Zeb1

Summary

Gene Symbol: Zeb1
Description: zinc finger E-box binding homeobox 1
Alias: 3110032K11Rik, AREB6, BZP, MEB1, Nil2, TCF-8, Tcf18, Tcf8, ZEB, Zfhep, Zfhx1a, Zfx1a, Zfx1ha, [delta]EF1, zinc finger E-box-binding homeobox 1, transcription factor 8, twirler, zinc finger homeobox protein 1a
Species: mouse
Products:     Zeb1

Top Publications

  1. Shirakihara T, Horiguchi K, Miyazawa K, Ehata S, Shibata T, Morita I, et al. TGF-? regulates isoform switching of FGF receptors and epithelial-mesenchymal transition. EMBO J. 2011;30:783-95 pubmed publisher
    ..and subsequently enhanced EMT through the formation of MEK-Erk-dependent complexes of the transcription factor ?EF1/ZEB1 with the transcriptional corepressor CtBP1...
  2. Tylzanowski P, De Valck D, Maes V, Peeters J, Luyten F. Zfhx1a and Zfhx1b mRNAs have non-overlapping expression domains during chick and mouse midgestation limb development. Gene Expr Patterns. 2003;3:39-42 pubmed
    Smad-interacting protein 1 (Zfhx1b, Sip1) and Zfhx1a (deltaEF1) are transcriptional repressors belonging to the family of two-handed zinc finger/homeodomain proteins...
  3. Jin J, Li Q, Higashi Y, Darling D, Ding J. Analysis of Zfhx1a mutant mice reveals palatal shelf contact-independent medial edge epithelial differentiation during palate fusion. Cell Tissue Res. 2008;333:29-38 pubmed publisher
    ..Here, we report that the loss of Zfhx1a function in mice leads to a cleft palate phenotype that is mainly attributable to a delay in palate elevation...
  4. Franklin A, Jetton T, Shelton K, Magnuson M. BZP, a novel serum-responsive zinc finger protein that inhibits gene transcription. Mol Cell Biol. 1994;14:6773-88 pubmed
    We report the fortuitous isolation of cDNA clones encoding a novel zinc finger DNA-binding protein termed BZP. The protein encoded is 114 kDa and contains eight zinc finger motifs, seven of which are present in two clusters at opposite ..
  5. Bracken C, Gregory P, Kolesnikoff N, Bert A, Wang J, Shannon M, et al. A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. Cancer Res. 2008;68:7846-54 pubmed publisher
    ..plays a major role in specifying the epithelial phenotype by preventing expression of the transcription repressors, ZEB1/deltaEF1 and SIP1/ZEB2. We show here that miR-200a, miR-200b, and the related miR-429 are all encoded on a 7...
  6. Takagi T, Moribe H, Kondoh H, Higashi Y. DeltaEF1, a zinc finger and homeodomain transcription factor, is required for skeleton patterning in multiple lineages. Development. 1998;125:21-31 pubmed
    ..Since the skeletal defects were not observed in deltaEF1deltaC727 mice, deltaEF1 bears distinct regulatory activities which are dependent on different domains of the molecule. ..
  7. Liu Y, El Naggar S, Darling D, Higashi Y, Dean D. Zeb1 links epithelial-mesenchymal transition and cellular senescence. Development. 2008;135:579-88 pubmed publisher
    Overexpression of zinc finger E-box binding homeobox transcription factor 1 (Zeb1) in cancer leads to epithelial-to-mesenchymal transition (EMT) and increased metastasis...
  8. Lyon M. Twirler: a mutant affecting the inner ear of the house mouse. J Embryol Exp Morphol. 1958;6:105-16 pubmed
  9. Liu Y, Peng X, Tan J, Darling D, Kaplan H, Dean D. Zeb1 mutant mice as a model of posterior corneal dystrophy. Invest Ophthalmol Vis Sci. 2008;49:1843-9 pubmed publisher
    The zinc finger transcription factor Zeb1 binds to E-box-like sequences and is important for maintaining repression of epithelial specification genes in vivo...

More Information

Publications86

  1. Ponticos M, Partridge T, Black C, Abraham D, Bou Gharios G. Regulation of collagen type I in vascular smooth muscle cells by competition between Nkx2.5 and deltaEF1/ZEB1. Mol Cell Biol. 2004;24:6151-61 pubmed
    ..In contrast, this element was repressed by the binding of the zinc-finger protein deltaEF1/ZEB1. We propose a model of regulation where the activating transcription factor Nkx2...
  2. Eger A, Aigner K, Sonderegger S, Dampier B, Oehler S, Schreiber M, et al. DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells. Oncogene. 2005;24:2375-85 pubmed
    ..RNA interference-mediated downregulation of deltaEF1 in cancer cells was sufficient to derepress E-cadherin expression and restore cell to cell adhesion, suggesting that deltaEF1 is a key player in late stage carcinogenesis. ..
  3. Furusawa T, Moribe H, Kondoh H, Higashi Y. Identification of CtBP1 and CtBP2 as corepressors of zinc finger-homeodomain factor deltaEF1. Mol Cell Biol. 1999;19:8581-90 pubmed
  4. Higashi Y, Moribe H, Takagi T, Sekido R, Kawakami K, Kikutani H, et al. Impairment of T cell development in deltaEF1 mutant mice. J Exp Med. 1997;185:1467-79 pubmed
    ..In contrast to T cells, other hematopoietic lineages appeared to be normal. The data indicated that deltaEF1 is involved in regulation of T cell development at multiple stages. ..
  5. Jethanandani P, Kramer R. Alpha7 integrin expression is negatively regulated by deltaEF1 during skeletal myogenesis. J Biol Chem. 2005;280:36037-46 pubmed
    ..These findings suggest that deltaEF1 has a role in suppressing integrin expression in myoblasts by displacing MYOD and competing for p300/CBP co-activator. ..
  6. Shirakihara T, Saitoh M, Miyazono K. Differential regulation of epithelial and mesenchymal markers by deltaEF1 proteins in epithelial mesenchymal transition induced by TGF-beta. Mol Biol Cell. 2007;18:3533-44 pubmed
    ..In this study, we show that expression of the deltaEF1 family proteins, deltaEF1 (ZEB1) and SIP1, is gradually increased by TGF-beta with expression profiles reciprocal to that of E-cadherin...
  7. Lane P, Searle A, Beechey C, Eicher E. Chromosome 18 of the house mouse. J Hered. 1981;72:409-12 pubmed
    ..They occupy a total genetic length of 35 cM. The positions of the breakpoints of the two reciprocal translocations T(10;18) 18H and T(7;18) 5OH are discussed and shown to be closely linked to the sy locus. ..
  8. Kurima K, Hertzano R, Gavrilova O, Monahan K, Shpargel K, Nadaraja G, et al. A noncoding point mutation of Zeb1 causes multiple developmental malformations and obesity in Twirler mice. PLoS Genet. 2011;7:e1002307 pubmed publisher
    Heterozygous Twirler (Tw) mice develop obesity and circling behavior associated with malformations of the inner ear, whereas homozygous Tw mice have cleft palate and die shortly after birth...
  9. Inuzuka T, Tsuda M, Tanaka S, Kawaguchi H, Higashi Y, Ohba Y. Integral role of transcription factor 8 in the negative regulation of tumor angiogenesis. Cancer Res. 2009;69:1678-84 pubmed publisher
    ..Here, we show that transcription factor 8 (TCF8) is up-regulated in endothelial cells during angiogenesis, acting as a negative regulator...
  10. Liu H, Liu W, Maltby K, Lan Y, Jiang R. Identification and developmental expression analysis of a novel homeobox gene closely linked to the mouse Twirler mutation. Gene Expr Patterns. 2006;6:632-6 pubmed
    The Twirler mutation arose spontaneously and causes inner ear defects in heterozygous and cleft lip and/or cleft palate in homozygous mutant mice, providing a unique animal model for investigating the molecular mechanisms of inner ear ..
  11. Nishimura G, Manabe I, Tsushima K, Fujiu K, Oishi Y, Imai Y, et al. DeltaEF1 mediates TGF-beta signaling in vascular smooth muscle cell differentiation. Dev Cell. 2006;11:93-104 pubmed
    ..It thus appears deltaEF1 mediates SMC differentiation via interaction with SRF and Smad3 during development and in vascular disease. ..
  12. Korpal M, Lee E, Hu G, Kang Y. The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem. 2008;283:14910-4 pubmed publisher
    ..or as clusters in NMuMG cells hindered EMT by enhancing E-cadherin expression through direct targeting of ZEB1 and ZEB2, which encode transcriptional repressors of E-cadherin...
  13. Saykally J, Dogan S, Cleary M, Sanders M. The ZEB1 transcription factor is a novel repressor of adiposity in female mice. PLoS ONE. 2009;4:e8460 pubmed publisher
    ..As the zinc finger E-box binding homeobox 1 (ZEB1) transcription factor is encoded by the TCF8 gene located in that region, and as it influences the differentiation ..
  14. Sekido R, Takagi T, Okanami M, Moribe H, Yamamura M, Higashi Y, et al. Organization of the gene encoding transcriptional repressor deltaEF1 and cross-species conservation of its domains. Gene. 1996;173:227-32 pubmed
    ..cDNA and genomic sequences of the mouse delta EF1 were cloned and compared with the chicken sequence...
  15. Jin J, Tan M, Warner D, Darling D, Higashi Y, Gridley T, et al. Mesenchymal cell remodeling during mouse secondary palate reorientation. Dev Dyn. 2010;239:2110-7 pubmed publisher
    ..Because palate elevation represents a classic example of embryonic tissue re-orientation, our findings here may also shed light on the process of tissue re-orientation in general. ..
  16. Ting C, Kohrman D, Burgess D, Boyle A, Altschuler R, Gholizadeh G, et al. Insertional mutation on mouse chromosome 18 with vestibular and craniofacial abnormalities. Genetics. 1994;136:247-54 pubmed
    ..7 +/- 4.3--Pdgfr. The phenotype and the mapping data suggest that the transgene may be inserted at the Twirler locus...
  17. Sidman R, Conover C, Carson J. Shiverer gene maps near the distal end of chromosome 18 in the house mouse. Cytogenet Cell Genet. 1985;39:241-5 pubmed
    ..Recombination of shimld with twirler (Tw), a marker near the centromere, is 45.7 +/- 4.9%...
  18. Bellon E, Luyten F, Tylzanowski P. delta-EF1 is a negative regulator of Ihh in the developing growth plate. J Cell Biol. 2009;187:685-99 pubmed publisher
    ..In summary, we have identified delta-EF1 as an in vivo negative regulator of Ihh expression in the growth plate. ..
  19. Manthey A, Lachke S, FitzGerald P, Mason R, Scheiblin D, McDonald J, et al. Loss of Sip1 leads to migration defects and retention of ectodermal markers during lens development. Mech Dev. 2014;131:86-110 pubmed publisher
  20. Miyoshi T, Maruhashi M, Van de Putte T, Kondoh H, Huylebroeck D, Higashi Y. Complementary expression pattern of Zfhx1 genes Sip1 and deltaEF1 in the mouse embryo and their genetic interaction revealed by compound mutants. Dev Dyn. 2006;235:1941-52 pubmed
    ..These findings indicate that complex synergistic interactions occur between Zfhx1 transcription factor genes during mouse embryogenesis. ..
  21. McMurtrie E, Barbosa M, Zerial M, Kingsmore S. Rab17 and rab18, small GTPases with specificity for polarized epithelial cells: genetic mapping in the mouse. Genomics. 1997;45:623-5 pubmed
    ..We also discuss some implications of Rab17 and Rab18 mapping, including their candidacy for the mouse mutations ln (leaden), Tw (twirler), and ax (ataxia).
  22. Brabletz S, Lasierra Losada M, Schmalhofer O, Mitschke J, Krebs A, Brabletz T, et al. Generation and characterization of mice for conditional inactivation of Zeb1. Genesis. 2017;55: pubmed publisher
    The multizinc finger containing transcription factor ZEB1 plays crucial roles during various aspects of mammalian development and tumorigenesis...
  23. Messina A, Langlet F, Chachlaki K, Roa J, Rasika S, Jouy N, et al. A microRNA switch regulates the rise in hypothalamic GnRH production before puberty. Nat Neurosci. 2016;19:835-44 pubmed publisher
    ..Two essential components of this switch, miR-200 and miR-155, respectively regulate Zeb1, a repressor of Gnrh transcriptional activators and Gnrh itself, and Cebpb, a nitric oxide-mediated repressor of ..
  24. Jin J, Warner D, Lu Q, Pisano M, Greene R, Ding J. Deciphering TGF-?3 function in medial edge epithelium specification and fusion during mouse secondary palate development. Dev Dyn. 2014;243:1536-43 pubmed publisher
    ..In addition, cytokeratin 6? and 17 are two TGF-?3 downstream target genes in palate medial edge epithelium differentiation. ..
  25. Shin J, Kim E, Cho K, Nakagawa E, Kwon H, Cho S, et al. BMP4 signaling mediates Zeb family in developing mouse tooth. Histochem Cell Biol. 2012;137:791-800 pubmed publisher
    ..Therefore, this study aimed to investigate the expression profiles of Zeb1 and Zeb2 during craniofacial development focusing on mesenchyme of palate, hair follicle, and tooth germ from E12...
  26. Gong S, White N, Sakasegawa A. The Twirler mouse, a model for the study of cleft lip and palate. Arch Oral Biol. 2000;45:87-94 pubmed
    b>Twirler (Tw) is a semidominant mutation in the mouse affecting the embryonic development of the midfacial region. Most heterozygous Tw mice, +/-, become obese at adulthood with a concomitant decrease in fertility...
  27. Yan L, Li Y, Shi Z, Lu X, Ma J, Hu B, et al. The zinc finger E-box-binding homeobox 1 (Zeb1) promotes the conversion of mouse fibroblasts into functional neurons. J Biol Chem. 2017;292:12959-12970 pubmed publisher
    The zinc finger E-box-binding transcription factor Zeb1 plays a pivotal role in the epithelial-mesenchymal transition. Numerous studies have focused on the molecular mechanisms by which Zeb1 contributes to this process...
  28. Sen A, Kumar P, Garg R, Lindsey S, Katakam P, Bloodworth M, et al. Transforming growth factor β1 antagonizes the transcription, expression and vascular signaling of guanylyl cyclase/natriuretic peptide receptor A - role of δEF1. FEBS J. 2016;283:1767-81 pubmed publisher
  29. Williams T, Montoya G, Wu Y, Eddy R, Byers M, Shows T. The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2. Genomics. 1992;14:194-6 pubmed
    The TCF8 gene encodes a zinc finger protein (Nil-2-a). Nil-2-a inhibits T-lymphocyte-specific interleukin 2 (IL2) gene expression by binding to a negative regulatory domain 100 nucleotides 5' of the IL2 transcription start site...
  30. Das S, Becker B, Hoffmann F, Mertz J. Complete reversal of epithelial to mesenchymal transition requires inhibition of both ZEB expression and the Rho pathway. BMC Cell Biol. 2009;10:94 pubmed publisher
    ..To explore the molecular basis underlying EMT reversal, we also targeted the transcriptional repressors ZEB1 and ZEB2/SIP1...
  31. Darling D, Stearman R, Qi Y, Qiu M, Feller J. Expression of Zfhep/deltaEF1 protein in palate, neural progenitors, and differentiated neurons. Gene Expr Patterns. 2003;3:709-17 pubmed
    b>Zfhep/deltaEF1 is essential for embryonic development. We have investigated the expression pattern of Zfhep protein during mouse embryogenesis...
  32. Liu Y, Sánchez Tilló E, Lu X, Huang L, Clem B, Telang S, et al. The ZEB1 transcription factor acts in a negative feedback loop with miR200 downstream of Ras and Rb1 to regulate Bmi1 expression. J Biol Chem. 2014;289:4116-25 pubmed publisher
    ..Ras also induces the EMT transcription factor ZEB1 to trigger tumor invasion and metastasis...
  33. Gu Y, Zhao Y, Zhou Y, Xie Y, Ju P, Long Y, et al. Zeb1 Is a Potential Regulator of Six2 in the Proliferation, Apoptosis and Migration of Metanephric Mesenchyme Cells. Int J Mol Sci. 2016;17: pubmed publisher
    ..It has been reported that Zeb1 regulates the proliferation of mesenchymal cells in mouse embryos...
  34. Yang Y, Ahn Y, Chen Y, Tan X, Guo L, Gibbons D, et al. ZEB1 sensitizes lung adenocarcinoma to metastasis suppression by PI3K antagonism. J Clin Invest. 2014;124:2696-708 pubmed publisher
    ..The transcription factor ZEB1 is a known driver of EMT, and mediators of ZEB1 represent potential therapeutic targets for metastasis suppression...
  35. Manthey A, Terrell A, Wang Y, Taube J, Yallowitz A, Duncan M. The Zeb proteins ?EF1 and Sip1 may have distinct functions in lens cells following cataract surgery. Invest Ophthalmol Vis Sci. 2014;55:5445-55 pubmed publisher
    ..Here, we used a murine cataract surgery model to investigate the role of the Zeb proteins, Smad interacting protein 1 (Sip1) and ?-crystallin enhancer-binding factor 1 (?EF1), during PCO...
  36. Branco M, King M, Perez García V, Bogutz A, Caley M, Fineberg E, et al. Maternal DNA Methylation Regulates Early Trophoblast Development. Dev Cell. 2016;36:152-63 pubmed publisher
    ..Our results reveal that maternal DNA methylation controls multiple differentiation-related and physiological processes in trophoblast via both imprinting-dependent and -independent mechanisms. ..
  37. Bui T, Sequeira J, Wen T, Sola A, Higashi Y, Kondoh H, et al. ZEB1 links p63 and p73 in a novel neuronal survival pathway rapidly induced in response to cortical ischemia. PLoS ONE. 2009;4:e4373 pubmed publisher
    ..We demonstrate here that the transcriptional repressor ZEB1, thought to be involved in regulating the timing and spatial boundaries of basic-Helix-Loop-Helix transactivator-..
  38. Chan A, van Oers N, Tran A, Turka L, Law C, Ryan J, et al. Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling. J Immunol. 1994;152:4758-66 pubmed
    ..Thus, the differential expression of these kinases suggests the possibility of different roles for ZAP-70 and Syk in TCR signaling and thymic development. ..
  39. Liu Y, Lu X, Huang L, Wang W, Jiang G, Dean K, et al. Different thresholds of ZEB1 are required for Ras-mediated tumour initiation and metastasis. Nat Commun. 2014;5:5660 pubmed publisher
    Ras pathway mutation is frequent in carcinomas where it induces expression of the transcriptional repressor ZEB1. Although ZEB1 is classically linked to epithelial-mesenchymal transition and tumour metastasis, it has an emerging second ..
  40. Ohayon D, Ventéo S, Sonrier C, Lafon P, Garcès A, Valmier J, et al. Zeb family members and boundary cap cells underlie developmental plasticity of sensory nociceptive neurons. Dev Cell. 2015;33:343-50 pubmed publisher
    ..We show here that transgenic mice expressing a Zeb1/2 dominant-negative form (DBZEB) exhibit reduced numbers of nociceptors and altered pain sensitivity...
  41. Settle S, Rountree R, Sinha A, Thacker A, Higgins K, Kingsley D. Multiple joint and skeletal patterning defects caused by single and double mutations in the mouse Gdf6 and Gdf5 genes. Dev Biol. 2003;254:116-30 pubmed
  42. Kolesnikoff N, Attema J, Roslan S, Bert A, Schwarz Q, Gregory P, et al. Specificity protein 1 (Sp1) maintains basal epithelial expression of the miR-200 family: implications for epithelial-mesenchymal transition. J Biol Chem. 2014;289:11194-205 pubmed publisher
    ..EMT can be mediated by activation of the ZEB1 and ZEB2 (ZEB) transcription factors, which repress miR-200 expression via a self-reinforcing double negative ..
  43. Mathow D, Chessa F, Rabionet M, Kaden S, Jennemann R, Sandhoff R, et al. Zeb1 affects epithelial cell adhesion by diverting glycosphingolipid metabolism. EMBO Rep. 2015;16:321-31 pubmed publisher
    This study proposes that the transcription factor Zeb1 modulates epithelial cell adhesion by diverting glycosphingolipid metabolism...
  44. Gubelmann C, Schwalie P, Raghav S, Röder E, Delessa T, Kiehlmann E, et al. Identification of the transcription factor ZEB1 as a central component of the adipogenic gene regulatory network. elife. 2014;3:e03346 pubmed publisher
    ..We identified 22 novel pro-adipogenic TFs and characterized the top ranking TF, ZEB1, as being essential for adipogenesis both in vitro and in vivo...
  45. Fontemaggi G, Gurtner A, Damalas A, Costanzo A, Higashi Y, Sacchi A, et al. deltaEF1 repressor controls selectively p53 family members during differentiation. Oncogene. 2005;24:7273-80 pubmed
    ..Ectopic expression of the transcriptional repressor deltaEF1/ZEB/zfhx1a counteracts MyoD/Myf5- or MyoD/Myf6-mediated transcriptional activation of p73...
  46. Guo W, Benlhabib H, Mendelson C. The MicroRNA 29 Family Promotes Type II Cell Differentiation in Developing Lung. Mol Cell Biol. 2016;36:2141 pubmed publisher
    ..Together, these findings identify miR-29 family members as TTF-1-driven mediators of SP-A expression and type II cell differentiation through repression of TGF-β signaling. ..
  47. Liu M, Su M, Lyons G, Bodmer R. Functional conservation of zinc-finger homeodomain gene zfh1/SIP1 in Drosophila heart development. Dev Genes Evol. 2006;216:683-93 pubmed publisher
  48. Sánchez Tilló E, de Barrios O, Siles L, Amendola P, Darling D, Cuatrecasas M, et al. ZEB1 Promotes invasiveness of colorectal carcinoma cells through the opposing regulation of uPA and PAI-1. Clin Cancer Res. 2013;19:1071-82 pubmed publisher
    ..A key activator of this process is the ZEB1 transcription factor, which is induced in invading cancer cells by canonical Wnt signaling (?-catenin/TCF4)...
  49. Lane P, Eicher E. Location of plucked (pk) on chromosome 18 of the mouse. J Hered. 1985;76:476-7 pubmed
    ..The Robertsonian translocation Rb(7.18)9Lub was found to suppress crossing over in the proximal half of this chromosome. ..
  50. Liu Y, Xin Y, Ye F, Wang W, Lu Q, Kaplan H, et al. Taz-tead1 links cell-cell contact to zeb1 expression, proliferation, and dedifferentiation in retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2010;51:3372-8 pubmed publisher
    ..authors provide evidence that Taz and its coactivator, Tead1, regulate expression of the EMT transcription factor Zeb1 to control RPE cell proliferation and differentiation. METHODS...
  51. Renthal N, Chen C, Williams K, Gerard R, Prange Kiel J, Mendelson C. miR-200 family and targets, ZEB1 and ZEB2, modulate uterine quiescence and contractility during pregnancy and labor. Proc Natl Acad Sci U S A. 2010;107:20828-33 pubmed publisher
    ..mice and humans as well as two coordinately down-regulated targets, zinc finger E-box binding homeobox proteins ZEB1 and ZEB2, which act as transcriptional repressors...
  52. Ravanpay A, Hansen S, Olson J. Transcriptional inhibition of REST by NeuroD2 during neuronal differentiation. Mol Cell Neurosci. 2010;44:178-89 pubmed publisher
    ..related bHLH transcription factors induce neuronal differentiation, REST represses neuronal differentiation, and Zfhx1a prevents myogenic gene expression. We demonstrate that NeuroD2 suppresses REST during differentiation in culture...
  53. Liu Y, Ye F, Li Q, Tamiya S, Darling D, Kaplan H, et al. Zeb1 represses Mitf and regulates pigment synthesis, cell proliferation, and epithelial morphology. Invest Ophthalmol Vis Sci. 2009;50:5080-8 pubmed publisher
    ..b>Zeb1 represses epithelial specification genes to enforce epithelial-mesenchymal phenotypic boundaries during development,..
  54. Hasuwa H, Ueda J, Ikawa M, Okabe M. miR-200b and miR-429 function in mouse ovulation and are essential for female fertility. Science. 2013;341:71-3 pubmed publisher
    ..are strongly expressed in the pituitary gland, where they suppress expression of the transcriptional repressor ZEB1. Eliminating these miRNAs, in turn, inhibits luteinizing hormone (LH) synthesis by repressing transcription of its ?..
  55. Kudo S, Saito H, Motoyama S, Sasaki T, Imai K, Konno H, et al. C-reactive protein inhibits expression of N-cadherin and ZEB-1 in murine colon adenocarcinoma. Tumour Biol. 2015;36:7035-43 pubmed publisher
    ..01), a mesenchymal marker of EMT, and ZEB-1, an EMT-related transcription factor (p < 0.01)...
  56. Michalides R, Verstraeten R, Shen F, Hilgers J. Characterization and chromosomal distribution of endogenous mouse mammary tumor viruses of European mouse strains STS/A and GR/A. Virology. 1985;142:278-90 pubmed
    ..R. Callahan, D. Gallahan, and Ch. Kozak (1984), J. Virol. 49, 1005-1008). GR and GR.Mtv-2 furthermore contain two incomplete MMTV proviral elements, one of which is also present in STS/A. ..
  57. Hertzano R, Elkon R, Kurima K, Morrisson A, Chan S, Sallin M, et al. Cell type-specific transcriptome analysis reveals a major role for Zeb1 and miR-200b in mouse inner ear morphogenesis. PLoS Genet. 2011;7:e1002309 pubmed publisher
    ..Furthermore, we detected a misregulation of the ZEB1 pathway in the inner ear of Twirler mice, which manifest, among other phenotypes, malformations of the auditory and vestibular labyrinth...
  58. Jin J, Warner D, Ding J. Regional divergence of palate medial edge epithelium along the anterior to posterior axis. Int J Dev Biol. 2014;58:713-7 pubmed publisher
    ..Mouse palate medial edge epithelium along the A-P axis can be divided into different regions according to the differential response to the loss of TGF-beta3. ..
  59. Denecker G, Vandamme N, Akay O, Koludrovic D, Taminau J, Lemeire K, et al. Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression. Cell Death Differ. 2014;21:1250-61 pubmed publisher
    ..several epithelial-to-mesenchymal (EMT) transcription factors, such as zinc finger E-box binding protein 1 (ZEB1) and ZEB2, have been implicated in neural crest cell biology, little is known about their role in melanocyte ..
  60. Brabletz S, Bajdak K, Meidhof S, Burk U, Niedermann G, Firat E, et al. The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells. EMBO J. 2011;30:770-82 pubmed publisher
    ..Nevertheless, mutations in Notch pathway components are rare in solid tumours. ZEB1 is an activator of an epithelial-mesenchymal transition (EMT) and has crucial roles in tumour progression towards ..
  61. Sabourin J, Ackema K, Ohayon D, Guichet P, Perrin F, Garces A, et al. A mesenchymal-like ZEB1(+) niche harbors dorsal radial glial fibrillary acidic protein-positive stem cells in the spinal cord. Stem Cells. 2009;27:2722-33 pubmed publisher
    ..mesenchymal traits such as expression of epithelial-mesenchymal-transition zinc finger E-box-binding protein 1 (ZEB1) transcription factor and smooth muscle actin. We found ZEB1 to be essential for neural stem cell survival in vitro...
  62. Gong S. Characterization of olfactory nerve abnormalities in Twirler mice. Differentiation. 2001;69:58-65 pubmed
    ..We characterized the defects in the nasal cavity and olfactory nervous supply of Twirler (Tw) mice by histological and immunohistochemical means...
  63. Kato M, Zhang J, Wang M, Lanting L, Yuan H, Rossi J, et al. MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors. Proc Natl Acad Sci U S A. 2007;104:3432-7 pubmed
    ..These results uncover a role for miRs in the kidney and DN in controlling TGF-beta-induced Col1a2 expression by down-regulating E-box repressors. ..
  64. Wang Y, Bu F, Royer C, Serres S, Larkin J, Soto M, et al. ASPP2 controls epithelial plasticity and inhibits metastasis through β-catenin-dependent regulation of ZEB1. Nat Cell Biol. 2014;16:1092-104 pubmed publisher
    ..ASPP2 prevents β-catenin from transactivating ZEB1, directly by forming an ASPP2-β-catenin-E-cadherin ternary complex and indirectly by inhibiting β-catenin's N-..
  65. Almaidhan A, Cesario J, Landin Malt A, Zhao Y, Sharma N, Choi V, et al. Neural crest-specific deletion of Ldb1 leads to cleft secondary palate with impaired palatal shelf elevation. BMC Dev Biol. 2014;14:3 pubmed publisher
    ..The function of Ldb1 in the neural crest-derived palatal mesenchyme is essential for normal morphogenesis of the secondary palate. ..
  66. Horiguchi K, Sakamoto K, Koinuma D, Semba K, Inoue A, Inoue S, et al. TGF-? drives epithelial-mesenchymal transition through ?EF1-mediated downregulation of ESRP. Oncogene. 2012;31:3190-201 pubmed publisher
    ..Therefore, ?EF1 family proteins repress the expression of ESRPs to regulate alternative splicing during TGF-?-induced EMT and the progression of breast cancers. ..
  67. van Grunsven L, Michiels C, Van de Putte T, Nelles L, Wuytens G, Verschueren K, et al. Interaction between Smad-interacting protein-1 and the corepressor C-terminal binding protein is dispensable for transcriptional repression of E-cadherin. J Biol Chem. 2003;278:26135-45 pubmed
    deltaEF1 and SIP1 (or Zfhx1a and Zfhx1b, respectively) are the only known members of the vertebrate Zfh1 family of homeodomain/zinc finger-containing proteins...
  68. Song Y, Liu C, Liu X, Trottier J, Beaudoin M, Zhang L, et al. H19 promotes cholestatic liver fibrosis by preventing ZEB1-mediated inhibition of epithelial cell adhesion molecule. Hepatology. 2017;66:1183-1196 pubmed publisher
    ..H19 down-regulated hepatic zinc finger E-box-binding homeobox 1 (ZEB1) but up-regulated epithelial cell adhesion molecule (EpCAM) and SRY (sex determining region Y)-box 9 expression...
  69. Liu Y, Costantino M, Montoya Durango D, Higashi Y, Darling D, Dean D. The zinc finger transcription factor ZFHX1A is linked to cell proliferation by Rb-E2F1. Biochem J. 2007;408:79-85 pubmed
    b>ZFHX1A is expressed in proliferating cells in the developing embryo, and in the present study we provide evidence that its expression is confined to proliferating cells through dependence on the Rb (retinoblastoma protein) family/E2F cell ..
  70. Chen L, Gibbons D, Goswami S, Cortez M, Ahn Y, Byers L, et al. Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression. Nat Commun. 2014;5:5241 pubmed publisher
    ..We show that microRNA-200 (miR-200), a cell-autonomous suppressor of EMT and metastasis, targets PD-L1. Moreover, ZEB1, an EMT activator and transcriptional repressor of miR-200, relieves miR-200 repression of PD-L1 on tumour cells, ..
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    The development of the secondary palate of Twirler (Tw) mice was characterized, and a quantitative coronal plane evaluation of the width and length of the craniofacial regions of homozygous mutant embryos was conducted...
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    ..Taken together, these observations suggest a dual effect of deltaEF1 in promoting breast cancer cell proliferation, by differentially regulating the cell cycle regulatory proteins. ..
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    ..Zinc-finger E-box binding homeobox 1 (ZEB1) is a transcription factor for regulating tumor progression, and contributes to maintenance of CSC-like properties...
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    ..2 revealed that in ATLL cells, transcription factor 8 (TCF8) was frequently disrupted by several mechanisms, including mainly epigenetic dysregulation...
  75. Liu Y, Mukhopadhyay P, Pisano M, Lu X, Huang L, Lu Q, et al. Repression of Zeb1 and hypoxia cause sequential mesenchymal-to-epithelial transition and induction of aid, Oct4, and Dnmt1, leading to immortalization and multipotential reprogramming of fibroblasts in spheres. Stem Cells. 2013;31:1350-62 pubmed publisher
    ..contact signaling in spheres causes downregulation of the epithelial-to-mesenchymal transition transcription factor Zeb1 leading to rapid mesenchymal-to-epithelial transition...
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    ..b>Zeb1 and Zeb2 regulate epithelial cadherin (E-cadherin) and EMT during organogenesis...
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    ..We show here that ZEB1 is expressed in non-stimulated and stimulated T cells and using chromatin immunoprecipitation assays we show that ..