Xrcc2

Summary

Gene Symbol: Xrcc2
Description: X-ray repair complementing defective repair in Chinese hamster cells 2
Alias: 4921524O04Rik, 8030409M04Rik, RAD51, RecA, DNA repair protein XRCC2, X-ray repair cross-complementing protein 2, recA/RAD51 family protein
Species: mouse
Products:     Xrcc2

Top Publications

  1. Deans B, Griffin C, Maconochie M, Thacker J. Xrcc2 is required for genetic stability, embryonic neurogenesis and viability in mice. EMBO J. 2000;19:6675-85 pubmed
    ..The recently cloned Xrcc2 gene is a member of the mammalian Rad51 gene family, thought to be central to homologous recombination repair...
  2. Rajesh C, Gruver A, Basrur V, Pittman D. The interaction profile of homologous recombination repair proteins RAD51C, RAD51D and XRCC2 as determined by proteomic analysis. Proteomics. 2009;9:4071-86 pubmed publisher
    ..To identify candidates that interact with HR proteins, the mouse RAD51C, RAD51D and XRCC2 proteins were purified using bacterial expression systems and each of them used to co-precipitate interacting ..
  3. Deans B, Griffin C, O Regan P, Jasin M, Thacker J. Homologous recombination deficiency leads to profound genetic instability in cells derived from Xrcc2-knockout mice. Cancer Res. 2003;63:8181-7 pubmed
    ..b>Xrcc2 is a protein with homology to Rad51, the core component of HR, but with a nonredundant role in damage repair...
  4. Orii K, Lee Y, Kondo N, McKinnon P. Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development. Proc Natl Acad Sci U S A. 2006;103:10017-22 pubmed
    ..DNA damage-induced apoptosis resulting from inactivation of HR (Xrcc2 deficiency) only occurred in proliferating neural precursor cells, whereas disruption of NHEJ (DNA ligase IV ..
  5. Caddle L, Hasham M, Schott W, Shirley B, Mills K. Homologous recombination is necessary for normal lymphocyte development. Mol Cell Biol. 2008;28:2295-303 pubmed publisher
    ..We have investigated roles of the X-ray cross-complementing 2 (Xrcc2) HR gene in lymphocyte development...
  6. Adam J, Deans B, Thacker J. A role for Xrcc2 in the early stages of mouse development. DNA Repair (Amst). 2007;6:224-34 pubmed
    b>Xrcc2 is one of a family of five Rad51-like genes with important roles in the repair of DNA damage by homologous recombination (HR) in mammals...
  7. Barlow J, Faryabi R, Callén E, Wong N, Malhowski A, Chen H, et al. Identification of early replicating fragile sites that contribute to genome instability. Cell. 2013;152:620-32 pubmed publisher
    ..Moreover, greater than 50% of recurrent amplifications/deletions in human diffuse large B cell lymphoma map to ERFSs. In summary, we have identified a source of spontaneous DNA lesions that drives instability at preferred genomic sites. ..
  8. Gruver A, Yard B, McInnes C, Rajesh C, Pittman D. Functional characterization and identification of mouse Rad51d splice variants. BMC Mol Biol. 2009;10:27 pubmed publisher
    ..The RAD51 paralogs (RAD51B, RAD51C, RAD51D, XRCC2, XRCC3) are essential for this process in vertebrates, and the RAD51D ..
  9. Frappart P, Lee Y, Russell H, Chalhoub N, Wang Y, Orii K, et al. Recurrent genomic alterations characterize medulloblastoma arising from DNA double-strand break repair deficiency. Proc Natl Acad Sci U S A. 2009;106:1880-5 pubmed publisher
    ..Here, we inactivated DNA double-strand break repair (DSBR) proteins, DNA Ligase IV (Lig4), Xrcc2, and Brca2, or combined Lig4/Xrcc2 during neural development using Nestin-cre...

More Information

Publications21

  1. Cartwright R, Tambini C, Simpson P, Thacker J. The XRCC2 DNA repair gene from human and mouse encodes a novel member of the recA/RAD51 family. Nucleic Acids Res. 1998;26:3084-9 pubmed
    ..the cDNA for this gene from both human and mouse and show that it is a highly conserved novel member of the recA / RAD51 recombination repair gene family...
  2. Griffin C, Waard H, Deans B, Thacker J. The involvement of key DNA repair pathways in the formation of chromosome rearrangements in embryonic stem cells. DNA Repair (Amst). 2005;4:1019-27 pubmed
    ..We chose cells deficient in Ku70 (DNA end joining), Xrcc2 (gene conversion), Ercc1 (single-strand annealing) and Csb (transcription-coupled repair) to represent potentially-..
  3. Pieraccioli M, Nicolai S, Antonov A, Somers J, Malewicz M, Melino G, et al. ZNF281 contributes to the DNA damage response by controlling the expression of XRCC2 and XRCC4. Oncogene. 2016;35:2592-601 pubmed publisher
    ..In line with this finding, XRCC2 and XRCC4, two genes that take part in homologous recombination and non-homologous end joining, respectively, were ..
  4. Lee Y, Brown E, Chang S, McKinnon P. Pot1a prevents telomere dysfunction and ATM-dependent neuronal loss. J Neurosci. 2014;34:7836-44 pubmed publisher
    ..These data reveal that neural cell loss after DNA damage selectively engages Atm signaling, highlighting how specific DNA lesions can dictate neuropathology arising in human neurodegenerative syndromes. ..
  5. Hasham M, Donghia N, Coffey E, Maynard J, Snow K, Ames J, et al. Widespread genomic breaks generated by activation-induced cytidine deaminase are prevented by homologous recombination. Nat Immunol. 2010;11:820-6 pubmed publisher
    ..We demonstrate that the homologous-recombination factor XRCC2 suppressed AID-induced off-target DSBs, promoting B cell survival...
  6. Haines J, Coster M, Adam J, Cheeseman M, Ainsbury E, Thacker J, et al. Xrcc2 modulates spontaneous and radiation-induced tumorigenesis in Apcmin/+ mice. Mol Cancer Res. 2010;8:1227-33 pubmed publisher
    b>XRCC2 has an important role in repair of DNA damage by homologous recombination. Adult Apc(min/+) (min, multiple intestinal neoplasia) mice, wild-type or heterozygous for Xrcc2 deficiency, were sham-irradiated or 2-Gy X-irradiated...
  7. Rajesh C, Baker D, Pierce A, Pittman D. The splicing-factor related protein SFPQ/PSF interacts with RAD51D and is necessary for homology-directed repair and sister chromatid cohesion. Nucleic Acids Res. 2011;39:132-45 pubmed publisher
    ..The RAD51 family plays an integral role in preserving genome stability by homology directed repair of DSBs...
  8. Cappelli E, Townsend S, Griffin C, Thacker J. Homologous recombination proteins are associated with centrosomes and are required for mitotic stability. Exp Cell Res. 2011;317:1203-13 pubmed publisher
    ..Severe forms of DNA damage are repaired by homologous recombination (HR), in which the XRCC2 protein plays a vital role...
  9. Yard B, Reilly N, Bedenbaugh M, Pittman D. RNF138 interacts with RAD51D and is required for DNA interstrand crosslink repair and maintaining chromosome integrity. DNA Repair (Amst). 2016;42:82-93 pubmed publisher
    ..Presence of RNF138 also enhanced the interaction between RAD51D and a known interacting RAD51 family member XRCC2 in a yeast three-hybrid assay...
  10. Tambini C, Spink K, Ross C, Hill M, Thacker J. The importance of XRCC2 in RAD51-related DNA damage repair. DNA Repair (Amst). 2010;9:517-25 pubmed publisher
    ..The central HR protein is RAD51, which ensures high fidelity DNA repair by facilitating strand exchange between damaged and undamaged homologous ..
  11. Kondo N, Takahashi A, Mori E, Ohnishi K, McKinnon P, Sakaki T, et al. DNA ligase IV as a new molecular target for temozolomide. Biochem Biophys Res Commun. 2009;387:656-60 pubmed publisher
    ..DSB repair genes such as homologous recombination repair-related genes X-ray repair cross-complementing group 2 (XRCC2)and radiation sensitive mutant54 (Rad54), non-homologous end joining repair-related gene DNAligase IV (Lig4)...
  12. Rukść A, Birmingham E, Baker M. Altered DNA repair and recombination responses in mouse cells expressing wildtype or mutant forms of RAD51. DNA Repair (Amst). 2007;6:1876-89 pubmed
    b>Rad51, a homolog of Esherichia coli RecA, is a DNA-dependent ATPase that binds cooperatively to single-stranded DNA forming a nucleoprotein filament, which functions in the strand invasion step of homologous recombination...