Ywhae

Summary

Gene Symbol: Ywhae
Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
Alias: AU019196, 14-3-3 epsilon, 14-3-3 protein epsilon, 14-3-3E, OTTMUSP00000006521, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activatioprotein, epsilon polypeptide
Species: mouse

Publications

  1. The mouse 14-3-3 epsilon isoform, a kinase regulator whose expression pattern is modulated in mesenchyme and neuronal differentiation
    J E McConnell
    MRC Human Genetics Unit, Edinburgh, United Kingdom
    Dev Biol 169:218-28
  2. Miller-Dieker syndrome: analysis of a human contiguous gene syndrome in the mouse
    Jessica Yingling
    Departments of Pediatrics and Medicine, University of California at San Diego School of Medicine, La Jolla, CA, 92093, USA
    Am J Hum Genet 73:475-88
  3. CD81 associates with 14-3-3 in a redox-regulated palmitoylation-dependent manner
    Krista L Clark
    Program in Molecular, Cellular and Developmental Biology, Division of Biology, 239C Chalmers Hall, Kansas State University, Manhattan, KS 66506, USA
    J Biol Chem 279:19401-6
  4. MAP kinase phosphatase 3 (MKP3) interacts with and is phosphorylated by protein kinase CK2alpha
    Marco Castelli
    Serono Pharmaceutical Research Institute, Serono International S A, Plan les Ouates 1228, Geneva CH1228, Switzerland
    J Biol Chem 279:44731-9
  5. Interactions between extracellular signal-regulated protein kinase 1, 14-3-3epsilon, and heat shock factor 1 during stress
    XiaoZhe Wang
    Dana Farber Cancer Institute and Division of Molecular and Cellular Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 279:49460-9
  6. Identification of Dll1 (Delta1) target genes during mouse embryogenesis using differential expression profiling
    C Machka
    Institute of Experimental Genetics, GSF National Research Center, Ingolstädter Landstr 1, 85764 Neuherberg, Germany
    Gene Expr Patterns 6:94-101
  7. 14-3-3-dependent inhibition of the deubiquitinating activity of UBPY and its cancellation in the M phase
    Emi Mizuno
    Department of Biological Sciences, Tokyo Institute of Technology, 4259 B 16 Nagatsuta, Yokohama, Japan
    Exp Cell Res 313:3624-34
  8. Nudel binds Cdc42GAP to modulate Cdc42 activity at the leading edge of migrating cells
    Yidong Shen
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    Dev Cell 14:342-53
  9. Fibroblast growth factor receptor 2 phosphorylation on serine 779 couples to 14-3-3 and regulates cell survival and proliferation
    Ana Lonic
    Division of Human Immunology, Institute of Medical and Veterinary Science, Frome Rd Adelaide, South Australia, Australia
    Mol Cell Biol 28:3372-85
  10. Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia
    Masashi Ikeda
    Department of Psychiatry, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470 1192, Japan
    Hum Mol Genet 17:3212-22

Scientific Experts

  • H C Baxter
  • Kazuhito Toyo oka
  • Anthony Wynshaw-Boris
  • Kazuhito Toyo-oka
  • Xiubin Liang
  • Yidong Shen
  • Ana Lonic
  • Masashi Ikeda
  • Emi Mizuno
  • Anthony Wynshaw Boris
  • C Machka
  • Krista L Clark
  • XiaoZhe Wang
  • Marco Castelli
  • Jessica Yingling
  • Jiaxin Niu
  • Alanna L Eilers
  • S S Chong
  • Kathryn W Peters
  • Yongli Shan
  • Shinichiro Taya
  • Xueliang Zhu
  • Kozo Kaibuchi
  • Bostjan Kobe
  • Chong Ding
  • Toshiya Inada
  • Junko Uraguchi Asaki
  • Ning Li
  • B S Finlin
  • Shuang Wu
  • Quan Yuan
  • Neil Saunders
  • Norio Ozaki
  • Raymond A Frizzell
  • Mark A Guthridge
  • Nakao Iwata
  • Yizhuo Zhou
  • Rong Zeng
  • Michael B Butterworth
  • William H Walker
  • Fukun Zhao
  • Takao Hikita
  • Cindy Quach
  • Hiroshi Ujike
  • Junko Uraguchi-Asaki
  • Emma F Barry
  • Keizo Takao
  • Tsuyoshi Miyakawa
  • Qiangge Zhang
  • Naomi Kitamura
  • Masayuki Komada
  • T Halder
  • A Harder
  • M Zobawa
  • M Horsch
  • M Kersten
  • J Beckers
  • F Lottspeich
  • B A Hamilton
  • Megan E Johnson
  • Didier Leroy
  • Alisha Oelke
  • L Han
  • Mary Ann Stevenson
  • Patrick C Simpson
  • S Hirotsune
  • Anthony Nichols
  • Christian Rommel
  • Montserrat Camps
  • Scott C Todd
  • Kenneth D Eilert
  • Nicholas Grammatikakis
  • Steve Arkinstall
  • Stuart K Calderwood
  • Aliki Siganou
  • Corine Gillieron
  • William Dobyns
  • Aki Shionoya
  • D H Ledbetter
  • David Ledbetter
  • Ramses Ayala
  • Michael J Gambello
  • Carlos Cardoso
  • Li-Huei Tsai
  • Heather L Ward
  • Richard Leventer
  • Li Huei Tsai
  • Shinji Hirotsune
  • Kirk M Druey
  • Donald E Ayer

Detail Information

Publications22

  1. The mouse 14-3-3 epsilon isoform, a kinase regulator whose expression pattern is modulated in mesenchyme and neuronal differentiation
    J E McConnell
    MRC Human Genetics Unit, Edinburgh, United Kingdom
    Dev Biol 169:218-28
    ..The results as a whole thus argue for the 14-3-3 epsilon isoform playing roles in neural development and in early mesenchyme, with this latter function being lost or replaced as the tissue differentiates...
  2. Miller-Dieker syndrome: analysis of a human contiguous gene syndrome in the mouse
    Jessica Yingling
    Departments of Pediatrics and Medicine, University of California at San Diego School of Medicine, La Jolla, CA, 92093, USA
    Am J Hum Genet 73:475-88
  3. CD81 associates with 14-3-3 in a redox-regulated palmitoylation-dependent manner
    Krista L Clark
    Program in Molecular, Cellular and Developmental Biology, Division of Biology, 239C Chalmers Hall, Kansas State University, Manhattan, KS 66506, USA
    J Biol Chem 279:19401-6
    ..These finding suggest that CD81 signaling events could be mediated by 14-3-3 adapter proteins, and these signals may be dependent on cellular redox...
  4. MAP kinase phosphatase 3 (MKP3) interacts with and is phosphorylated by protein kinase CK2alpha
    Marco Castelli
    Serono Pharmaceutical Research Institute, Serono International S A, Plan les Ouates 1228, Geneva CH1228, Switzerland
    J Biol Chem 279:44731-9
    ..In addition, we demonstrated that CK2 selectively phosphorylates MKP3, suggesting cross-regulation between CK2alpha and MKP3, as well as a modulation of ERK2-MAPK signaling by CK2alpha via MKP3...
  5. Interactions between extracellular signal-regulated protein kinase 1, 14-3-3epsilon, and heat shock factor 1 during stress
    XiaoZhe Wang
    Dana Farber Cancer Institute and Division of Molecular and Cellular Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 279:49460-9
    ..Association of HSF1 with ERK and 14-3-3epsilon during heat shock may thus modulate the amplitude of the response and lead to efficient termination of HSP expression on resumption of growth conditions...
  6. Identification of Dll1 (Delta1) target genes during mouse embryogenesis using differential expression profiling
    C Machka
    Institute of Experimental Genetics, GSF National Research Center, Ingolstädter Landstr 1, 85764 Neuherberg, Germany
    Gene Expr Patterns 6:94-101
    ..The large set of regulated genes identified in this differential expression profiling approach is an important resource for further functional studies...
  7. 14-3-3-dependent inhibition of the deubiquitinating activity of UBPY and its cancellation in the M phase
    Emi Mizuno
    Department of Biological Sciences, Tokyo Institute of Technology, 4259 B 16 Nagatsuta, Yokohama, Japan
    Exp Cell Res 313:3624-34
    ..We conclude that UBPY is catalytically inhibited in a phosphorylation-dependent manner by 14-3-3s during the interphase, and this regulation is cancelled in the M phase...
  8. Nudel binds Cdc42GAP to modulate Cdc42 activity at the leading edge of migrating cells
    Yidong Shen
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    Dev Cell 14:342-53
    ..Nudel facilitates cell migration by sequestering Cdc42GAP at the leading edge to stabilize active Cdc42 in response to extracellular stimuli. Excess active Cdc42 may in turn control its own activity by recruiting Cdc42GAP from Nudel...
  9. Fibroblast growth factor receptor 2 phosphorylation on serine 779 couples to 14-3-3 and regulates cell survival and proliferation
    Ana Lonic
    Division of Human Immunology, Institute of Medical and Veterinary Science, Frome Rd Adelaide, South Australia, Australia
    Mol Cell Biol 28:3372-85
    ..In this regard, we have identified conserved putative phosphotyrosine/phosphoserine motifs in the cytoplasmic domains of diverse cell surface receptors, suggesting that they may perform important functional roles beyond the FGFRs...
  10. Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia
    Masashi Ikeda
    Department of Psychiatry, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470 1192, Japan
    Hum Mol Genet 17:3212-22
    ..we screened for DISC1-interacting molecules [NudE-like (NUDEL), Lissencephaly-1 (LIS1), 14-3-3epsilon (YWHAE), growth factor receptor bound protein 2 (GRB2) and Kinesin family 5A of Kinesen1 (KIF5A)], assessing a total of ..
  11. 14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome
    Kazuhito Toyo oka
    Department of Pediatrics, UCSD Cancer Center, University of California, San Diego School of Medicine, 9500 Gilman Drive, Mailstop 0627, La Jolla, California 92093 0627, USA
    Nat Genet 34:274-85
    ..Here, we show that the gene encoding 14-3-3epsilon (YWHAE), one of a family of ubiquitous phosphoserine/threonine-binding proteins, is always deleted in individuals with ..
  12. A novel heterodimerization domain, CRM1, and 14-3-3 control subcellular localization of the MondoA-Mlx heterocomplex
    Alanna L Eilers
    Huntsman Cancer Institute, Department of Oncological Sciences, University of Utah, Salt Lake City, Utah 84112 5550, USA
    Mol Cell Biol 22:8514-26
    ..Second, an extracellular signal(s) must overcome the cytoplasmic localization function imparted by CRM1 and 14-3-3 binding to the N terminus of MondoA...
  13. Function of 14-3-3 proteins
    D Y Jin
    Nature 382:308
  14. Molecular evolution of the 14-3-3 protein family
    W Wang
    Department of Biology, University of Houston, Houston, TX 77204 5513, USA
    J Mol Evol 43:384-98
    ..A possible ancestral 14-3-3 sequence is proposed...
  15. 14-3-3 epsilon has no homology to LIS1 and lies telomeric to it on chromosome 17p13.3 outside the Miller-Dieker syndrome chromosome region
    S S Chong
    National Center for Human Genome Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Res 6:735-41
    ..3). However, 14-3-3 epsilon lies telomeric to LIS1 and outside the Miller-Dieker syndrome chromosome region but in a region frequently deleted in several types of cancer, and is a reasonable candidate tumor suppressor gene...
  16. Protein binding and signaling properties of RIN1 suggest a unique effector function
    L Han
    Department of Biological Chemistry, Molecular Genetics, and Immunology, University of California, Los Angeles, School of Medicine, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 94:4954-9
    ..These data suggest that RIN1 is able to mediate multiple signals. A differential pattern of expression and alternate splicing indicate several levels of RIN1 regulation...
  17. The vibrator mutation causes neurodegeneration via reduced expression of PITP alpha: positional complementation cloning and extragenic suppression
    B A Hamilton
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Neuron 18:711-22
    ..The vibrator phenotype is suppressed in one intercross. We performed a complete genome scan and mapped a major suppressor locus (Mvb-1) to proximal chromosome 19...
  18. Genomic organization of the murine Miller-Dieker/lissencephaly region: conservation of linkage with the human region
    S Hirotsune
    Genome Res 7:625-34
    ..Our results demonstrate that the MDS region is conserved between human and mouse. This conservation of linkage suggests that the mouse can be used to model microdeletions that occur in ILS and MDS...
  19. Phosphorylation-dependent association of the Ras-related GTP-binding protein Rem with 14-3-3 proteins
    B S Finlin
    Department of Biochemistry, University of Kentucky College of Medicine, 800 Rose Street, Lexington, Kentucky, 40536 0084, USA
    Arch Biochem Biophys 368:401-12
    ..These results suggest that 14-3-3 may allow the recruitment of distinct proteins that participate in Rem-mediated signal transduction pathways...
  20. Immunolocalisation of 14-3-3 isoforms in normal and scrapie-infected murine brain
    H C Baxter
    Department of Biomedical Sciences, University of Edinburgh, George Square, Edinburgh EH8 9XD, Scotland, UK
    Neuroscience 109:5-14
    ..The fact that isoform labelling in terminal scrapie CNS is lost in some brain areas, but increases in others, suggests that the processing of these proteins during neurodegeneration may be much more complex than previously recognised...
  21. RGS3 interacts with 14-3-3 via the N-terminal region distinct from the RGS (regulator of G-protein signalling) domain
    Jiaxin Niu
    Department of Pharmacology, University of Illinois at Chicago College of Medicine, Chicago, IL 60612
    Biochem J 365:677-84
    ..This study describes a new level in the regulation of G-protein signalling, in which the inhibitors of G-proteins, RGS proteins, can themselves be regulated by phosphorylation and binding 14-3-3...
  22. An obligatory heterodimer of 14-3-3beta and 14-3-3epsilon is required for aldosterone regulation of the epithelial sodium channel
    Xiubin Liang
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 283:27418-25
    ....