Zeb2

Summary

Gene Symbol: Zeb2
Description: zinc finger E-box binding homeobox 2
Alias: 9130203F04Rik, D130016B08Rik, SIP1, Zfhx1b, Zfx1b, Zfxh1b, zinc finger E-box-binding homeobox 2, smad-interacting protein 1, zinc finger homeobox protein 1b
Species: mouse
Products:     Zeb2

Top Publications

  1. Jeub M, Emrich M, Pradier B, Taha O, Gailus Durner V, Fuchs H, et al. The transcription factor Smad-interacting protein 1 controls pain sensitivity via modulation of DRG neuron excitability. Pain. 2011;152:2384-98 pubmed publisher
    ..We demonstrate here a central role of the transcription factor Smad-interacting protein 1 (Sip1/Zfhx1b/Zeb2), a 2-handed zinc finger DNA-binding protein with essential functions in neural crest and forebrain ..
  2. Verstappen G, van Grunsven L, Michiels C, Van de Putte T, Souopgui J, Van Damme J, et al. Atypical Mowat-Wilson patient confirms the importance of the novel association between ZFHX1B/SIP1 and NuRD corepressor complex. Hum Mol Genet. 2008;17:1175-83 pubmed publisher
    Mutations in ZFHX1B cause Mowat-Wilson syndrome (MWS) but the precise mechanisms underlying the aberrant functions of mutant ZFHX1B proteins (also named Smad-interacting protein-1, SIP1) in patients are unknown...
  3. Tylzanowski P, De Valck D, Maes V, Peeters J, Luyten F. Zfhx1a and Zfhx1b mRNAs have non-overlapping expression domains during chick and mouse midgestation limb development. Gene Expr Patterns. 2003;3:39-42 pubmed
    Smad-interacting protein 1 (Zfhx1b, Sip1) and Zfhx1a (deltaEF1) are transcriptional repressors belonging to the family of two-handed zinc finger/homeodomain proteins...
  4. Bracken C, Gregory P, Kolesnikoff N, Bert A, Wang J, Shannon M, et al. A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. Cancer Res. 2008;68:7846-54 pubmed publisher
    ..in specifying the epithelial phenotype by preventing expression of the transcription repressors, ZEB1/deltaEF1 and SIP1/ZEB2. We show here that miR-200a, miR-200b, and the related miR-429 are all encoded on a 7...
  5. Shirakihara T, Saitoh M, Miyazono K. Differential regulation of epithelial and mesenchymal markers by deltaEF1 proteins in epithelial mesenchymal transition induced by TGF-beta. Mol Biol Cell. 2007;18:3533-44 pubmed
    ..In this study, we show that expression of the deltaEF1 family proteins, deltaEF1 (ZEB1) and SIP1, is gradually increased by TGF-beta with expression profiles reciprocal to that of E-cadherin...
  6. Das S, Becker B, Hoffmann F, Mertz J. Complete reversal of epithelial to mesenchymal transition requires inhibition of both ZEB expression and the Rho pathway. BMC Cell Biol. 2009;10:94 pubmed publisher
    ..explore the molecular basis underlying EMT reversal, we also targeted the transcriptional repressors ZEB1 and ZEB2/SIP1. Decreasing ZEB1 and ZEB2 expression in mouse mammary gland cells with shRNAs was sufficient to up-regulate ..
  7. Cacheux V, Dastot Le Moal F, Kaariainen H, Bondurand N, Rintala R, Boissier B, et al. Loss-of-function mutations in SIP1 Smad interacting protein 1 result in a syndromic Hirschsprung disease. Hum Mol Genet. 2001;10:1503-10 pubmed
    ..SIP1 encodes Smad interacting protein 1, a new member of the delta EF1/Zfh-1 family of two-handed zinc finger/homeodomain transcription factors...
  8. Tatari M, De Craene B, Soen B, Taminau J, Vermassen P, Goossens S, et al. ZEB2-transgene expression in the epidermis compromises the integrity of the epidermal barrier through the repression of different tight junction proteins. Cell Mol Life Sci. 2014;71:3599-609 pubmed publisher
    ..In order to gain a better understanding of the functional role of ZEB2 in epidermal homeostasis, we generated a mouse model with conditional overexpression of Zeb2 in the epidermis...
  9. Weng Q, Chen Y, Wang H, Xu X, Yang B, He Q, et al. Dual-mode modulation of Smad signaling by Smad-interacting protein Sip1 is required for myelination in the central nervous system. Neuron. 2012;73:713-28 pubmed publisher
    ..opposing regulators of myelination are functionally linked by the Olig1/2 common target Smad-interacting protein-1 (Sip1). We demonstrate that Sip1 is an essential modulator of CNS myelination...

More Information

Publications62

  1. Goossens S, Janzen V, Bartunkova S, Yokomizo T, Drogat B, Crisan M, et al. The EMT regulator Zeb2/Sip1 is essential for murine embryonic hematopoietic stem/progenitor cell differentiation and mobilization. Blood. 2011;117:5620-30 pubmed publisher
    Zeb2 (Sip1/Zfhx1b) is a member of the zinc-finger E-box-binding (ZEB) family of transcriptional repressors previously demonstrated to regulate epithelial-to-mesenchymal transition (EMT) processes during embryogenesis and tumor progression...
  2. Dang L, Tropepe V. FGF dependent regulation of Zfhx1b gene expression promotes the formation of definitive neural stem cells in the mouse anterior neurectoderm. Neural Dev. 2010;5:13 pubmed publisher
    ..Here we tested whether FGF and Wnt signaling pathways can regulate Zfhx1b expression to control early neural stem cell development...
  3. Korpal M, Lee E, Hu G, Kang Y. The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem. 2008;283:14910-4 pubmed publisher
    ..or as clusters in NMuMG cells hindered EMT by enhancing E-cadherin expression through direct targeting of ZEB1 and ZEB2, which encode transcriptional repressors of E-cadherin...
  4. Higashi Y, Maruhashi M, Nelles L, Van de Putte T, Verschueren K, Miyoshi T, et al. Generation of the floxed allele of the SIP1 (Smad-interacting protein 1) gene for Cre-mediated conditional knockout in the mouse. Genesis. 2002;32:82-4 pubmed
  5. Dang L, Wong L, Tropepe V. Zfhx1b induces a definitive neural stem cell fate in mouse embryonic stem cells. Stem Cells Dev. 2012;21:2838-51 pubmed publisher
    ..promotes definitive neural stem cell (NSC) development through the upregulation of the transcription factor Zfhx1b. Here, we asked whether Zfhx1b is similarly required during neural lineage development of embryonic stem (ES) ..
  6. Van de Putte T, Maruhashi M, Francis A, Nelles L, Kondoh H, Huylebroeck D, et al. Mice lacking ZFHX1B, the gene that codes for Smad-interacting protein-1, reveal a role for multiple neural crest cell defects in the etiology of Hirschsprung disease-mental retardation syndrome. Am J Hum Genet. 2003;72:465-70 pubmed
    Recently, mutations in ZFHX1B, the gene that encodes Smad-interacting protein-1 (SIP1), were found to be implicated in the etiology of a dominant form of Hirschsprung disease-mental retardation syndrome in humans...
  7. Verschueren K, Remacle J, Collart C, Kraft H, Baker B, Tylzanowski P, et al. SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5'-CACCT sequences in candidate target genes. J Biol Chem. 1999;274:20489-98 pubmed
    ..We describe a novel Smad-interacting protein, SIP1, which was identified using the yeast two-hybrid system...
  8. Caudell D, Harper D, Novak R, Pierce R, Slape C, Wolff L, et al. Retroviral insertional mutagenesis identifies Zeb2 activation as a novel leukemogenic collaborating event in CALM-AF10 transgenic mice. Blood. 2010;115:1194-203 pubmed publisher
    ..polymerase chain reaction was used to identify retroviral insertions at 19 common insertion sites, including Zeb2, Nf1, Mn1, Evi1, Ift57, Mpl, Plag1, Kras, Erg, Vav1, and Gata1...
  9. van den Berghe V, Stappers E, Vandesande B, Dimidschstein J, Kroes R, Francis A, et al. Directed migration of cortical interneurons depends on the cell-autonomous action of Sip1. Neuron. 2013;77:70-82 pubmed publisher
    ..We found that Sip1 (Zfhx1b, Zeb2), a transcription factor enriched in migrating cortical interneurons, is required for their proper ..
  10. Hellemans J, Preobrazhenska O, Willaert A, Debeer P, Verdonk P, Costa T, et al. Loss-of-function mutations in LEMD3 result in osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis. Nat Genet. 2004;36:1213-8 pubmed
    ..XMAN1, the Xenopus laevis ortholog, antagonizes BMP signaling during embryogenesis. In this study, LEMD3 interacted with BMP and activin-TGFbeta receptor-activated Smads and antagonized both signaling pathways in human cells...
  11. Perez Millan M, Brinkmeier M, Mortensen A, Camper S. PROP1 triggers epithelial-mesenchymal transition-like process in pituitary stem cells. elife. 2016;5: pubmed publisher
    ..reveals that PROP1 binds to genes expressed in epithelial cells like Claudin 23, and to EMT inducer genes like Zeb2, Notch2 and Gli2. Zeb2 activation appears to be a key step in the EMT process...
  12. Nelles L, Van de Putte T, van Grunsven L, Huylebroeck D, Verschueren K. Organization of the mouse Zfhx1b gene encoding the two-handed zinc finger repressor Smad-interacting protein-1. Genomics. 2003;82:460-9 pubmed
    ..Recently, mutations in the human SIP1 gene (ZFHX1B) have been implicated in Hirschsprung disease...
  13. Manthey A, Terrell A, Wang Y, Taube J, Yallowitz A, Duncan M. The Zeb proteins ?EF1 and Sip1 may have distinct functions in lens cells following cataract surgery. Invest Ophthalmol Vis Sci. 2014;55:5445-55 pubmed publisher
    ..Here, we used a murine cataract surgery model to investigate the role of the Zeb proteins, Smad interacting protein 1 (Sip1) and ?-crystallin enhancer-binding factor 1 (?EF1), during PCO...
  14. Parthasarathy S, Srivatsa S, Nityanandam A, Tarabykin V. Ntf3 acts downstream of Sip1 in cortical postmitotic neurons to control progenitor cell fate through feedback signaling. Development. 2014;141:3324-30 pubmed publisher
    ..We showed that Sip1 (Zeb2), a transcriptional repressor, controls this feedback signaling...
  15. Yoshimoto A, Saigou Y, Higashi Y, Kondoh H. Regulation of ocular lens development by Smad-interacting protein 1 involving Foxe3 activation. Development. 2005;132:4437-48 pubmed
    b>Sip1, a Smad-binding zinc-finger homeodomain transcription factor, has essential functions in embryonic development, but its role in individual tissues and the significance of its interaction with Smad proteins have not been fully ..
  16. Pradier B, Jeub M, Markert A, Mauer D, Tolksdorf K, Van de Putte T, et al. Smad-interacting protein 1 affects acute and tonic, but not chronic pain. Eur J Pain. 2014;18:249-57 pubmed publisher
    Smad-interacting protein 1 (also named Zeb2 and Zfhx1b) is a transcription factor that plays an important role in neuronal development and, when mutated, causes Mowat-Wilson syndrome (MWS)...
  17. Takagi T, Nishizaki Y, Matsui F, Wakamatsu N, Higashi Y. De novo inbred heterozygous Zeb2/Sip1 mutant mice uniquely generated by germ-line conditional knockout exhibit craniofacial, callosal and behavioral defects associated with Mowat-Wilson syndrome. Hum Mol Genet. 2015;24:6390-402 pubmed publisher
    Mowat-Wilson syndrome (MOWS) is caused by de novo heterozygous mutation at ZEB2 (SIP1, ZFHX1B) gene, and exhibit moderate to severe intellectual disability (ID), a characteristic facial appearance, epilepsy and other congenital anomalies...
  18. Leshem O, Madar S, Kogan Sakin I, Kamer I, Goldstein I, Brosh R, et al. TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model. PLoS ONE. 2011;6:e21650 pubmed publisher
    ..analysis that revealed a distinct EMT expression program, including up-regulation of the EMT facilitators, ZEB1 and ZEB2, and down-regulation of the epithelial marker CDH1(E-Cadherin)...
  19. Kim H, Kang K, Ekram M, Roh T, Kim J. Aebp2 as an epigenetic regulator for neural crest cells. PLoS ONE. 2011;6:e25174 pubmed publisher
    ..Taken together, these results suggest that Aebp2 may regulate the migration and development of the neural crest cells through the PRC2-mediated epigenetic mechanism. ..
  20. Ohayon D, Ventéo S, Sonrier C, Lafon P, Garcès A, Valmier J, et al. Zeb family members and boundary cap cells underlie developmental plasticity of sensory nociceptive neurons. Dev Cell. 2015;33:343-50 pubmed publisher
  21. Omilusik K, Best J, Yu B, Goossens S, Weidemann A, Nguyen J, et al. Transcriptional repressor ZEB2 promotes terminal differentiation of CD8+ effector and memory T cell populations during infection. J Exp Med. 2015;212:2027-39 pubmed publisher
    b>ZEB2 is a multi-zinc-finger transcription factor known to play a significant role in early neurogenesis and in epithelial-mesenchymal transition-dependent tumor metastasis...
  22. Dominguez C, Amezquita R, Guan T, Marshall H, Joshi N, Kleinstein S, et al. The transcription factors ZEB2 and T-bet cooperate to program cytotoxic T cell terminal differentiation in response to LCMV viral infection. J Exp Med. 2015;212:2041-56 pubmed publisher
    ..We find that, at high concentrations, T-bet induced expression of Zeb2 mRNA, which then triggered CTLs to adopt terminally differentiated states...
  23. He L, Yu K, Lu F, Wang J, Wu L, Zhao C, et al. Transcriptional Regulator ZEB2 Is Essential for Bergmann Glia Development. J Neurosci. 2018;38:1575-1587 pubmed publisher
    ..In this report, we show that ZEB2 (aka, SIP1 or ZFHX1B), a Mowat-Wilson syndrome-associated transcriptional regulator, is highly expressed in Bergmann glia, but hardly ..
  24. Barbu E, Zhang J, Berenstein E, Groves J, Parks L, Siraganian R. The transcription factor Zeb2 regulates signaling in mast cells. J Immunol. 2012;188:6278-86 pubmed publisher
    ..We found that Zeb2 (also named Sip1, Zfhx1b), a zinc finger transcription factor, regulates both early and late mast cell responses...
  25. Vohra B, Planer W, Armon J, Fu M, Jain S, Heuckeroth R. Reduced endothelin converting enzyme-1 and endothelin-3 mRNA in the developing bowel of male mice may increase expressivity and penetrance of Hirschsprung disease-like distal intestinal aganglionosis. Dev Dyn. 2007;236:106-17 pubmed
    ..5 male RetDN heterozygous mouse gut explants in organ culture significantly increased the rate of ENS precursor migration through the bowel. ..
  26. Kumar P, Kotlyarevska K, Dejkhmaron P, Reddy G, Lu C, Bhojani M, et al. Growth hormone (GH)-dependent expression of a natural antisense transcript induces zinc finger E-box-binding homeobox 2 (ZEB2) in the glomerular podocyte: a novel action of gh with implications for the pathogenesis of diabetic nephropathy. J Biol Chem. 2010;285:31148-56 pubmed publisher
    ..RT-quantitative PCR analyses of immortalized human podocytes and identified zinc finger E-box-binding homeobox 2 (ZEB2) to be up-regulated in a GH dose- and time-dependent manner...
  27. Brinkmeier M, Davis S, Carninci P, MacDonald J, Kawai J, Ghosh D, et al. Discovery of transcriptional regulators and signaling pathways in the developing pituitary gland by bioinformatic and genomic approaches. Genomics. 2009;93:449-60 pubmed publisher
    ..These genes are exciting candidates for regulators of pituitary development and function. ..
  28. Hegarty S, Wyatt S, Howard L, Stappers E, Huylebroeck D, Sullivan A, et al. Zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation. Sci Rep. 2017;7:8568 pubmed publisher
    ..Here we show that the transcription factor Zeb2 cell-autonomously represses Smad signalling to limit midbrain dopaminergic axon growth and target innervation...
  29. Renthal N, Chen C, Williams K, Gerard R, Prange Kiel J, Mendelson C. miR-200 family and targets, ZEB1 and ZEB2, modulate uterine quiescence and contractility during pregnancy and labor. Proc Natl Acad Sci U S A. 2010;107:20828-33 pubmed publisher
    ..and humans as well as two coordinately down-regulated targets, zinc finger E-box binding homeobox proteins ZEB1 and ZEB2, which act as transcriptional repressors...
  30. Li H, Mar B, Zhang H, Puram R, Vazquez F, Weir B, et al. The EMT regulator ZEB2 is a novel dependency of human and murine acute myeloid leukemia. Blood. 2017;129:497-508 pubmed publisher
    ..of these interference RNA screens and additional gene expression data, we identified the transcription factor ZEB2 as a novel AML dependency...
  31. Alfonso J, Penkert H, Duman C, Zuccotti A, Monyer H. Downregulation of Sphingosine 1-Phosphate Receptor 1 Promotes the Switch from Tangential to Radial Migration in the OB. J Neurosci. 2015;35:13659-72 pubmed publisher
    ..Finally, we also propose adhesion molecules that act downstream of S1P1 and initiate the transition from tangential chain migration to individual radial migration outside of the stream. ..
  32. Dykxhoorn D, Wu Y, Xie H, Yu F, Lal A, Petrocca F, et al. miR-200 enhances mouse breast cancer cell colonization to form distant metastases. PLoS ONE. 2009;4:e7181 pubmed publisher
    ..family was previously shown to promote epithelial characteristics by inhibiting the transcriptional repressor Zeb2 and thereby enhancing E-cadherin expression. We confirmed these findings in these cells...
  33. Chen A, Donovan A, Ned Sykes R, Andrews N. Noncanonical role of transferrin receptor 1 is essential for intestinal homeostasis. Proc Natl Acad Sci U S A. 2015;112:11714-9 pubmed publisher
    ..Our results implicate Tfr1 in homeostatic maintenance of the intestinal epithelium, acting through a role that is independent of its iron-uptake function. ..
  34. Goossens S, Radaelli E, Blanchet O, Durinck K, Van der Meulen J, Peirs S, et al. ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling. Nat Commun. 2015;6:5794 pubmed publisher
    ..Here we report translocations targeting the zinc finger E-box-binding transcription factor ZEB2 as a recurrent genetic lesion in immature/ETP-ALL...
  35. Branco M, King M, Perez García V, Bogutz A, Caley M, Fineberg E, et al. Maternal DNA Methylation Regulates Early Trophoblast Development. Dev Cell. 2016;36:152-63 pubmed publisher
    ..Our results reveal that maternal DNA methylation controls multiple differentiation-related and physiological processes in trophoblast via both imprinting-dependent and -independent mechanisms. ..
  36. Nishizaki Y, Takagi T, Matsui F, Higashi Y. SIP1 expression patterns in brain investigated by generating a SIP1-EGFP reporter knock-in mouse. Genesis. 2014;52:56-67 pubmed publisher
    A loss of function of SIP1 (Smad interacting protein 1) in the mouse as well as in human of Mowat-Wilson syndrome results in severe and multiple defects in neural tissue development, especially in the brain...
  37. Rosati J, Spallotta F, Nanni S, Grasselli A, Antonini A, Vincenti S, et al. Smad-interacting protein-1 and microRNA 200 family define a nitric oxide-dependent molecular circuitry involved in embryonic stem cell mesendoderm differentiation. Arterioscler Thromb Vasc Biol. 2011;31:898-907 pubmed publisher
    Smad-interacting protein-1 (Sip1/ZEB2) is a transcriptional repressor of the telomerase reverse transcriptase catalytic subunit (Tert) and has recently been identified as a key regulator of embryonic cell fate with a phenotypic effect ..
  38. Srivatsa S, Parthasarathy S, Molnár Z, Tarabykin V. Sip1 downstream Effector ninein controls neocortical axonal growth, ipsilateral branching, and microtubule growth and stability. Neuron. 2015;85:998-1012 pubmed publisher
    b>Sip1 is an important transcription factor that regulates several aspects of CNS development...
  39. Stryjewska A, Dries R, Pieters T, Verstappen G, Conidi A, Coddens K, et al. Zeb2 Regulates Cell Fate at the Exit from Epiblast State in Mouse Embryonic Stem Cells. Stem Cells. 2017;35:611-625 pubmed publisher
    In human embryonic stem cells (ESCs) the transcription factor Zeb2 regulates neuroectoderm versus mesendoderm formation, but it is unclear how Zeb2 affects the global transcriptional regulatory network in these cell-fate decisions...
  40. Li J, Riedt T, Goossens S, Carrillo García C, Szczepanski S, Brandes M, et al. The EMT transcription factor Zeb2 controls adult murine hematopoietic differentiation by regulating cytokine signaling. Blood. 2017;129:460-472 pubmed publisher
    ..Moreover, we detected some previously unknown mutations within the human Zeb2 gene (ZFX1B locus) from patients with myeloid disease...
  41. Shen W, Plachez C, Mongi A, Richards L. Identification of candidate genes at the corticoseptal boundary during development. Gene Expr Patterns. 2006;6:471-81 pubmed
    ..An RNase Protection Assay (RPA) revealed that the expression of G39F8, G24F3 and LZIP increase markedly in the telencephalon at E16 and continue to be expressed until at least P0, during the period when the corpus callosum is forming. ..
  42. Beclin C, Follert P, Stappers E, Barral S, Coré N, de Chevigny A, et al. miR-200 family controls late steps of postnatal forebrain neurogenesis via Zeb2 inhibition. Sci Rep. 2016;6:35729 pubmed publisher
    ..This function is mediated by targeting the transcription factor Zeb2. Interestingly, so far functional interaction between miR-200 and Zeb2 has been exclusively reported in cancer or ..
  43. Wu L, Wang J, Conidi A, Zhao C, Wang H, Ford Z, et al. Zeb2 recruits HDAC-NuRD to inhibit Notch and controls Schwann cell differentiation and remyelination. Nat Neurosci. 2016;19:1060-72 pubmed publisher
    ..Here we demonstrate that zinc-finger E-box-binding homeobox 2 (Zeb2, also called Sip1) transcription factor is a critical intrinsic timer that controls the onset of SC differentiation ..
  44. Britanova O, Alifragis P, Junek S, Jones K, Gruss P, Tarabykin V. A novel mode of tangential migration of cortical projection neurons. Dev Biol. 2006;298:299-311 pubmed
    ..In vitro and in vivo analysis of reeler mutant brains demonstrated that although reeler mutation does not influence tangential migration of interneurons, it affects the tangential migration of cortical projection neurons. ..
  45. Ray H, Niswander L. Grainyhead-like 2 downstream targets act to suppress epithelial-to-mesenchymal transition during neural tube closure. Development. 2016;143:1192-204 pubmed publisher
    ..Thus, GRHL2 promotes the epithelial nature of the NNE during the dynamic events of neural tube formation by both activating key epithelial genes and actively suppressing EMT through novel downstream EMT suppressors. ..
  46. Miyoshi T, Maruhashi M, Van de Putte T, Kondoh H, Huylebroeck D, Higashi Y. Complementary expression pattern of Zfhx1 genes Sip1 and deltaEF1 in the mouse embryo and their genetic interaction revealed by compound mutants. Dev Dyn. 2006;235:1941-52 pubmed
    In mouse embryos, the Zfhx1 transcription factor genes, Sip1 and deltaEF1, are expressed in complementary domains in many tissues...
  47. Roy A, Francius C, Rousso D, Seuntjens E, Debruyn J, Luxenhofer G, et al. Onecut transcription factors act upstream of Isl1 to regulate spinal motoneuron diversification. Development. 2012;139:3109-19 pubmed publisher
    ..Furthermore, we identify Sip1 (Zeb2) as a novel developmental regulator of visceral MN differentiation...
  48. Scott C, Soen B, Martens L, Skrypek N, Saelens W, Taminau J, et al. The transcription factor Zeb2 regulates development of conventional and plasmacytoid DCs by repressing Id2. J Exp Med. 2016;213:897-911 pubmed publisher
    ..Here, we identify the TF zinc finger E box-binding homeobox 2 (Zeb2) to play a crucial role in regulating DC development...
  49. Maruhashi M, Van de Putte T, Huylebroeck D, Kondoh H, Higashi Y. Involvement of SIP1 in positioning of somite boundaries in the mouse embryo. Dev Dyn. 2005;234:332-8 pubmed
    ..This study reports production of somites with roughly half rostro-caudal length in homozygous Sip1 (Smad-interacting protein 1) knockout mouse embryos...
  50. Iwafuchi Doi M, Matsuda K, Murakami K, Niwa H, Tesar P, Aruga J, et al. Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells. Development. 2012;139:3926-37 pubmed publisher
    ..The direct interaction of these factors with enhancers of Otx2, Hesx1 and Sox2 genes was demonstrated. Thus, a combination of regulatory processes that suppresses non-ANP lineages and promotes neural plate development determines the ANP...
  51. Nityanandam A, Parthasarathy S, Tarabykin V. Postnatal subventricular zone of the neocortex contributes GFAP+ cells to the rostral migratory stream under the control of Sip1. Dev Biol. 2012;366:341-56 pubmed publisher
    ..By analyzing a neocortex-specific conditional knockout of the transcriptional repressor Sip1 (Smad-interacting protein 1), we have now identified a novel pool of progenitors located within the dorsal SVZ (..
  52. Batista Brito R, Machold R, Klein C, Fishell G. Gene expression in cortical interneuron precursors is prescient of their mature function. Cereb Cortex. 2008;18:2306-17 pubmed publisher
    ..Moreover, our work has revealed that many of the genes expressed in cortical interneuron precursors have been independently linked to neurological disorders in both mice and humans. ..
  53. Tylzanowski P, Verschueren K, Huylebroeck D, Luyten F. Smad-interacting protein 1 is a repressor of liver/bone/kidney alkaline phosphatase transcription in bone morphogenetic protein-induced osteogenic differentiation of C2C12 cells. J Biol Chem. 2001;276:40001-7 pubmed
    ..One of them, Smad-interacting protein 1 (SIP1), belongs to the family of two-handed zinc finger proteins binding to E2-box sequences present, among others, in ..