Yap1

Summary

Gene Symbol: Yap1
Description: yes-associated protein 1
Alias: AI325207, Yap, Yap65, Yki, Yorkie, transcriptional coactivator YAP1, 65 kDa Yes-associated protein, protein yorkie homolog, yes-associated protein YAP65 homolog, yes-associated protein, 65 kDa, yorkie homolog
Species: mouse
Products:     Yap1

Top Publications

  1. Camargo F, Gokhale S, Johnnidis J, Fu D, Bell G, Jaenisch R, et al. YAP1 increases organ size and expands undifferentiated progenitor cells. Curr Biol. 2007;17:2054-60 pubmed
    ..A highly expressed gene in stem cells is YAP1, the ortholog of Drosophila Yorkie, a downstream component of the Hippo pathway...
  2. Varelas X, Samavarchi Tehrani P, Narimatsu M, Weiss A, Cockburn K, Larsen B, et al. The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-?-SMAD pathway. Dev Cell. 2010;19:831-44 pubmed publisher
    ..information to control tissue growth by regulating the localization of the transcriptional regulators TAZ and YAP (TAZ/YAP)...
  3. Azzolin L, Panciera T, Soligo S, Enzo E, Bicciato S, Dupont S, et al. YAP/TAZ incorporation in the ?-catenin destruction complex orchestrates the Wnt response. Cell. 2014;158:157-70 pubmed publisher
    The Hippo transducers YAP/TAZ have been shown to play positive, as well as negative, roles in Wnt signaling, but the underlying mechanisms remain unclear...
  4. Schlegelmilch K, Mohseni M, Kirak O, Pruszak J, Rodriguez J, Zhou D, et al. Yap1 acts downstream of ?-catenin to control epidermal proliferation. Cell. 2011;144:782-95 pubmed publisher
    ..The molecular determinants of this process remain poorly understood. Here, we investigate the function of Yap1, the transcriptional effector of the Hippo signaling pathway, in skin biology...
  5. Yu F, Zhang Y, Park H, Jewell J, Chen Q, Deng Y, et al. Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation. Genes Dev. 2013;27:1223-32 pubmed publisher
    ..The YAP transcription coactivator is a major effector of the Hippo pathway and is phosphorylated and inactivated by the ..
  6. Kowalik M, Saliba C, Pibiri M, Perra A, Ledda Columbano G, Sarotto I, et al. Yes-associated protein regulation of adaptive liver enlargement and hepatocellular carcinoma development in mice. Hepatology. 2011;53:2086-96 pubmed publisher
    ..a growth-suppressive pathway that ultimately antagonizes the transcriptional coactivator Yes-associated protein (YAP), has been shown in transgenic animals to orchestrate organ size regulation...
  7. Oka T, Mazack V, Sudol M. Mst2 and Lats kinases regulate apoptotic function of Yes kinase-associated protein (YAP). J Biol Chem. 2008;283:27534-46 pubmed publisher
    ..Overexpression of YAP2 in HEK293 cells promoted apoptosis, whereas the Mst2/Lats1-induced phosphorylation of YAP partially rescued the cells from apoptotic death...
  8. Zhang H, Pasolli H, Fuchs E. Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin. Proc Natl Acad Sci U S A. 2011;108:2270-5 pubmed publisher
    ..Here, we uncover a critical and hitherto unappreciated role for Yes-associated protein (YAP), an evolutionarily conserved transcriptional coactivator with potent oncogenic potential...
  9. Cai J, Zhang N, Zheng Y, de Wilde R, Maitra A, Pan D. The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program. Genes Dev. 2010;24:2383-8 pubmed publisher
    ..We find that regenerating crypts express elevated Yes-associated protein (YAP) levels...

More Information

Publications62

  1. Happé H, van der Wal A, Leonhard W, Kunnen S, Breuning M, De Heer E, et al. Altered Hippo signalling in polycystic kidney disease. J Pathol. 2011;224:133-42 pubmed publisher
    ..Therefore, we examined its final effector molecule, the transcriptional co-activator Yes-associated protein (YAP) and observed that during tissue repair, YAP expression was not different between Pkd1-deletion mice and controls, ..
  2. Tamm C, Böwer N, Annerén C. Regulation of mouse embryonic stem cell self-renewal by a Yes-YAP-TEAD2 signaling pathway downstream of LIF. J Cell Sci. 2011;124:1136-44 pubmed publisher
    ..Here, we show that TEAD2 and its transcriptional co-activator, the Yes-associated protein YAP, co-operate in a signaling pathway downstream of Yes...
  3. Morin Kensicki E, Boone B, Howell M, Stonebraker J, Teed J, Alb J, et al. Defects in yolk sac vasculogenesis, chorioallantoic fusion, and embryonic axis elongation in mice with targeted disruption of Yap65. Mol Cell Biol. 2006;26:77-87 pubmed
    b>YAP is a multifunctional adapter protein and transcriptional coactivator with several binding partners well described in vitro and in cell culture...
  4. Oudhoff M, Freeman S, Couzens A, Antignano F, Kuznetsova E, Min P, et al. Control of the hippo pathway by Set7-dependent methylation of Yap. Dev Cell. 2013;26:188-94 pubmed publisher
    ..a larger progenitor compartment in the intestine, coinciding with increased expression of Yes-associated protein (Yap) target genes. Mechanistically, monomethylation of lysine 494 of Yap is critical for cytoplasmic retention...
  5. Yu F, Luo J, Mo J, Liu G, Kim Y, Meng Z, et al. Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP. Cancer Cell. 2014;25:822-30 pubmed publisher
    ..Herein, we show in both cell culture and human tumors that cancer-associated Gq/11 mutants activate YAP, a major effector of the Hippo tumor suppressor pathway that is also regulated by G protein-coupled receptor ..
  6. Hossain Z, Ali S, Ko H, Xu J, Ng C, Guo K, et al. Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1. Proc Natl Acad Sci U S A. 2007;104:1631-6 pubmed
    ..Thus, Wwtr1 is critical for the integrity of renal cilia and its absence in mice leads to the development of renal cysts, indicating that Wwtr1 may represent a candidate gene for polycystic kidney disease in humans. ..
  7. Silvis M, Kreger B, Lien W, Klezovitch O, Rudakova G, Camargo F, et al. ?-catenin is a tumor suppressor that controls cell accumulation by regulating the localization and activity of the transcriptional coactivator Yap1. Sci Signal. 2011;4:ra33 pubmed publisher
    ..Inactivation of the Hippo pathway promotes nuclear localization of the transcriptional coactivator Yap1, a Hippo pathway effector, and can cause cancer...
  8. Del Re D, Yang Y, Nakano N, Cho J, Zhai P, Yamamoto T, et al. Yes-associated protein isoform 1 (Yap1) promotes cardiomyocyte survival and growth to protect against myocardial ischemic injury. J Biol Chem. 2013;288:3977-88 pubmed publisher
    b>Yap1 is an important regulator of cardiomyocyte proliferation and embryonic heart development, yet the function of endogenous Yap1 in the adult heart remains unknown...
  9. Zhou D, Zhang Y, Wu H, Barry E, Yin Y, Lawrence E, et al. Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance. Proc Natl Acad Sci U S A. 2011;108:E1312-20 pubmed publisher
    ..enhanced abundance, and nuclear localization of the transcriptional coactivator Yes-associated protein 1 (Yap1) is evident in Mst1/Mst2-deficient intestinal epithelium, as is strong activation of ?-catenin and Notch signaling...
  10. Kim M, Kim M, Lee S, Kuninaka S, Saya H, Lee H, et al. cAMP/PKA signalling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes. EMBO J. 2013;32:1543-55 pubmed publisher
    Actin cytoskeletal damage induces inactivation of the oncoprotein YAP (Yes-associated protein). It is known that the serine/threonine kinase LATS (large tumour suppressor) inactivates YAP by phosphorylating its Ser127 and Ser381 residues...
  11. Song H, Mak K, Topol L, Yun K, Hu J, Garrett L, et al. Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci U S A. 2010;107:1431-6 pubmed publisher
    ..We show that Mst1 and Mst2 were required in vivo to control Yap phosphorylation and activity...
  12. Zhang N, Bai H, David K, Dong J, Zheng Y, Cai J, et al. The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals. Dev Cell. 2010;19:27-38 pubmed publisher
    ..cascade leading from the protein kinase Hippo (Hpo) (Mst1 and Mst2 in mammals) to the transcription coactivator Yorkie (Yki) (YAP in mammals) has been established, upstream regulators of the Hippo kinase cascade are less well defined,..
  13. Yagi R, Chen L, Shigesada K, Murakami Y, Ito Y. A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator. EMBO J. 1999;18:2551-62 pubmed
    ..Using yeast two-hybrid screening, we demonstrate that Yes-associated protein (YAP) binds to the PY motif of PEBP2alpha through its WW domain...
  14. Dupont S, Morsut L, Aragona M, Enzo E, Giulitti S, Cordenonsi M, et al. Role of YAP/TAZ in mechanotransduction. Nature. 2011;474:179-83 pubmed publisher
    ..Here we report the identification of the Yorkie-homologues YAP (Yes-associated protein) and TAZ (transcriptional coactivator with PDZ-binding motif, also known as ..
  15. Overholtzer M, Zhang J, Smolen G, Muir B, Li W, Sgroi D, et al. Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon. Proc Natl Acad Sci U S A. 2006;103:12405-10 pubmed
    ..The mouse amplicon contains only one known gene, Yap, encoding the mammalian ortholog of Drosophila Yorkie (Yki), a downstream effector of the Hippo(Hpo)-Salvador(Sav)-Warts(Wts) signaling cascade, recently identified in ..
  16. Nishioka N, Inoue K, Adachi K, Kiyonari H, Ota M, Ralston A, et al. The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass. Dev Cell. 2009;16:398-410 pubmed publisher
    ..In embryos, the Tead4 coactivator protein Yap localizes to nuclei of outside cells, and modulation of Tead4 or Yap activity leads to changes in Cdx2 expression...
  17. Lian I, Kim J, Okazawa H, Zhao J, Zhao B, Yu J, et al. The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation. Genes Dev. 2010;24:1106-18 pubmed publisher
    Yes-associated protein (YAP) is a potent transcription coactivator acting via binding to the TEAD transcription factor, and plays a critical role in organ size regulation...
  18. Vassilev A, Kaneko K, Shu H, Zhao Y, DePamphilis M. TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm. Genes Dev. 2001;15:1229-41 pubmed
    ..purified from mouse cells was associated predominantly with a novel TEAD-binding domain at the amino terminus of YAP65, a powerful transcriptional coactivator...
  19. Murakami M, Nakagawa M, Olson E, Nakagawa O. A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome. Proc Natl Acad Sci U S A. 2005;102:18034-9 pubmed
    ..b>YAP, a TAZ-related protein with conserved functional domains, also stimulates TBX5-dependent transcription, possibly by ..
  20. Dong J, Feldmann G, Huang J, Wu S, Zhang N, Comerford S, et al. Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell. 2007;130:1120-33 pubmed
    ..the Hippo kinase cascade, a growth-suppressive pathway that ultimately antagonizes the transcriptional coactivator Yorkie (Yki)...
  21. Lamar J, Stern P, Liu H, Schindler J, Jiang Z, Hynes R. The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain. Proc Natl Acad Sci U S A. 2012;109:E2441-50 pubmed publisher
    ..Although no activating mutations in the yap1 gene have been identified in human cancer, yap1 is located on the 11q22 amplicon, which is amplified in several ..
  22. Lee J, Kim T, Yang T, Koo B, Oh S, Lee K, et al. A crucial role of WW45 in developing epithelial tissues in the mouse. EMBO J. 2008;27:1231-42 pubmed publisher
    ..LATS1/2 phosphorylates YAP, which, in turn, translocates from the nucleus into the cytoplasm, resulting in cell-cycle exit and terminal ..
  23. Fernandez L A, Northcott P, Dalton J, Fraga C, Ellison D, Angers S, et al. YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation. Genes Dev. 2009;23:2729-41 pubmed publisher
    ..We report up-regulation of the oncogenic transcriptional coactivator yes-associated protein 1 (YAP1), which is negatively regulated by the Hippo pathway, in human medulloblastomas with aberrant Shh signaling...
  24. Liu Chittenden Y, Huang B, Shim J, Chen Q, Lee S, Anders R, et al. Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP. Genes Dev. 2012;26:1300-5 pubmed publisher
    ..suggesting that its mammalian counterpart may be exploited for selective inhibition of oncogenic growth driven by YAP hyperactivation. Here we test this hypothesis genetically and pharmacologically...
  25. Reginensi A, Scott R, Gregorieff A, Bagherie Lachidan M, Chung C, Lim D, et al. Yap- and Cdc42-dependent nephrogenesis and morphogenesis during mouse kidney development. PLoS Genet. 2013;9:e1003380 pubmed publisher
    b>Yap is a transcriptional co-activator that regulates cell proliferation and apoptosis downstream of the Hippo kinase pathway...
  26. Heallen T, Zhang M, Wang J, Bonilla Claudio M, Klysik E, Johnson R, et al. Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size. Science. 2011;332:458-61 pubmed publisher
    ..Furthermore, the Hippo effector Yap interacts with β-catenin on Sox2 and Snai2 genes...
  27. Varelas X, Miller B, Sopko R, Song S, Gregorieff A, Fellouse F, et al. The Hippo pathway regulates Wnt/beta-catenin signaling. Dev Cell. 2010;18:579-91 pubmed publisher
    ..These results uncover a cytoplasmic function of TAZ in regulating Wnt signaling and highlight the role of the Hippo pathway in coordinating morphogenetic signaling with growth control. ..
  28. Dong G, Loukinova E, Smith C, Chen Z, Van Waes C. Genes differentially expressed with malignant transformation and metastatic tumor progression of murine squamous cell carcinoma. J Cell Biochem Suppl. 1997;28-29:90-100 pubmed
    ..alpha was preferentially expressed in primary keratinocytes; genes for tyrosine kinase Yes-associated protein (YAP65) and ribosomal protein L18a were preferentially expressed in transformed and metastatic tumor cell lines; and ..
  29. Jansson L, Larsson J. Normal hematopoietic stem cell function in mice with enforced expression of the Hippo signaling effector YAP1. PLoS ONE. 2012;7:e32013 pubmed publisher
    ..The transcriptional cofactor yes-associated protein 1 (Yap1) is the most downstream effector of Hippo signaling and is functionally repressed by the upstream components of the ..
  30. Liu Z, Wu H, Jiang K, Wang Y, Zhang W, Chu Q, et al. MAPK-Mediated YAP Activation Controls Mechanical-Tension-Induced Pulmonary Alveolar Regeneration. Cell Rep. 2016;16:1810-9 pubmed publisher
    ..In this study, we demonstrate that mechanical-tension-induced YAP activation in alveolar stem cells plays a major role in promoting post-PNX alveolar regeneration...
  31. Swiderska Syn M, Xie G, Michelotti G, Jewell M, Premont R, Syn W, et al. Hedgehog regulates yes-associated protein 1 in regenerating mouse liver. Hepatology. 2016;64:232-44 pubmed publisher
    ..signaling pathways that are active during fetal development, including Hedgehog and Hippo/Yes-associated protein 1 (Yap1), regulate liver regeneration in adulthood...
  32. Ragni C, Diguet N, Le Garrec J, Novotova M, Resende T, Pop S, et al. Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth. Nat Commun. 2017;8:14582 pubmed publisher
    ..cardiomyocyte size and proliferation, and this is mediated by an upregulation of the transcriptional activity of Yap1, an effector of the Hippo pathway...
  33. Liang N, Zhang C, Dill P, Panasyuk G, Pion D, Koka V, et al. Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex. J Exp Med. 2014;211:2249-63 pubmed publisher
    ..sclerosis complex (TSC) 1-TSC2-mammalian target of Rapamycin (mTOR) and the Hippo-Yes-associated protein 1 (YAP) pathways are master regulators of organ size, which are often involved in tumorigenesis...
  34. Lee M, Byun M, Furutani Seiki M, Hong J, Jung H. YAP and TAZ regulate skin wound healing. J Invest Dermatol. 2014;134:518-525 pubmed publisher
    ..The two key downstream transcription coactivators in this pathway, Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ), mediate the major gene regulation and biological ..
  35. Ye H, Li X, Zheng T, Hu C, Pan Z, Huang J, et al. The Hippo Signaling Pathway Regulates Ovarian Function via the Proliferation of Ovarian Germline Stem Cells. Cell Physiol Biochem. 2017;41:1051-1062 pubmed publisher
    ..of ovarian germline stem cells (OGSCs), to clarify the relationship between the Hippo signaling pathway effector YAP1 and the proliferation and differentiation of OGSCs in vitro and to identify the major contribution of Hippo ..
  36. Ma X, Zhang H, Xue X, Shah Y. Hypoxia-inducible factor 2? (HIF-2?) promotes colon cancer growth by potentiating Yes-associated protein 1 (YAP1) activity. J Biol Chem. 2017;292:17046-17056 pubmed publisher
    ..Data mining of RNA-Seq experiments with mouse models of intestinal HIF-2? or Yes-associated protein 1 (YAP1) overexpression indicates a significant overlap of genes in these conditions...
  37. Stephenson R, Yamanaka Y, Rossant J. Disorganized epithelial polarity and excess trophectoderm cell fate in preimplantation embryos lacking E-cadherin. Development. 2010;137:3383-91 pubmed publisher
    ..They also show that Cdx2 expression is strongly linked to apical membrane polarization. ..
  38. Badouel C, Zander M, Liscio N, Bagherie Lachidan M, Sopko R, Coyaud E, et al. Fat1 interacts with Fat4 to regulate neural tube closure, neural progenitor proliferation and apical constriction during mouse brain development. Development. 2015;142:2781-91 pubmed publisher
    ..We propose a model in which Fat1 and Fat4 binding coordinates distinct pathways at apical junctions to regulate neural progenitor proliferation, neural tube closure and apical constriction. ..
  39. Shao D, Zhai P, Del Re D, Sciarretta S, Yabuta N, Nojima H, et al. A functional interaction between Hippo-YAP signalling and FoxO1 mediates the oxidative stress response. Nat Commun. 2014;5:3315 pubmed publisher
    ..Here we report that Yes-associated protein (YAP), the terminal effector of the Hippo pathway, interacts with FoxO1 in the nucleus of cardiomyocytes, thereby ..
  40. Han D, Byun S, Park S, Kim J, Kim I, Ha S, et al. YAP/TAZ enhance mammalian embryonic neural stem cell characteristics in a Tead-dependent manner. Biochem Biophys Res Commun. 2015;458:110-6 pubmed publisher
    ..Here we show that YAP/TAZ enhance embryonic neural stem cell characteristics in a cell autonomous fashion using diverse experimental ..
  41. Xin M, Kim Y, Sutherland L, Qi X, McAnally J, Schwartz R, et al. Regulation of insulin-like growth factor signaling by Yap governs cardiomyocyte proliferation and embryonic heart size. Sci Signal. 2011;4:ra70 pubmed publisher
    ..Hippo pathway kinases influence the activity of various targets, including the transcriptional coactivator Yap, but the specific role of Yap in heart growth has not been investigated...
  42. Yao Y, Minor P, Zhao Y, Jeong Y, Pani A, King A, et al. Cis-regulatory architecture of a brain signaling center predates the origin of chordates. Nat Genet. 2016;48:575-80 pubmed publisher
    ..These findings support a strategy for delineating functionally conserved enhancers in the absence of overt sequence homologies and over extensive evolutionary distances. ..
  43. Li C, Hu J, Lu H, Lan J, Du W, Galicia N, et al. ?E-catenin inhibits YAP/TAZ activity to regulate signalling centre formation during tooth development. Nat Commun. 2016;7:12133 pubmed publisher
    ..Here we report, using the murine incisor as a model, that ?E-catenin is essential for inhibiting nuclear YAP localization and cell proliferation...
  44. Tang Y, Feinberg T, Keller E, Li X, Weiss S. Snail/Slug binding interactions with YAP/TAZ control skeletal stem cell self-renewal and differentiation. Nat Cell Biol. 2016;18:917-29 pubmed publisher
    ..Mechanistically, Snail/Slug regulate SSC function by forming complexes with the transcriptional co-activators YAP and TAZ in tandem with the inhibition of the Hippo-pathway-dependent regulation of YAP/TAZ signalling cascades...
  45. Yao M, Wang Y, Zhang P, Chen H, Xu Z, Jiao J, et al. BMP2-SMAD signaling represses the proliferation of embryonic neural stem cells through YAP. J Neurosci. 2014;34:12039-48 pubmed publisher
    Previous studies have shown that the Hippo pathway effector yes-associated protein (YAP) plays an important role in maintaining stem cell proliferation...
  46. Basu Roy U, Han E, Rattanakorn K, Gadi A, Verma N, Maurizi G, et al. PPARγ agonists promote differentiation of cancer stem cells by restraining YAP transcriptional activity. Oncotarget. 2016;7:60954-60970 pubmed publisher
    ..Gene expression analysis reveals that TZDs induce lipid metabolism pathways while suppressing targets of the Hippo-YAP pathway, Wnt signaling and cancer-related proliferation pathways...
  47. Noritake K, Aki T, Kimura M, Funakoshi T, Unuma K, Uemura K. Restoration of YAP activation rescues HL-1 cardiomyocytes from apoptotic death by ethanol. J Toxicol Sci. 2017;42:545-551 pubmed publisher
    ..cytoskeleton is severely disrupted and the anti-apoptotic transcriptional co-activator Yes-associated protein (YAP) is inactivated...
  48. Tian Y, Liu Y, Wang T, Zhou N, Kong J, Chen L, et al. A microRNA-Hippo pathway that promotes cardiomyocyte proliferation and cardiac regeneration in mice. Sci Transl Med. 2015;7:279ra38 pubmed publisher
    ..Our data demonstrate the ability of microRNA-based therapeutic approaches to promote mammalian cardiac repair and regeneration through the transient activation of cardiomyocyte proliferation. ..
  49. Hu Y, Shin D, Pan H, Lin Z, Dreyfuss J, Camargo F, et al. YAP suppresses gluconeogenic gene expression through PGC1?. Hepatology. 2017;66:2029-2041 pubmed publisher
    ..The transcriptional regulator Yes-associated protein 1 (YAP) is a key regulator of liver size, development, and function...
  50. Tao H, Inoue K, Kiyonari H, Bassuk A, Axelrod J, Sasaki H, et al. Nuclear localization of Prickle2 is required to establish cell polarity during early mouse embryogenesis. Dev Biol. 2012;364:138-48 pubmed publisher
    ..The cell polarity phenotype was efficiently rescued by nuclear but not cytoplasmic Pk2, demonstrating the nuclear localization of Pk2 is critical for its function. ..
  51. Cai J, Maitra A, Anders R, Taketo M, Pan D. β-Catenin destruction complex-independent regulation of Hippo-YAP signaling by APC in intestinal tumorigenesis. Genes Dev. 2015;29:1493-506 pubmed publisher
    ..Here we report that activation of YAP, the downstream effector of the Hippo signaling pathway, is a general hallmark of tubular adenomas from FAP ..
  52. Lin Y, Ding J, Li M, Yeh T, Wang T, Yu J. YAP regulates neuronal differentiation through Sonic hedgehog signaling pathway. Exp Cell Res. 2012;318:1877-88 pubmed publisher
    ..Here, we used P19 cells, a mouse embryonic carcinoma cell line, as a model to study roles of YAP, a core component of the Hippo pathway, in neuronal differentiation...
  53. Ferrigno O, Lallemand F, Verrecchia F, L Hoste S, Camonis J, Atfi A, et al. Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling. Oncogene. 2002;21:4879-84 pubmed
    ..a human placental cDNA expression library using full-length mouse Smad7 as bait identified Yes-Associated Protein (YAP65) as a novel Smad7-interacting protein...