Zbtb16

Summary

Gene Symbol: Zbtb16
Description: zinc finger and BTB domain containing 16
Alias: AI467657, PLZF, Zfp145, zinc finger and BTB domain-containing protein 16, Green's luxoid, luxoid, zinc finger protein 145
Species: mouse
Products:     Zbtb16

Top Publications

  1. Buaas F, Kirsh A, Sharma M, McLean D, Morris J, Griswold M, et al. Plzf is required in adult male germ cells for stem cell self-renewal. Nat Genet. 2004;36:647-52 pubmed
    ..We show here that the classical mouse mutant luxoid affects adult germline stem cell self-renewal...
  2. Costoya J, Hobbs R, Barna M, Cattoretti G, Manova K, Sukhwani M, et al. Essential role of Plzf in maintenance of spermatogonial stem cells. Nat Genet. 2004;36:653-9 pubmed
    ..Here we show that Zfp145, encoding the transcriptional repressor Plzf, has a crucial role in spermatogenesis...
  3. Kovalovsky D, ALONZO E, Uche O, Eidson M, Nichols K, Sant Angelo D. PLZF induces the spontaneous acquisition of memory/effector functions in T cells independently of NKT cell-related signals. J Immunol. 2010;184:6746-55 pubmed publisher
    ..broad complex, tramtrack, bric-a-brac-zinc finger (BTB-ZF) transcription factor promyelocytic leukemia zinc finger (PLZF) is required for development of the characteristic innate/effector functions of NKT cells...
  4. Savage A, Constantinides M, Bendelac A. Promyelocytic leukemia zinc finger turns on the effector T cell program without requirement for agonist TCR signaling. J Immunol. 2011;186:5801-6 pubmed publisher
    ..thought to undergo agonist interactions with CD1d ligands prior to expressing promyelocytic leukemia zinc finger (PLZF), a broad complex, tramtrack, bric-a-brac, poxvirus, and zinc finger transcription factor that directs acquisition ..
  5. Filipponi D, Hobbs R, Ottolenghi S, Rossi P, Jannini E, Pandolfi P, et al. Repression of kit expression by Plzf in germ cells. Mol Cell Biol. 2007;27:6770-81 pubmed
    Male mice lacking expression of Plzf, a DNA sequence-specific transcriptional repressor, show progressive germ cell depletion due to exhaustion of the spermatogonial stem cell population...
  6. ALONZO E, Gottschalk R, Das J, Egawa T, Hobbs R, Pandolfi P, et al. Development of promyelocytic zinc finger and ThPOK-expressing innate gamma delta T cells is controlled by strength of TCR signaling and Id3. J Immunol. 2010;184:1268-79 pubmed publisher
    ..tramtrack and bric a brac-zinc finger transcriptional regulator (BTB-ZF), promyelocytic leukemia zinc finger (PLZF), was recently shown to control the development of the characteristic innate T cell phenotype and effector ..
  7. Chen Z, Brand N, Chen A, Chen S, Tong J, Wang Z, et al. Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia. EMBO J. 1993;12:1161-7 pubmed
    ..The above gene, which we have termed PLZF (for promyelocytic leukaemia zinc finger), encodes a potential transcription factor containing nine zinc finger ..
  8. Watanabe N, Mii S, Asai N, Asai M, Niimi K, Ushida K, et al. The REV7 subunit of DNA polymerase ? is essential for primordial germ cell maintenance in the mouse. J Biol Chem. 2013;288:10459-71 pubmed publisher
    ..5. These findings indicate that Rev7 is essential for PGC maintenance by prevention of apoptotic cell death in the mouse. ..
  9. Barna M, Merghoub T, Costoya J, Ruggero D, Branford M, Bergia A, et al. Plzf mediates transcriptional repression of HoxD gene expression through chromatin remodeling. Dev Cell. 2002;3:499-510 pubmed
    ..Here we demonstrate that Plzf regulates the spatial expression of the AbdB HoxD gene complex by binding to regulatory elements required for ..

More Information

Publications92

  1. Weinreich M, Odumade O, Jameson S, Hogquist K. T cells expressing the transcription factor PLZF regulate the development of memory-like CD8+ T cells. Nat Immunol. 2010;11:709-16 pubmed publisher
    ..was due to interleukin 4 (IL-4) produced by an expanded population of T cells expressing the transcription factor PLZF. The development of innate CD8(+) T cells in mice deficient in the tyrosine kinase Itk and coactivator CBP was also ..
  2. Tachibana M, Nozaki M, Takeda N, Shinkai Y. Functional dynamics of H3K9 methylation during meiotic prophase progression. EMBO J. 2007;26:3346-59 pubmed
    ..This genetic and biochemical evidence strongly suggests that a specific set of H3K9 methyltransferase(s) and demethylase(s) coordinately regulate gametogenesis. ..
  3. Wang N, Frank G, Ding R, Tan Z, Rachakonda A, Pandolfi P, et al. Promyelocytic leukemia zinc finger protein activates GATA4 transcription and mediates cardiac hypertrophic signaling from angiotensin II receptor 2. PLoS ONE. 2012;7:e35632 pubmed publisher
    ..Promyelocytic leukemia zinc finger protein (PLZF) was shown to bind to the AT(2) receptor and transmit the hypertrophic signal...
  4. Raberger J, Schebesta A, Sakaguchi S, Boucheron N, Blomberg K, Berglof A, et al. The transcriptional regulator PLZF induces the development of CD44 high memory phenotype T cells. Proc Natl Acad Sci U S A. 2008;105:17919-24 pubmed publisher
    ..that the BTB (bric-a-brac, tramtrack, broad complex) domain-containing protein promyelocytic leukemia zinc finger (PLZF) is expressed in CD44(hi), but not in CD44(lo), CD4(+) T cells...
  5. Gaber Z, Butler S, Novitch B. PLZF regulates fibroblast growth factor responsiveness and maintenance of neural progenitors. PLoS Biol. 2013;11:e1001676 pubmed publisher
    ..Here, we show that the transcription factor Promyelocytic Leukemia Zinc Finger (PLZF) plays a critical role shaping patterns of neuronal differentiation by gating the expression of Fibroblast Growth ..
  6. Barna M, Hawe N, Niswander L, Pandolfi P. Plzf regulates limb and axial skeletal patterning. Nat Genet. 2000;25:166-72 pubmed
    The promyelocytic leukaemia zinc finger (Plzf) protein (encoded by the gene Zfp145) belongs to the POZ/zinc-finger family of transcription factors...
  7. Kreslavsky T, Savage A, Hobbs R, Gounari F, Bronson R, Pereira P, et al. TCR-inducible PLZF transcription factor required for innate phenotype of a subset of gammadelta T cells with restricted TCR diversity. Proc Natl Acad Sci U S A. 2009;106:12453-8 pubmed publisher
    ..The PLZF transcription factor is essential for the innate phenotype of NKT cells...
  8. Cook M, Gould A, Brand N, Davies J, Strutt P, Shaknovich R, et al. Expression of the zinc-finger gene PLZF at rhombomere boundaries in the vertebrate hindbrain. Proc Natl Acad Sci U S A. 1995;92:2249-53 pubmed
    To investigate the potential biological role(s) of the PLZF gene, discovered as a fusion with the RARA locus in a patient with acute promyelocytic leukemia harboring a t(11;17) chromosomal translocation, we have isolated its murine ..
  9. Savage A, Constantinides M, Han J, Picard D, Martin E, Li B, et al. The transcription factor PLZF directs the effector program of the NKT cell lineage. Immunity. 2008;29:391-403 pubmed publisher
    ..We report that PLZF (promyelocytic leukemia zinc finger, Zbtb16), a member of the BTB/POZ-ZF family of transcription factors that includes the CD4-lineage-specific c-Krox (Th-POK)..
  10. Hobbs R, Seandel M, Falciatori I, Rafii S, Pandolfi P. Plzf regulates germline progenitor self-renewal by opposing mTORC1. Cell. 2010;142:468-79 pubmed publisher
    ..We find that SPCs lacking Plzf, a transcription factor essential for SPC maintenance, have enhanced mTORC1 activity...
  11. Barna M, Pandolfi P, Niswander L. Gli3 and Plzf cooperate in proximal limb patterning at early stages of limb development. Nature. 2005;436:277-81 pubmed
    ..between Gli3 (GLI-Kruppel family member 3) and Plzf (promyelocytic leukaemia zinc finger, also known as Zbtb16 and Zfp145), which is required specifically at very early stages of limb development for all proximal cartilage condensations ..
  12. Ballow D, Meistrich M, Matzuk M, Rajkovic A. Sohlh1 is essential for spermatogonial differentiation. Dev Biol. 2006;294:161-7 pubmed
    ..testes without Sohlh1 still express the testis-specific transcription factors Etv5, Taf4b, Zfp148, and Plzf, overexpress a novel Tohlh2 bHLH transcription factor, but lack LIM homeobox gene Lhx8 and show reduced expression ..
  13. Avantaggiato V, Pandolfi P, Ruthardt M, Hawe N, Acampora D, Pelicci P, et al. Developmental analysis of murine Promyelocyte Leukemia Zinc Finger (PLZF) gene expression: implications for the neuromeric model of the forebrain organization. J Neurosci. 1995;15:4927-42 pubmed
    Promyelocyte Leukemia Zinc Finger (PLZF) is a Kruppel-like zinc finger gene previously identified in a unique case of acute promyelocytic leukemia (APL) as the counterpart of a reciprocal chromosomal translocation involving the retinoic ..
  14. Constantinides M, Picard D, Savage A, Bendelac A. A naive-like population of human CD1d-restricted T cells expressing intermediate levels of promyelocytic leukemia zinc finger. J Immunol. 2011;187:309-15 pubmed publisher
    ..Notably, these cells expressed the NKT lineage-specific transcription promyelocytic leukemia zinc finger (PLZF), indicating a developmental relationship with NKT cells and ruling out the possibility that they were conventional ..
  15. Kovalovsky D, Uche O, Eladad S, Hobbs R, Yi W, Alonzo E, et al. The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions. Nat Immunol. 2008;9:1055-64 pubmed publisher
    ..We show here that iNKT cells specifically expressed the BTB-zinc finger transcriptional regulator PLZF. In the absence of PLZF, iNKT cells developed, but they lacked many features of innate T cells...
  16. O Hagan K, Zhao J, Pryshchep O, Wang C, Phee H. Pak2 Controls Acquisition of NKT Cell Fate by Regulating Expression of the Transcription Factors PLZF and Egr2. J Immunol. 2015;195:5272-84 pubmed publisher
    ..Mechanistically, expression of Egr2 and promyelocytic leukemia zinc finger (PLZF), two key transcription factors for acquiring the NKT cell fate, were markedly diminished in the absence of Pak2...
  17. Rahimpour A, Koay H, Enders A, Clanchy R, Eckle S, Meehan B, et al. Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant T cells using MR1 tetramers. J Exp Med. 2015;212:1095-108 pubmed publisher
    ..Most MAIT cells express the promyelocytic leukemia zinc finger (PLZF) transcription factor, and their development is largely PLZF dependent...
  18. Chattopadhyay A, Tate S, Beswick R, Wagner S, Ko Ferrigno P. A peptide aptamer to antagonize BCL-6 function. Oncogene. 2006;25:2223-33 pubmed
    ..Thus, we have identified a peptide aptamer that affects a function of BCL-6 that is required to prevent differentiation of proliferating B cells. ..
  19. Payne C, Braun R. Histone lysine trimethylation exhibits a distinct perinuclear distribution in Plzf-expressing spermatogonia. Dev Biol. 2006;293:461-72 pubmed
    ..Maintenance of spermatogonial stem cells requires the transcriptional repressor Plzf, but a role for histone methylation has not been established...
  20. Shinomura M, Kishi K, Tomita A, Kawasumi M, Kanezashi H, Kuroda Y, et al. A novel Amh-Treck transgenic mouse line allows toxin-dependent loss of supporting cells in gonads. Reproduction. 2014;148:H1-9 pubmed publisher
  21. Center E, Hunter R, Dodge A. Effects of the luxoid gene (lu) on liver esterase isozymes of the mouse. Genetics. 1967;55:349-58 pubmed
  22. Vincent Fabert C, Platet N, Vandevelde A, Poplineau M, Koubi M, Finetti P, et al. PLZF mutation alters mouse hematopoietic stem cell function and cell cycle progression. Blood. 2016;127:1881-5 pubmed publisher
    ..investigated the role of the transcription factor promyelocytic leukemia zinc finger (plzf) in HSC fate using the Zbtb16(lu/lu)mouse model, which harbors a natural spontaneous mutation that inactivates plzf...
  23. Dutta M, Kraus Z, Gomez Rodriguez J, Hwang S, Cannons J, Cheng J, et al. A role for Ly108 in the induction of promyelocytic zinc finger transcription factor in developing thymocytes. J Immunol. 2013;190:2121-8 pubmed publisher
    ..with Ly108 increased expression of early growth response protein (Egr)-2 and binding of Egr-2 to the promoter of Zbtb16, which encodes PLZF, and resulted in PLZF levels similar to those seen in NKT cells...
  24. Górnikiewicz B, Ronowicz A, Krzemiński M, Sachadyn P. Changes in gene methylation patterns in neonatal murine hearts: Implications for the regenerative potential. BMC Genomics. 2016;17:231 pubmed publisher
    ..This conclusion is supported by the evidence that an increase in DNA methylation in the neonatal murine heart from day 1 to day 7 occurs in the promoter regions of genes playing important roles in cardiovascular system development. ..
  25. Sadate Ngatchou P, Payne C, Dearth A, Braun R. Cre recombinase activity specific to postnatal, premeiotic male germ cells in transgenic mice. Genesis. 2008;46:738-42 pubmed publisher
    ..green fluorescent protein (EGFP) with the protein encoded by the zinc finger and BTB domain containing 16 (Zbtb16) gene, PLZF-a marker for undifferentiated spermatogonia...
  26. Ono R, Masuya M, Nakajima H, Enomoto Y, Miyata E, Nakamura A, et al. Plzf drives MLL-fusion-mediated leukemogenesis specifically in long-term hematopoietic stem cells. Blood. 2013;122:1271-83 pubmed publisher
    ..subpopulation of hematopoietic stem cells (HSCs) through upregulation of promyelocytic leukemia zinc finger (Plzf)...
  27. Gavalas A, Studer M, Lumsden A, Rijli F, Krumlauf R, Chambon P. Hoxa1 and Hoxb1 synergize in patterning the hindbrain, cranial nerves and second pharyngeal arch. Development. 1998;125:1123-36 pubmed
    ..Taken together, our results unveil an extensive functional synergy between Hoxa1 and Hoxb1 that was not anticipated from the phenotypes of the simple null mutants. ..
  28. Gavalas A, Davenne M, Lumsden A, Chambon P, Rijli F. Role of Hoxa-2 in axon pathfinding and rostral hindbrain patterning. Development. 1997;124:3693-702 pubmed
    ..These results point to a novel role for Hoxa-2 in the control of r2-r3 motor axon guidance, and also suggest that its absence may lead to homeotic changes in the alar plates of these rhombomeres. ..
  29. Luria V, Laufer E. Lateral motor column axons execute a ternary trajectory choice between limb and body tissues. Neural Dev. 2007;2:13 pubmed
    ..When making this choice, medial and lateral LMC axons exhibit different and asymmetric relative preferences for these three trajectories. These data redefine the LMC as a motor column that innervates both limb and body tissues. ..
  30. Bördlein A, Scherthan H, Nelkenbrecher C, Molter T, Bösl M, Dippold C, et al. SPOC1 (PHF13) is required for spermatogonial stem cell differentiation and sustained spermatogenesis. J Cell Sci. 2011;124:3137-48 pubmed publisher
    ..Here, we report on the expression of SPOC1 in promyelocytic leukaemia zinc finger (PLZF)-positive undifferentiated spermatogonial stem cells (SSCs) of the mouse testis...
  31. Pirouz M, Pilarski S, Kessel M. A critical function of Mad2l2 in primordial germ cell development of mice. PLoS Genet. 2013;9:e1003712 pubmed publisher
    ..Together, these results demonstrate the potential of Mad2l2 in the regulation of both cell cycle and the epigenetic status. The function of Mad2l2 is essential in PGCs, and thus of high relevance for fertility. ..
  32. Xu B, Hrycaj S, McIntyre D, Baker N, Takeuchi J, Jeannotte L, et al. Hox5 interacts with Plzf to restrict Shh expression in the developing forelimb. Proc Natl Acad Sci U S A. 2013;110:19438-43 pubmed publisher
    ..These findings, along with previous reports showing that point mutations in the Shh limb enhancer lead to similar anterior limb defects, highlight the importance of Shh repression for proper patterning of the vertebrate limb. ..
  33. Lin D, Huang C, Hsieh Y, Lin H, Pao P, Tsou J, et al. Analysis of the interaction between Zinc finger protein 179 (Znf179) and promyelocytic leukemia zinc finger (Plzf). J Biomed Sci. 2013;20:98 pubmed publisher
    ..Using a yeast two-hybrid screen, we have identified promyelocytic leukemia zinc finger (Plzf) as a specific interacting protein of Znf179...
  34. Vanhoutteghem A, Messiaen S, Hervé F, Delhomme B, Moison D, Petit J, et al. The zinc-finger protein basonuclin 2 is required for proper mitotic arrest, prevention of premature meiotic initiation and meiotic progression in mouse male germ cells. Development. 2014;141:4298-310 pubmed publisher
    ..In view of the extreme evolutionary conservation of BNC2, the findings described here are likely to apply to many species. ..
  35. Shin J, Wang S, Deng W, Wu J, Gao J, Zhong X. Mechanistic target of rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function. Proc Natl Acad Sci U S A. 2014;111:E776-83 pubmed publisher
    ..Our findings define an essential role of mTORC1 to direct iNKT-cell lineage development and effector function. ..
  36. Wu R, Zeng Y, Chen Y, Lanz R, Wu M. Temporal-Spatial Establishment of Initial Niche for the Primary Spermatogonial Stem Cell Formation Is Determined by an ARID4B Regulatory Network. Stem Cells. 2017;35:1554-1565 pubmed publisher
    ..Stem Cells 2017;35:1554-1565. ..
  37. Frost R, Hamra F, Richardson J, Qi X, Bassel Duby R, Olson E. MOV10L1 is necessary for protection of spermatocytes against retrotransposons by Piwi-interacting RNAs. Proc Natl Acad Sci U S A. 2010;107:11847-52 pubmed publisher
  38. Koay H, Gherardin N, Enders A, Loh L, Mackay L, Almeida C, et al. A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage. Nat Immunol. 2016;17:1300-1311 pubmed publisher
    ..that generated mature functional MAIT cells was controlled by multiple factors, including the transcription factor PLZF and microbial colonization...
  39. Kato Y, Alavattam K, Sin H, Meetei A, Pang Q, Andreassen P, et al. FANCB is essential in the male germline and regulates H3K9 methylation on the sex chromosomes during meiosis. Hum Mol Genet. 2015;24:5234-49 pubmed publisher
    ..Taken together, these results indicate that FANCB functions at critical stages of germ cell development and reveal a novel function of the FA pathway in the regulation of H3K9 methylation in the germline. ..
  40. Saba R, Wu Q, Saga Y. CYP26B1 promotes male germ cell differentiation by suppressing STRA8-dependent meiotic and STRA8-independent mitotic pathways. Dev Biol. 2014;389:173-81 pubmed publisher
  41. He L, Bhaumik M, Tribioli C, Rego E, Ivins S, Zelent A, et al. Two critical hits for promyelocytic leukemia. Mol Cell. 2000;6:1131-41 pubmed
    ..that always involve the RARalpha gene, which variably fuses to one of several distinct loci, including PML or PLZF (X genes)...
  42. Ivins S, Pemberton K, Guidez F, Howell L, Krumlauf R, Zelent A. Regulation of Hoxb2 by APL-associated PLZF protein. Oncogene. 2003;22:3685-97 pubmed
    The PLZF gene is translocated in a subset of all-trans-retinoic acid resistant acute promyelocytic leukaemia (APL) cases, encodes a DNA binding transcription factor and is expressed highly in haematopoietic progenitor cells as well-..
  43. Pobezinsky L, Etzensperger R, Jeurling S, Alag A, Kadakia T, McCaughtry T, et al. Let-7 microRNAs target the lineage-specific transcription factor PLZF to regulate terminal NKT cell differentiation and effector function. Nat Immunol. 2015;16:517-24 pubmed publisher
    ..We found that let-7 miRNAs targeted Zbtb16 mRNA, which encodes the lineage-specific transcription factor PLZF, to post-transcriptionally regulate PLZF ..
  44. Lovelace D, Gao Z, Mutoji K, Song Y, Ruan J, Hermann B. The regulatory repertoire of PLZF and SALL4 in undifferentiated spermatogonia. Development. 2016;143:1893-906 pubmed publisher
    ..The transcription factors Sal-like 4 (SALL4) and promyelocytic leukemia zinc finger (PLZF; also known as ZBTB16) are known to be required for normal SSC function, but their targets are largely unknown...
  45. Huang X, Andreu Vieyra C, York J, Hatcher R, Lu T, Matzuk M, et al. Inhibitory phosphorylation of separase is essential for genome stability and viability of murine embryonic germ cells. PLoS Biol. 2008;6:e15 pubmed publisher
    ..Our results indicate that inhibitory phosphorylation of separase plays a critical role in the maintenance of sister chromatid cohesion and genome stability in proliferating postmigratory primordial germ cells. ..
  46. Mao A, Constantinides M, Mathew R, Zuo Z, Chen X, Weirauch M, et al. Multiple layers of transcriptional regulation by PLZF in NKT-cell development. Proc Natl Acad Sci U S A. 2016;113:7602-7 pubmed publisher
    The transcription factor PLZF [promyelocytic leukemia zinc finger, encoded by zinc finger BTB domain containing 16 (Zbtb16)] is induced during the development of innate and innate-like lymphocytes to direct their acquisition of a T-helper ..
  47. Olive V, Wagner N, Chan S, Kastner P, Vannetti C, Cuzin F, et al. PU.1 (Sfpi1), a pleiotropic regulator expressed from the first embryonic stages with a crucial function in germinal progenitors. Development. 2007;134:3815-25 pubmed
    ..5 in the embryonic ectoderm. PU.1 therefore appears to play a determinant role in at least two distinct lineages and, given its wide range of expression, possibly in other stem cells. ..
  48. Chatterjee G, Rosner A, Han Y, Zelazny E, Li B, Cardiff R, et al. Acceleration of mouse mammary tumor virus-induced murine mammary tumorigenesis by a p53 172H transgene: influence of FVB background on tumor latency and identification of novel sites of proviral insertion. Am J Pathol. 2002;161:2241-53 pubmed
    ..1). These may represent cellular functions that are likely not deregulated by mutation in p53...
  49. Hobbs R, Fagoonee S, Papa A, Webster K, Altruda F, Nishinakamura R, et al. Functional antagonism between Sall4 and Plzf defines germline progenitors. Cell Stem Cell. 2012;10:284-98 pubmed publisher
    ..In differentiating SPCs, Sall4 levels transiently increase and Sall4 physically interacts with Plzf, a transcription factor exclusively required for adult stem cell maintenance...
  50. Deol M, Green M. Snell's waltzer, a new mutation affecting behaviour and the inner ear in the mouse. Genet Res. 1966;8:339-45 pubmed
  51. Unhavaithaya Y, Hao Y, Beyret E, Yin H, Kuramochi Miyagawa S, Nakano T, et al. MILI, a PIWI-interacting RNA-binding protein, is required for germ line stem cell self-renewal and appears to positively regulate translation. J Biol Chem. 2009;284:6507-19 pubmed publisher
    ..These observations indicate that MILI may positively regulate translation and that such regulation is required for germ line stem cell self-renewal. ..
  52. Constantinides M, Gudjonson H, McDonald B, Ishizuka I, Verhoef P, Dinner A, et al. PLZF expression maps the early stages of ILC1 lineage development. Proc Natl Acad Sci U S A. 2015;112:5123-8 pubmed publisher
    ..have been shown to represent a distinct lineage that originates from a novel promyelocytic leukaemia zinc finger (PLZF)-expressing ILC precursor (ILCP) strictly committed to the ILC1, ILC2, and ILC3 lineages...
  53. Butler S, Bronner M. From classical to current: analyzing peripheral nervous system and spinal cord lineage and fate. Dev Biol. 2015;398:135-46 pubmed publisher
    ..Here, we review how both classical and modern lineage and marker analyses have expanded our knowledge of early peripheral nervous system and spinal cord development. ..
  54. Tschismarov R, Firner S, Gil Cruz C, Göschl L, Boucheron N, Steiner G, et al. HDAC1 controls CD8+ T cell homeostasis and antiviral response. PLoS ONE. 2014;9:e110576 pubmed publisher
  55. Sadler A, Suliman B, Yu L, Yuan X, Wang D, Irving A, et al. The acetyltransferase HAT1 moderates the NF-κB response by regulating the transcription factor PLZF. Nat Commun. 2015;6:6795 pubmed publisher
    ..kinase (CaMK2) to activate histone acetyltransferase-1 (HAT1), which then acetylates the transcriptional regulator PLZF. Acetylation of PLZF promotes the assembly of a repressor complex incorporating HDAC3 and the NF-κB p50 subunit ..
  56. Ikeda R, Yoshida K, Tsukahara S, Sakamoto Y, Tanaka H, Furukawa K, et al. The promyelotic leukemia zinc finger promotes osteoblastic differentiation of human mesenchymal stem cells as an upstream regulator of CBFA1. J Biol Chem. 2005;280:8523-30 pubmed
    ..Twenty-four genes were up-regulated during osteoblastic differentiation in OPLL cells. Zinc finger protein 145 (promyelotic leukemia zinc finger or PLZF) was one of the highly expressed genes during osteoblastic ..
  57. Qiao Y, Zhu L, Sofi H, Lapinski P, Horai R, Mueller K, et al. Development of promyelocytic leukemia zinc finger-expressing innate CD4 T cells requires stronger T-cell receptor signals than conventional CD4 T cells. Proc Natl Acad Sci U S A. 2012;109:16264-9 pubmed publisher
  58. Thomas S, Scanlon S, Griewank K, Constantinides M, Savage A, Barr K, et al. PLZF induces an intravascular surveillance program mediated by long-lived LFA-1-ICAM-1 interactions. J Exp Med. 2011;208:1179-88 pubmed publisher
    ..could be induced in conventional CD4 T cells by the sole expression of promyelocytic leukemia zinc finger (PLZF), a transcription factor specifically expressed in the NKT lineage...
  59. Gordon S, Carty S, Kim J, Zou T, Smith Garvin J, ALONZO E, et al. Requirements for eomesodermin and promyelocytic leukemia zinc finger in the development of innate-like CD8+ T cells. J Immunol. 2011;186:4573-8 pubmed publisher
    ..Taken together, these data shed light on the cell-intrinsic and cell-extrinsic factors that drive CD8(+) ILL differentiation. ..
  60. Mao A, Ishizuka I, Kasal D, Mandal M, Bendelac A. A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development. Nat Commun. 2017;8:863 pubmed publisher
    b>Zbtb16-encoded PLZF is a signature transcription factor (TF) that directs the acquisition of T-helper effector programs during the development of multiple innate lymphocyte lineages, including natural killer T cell, innate lymphoid cell, ..
  61. Petrie K, Guidez F, Zhu J, Howell L, Owen G, Chew Y, et al. Retinoblastoma protein and the leukemia-associated PLZF transcription factor interact to repress target gene promoters. Oncogene. 2008;27:5260-6 pubmed publisher
    Translocations of the retinoic acid receptor-alpha (RARalpha) locus with the promyelocytic leukemia zinc-finger (PLZF) or PML genes lead to expression of oncogenic PLZF-RARalpha or PML-RARalpha fusion proteins, respectively...
  62. Johnson D, Hunt D. Hop-sterile, a mutant gene affecting sperm tail development in the mouse. J Embryol Exp Morphol. 1971;25:223-36 pubmed
  63. Xiao J, Vemula S, Xue Y, Khan M, Kuruvilla K, Marquez Lona E, et al. Motor phenotypes and molecular networks associated with germline deficiency of Ciz1. Exp Neurol. 2016;283:110-20 pubmed publisher
    ..Although CIZ1 deficiency was associated with mild motor abnormalities, germline loss of Ciz1 was not associated with dystonia on the C57BL/6J background. ..
  64. Lu Y, Cao X, Zhang X, Kovalovsky D. PLZF Controls the Development of Fetal-Derived IL-17+Vγ6+ γδ T Cells. J Immunol. 2015;195:4273-81 pubmed publisher
    Expression of promyelocytic leukemia zinc finger (PLZF) protein directs the effector differentiation of invariant NKT (iNKT) cells and IL-4(+) γδ NKT cells...
  65. McDermott J, Sanchez G, Chennathukuzhi V, Blanco G. Green fluorescence protein driven by the Na,K-ATPase ?4 isoform promoter is expressed only in male germ cells of mouse testis. J Assist Reprod Genet. 2012;29:1313-25 pubmed publisher
    ..These findings highlight the exquisite spatial and temporal control of expression exerted by the Atp1a4 promoter on Na,K-ATPase ?4, which is particularly well suited to fulfill the special functions of spermatozoa. ..
  66. Zhao J, Weng X, Bagchi S, Wang C. Polyclonal type II natural killer T cells require PLZF and SAP for their development and contribute to CpG-mediated antitumor response. Proc Natl Acad Sci U S A. 2014;111:2674-9 pubmed publisher
    ..an activated phenotype and are dependent on the transcriptional regulator promyelocytic leukemia zinc finger (PLZF) and the adaptor molecule signaling lymphocyte activation molecule-associated protein (SAP) for their development...
  67. Daniel J, Reynolds A. The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain zinc finger transcription factor. Mol Cell Biol. 1999;19:3614-23 pubmed
    ..include the Drosophila developmental regulators Tramtrak and Bric à brac, and the human oncoproteins BCL-6 and PLZF, which are causally linked to non-Hodgkins' lymphoma and acute promyelocytic leukemia, respectively...
  68. Pereira R, Martinez G, Engel I, Cruz Guilloty F, Barboza B, Tsagaratou A, et al. Jarid2 is induced by TCR signalling and controls iNKT cell maturation. Nat Commun. 2014;5:4540 pubmed publisher
    ..Jarid2 binds to the Zbtb16 locus, which encodes PLZF, and thymocytes lacking Jarid2 show increased PLZF and decreased H3K9me3 levels...
  69. Mu W, Starmer J, Shibata Y, Yee D, Magnuson T. EZH1 in germ cells safeguards the function of PRC2 during spermatogenesis. Dev Biol. 2017;424:198-207 pubmed publisher
    ..Taken together, our findings suggest that the expression level of Ezh1 determines the restoration of H3K27 methylation in the absence of the canonical EZH2-PRC2. ..
  70. Suzuki H, Dann C, Rajkovic A. Generation of a germ cell-specific mouse transgenic CHERRY reporter, Sohlh1-mCherryFlag. Genesis. 2013;51:50-8 pubmed publisher
    ..The Sohlh1-mCherryFlag transgenic mouse provides a unique model to study early germ cell differentiation, as well as in vivo imaging and purification of differentiating germ cells. ..
  71. Mizuhara E, Nakatani T, Minaki Y, Sakamoto Y, Ono Y. Corl1, a novel neuronal lineage-specific transcriptional corepressor for the homeodomain transcription factor Lbx1. J Biol Chem. 2005;280:3645-55 pubmed
    ..Identification of a novel transcriptional corepressor with neuronal subtype-restricted expression might provide insights into the mechanisms of cell fate determination in neurons. ..
  72. Verhoef P, Constantinides M, McDonald B, Urban J, Sperling A, Bendelac A. Intrinsic functional defects of type 2 innate lymphoid cells impair innate allergic inflammation in promyelocytic leukemia zinc finger (PLZF)-deficient mice. J Allergy Clin Immunol. 2016;137:591-600.e1 pubmed publisher
    The transcription factor promyelocytic leukemia zinc finger (PLZF) is transiently expressed during development of type 2 innate lymphoid cells (ILC2s) but is not present at the mature stage...
  73. Peppi M, Kujawa S, Sewell W. A corticosteroid-responsive transcription factor, promyelocytic leukemia zinc finger protein, mediates protection of the cochlea from acoustic trauma. J Neurosci. 2011;31:735-41 pubmed publisher
    ..Heterozygous mutant (luxoid.Zbtb16(LU)/J) mice deficient in PLZF have hearing and responses to acoustic trauma similar to their wild type ..
  74. Davenne M, Maconochie M, Neun R, Pattyn A, Chambon P, Krumlauf R, et al. Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal development in the rostral hindbrain. Neuron. 1999;22:677-91 pubmed
  75. Weng J, Symons M, Singh S. Ethanol-responsive genes (Crtam, Zbtb16, and Mobp) located in the alcohol-QTL region of chromosome 9 are associated with alcohol preference in mice. Alcohol Clin Exp Res. 2009;33:1409-16 pubmed publisher
    ..our group identified cytotoxic and regulatory T-cell molecule (Crtam), zinc finger and BTB domain containing 16 (Zbtb16), and myelin-associated oligodendrocytic basic protein (Mobp) as ethanol-responsive genes in the mouse brain by ..
  76. Mowel W, McCright S, Kotzin J, Collet M, Uyar A, Chen X, et al. Group 1 Innate Lymphoid Cell Lineage Identity Is Determined by a cis-Regulatory Element Marked by a Long Non-coding RNA. Immunity. 2017;47:435-449.e8 pubmed publisher
    ..Thus, non-coding elements responsive to extracellular cues unique to each ILC subset represent a key regulatory layer for controlling the identity and function of ILCs. ..
  77. Green M. The position of luxoid in linkage group II of the mouse. J Hered. 1961;52:297-300 pubmed
  78. Kim Y, Kumar A, Chang C, Pyaram K. Reactive Oxygen Species Regulate the Inflammatory Function of NKT Cells through Promyelocytic Leukemia Zinc Finger. J Immunol. 2017;199:3478-3487 pubmed publisher
    ..The transcription factor promyelocytic leukemia zinc finger (PLZF) seemed to control the ROS levels...
  79. Ghosh A, Holland A, Dogan Y, Yim N, Rao U, Young L, et al. PLZF confers effector functions to donor T cells that preserve graft-versus-tumor effects while attenuating GVHD. Cancer Res. 2013;73:4687-96 pubmed publisher
    ..adoptively transferred conventional T cells expressing the transcription factor promyelocytic leukemia zinc finger (PLZF), which confers effector properties resembling invariant natural killer T cells, such as copious production of ..
  80. Lovasco L, Gustafson E, Seymour K, de Rooij D, Freiman R. TAF4b is required for mouse spermatogonial stem cell development. Stem Cells. 2015;33:1267-76 pubmed publisher
  81. Sadler A, Rossello F, Yu L, Deane J, Yuan X, Wang D, et al. BTB-ZF transcriptional regulator PLZF modifies chromatin to restrain inflammatory signaling programs. Proc Natl Acad Sci U S A. 2015;112:1535-40 pubmed publisher
    ..and Bric-a-brac/poxvirus and zinc finger (BTB/POZ), transcriptional regulator promyelocytic leukemia zinc finger (PLZF) limits the expression of inflammatory gene products...
  82. Hutton J, Roderick T. Linkage analyses using biochemical variants in mice. 3. Linkage relationships of eleven biochemical markers. Biochem Genet. 1970;4:339-50 pubmed
  83. Liu B, Ye B, Yang L, Zhu X, Huang G, Zhu P, et al. Long noncoding RNA lncKdm2b is required for ILC3 maintenance by initiation of Zfp292 expression. Nat Immunol. 2017;18:499-508 pubmed publisher
    ..Therefore, our findings reveal that lncRNAs may represent an additional layer of regulation of ILC development and function. ..