Yy1

Summary

Gene Symbol: Yy1
Description: YY1 transcription factor
Alias: AW488674, NF-E1, transcriptional repressor protein YY1, UCR-motif DNA-binding protein, UCRBP transcription factor, YY-1, Yin Yang 1, delta transcription factor, yin and yang 1
Species: mouse
Products:     Yy1

Top Publications

  1. Wang H, Hertlein E, Bakkar N, Sun H, Acharyya S, Wang J, et al. NF-kappaB regulation of YY1 inhibits skeletal myogenesis through transcriptional silencing of myofibrillar genes. Mol Cell Biol. 2007;27:4374-87 pubmed
    ..In the search for an indirect mediator, the transcriptional repressor YinYang1 (YY1) was identified...
  2. Liu H, Schmidt Supprian M, Shi Y, Hobeika E, Barteneva N, Jumaa H, et al. Yin Yang 1 is a critical regulator of B-cell development. Genes Dev. 2007;21:1179-89 pubmed
    The role of the transcription factor Yin Yang 1 (YY1) in development is largely unknown...
  3. Donohoe M, Zhang X, McGinnis L, Biggers J, Li E, Shi Y. Targeted disruption of mouse Yin Yang 1 transcription factor results in peri-implantation lethality. Mol Cell Biol. 1999;19:7237-44 pubmed
    b>Yin Yang 1 (YY1) is a zinc finger-containing transcription factor and a target of viral oncoproteins. To determine the biological role of YY1 in mammalian development, we generated mice deficient for YY1 by gene targeting...
  4. Erkeland S, Valkhof M, Heijmans Antonissen C, Delwel R, Valk P, Hermans M, et al. The gene encoding the transcriptional regulator Yin Yang 1 (YY1) is a myeloid transforming gene interfering with neutrophilic differentiation. Blood. 2003;101:1111-7 pubmed
    ..4-induced AML frequently harbors virus integrations in the gene encoding the transcription factor Yin Yang 1 (YY1)...
  5. Rhee S, Guerrero Zayas M, Wallingford M, Ortíz Pineda P, Mager J, Tremblay K. Visceral endoderm expression of Yin-Yang1 (YY1) is required for VEGFA maintenance and yolk sac development. PLoS ONE. 2013;8:e58828 pubmed publisher
    Mouse embryos lacking the polycomb group gene member Yin-Yang1 (YY1) die during the peri-implantation stage...
  6. Gregoire S, Karra R, Passer D, Deutsch M, Krane M, Feistritzer R, et al. Essential and unexpected role of Yin Yang 1 to promote mesodermal cardiac differentiation. Circ Res. 2013;112:900-10 pubmed publisher
    ..From 32 candidate transcription factors screened, we found that Yin Yang 1 (YY1), a repressor of sarcomeric gene expression, is present in CPCs in vivo...
  7. Gilthorpe J, Vandromme M, Brend T, Gutman A, Summerbell D, Totty N, et al. Spatially specific expression of Hoxb4 is dependent on the ubiquitous transcription factor NFY. Development. 2002;129:3887-99 pubmed
    ..Enhancer function depends on a motif that contains overlapping binding sites for the transcription factors NFY and YY1. Specific mutations that either abolish or reduce NFY binding show that it is crucial for enhancer activity...
  8. Parija T, Das B. Involvement of YY1 and its correlation with c-myc in NDEA induced hepatocarcinogenesis, its prevention by d-limonene. Mol Biol Rep. 2003;30:41-6 pubmed
    ..To work further in this direction, an attempt has been made here to know the role of YY1 (Yin Yang 1) transcription factor in N-nitrodiethylamine (NDEA) induced hepatocarcinogenesis and its chemoprevention by d-..
  9. Wu S, Hu Y, Liu H, Shi Y. Loss of YY1 impacts the heterochromatic state and meiotic double-strand breaks during mouse spermatogenesis. Mol Cell Biol. 2009;29:6245-56 pubmed publisher
    ..we describe both in vivo RNA interference and genetic mouse knockout studies that identify a critical role for Yin Yang 1 (YY1) in mammalian spermatogenesis...

More Information

Publications62

  1. Shi Y, Lee J, Galvin K. Everything you have ever wanted to know about Yin Yang 1. Biochim Biophys Acta. 1997;1332:F49-66 pubmed
  2. Zabel M, Wheeler W, Weis J, Weis J. Yin Yang 1, Oct1, and NFAT-4 form repeating, cyclosporin-sensitive regulatory modules within the murine CD21 intronic control region. J Immunol. 2002;168:3341-50 pubmed
    ..and supershift analyses reveal the formation of multiple DNA-protein complexes at these sites that include Yin Yang 1, Oct1, and NFAT-4...
  3. Trask M, Tremblay K, Mager J. Yin-Yang1 is required for epithelial-to-mesenchymal transition and regulation of Nodal signaling during mammalian gastrulation. Dev Biol. 2012;368:273-82 pubmed publisher
    The ubiquitously expressed Polycomb Group protein Yin-Yang1 (YY1) is believed to regulate gene expression through direct binding to DNA elements found in promoters or enhancers of target loci...
  4. He Y, Casaccia Bonnefil P. The Yin and Yang of YY1 in the nervous system. J Neurochem. 2008;106:1493-502 pubmed publisher
    The transcription factor Yin Yang 1 (YY1) is a multifunctional protein that can activate or repress gene expression depending on the cellular context. YY1 is ubiquitously expressed and highly conserved between species...
  5. Affar E, Gay F, Shi Y, Liu H, Huarte M, Wu S, et al. Essential dosage-dependent functions of the transcription factor yin yang 1 in late embryonic development and cell cycle progression. Mol Cell Biol. 2006;26:3565-81 pubmed
    Constitutive ablation of the Yin Yang 1 (YY1) transcription factor in mice results in peri-implantation lethality...
  6. Blättler S, Cunningham J, Verdeguer F, Chim H, Haas W, Liu H, et al. Yin Yang 1 deficiency in skeletal muscle protects against rapamycin-induced diabetic-like symptoms through activation of insulin/IGF signaling. Cell Metab. 2012;15:505-17 pubmed publisher
    ..Importantly, skeletal muscle-specific YY1 knockout mice were protected from rapamycin-induced diabetic-like symptoms...
  7. Klar M, Bode J. Enhanceosome formation over the beta interferon promoter underlies a remote-control mechanism mediated by YY1 and YY2. Mol Cell Biol. 2005;25:10159-70 pubmed
    ..5, -2, and -3 kb. Our present study delineates the interplay of factors YY1 and YY2 as it occurs at the sites at -3 kb and -2 kb (otherwise called HS1 and HS2), consistent with the idea that ..
  8. Kim S, Paylor S, Magnuson T, Schumacher A. Juxtaposed Polycomb complexes co-regulate vertebral identity. Development. 2006;133:4957-68 pubmed
    ..EED and BMI1 formed separate biochemical entities with EzH2 and Ring1B, respectively, in mid-gestation embryos, YY1 engaged in both Polycomb complexes...
  9. Safrany G, Perry R. Characterization of the mouse gene that encodes the delta/YY1/NF-E1/UCRBP transcription factor. Proc Natl Acad Sci U S A. 1993;90:5559-63 pubmed
    The mouse gene that encodes the delta transcription factor has been cloned and characterized. This gene spans 23 kb and is composed of five exons and four introns...
  10. Jeon Y, Lee J. YY1 tethers Xist RNA to the inactive X nucleation center. Cell. 2011;146:119-33 pubmed publisher
    ..Here, we define the nucleation center for Xist RNA and show that YY1 docks Xist particles onto the X chromosome...
  11. Kim J, Hinz A, Choo J, Stubbs L, Kim J. YY1 as a controlling factor for the Peg3 and Gnas imprinted domains. Genomics. 2007;89:262-9 pubmed
    ..often harbor tandem arrays of transcription factor binding sites, as demonstrated by the identification of multiple YY1 binding sites within the ICRs of Peg3, Nespas, and Xist/Tsix domains...
  12. de Nigris F, Crudele V, Giovane A, Casamassimi A, Giordano A, Garban H, et al. CXCR4/YY1 inhibition impairs VEGF network and angiogenesis during malignancy. Proc Natl Acad Sci U S A. 2010;107:14484-9 pubmed publisher
    ..The multifunctional Yin Yang 1 (YY1) protein is highly expressed in different types of cancers and may regulate some cancer-related genes...
  13. Huang H, Li X, Liu M, Song T, He Q, Ma C, et al. Transcription factor YY1 promotes adipogenesis via inhibiting CHOP-10 expression. Biochem Biophys Res Commun. 2008;375:496-500 pubmed publisher
    ..In the present study, we reported that FBS induced the expression of YY1, which bound to CHOP-10 promoter via two adjacent YY1-binding sites, suppressing its expression...
  14. Wu S, Shi Y, Mulligan P, Gay F, Landry J, Liu H, et al. A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair. Nat Struct Mol Biol. 2007;14:1165-72 pubmed
    ..We found that loss of the mouse transcription factor YY1 resulted in polyploidy and chromatid aberrations, which are signatures of defects in homologous recombination...
  15. Gordon S, Saleque S, Birshtein B. Yin Yang 1 is a lipopolysaccharide-inducible activator of the murine 3' Igh enhancer, hs3. J Immunol. 2003;170:5549-57 pubmed
    ..We have found that the binding of the transcription factor, Yin Yang 1 (YY1), to hs3 and to the mu E1 site of the intronic enhancer, E mu, is induced in primary splenic B cells after ..
  16. Rylski M, Amborska R, Zybura K, Konopacki F, Wilczynski G, Kaczmarek L. Yin Yang 1 expression in the adult rodent brain. Neurochem Res. 2008;33:2556-64 pubmed publisher
    b>Yin Yang 1 (YY1) is a ubiquitous transcription factor belonging to Polycomb group proteins. Its expression patterns in the adult brain have not been before clearly elucidated...
  17. Donohoe M, Silva S, Pinter S, Xu N, Lee J. The pluripotency factor Oct4 interacts with Ctcf and also controls X-chromosome pairing and counting. Nature. 2009;460:128-32 pubmed publisher
    ..regulatory noncoding RNA genes of the X-inactivation centre, and also complexes with XCI trans-factors, Ctcf and Yy1 (ref. 17), through protein-protein interactions...
  18. Kim J, Kang K, Kim J. YY1's role in DNA methylation of Peg3 and Xist. Nucleic Acids Res. 2009;37:5656-64 pubmed publisher
    Unusual clusters of YY1 binding sites are located within several differentially methylated regions (DMRs), including Xist, Nespas and Peg3, which all become methylated during oogenesis...
  19. Griffith G, Trask M, HILLER J, Walentuk M, Pawlak J, Tremblay K, et al. Yin-yang1 is required in the mammalian oocyte for follicle expansion. Biol Reprod. 2011;84:654-63 pubmed publisher
    The multifaceted polycomb group gene Yin-Yang1 (Yy1) has been implicated in a variety of transcriptional regulatory roles both as an activator and silencer of gene expression...
  20. Blättler S, Verdeguer F, Liesa M, Cunningham J, Vogel R, Chim H, et al. Defective mitochondrial morphology and bioenergetic function in mice lacking the transcription factor Yin Yang 1 in skeletal muscle. Mol Cell Biol. 2012;32:3333-46 pubmed publisher
    ..A large number of these mitochondrial genes contain binding sites for the transcription factor Yin Yang 1 (YY1) in their proximal promoters, but the physiological relevance is unknown...
  21. Cunningham J, Rodgers J, Arlow D, Vazquez F, Mootha V, Puigserver P. mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Nature. 2007;450:736-40 pubmed
    ..Using computational genomics, we identified the transcription factor yin-yang 1 (YY1) as a common target of mTOR and PGC-1alpha...
  22. He Y, Dupree J, Wang J, Sandoval J, Li J, Liu H, et al. The transcription factor Yin Yang 1 is essential for oligodendrocyte progenitor differentiation. Neuron. 2007;55:217-30 pubmed
    ..Here, we identify the transcription factor Yin Yang 1 (YY1) as a critical regulator of oligodendrocyte progenitor differentiation...
  23. Kim J, Kim J. In vivo YY1 knockdown effects on genomic imprinting. Hum Mol Genet. 2008;17:391-401 pubmed
    The YY1 transcription factor is predicted to control several imprinted domains, including the Peg3, Gnas and Xist/Tsix regions...
  24. Donohoe M, Zhang L, Xu N, Shi Y, Lee J. Identification of a Ctcf cofactor, Yy1, for the X chromosome binary switch. Mol Cell. 2007;25:43-56 pubmed
    ..Here, we search for trans-factors and identify Yy1 as a required cofactor for Ctcf...
  25. Li J, Song J, Bell R, Tran T, Haq R, Liu H, et al. YY1 regulates melanocyte development and function by cooperating with MITF. PLoS Genet. 2012;8:e1002688 pubmed publisher
    ..Here, we generated Yy1 conditional knockout mice in the melanocyte-lineage and observed profound melanocyte deficiency and premature gray ..
  26. He Y, Kim J, Dupree J, Tewari A, MELENDEZ VASQUEZ C, Svaren J, et al. Yy1 as a molecular link between neuregulin and transcriptional modulation of peripheral myelination. Nat Neurosci. 2010;13:1472-80 pubmed publisher
    ..We found that the transcription factor Yin Yang 1 (YY1) is crucial for peripheral myelination...
  27. Trabucco S, Gerstein R, Zhang H. YY1 Regulates the Germinal Center Reaction by Inhibiting Apoptosis. J Immunol. 2016;197:1699-707 pubmed publisher
    ..It is important to understand how the GC reaction is regulated. In this study, we show that transcription factor YY1 is required to maintain a robust GC reaction in mice...
  28. Makhlouf M, Ouimette J, Oldfield A, Navarro P, Neuillet D, Rougeulle C. A prominent and conserved role for YY1 in Xist transcriptional activation. Nat Commun. 2014;5:4878 pubmed publisher
    ..Here we uncover an essential function for the ubiquitous autosomal transcription factor Yin-Yang 1 (YY1) in the transcriptional activation of Xist in both human and mouse...
  29. Itoh T, Miyake K, Yamaguchi T, Tsuge M, Kaneoka H, Iijima S. Constitutive expression of the brg1 gene requires GC-boxes near to the transcriptional start site. J Biochem. 2011;149:301-9 pubmed publisher
    ..One of the putative Sp1/3-binding sites (from -21 to -15 bp) overlapped with a putative YY1-binding site...
  30. Verdeguer F, Soustek M, Hatting M, Blättler S, McDonald D, Barrow J, et al. Brown Adipose YY1 Deficiency Activates Expression of Secreted Proteins Linked to Energy Expenditure and Prevents Diet-Induced Obesity. Mol Cell Biol. 2015;36:184-96 pubmed publisher
    ..Here, we show that the transcription factor Yin Yang 1 (YY1) in brown adipose tissue activates the canonical thermogenic and uncoupling gene expression program...
  31. Doetsch M, Gluch A, Poznanovic G, Bode J, Vidakovic M. YY1-binding sites provide central switch functions in the PARP-1 gene expression network. PLoS ONE. 2012;7:e44125 pubmed publisher
    Evidence is presented for the involvement of the interplay between transcription factor Yin Yang 1 (YY1) and poly(ADP-ribose) polymerase-1 (PARP-1) in the regulation of mouse PARP-1 gene (muPARP-1) promoter activity...
  32. Kuzmin A, Han Z, Golding M, Mann M, Latham K, Varmuza S. The PcG gene Sfmbt2 is paternally expressed in extraembryonic tissues. Gene Expr Patterns. 2008;8:107-16 pubmed
    ..This possibly identifies a new imprinted domain within the murine genome. We further demonstrate that murine SFMBT2 protein interacts with the transcription factor YY1, similar to the Drosophila PHO-RC.
  33. Beketaev I, Zhang Y, Kim E, Yu W, Qian L, Wang J. Critical role of YY1 in cardiac morphogenesis. Dev Dyn. 2015;244:669-80 pubmed publisher
    b>Yin Yang 1 (YY1), the only DNA binding polycomb group protein, was reported to regulate cardiomyocyte differentiation during early cardiac mesoderm development...
  34. Perekatt A, Valdez M, Davila M, Hoffman A, Bonder E, Gao N, et al. YY1 is indispensable for Lgr5+ intestinal stem cell renewal. Proc Natl Acad Sci U S A. 2014;111:7695-700 pubmed publisher
    ..Here, we provide evidence that the transcription factor YY1 is essential for intestinal stem cell renewal...
  35. Lu P, Hankel I, Hostager B, Swartzendruber J, Friedman A, Brenton J, et al. The developmental regulator protein Gon4l associates with protein YY1, co-repressor Sin3a, and histone deacetylase 1 and mediates transcriptional repression. J Biol Chem. 2011;286:18311-9 pubmed publisher
    ..by polypeptide sequence conservation, Gon4l interacted and co-localized with the DNA-binding protein YY1 (Yin Yang 1)...
  36. Shi Z, Silveira A, Patel P, Feng X. YY1 is involved in RANKL-induced transcription of the tartrate-resistant acid phosphatase gene in osteoclast differentiation. Gene. 2004;343:117-26 pubmed
    ..Computer analysis of the 21-bp sequence revealed that the sequence contains a putative Yin Yang 1 (YY1) binding site overlapped with a putative activator protein-2 (AP-2) binding site...
  37. Deshpande A, Akunowicz J, Reveles X, Patel B, Saria E, Gorlick R, et al. PHC3, a component of the hPRC-H complex, associates with E2F6 during G0 and is lost in osteosarcoma tumors. Oncogene. 2007;26:1714-22 pubmed
    ..Sequence analysis revealed that PHC3 was mutated in nine of 15 primary osteosarcoma tumors. These findings suggest that loss of PHC3 may favor tumorigenesis by potentially disrupting the ability of cells to remain in G(0). ..
  38. Medvedovic J, Ebert A, Tagoh H, Tamir I, Schwickert T, Novatchkova M, et al. Flexible long-range loops in the VH gene region of the Igh locus facilitate the generation of a diverse antibody repertoire. Immunity. 2013;39:229-44 pubmed publisher
    ..these local domains engaged in long-range interactions across the Igh locus, which depend on the regulators Pax5, YY1, and CTCF...
  39. Thompson R, Williams R, Kotb M, Sawtell N. A forward phenotypically driven unbiased genetic analysis of host genes that moderate herpes simplex virus virulence and stromal keratitis in mice. PLoS ONE. 2014;9:e92342 pubmed publisher
    ..To our knowledge this is the first report of a host genetic locus that modulates the severity of both herpetic disease in the nervous system and herpetic stromal keratitis. ..
  40. Shou Z, Yamada K, Inazu T, Kawata H, Hirano S, Mizutani T, et al. Genomic structure and analysis of transcriptional regulation of the mouse zinc-fingers and homeoboxes 1 (ZHX1) gene. Gene. 2003;302:83-94 pubmed
    ..Electrophoretic mobility shift assays with specific competitors and antibodies show that PEA3 and Yin and Yang 1 (YY1) bind to Box A and Box B, respectively...
  41. Groner B, Altiok S, Meier V. Hormonal regulation of transcription factor activity in mammary epithelial cells. Mol Cell Endocrinol. 1994;100:109-14 pubmed
    ..The transcription factor YY1 binds to the proximal half of the repressor element which overlaps with the MGF binding site...
  42. Kabotyanski E, Rijnkels M, Freeman Zadrowski C, Buser A, Edwards D, Rosen J. Lactogenic hormonal induction of long distance interactions between beta-casein gene regulatory elements. J Biol Chem. 2009;284:22815-24 pubmed publisher
    ..Collectively, these data suggest that the communication between these regulatory regions with intervening DNA looping is a crucial step required to both create and maintain active chromatin domains and regulate transcription. ..
  43. Tan D, Nonaka K, Nuckolls G, Liu Y, Maxson R, Slavkin H, et al. YY1 activates Msx2 gene independent of bone morphogenetic protein signaling. Nucleic Acids Res. 2002;30:1213-23 pubmed
    ..b>YY1 is a bi-functional zinc finger protein that serves as a repressor or activator to a variety of promoters...
  44. Tian F, An L, Wang G, Zhu J, Li Q, Zhang Y, et al. Elevated microRNA-155 promotes foam cell formation by targeting HBP1 in atherogenesis. Cardiovasc Res. 2014;103:100-10 pubmed publisher
    ..Furthermore, bioinformatics analysis identified three YY1 binding sites in the promoter region of pri-miR-155 and verified YY1 binding directly to its promoter region...
  45. L honoré A, Lamb N, Vandromme M, Turowski P, Carnac G, Fernandez A. MyoD distal regulatory region contains an SRF binding CArG element required for MyoD expression in skeletal myoblasts and during muscle regeneration. Mol Biol Cell. 2003;14:2151-62 pubmed
    ..CArG sequence, although slightly divergent, bound two complexes containing, respectively, the transcription factor YY1 and SRF associated with the acetyltransferase CBP and members of C/EBP family...
  46. Kleiman E, Jia H, Loguercio S, Su A, Feeney A. YY1 plays an essential role at all stages of B-cell differentiation. Proc Natl Acad Sci U S A. 2016;113:E3911-20 pubmed publisher
    Ying Yang 1 (YY1) is a ubiquitously expressed transcription factor shown to be essential for pro-B-cell development. However, the role of YY1 in other B-cell populations has never been investigated...
  47. Nishiyama C, Yokota T, Nishiyama M, Ra C, Okumura K, Ogawa H. Molecular cloning of rat transcription factor YY1. Biosci Biotechnol Biochem. 2003;67:654-8 pubmed
    b>YY1 is a ubiquitously expressed multifunctional transcription factor that is involved in both positive and negative regulation of gene expression as well as initiation of transcription...
  48. Guo J, Yao H, Lin X, Xu H, Dean D, Zhu Z, et al. IL-13 induces YY1 through the AKT pathway in lung fibroblasts. PLoS ONE. 2015;10:e0119039 pubmed publisher
    ..We previously reported that the transcription factor Yin Yang 1 (YY1) is upregulated in fibroblasts treated with TGF-β and in the lungs of mice and patients with pulmonary ..
  49. Vuong L, Brobst D, Saadi A, Ivanovic I, Al Ubaidi M. Pattern of expression of p53, its family members, and regulators during early ocular development and in the post-mitotic retina. Invest Ophthalmol Vis Sci. 2012;53:4821-31 pubmed publisher
    ..Expression patterns of p63, p73, Mdm2, Mdm4, and Yy1 did not follow that of p53...
  50. Debnath I, Roundy K, Weis J, Weis J. Defining in vivo transcription factor complexes of the murine CD21 and CD23 genes. J Immunol. 2007;178:7139-50 pubmed
    ..We found constitutive binding of Oct-1, NFAT species, YY1, NF-kappaB-p52, Pax5, E2A, and RBP-Jkappa to CD21 sequences and NF-kappaB-p52, Pax5, NFAT species, E2A, and RBP-..
  51. Ando H, Aoyama C, Horibata Y, Satou M, Mitsuhashi S, Itoh M, et al. Transcriptional suppression of CTP:phosphoethanolamine cytidylyltransferase by 25-hydroxycholesterol is mediated by nuclear factor-Y and Yin Yang 1. Biochem J. 2015;471:369-79 pubmed publisher
    ..Using the yeast one-hybrid system, we found that NF-Y (nuclear factor-Y) binds at C(-37)CAAT(-41) and YY1 (Yin Yang1) binds at C(-42)AT(-40) in the Pcyt2 promoter...
  52. Rangel Santiago J, Baay Guzman G, Durán Padilla M, Lopez Bochm K, Garcia Romero B, Hernandez Cueto D, et al. A novel role of Yin-Yang-1 in pulmonary tuberculosis through the regulation of the chemokine CCL4. Tuberculosis (Edinb). 2016;96:87-95 pubmed publisher
    ..Yin-Yang-1 (YY1) plays a major role in the maintenance and progression of some pulmonary diseases, including pulmonary fibrosis...
  53. Chen K, Paladugu A, Aldaz C, Gould M. Cloning and chromosomal localization of the rat Stat5 and Yy1 genes. Cytogenet Cell Genet. 1996;74:277-80 pubmed
    ..gene expression is controlled in part by the positively acting factor Stat5 and the negatively acting factor Yy1. Partial cDNAs encoding the SH2 domain of rat Stat5a and Stat5b and the zinc finger domain of rat Yy1 have been ..