publisher
    Zipper-interacting protein kinase (ZIPK) is a widely expressed serine/threonine kinase that has been implicated in cell death and transcriptional regulation, but its mechanism of regulation remains unknown...

More Information


  1. Weitzel D, Chambers J, Haystead T. Phosphorylation-dependent control of ZIPK nuclear import is species specific. Cell Signal. 2011;23:297-303 pubmed publisher
    b>ZIPK (zipper-interacting protein kinase) is a Ca(2+)-independent protein kinase that promotes myosin phosphorylation in both smooth muscle and non-muscle cells...
  2. Arif A, Chatterjee P, Moodt R, Fox P. Heterotrimeric GAIT complex drives transcript-selective translation inhibition in murine macrophages. Mol Cell Biol. 2012;32:5046-55 pubmed publisher
    ..kinase at Ser(999); L13a is phosphorylated at Ser(77) by death-associated protein kinases DAPK and ZIPK. Because profound differences in inflammatory responses between mice and humans are known, we investigated the GAIT ..
  3. Bomar J, Benke P, Slattery E, Puttagunta R, Taylor L, Seong E, et al. Mutations in a novel gene encoding a CRAL-TRIO domain cause human Cayman ataxia and ataxia/dystonia in the jittery mouse. Nat Genet. 2003;35:264-9 pubmed
    ..Three-dimensional protein structural modeling predicts that the caytaxin ligand is more polar than vitamin E. Identification of the caytaxin ligand may help develop a therapy for Cayman ataxia. ..
  4. Pike A, Rellos P, Niesen F, Turnbull A, Oliver A, Parker S, et al. Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites. EMBO J. 2008;27:704-14 pubmed publisher
    ..Based on the presented structural and functional data, a model for specific activation segment phosphorylation at non-consensus substrate sites is proposed that is likely to be common to other kinases from diverse subfamilies. ..
  5. Chang A, Chen G, Gerard R, Kamm K, Stull J. Cardiac myosin is a substrate for zipper-interacting protein kinase (ZIPK). J Biol Chem. 2010;285:5122-6 pubmed publisher
    Zipper-interacting protein kinase (ZIPK) is a member of the death-associated protein kinase family associated with apoptosis in nonmuscle cells where it phosphorylates myosin regulatory light chain (RLC) to promote membrane blebbing...
  6. Kocher B, White L, Piwnica Worms D. DAPK3 suppresses acini morphogenesis and is required for mouse development. Mol Cancer Res. 2015;13:358-67 pubmed publisher
    ..Novel cellular and mouse modeling studies of DAPK3 shed light on its tumor-suppressive mechanisms and provide direct evidence that DAPK3 has relevance in early development. ..