Genomes and Genes
Gene Symbol: Ywhaz
Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
Alias: 1110013I11Rik, 14-3-3zeta, AI596267, AL022924, AU020854, 14-3-3 protein zeta/delta, 14-3-3 zeta, KCIP-1, SEZ-2, protein kinase C inhibitor protein 1
- Chen N, Onisko B, Napoli J. The nuclear transcription factor RARalpha associates with neuronal RNA granules and suppresses translation. J Biol Chem. 2008;283:20841-7 pubmed publisher..These data afford a mechanism for rapid stimulation of dendritic growth by all-trans-retinoic acid and reveal that the ligand-dependent transcription factor RARalpha also regulates translation. ..
- Kim H, Han J, Park J, Oh M, James S, Chang S, et al. Delta-catenin-induced dendritic morphogenesis. An essential role of p190RhoGEF interaction through Akt1-mediated phosphorylation. J Biol Chem. 2008;283:977-87 pubmed..These results highlight signaling events in the regulation of delta-catenin-induced dendrogenesis and spine morphogenesis. ..
- Kajiwara K, Nagawawa H, Shimizu Nishikawa S, Ookuri T, Kimura M, Sugaya E. Molecular characterization of seizure-related genes isolated by differential screening. Biochem Biophys Res Commun. 1996;219:795-9 pubmed..These data and our previous results suggest that intracellular calcium may play an important role for seizure-related pathophysiological changes in neuronal cells. ..
- Bruce K, Sihota K, Byrne C, Cagampang F. The housekeeping gene YWHAZ remains stable in a model of developmentally primed non-alcoholic fatty liver disease. Liver Int. 2012;32:1315-21 pubmed publisher..We determined the expression stability of six candidates HKG (GAPDH, YWHAZ, B2M, EIF4A2, ACTB and CYC1) in a mouse model of developmentally primed NAFLD in both the day and night, using ..
- Winteringham L, Endersby R, Kobelke S, McCulloch R, Williams J, Stillitano J, et al. Myeloid leukemia factor 1 associates with a novel heterogeneous nuclear ribonucleoprotein U-like molecule. J Biol Chem. 2006;281:38791-800 pubmed..In summary, this study reveals that Mlf1 translocates between nucleus and cytoplasm, associates with a novel hnRNP, and influences gene expression. ..
- Lim R, Winteringham L, Williams J, McCulloch R, Ingley E, Tiao J, et al. MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1. J Biol Chem. 2002;277:40997-1008 pubmed..In summary, this study has identified two partner proteins of Mlf1 that may influence its subcellular localization and biological function. ..
- Lin N, Lin T, Yang W, Wang S, Wang K, Su Y, et al. Differential expression and functional analysis of the tristetraprolin family during early differentiation of 3T3-L1 preadipocytes. Int J Biol Sci. 2012;8:761-77 pubmed publisher..Inhibition of adipogenesis also occurred in ZFP36L1 and TTP knockdown cells. The findings indicate that the differential expression of TTP family members regulates immediate early gene expression and modulates adipogenesis. ..
- Suen K, Bustelo X, Barbacid M. Lack of evidence for the activation of the Ras/Raf mitogenic pathway by 14-3-3 proteins in mammalian cells. Oncogene. 1995;11:825-31 pubmed..These observations argue against a critical regulatory role of the 14-3-3 proteins in the Raf mitogenic pathway. ..
- Xing H, Kornfeld K, Muslin A. The protein kinase KSR interacts with 14-3-3 protein and Raf. Curr Biol. 1997;7:294-300 pubmed..Our finding suggest that KSR, 14-3-3 and Raf form an oligomeric signaling complex and that KSR positively regulates the Ras signaling pathway in vertebrate organisms. ..
- Li F, Huang Y, Huang Y, Kuang Y, Wei Y, Xiang L, et al. MicroRNA-146a promotes IgE class switch in B cells via upregulating 14-3-3? expression. Mol Immunol. 2017;92:180-189 pubmed publisher..These results demonstrate that miR-146a enhances class switch and secretion of IgE in B cells by upregulating 14-3-3? expression, and suggest that miR-146a may be a potential target for asthma therapy. ..
- Brennan G, Jimenez Mateos E, McKiernan R, Engel T, Tzivion G, Henshall D. Transgenic overexpression of 14-3-3 zeta protects hippocampus against endoplasmic reticulum stress and status epilepticus in vivo. PLoS ONE. 2013;8:e54491 pubmed publisher..Delivery of 14-3-3? may protect against pathologic changes resulting from prolonged or repeated seizures or where injuries provoke ER stress. ..
- Drobic B, Perez Cadahia B, Yu J, Kung S, Davie J. Promoter chromatin remodeling of immediate-early genes is mediated through H3 phosphorylation at either serine 28 or 10 by the MSK1 multi-protein complex. Nucleic Acids Res. 2010;38:3196-208 pubmed publisher..The recruited SWI/SNF remodels nucleosomes at the promoter of IE genes enabling the binding of transcription factors like JUN and the onset of transcription. ..
- Hong H, Jeon W, Bae E, Kim S, Lee H, Kim S, et al. 14-3-3 sigma and 14-3-3 zeta plays an opposite role in cell growth inhibition mediated by transforming growth factor-beta 1. Mol Cells. 2010;29:305-9 pubmed publisher..Taken together, our findings indicate that dysregulation of 14-3-3 sigma or 14-3-3 zeta contributes to TGF-beta1 resistance in cancer cells. ..
- Yam P, Kent C, Morin S, Farmer W, Alchini R, Lepelletier L, et al. 14-3-3 proteins regulate a cell-intrinsic switch from sonic hedgehog-mediated commissural axon attraction to repulsion after midline crossing. Neuron. 2012;76:735-49 pubmed publisher..Therefore, we identify a 14-3-3 protein-dependent mechanism for a cell-intrinsic temporal switch in the polarity of axon turning responses. ..
- Dumaz N, Marais R. Protein kinase A blocks Raf-1 activity by stimulating 14-3-3 binding and blocking Raf-1 interaction with Ras. J Biol Chem. 2003;278:29819-23 pubmed..These studies suggest that Raf-1 and cAMP form a signaling complex in cells. Upon activation of PKA, Raf-1 is phosphorylated and 14-3-3 binds, blocking Raf-1 recruitment to the plasma membrane and preventing its activation. ..
- Rock J, Lopez M, Baker H, Harfe B. Identification of genes expressed in the mouse limb using a novel ZPA microarray approach. Gene Expr Patterns. 2007;8:19-26 pubmed..The expression of two other genes was confirmed by rtPCR. The methods described in this report will be applicable for identifying genes enriched in Shh-expressing cells throughout development. ..
- Brouns M, de Castro S, Terwindt Rouwenhorst E, Massa V, Hekking J, Hirst C, et al. Over-expression of Grhl2 causes spina bifida in the Axial defects mutant mouse. Hum Mol Genet. 2011;20:1536-46 pubmed publisher..Overall, our data suggest that defects in Axd mutant embryos result from over-expression of Grhl2...
- DeYoung M, Horak P, Sofer A, Sgroi D, Ellisen L. Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling. Genes Dev. 2008;22:239-51 pubmed publisher..Together, these findings define a molecular mechanism of signal integration by TSC1/2 that provides insight into the ability of REDD1 to function in a hypoxia-dependent tumor suppressor pathway. ..
- Han L, Wong D, Dhaka A, Afar D, White M, Xie W, et al. Protein binding and signaling properties of RIN1 suggest a unique effector function. Proc Natl Acad Sci U S A. 1997;94:4954-9 pubmed..These data suggest that RIN1 is able to mediate multiple signals. A differential pattern of expression and alternate splicing indicate several levels of RIN1 regulation. ..
- Cahill C, Tzivion G, Nasrin N, Ogg S, Dore J, Ruvkun G, et al. Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways. J Biol Chem. 2001;276:13402-10 pubmed..Thus, our results demonstrate at least two mechanisms, one 14-3-3-dependent and the other 14-3-3-independent, whereby PI 3-kinase signaling regulates DAF-16 DNA binding and transcription function. ..
- Liao K, Tsay Y, Huang L, Huang H, Li C, Wu T. Search for the tumor-associated proteins of oral squamous cell carcinoma collected in Taiwan using proteomics strategy. J Proteome Res. 2011;10:2347-58 pubmed publisher..By this comprehensive study, we identified 14-3-3 zeta as the only prognosticator of local recurrence-free survival (LRFS) and also an independently predicted factor of disease-specific survival (DSS). ..
- Li X, Wang Q, Pan N, Lee S, Zhao Y, Chait B, et al. Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease. PLoS ONE. 2011;6:e17153 pubmed publisher..Furthermore, the reduction of phosphorylation/14-3-3 binding of LRRK2 due to the common familial PD-related mutations provides novel insight into the pathogenic mechanism of LRRK2-linked PD. ..
- Albershardt T, Iritani B, Ruddell A. Evaluation of reference genes for quantitative PCR analysis of mouse lymphocytes. J Immunol Methods. 2012;384:196-9 pubmed publisher..We provide a shortlist of reference genes to use for normalization and recommend freely available software programs as a rapid approach to validate potential reference genes. ..
- Hansraj N, Xiao L, Wu J, Chen G, Turner D, Wang J, et al. Posttranscriptional regulation of 14-3-3? by RNA-binding protein HuR modulating intestinal epithelial restitution after wounding. Physiol Rep. 2016;4: pubmed publisher..These results indicate that HuR induces 14-3-3? translation via interaction with its 3' UTR and that 14-3-3? is necessary for stimulation of IEC migration after wounding. ..
- Patrick D, Zhang C, Tao Y, Yao H, Qi X, Schwartz R, et al. Defective erythroid differentiation in miR-451 mutant mice mediated by 14-3-3zeta. Genes Dev. 2010;24:1614-9 pubmed publisher..These findings reveal an essential role of 14-3-3zeta as a mediator of the proerythroid differentiation actions of miR-451, and highlight the therapeutic potential of miR-451 inhibitors...
- Ramshaw H, Xu X, Jaehne E, McCarthy P, Greenberg Z, Saleh E, et al. Locomotor hyperactivity in 14-3-3? KO mice is associated with dopamine transporter dysfunction. Transl Psychiatry. 2013;3:e327 pubmed publisher..Taken together, our results identify a novel role for 14-3-3? in DA neurotransmission and provide support to the hyperdopaminergic basis of pathologies associated with schizophrenia and related disorders. ..
- Machka C, Kersten M, Zobawa M, Harder A, Horsch M, Halder T, et al. Identification of Dll1 (Delta1) target genes during mouse embryogenesis using differential expression profiling. Gene Expr Patterns. 2005;6:94-101 pubmed..The large set of regulated genes identified in this differential expression profiling approach is an important resource for further functional studies. ..
- Kosaka Y, Cieslik K, Li L, Lezin G, Maguire C, Saijoh Y, et al. 14-3-3? plays a role in cardiac ventricular compaction by regulating the cardiomyocyte cell cycle. Mol Cell Biol. 2012;32:5089-102 pubmed publisher..These data are consistent with the long-held view that human LVNC may result from compaction arrest, and they implicate 14-3-3? as a new candidate gene in congenital human cardiomyopathies. ..
- Agassandian M, Chen B, Schuster C, Houtman J, Mallampalli R. 14-3-3zeta escorts CCTalpha for calcium-activated nuclear import in lung epithelia. FASEB J. 2010;24:1271-83 pubmed publisher..Agassandian, M., Chen, B. B., Schuster, C. C., Houtman, J. C. D., Mallampalli, R. K. 14-3-3zeta escorts CCTalpha for calcium-activated nuclear import in lung epithelia. ..
- Moeller H, Slengerik Hansen J, Aroankins T, Assentoft M, MacAulay N, Moestrup S, et al. Regulation of the Water Channel Aquaporin-2 via 14-3-3Î¸ and -Î¶. J Biol Chem. 2016;291:2469-84 pubmed publisher..In conclusion, this study demonstrates phosphorylation-dependent interactions of AQP2 with 14-3-3Î¸ and -Î¶. These interactions play divergent roles in modulating AQP2 trafficking, phosphorylation, ubiquitylation, and degradation. ..
- Fantauzzo K, Soriano P. PI3K-mediated PDGFR? signaling regulates survival and proliferation in skeletal development through p53-dependent intracellular pathways. Genes Dev. 2014;28:1005-17 pubmed publisher..Our findings identify p53 as a novel effector downstream from PI3K-engaged PDGFR? signaling that regulates survival and proliferation during skeletal development in vivo...
- Woodcock J, Murphy J, Stomski F, Berndt M, Lopez A. The dimeric versus monomeric status of 14-3-3zeta is controlled by phosphorylation of Ser58 at the dimer interface. J Biol Chem. 2003;278:36323-7 pubmed..We propose that this regulated monomerization of 14-3-3 controls its ability to modulate the activity of target proteins and thus may have significant implications for 14-3-3 function and the regulation of many cellular processes. ..
- Sladeczek F, Camonis J, Burnol A, Le Bouffant F. The Cdk-like protein PCTAIRE-1 from mouse brain associates with p11 and 14-3-3 proteins. Mol Gen Genet. 1997;254:571-7 pubmed
- Kim H, Ullevig S, Nguyen H, Vanegas D, Asmis R. Redox regulation of 14-3-3? controls monocyte migration. Arterioscler Thromb Vasc Biol. 2014;34:1514-21 pubmed publisher..By preventing the inactivation of cofilin, metabolic stress-induced degradation of 14-3-3? promotes the conversion of blood monocytes into a hypermigratory, proatherogenic phenotype. ..
- Vieira M, Saraiva M. Transthyretin regulates hippocampal 14-3-3? protein levels. FEBS Lett. 2013;587:1482-8 pubmed publisher..Cellular studies ascribed this finding to increased degradation of 14-3-3? in lysosomes in the absence of TTR, increasing autophagy. ..
- Honda R, Ohba Y, Yasuda H. 14-3-3 zeta protein binds to the carboxyl half of mouse wee1 kinase. Biochem Biophys Res Commun. 1997;230:262-5 pubmed..The function of 14-3-3 zeta protein remained to be elucidated in relation to the regulation of G2 to M phase transition through wee1 kinase. ..
- Min S, Liang X, Zhang M, Zhang Y, Mei S, Liu J, et al. Multiple tumor-associated microRNAs modulate the survival and longevity of dendritic cells by targeting YWHAZ and Bcl2 signaling pathways. J Immunol. 2013;190:2437-46 pubmed publisher..Specifically, miR-22 targeted YWHAZ to interrupt the PI3K/Akt and MAPK signaling pathways, and miR-503 downregulated Bcl2 expression...
- Zhang J, Yuan Y, Liu Q, Yang D, Liu M, Shen L, et al. Differentially expressed genes in the testicular tissues of adenylyl cyclase 3 knockout mice. Gene. 2017;602:33-42 pubmed publisher..These data would help elucidate the general understanding of the mechanisms underlying the sterility in AC3-/- male mice. ..
- Li T, Wang Y, Khokhlova T, D Andrea S, Starr F, Chen H, et al. Pulsed High-Intensity Focused Ultrasound Enhances Delivery of Doxorubicin in a Preclinical Model of Pancreatic Cancer. Cancer Res. 2015;75:3738-46 pubmed publisher..Together, the data indicate that pHIFU treatment of pancreatic tumors when resulting in high and sustained cavitation can efficiently enhance chemotherapy delivery to pancreatic tumors. . ..
- Schoenwaelder S, Darbousset R, Cranmer S, Ramshaw H, Orive S, Sturgeon S, et al. 14-3-3? regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function. Nat Commun. 2016;7:12862 pubmed publisher..Our studies define an important role for 14-3-3? in regulating platelet bioenergetics, leading to decreased platelet PS exposure and procoagulant function. ..
- Barry E, Felquer F, Powell J, Biggs L, Stomski F, Urbani A, et al. 14-3-3:Shc scaffolds integrate phosphoserine and phosphotyrosine signaling to regulate phosphatidylinositol 3-kinase activation and cell survival. J Biol Chem. 2009;284:12080-90 pubmed publisher..Together, these results show that 14-3-3:Shc scaffolds can act as multivalent signaling nodes for the integration of both phosphoserine/threonine and phosphotyrosine pathways to regulate specific cellular responses. ..
- Lim G, Piske M, Lulo J, Ramshaw H, Lopez A, Johnson J. Ywhaz/14-3-3? Deletion Improves Glucose Tolerance Through a GLP-1-Dependent Mechanism. Endocrinology. 2016;157:2649-59 pubmed publisher..Herein, we report that Ywhaz gene knockout mice (14-3-3?KO) exhibited elevated fasting insulin levels while maintaining normal ?-cell ..
- Liu Q, Ye Y, Lin X, Yang Y, Wu K, Yu M. Expression of 14-3-3 Zeta Protein in Dexamethasone-Treated Mice and Human TM-1 Cells. Curr Eye Res. 2017;42:1124-1129 pubmed publisher..The effects of DEX on 14-3-3 zeta expression in vitro were both dose- and time-related. Our results suggest that alterations in 14-3-3 zeta protein may be implicated in DEX-induced pathological elevated IOP. ..
- Mohammad D, Nore B, Hussain A, Gustafsson M, Mohamed A, Smith C. Dual phosphorylation of Btk by Akt/protein kinase b provides docking for 14-3-3?, regulates shuttling, and attenuates both tonic and induced signaling in B cells. Mol Cell Biol. 2013;33:3214-26 pubmed publisher..Collectively, this suggests that Btk could become an important new candidate for the general study of 14-3-3-mediated regulation. ..
- BoseDasgupta S, Moes S, Jenoe P, Pieters J. Cytokine-induced macropinocytosis in macrophages is regulated by 14-3-3Î¶ through its interaction with serine-phosphorylated coronin 1. FEBS J. 2015;282:1167-81 pubmed publisher..Together these data define an essential role for 14-3-3Î¶ in the regulation of macropinocytosis in macrophages upon cytokine stimulation through modulation of the localization of coronin 1. ..
- Cornell B, Toyo oka K. Deficiency of 14-3-3? and 14-3-3? by the Wnt1 promoter-driven Cre recombinase results in pigmentation defects. BMC Res Notes. 2016;9:180 pubmed publisher..Our data obtained from the 14-3-3?/14-3-3?/Wnt1-Cre mice strongly indicate the importance of 14-3-3 proteins in the development of melanocyte lineages. ..
- Rosenberger C, Podyminogin R, Navarro G, Zhao G, Askovich P, Weiss M, et al. miR-451 regulates dendritic cell cytokine responses to influenza infection. J Immunol. 2012;189:5965-75 pubmed publisher..miR-451 negatively regulates YWHAZ/14-3-3? protein levels in various cell types, and we measured a similar inhibition of YWHAZ levels in DCs...
- Gerst F, Kaiser G, Panse M, Sartorius T, Pujol A, Hennige A, et al. Protein kinase CÎ´ regulates nuclear export of FOXO1 through phosphorylation of the chaperone 14-3-3Î¶. Diabetologia. 2015;58:2819-31 pubmed publisher..P-FOXO1 does not induce pro-apoptotic genes, but may rather exert beneficial effects on beta cells. ..
- Irwin S, Vandelft M, Pinchev D, Howell J, Graczyk J, Orr H, et al. RNA association and nucleocytoplasmic shuttling by ataxin-1. J Cell Sci. 2005;118:233-42 pubmed..These results suggest that the normal role of ataxin-1 may be in RNA processing, perhaps nuclear RNA export. Thus, nuclear retention of mutant ataxin-1 may be an important toxic gain of function in SCA1 disease. ..
- Lonic A, Barry E, Quach C, Kobe B, Saunders N, Guthridge M. Fibroblast growth factor receptor 2 phosphorylation on serine 779 couples to 14-3-3 and regulates cell survival and proliferation. Mol Cell Biol. 2008;28:3372-85 pubmed publisher..In this regard, we have identified conserved putative phosphotyrosine/phosphoserine motifs in the cytoplasmic domains of diverse cell surface receptors, suggesting that they may perform important functional roles beyond the FGFRs. ..
- Angrand P, Segura I, Volkel P, Ghidelli S, Terry R, Brajenovic M, et al. Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling. Mol Cell Proteomics. 2006;5:2211-27 pubmed