Xpo1

Summary

Gene Symbol: Xpo1
Description: exportin 1
Alias: AA420417, Crm1, Exp1, exportin-1, chromosome region maintenance 1 protein homolog, exportin 1, CRM1 homolog
Species: mouse
Products:     Xpo1

Top Publications

  1. Herrmann A, Vogt M, Mönnigmann M, Clahsen T, Sommer U, Haan S, et al. Nucleocytoplasmic shuttling of persistently activated STAT3. J Cell Sci. 2007;120:3249-61 pubmed
    ..We propose passage of persistently activated STAT3 through the nuclear pore complex as a new target for intervention in cancer. ..
  2. Inoue H, Kauffman M, Shacham S, Landesman Y, Yang J, Evans C, et al. CRM1 blockade by selective inhibitors of nuclear export attenuates kidney cancer growth. J Urol. 2013;189:2317-26 pubmed publisher
    ..We identified and evaluated the nuclear exporter protein CRM1 as a novel potential therapy for renal cell carcinoma...
  3. Guttler T, Madl T, Neumann P, Deichsel D, Corsini L, Monecke T, et al. NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1. Nat Struct Mol Biol. 2010;17:1367-76 pubmed publisher
    Classic nuclear export signals (NESs) confer CRM1-dependent nuclear export. Here we present crystal structures of the RanGTP-CRM1 complex alone and bound to the prototypic PKI or HIV-1 Rev NESs...
  4. Shinmura K, Tarapore P, Tokuyama Y, George K, Fukasawa K. Characterization of centrosomal association of nucleophosmin/B23 linked to Crm1 activity. FEBS Lett. 2005;579:6621-34 pubmed
    ..We further found that inhibition of Crm1 nuclear export receptor results in both accumulation of cyclin E at centrosomes and efficient dissociation of NPM/..
  5. Du J, Bialkowska A, McConnell B, Yang V. SUMOylation regulates nuclear localization of Krüppel-like factor 5. J Biol Chem. 2008;283:31991-2002 pubmed publisher
    ..The NES in KLF5 directs a fused green fluorescence protein to the cytoplasm, binds the nuclear export receptor CRM1, and is inhibited by leptomycin and site-directed mutagenesis...
  6. López Bueno A, Valle N, Gallego J, Pérez J, Almendral J. Enhanced cytoplasmic sequestration of the nuclear export receptor CRM1 by NS2 mutations developed in the host regulates parvovirus fitness. J Virol. 2004;78:10674-84 pubmed
    ..K96E, L103P, and L153 M) that were consistently selected in several mice clustered within the nuclear exportin CRM1 binding domain, in a reading frame that did not alter the overlapping NS1 coding region...
  7. Monecke T, Guttler T, Neumann P, Dickmanns A, Gorlich D, Ficner R. Crystal structure of the nuclear export receptor CRM1 in complex with Snurportin1 and RanGTP. Science. 2009;324:1087-91 pubmed publisher
    b>CRM1 mediates nuclear export of numerous unrelated cargoes, which may carry a short leucine-rich nuclear export signal or export signatures that include folded domains...
  8. Sakiyama H, Wynn R, Lee W, Fukasawa M, Mizuguchi H, Gardner K, et al. Regulation of nuclear import/export of carbohydrate response element-binding protein (ChREBP): interaction of an alpha-helix of ChREBP with the 14-3-3 proteins and regulation by phosphorylation. J Biol Chem. 2008;283:24899-908 pubmed publisher
    ..Phosphorylation of ChREBP at these sites was essential for its interaction with CRM1 for export to the cytosol, whereas nuclear import of ChREBP requires dephosphorylated ChREBP to interact with ..
  9. Simon Areces J, Acaz Fonseca E, Ruiz Palmero I, Garcia Segura L, Arevalo M. A CRM1-mediated nuclear export signal is essential for cytoplasmic localization of neurogenin 3 in neurons. PLoS ONE. 2013;8:e55237 pubmed publisher
    ..EGFP)-NES2 fusion protein was localized in the cytoplasm and its nucleo-cytoplasmic shuttling was blocked by the CRM1 specific export inhibitor leptomycin B...

More Information

Publications61

  1. Grespin M, Bonamy G, Roggero V, Cameron N, Adam L, Atchison A, et al. Thyroid hormone receptor alpha1 follows a cooperative CRM1/calreticulin-mediated nuclear export pathway. J Biol Chem. 2008;283:25576-88 pubmed publisher
    ..TRalpha export is not sensitive to treatment with the CRM1-specific inhibitor leptomycin B (LMB) in heterokaryon assays, suggesting a role for an export receptor other than ..
  2. Svärd J, Heby Henricson K, Henricson K, Persson Lek M, Rozell B, Lauth M, et al. Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway. Dev Cell. 2006;10:187-97 pubmed
    ..Our data demonstrate that, in striking contrast to Drosophila, in mammals, Sufu has a central role, and its loss of function leads to potent ligand-independent activation of the Hh pathway. ..
  3. McKinsey T, Kuwahara K, Bezprozvannaya S, Olson E. Class II histone deacetylases confer signal responsiveness to the ankyrin-repeat proteins ANKRA2 and RFXANK. Mol Biol Cell. 2006;17:438-47 pubmed
    ..Phosphorylation of class II HDACs by CaMK results in CRM1-dependent nuclear export of HDAC/RFXANK complexes...
  4. Zerfaoui M, Errami Y, Naura A, Suzuki Y, Kim H, Ju J, et al. Poly(ADP-ribose) polymerase-1 is a determining factor in Crm1-mediated nuclear export and retention of p65 NF-kappa B upon TLR4 stimulation. J Immunol. 2010;185:1894-902 pubmed publisher
    ..b>Crm1 inhibition promoted p65 NF-kappaB nuclear accumulation as well as reversed LPS-induced p65 NF-kappaB ..
  5. Fei E, Ma X, Zhu C, Xue T, Yan J, Xu Y, et al. Nucleocytoplasmic shuttling of dysbindin-1, a schizophrenia-related protein, regulates synapsin I expression. J Biol Chem. 2010;285:38630-40 pubmed publisher
    ..shuttling protein and translocated to the nucleus upon treatment with leptomycin B, an inhibitor of exportin-1/CRM1-mediated nuclear export...
  6. Ohno M, Segref A, Bachi A, Wilm M, Mattaj I. PHAX, a mediator of U snRNA nuclear export whose activity is regulated by phosphorylation. Cell. 2000;101:187-98 pubmed
    ..Export depends upon the RNA cap structure, nuclear cap-binding complex (CBC), the export receptor CRM1/Xpo1, and RanGTP. These components are however insufficient to support U snRNA export...
  7. von Knethen A, Tzieply N, Jennewein C, Brüne B. Casein-kinase-II-dependent phosphorylation of PPARgamma provokes CRM1-mediated shuttling of PPARgamma from the nucleus to the cytosol. J Cell Sci. 2010;123:192-201 pubmed publisher
    ..The CRM1 inhibitor leptomycin B abolished cytosolic PPARgamma localization, suggesting that this is a CRM1-dependent export ..
  8. Benzeno S, Diehl J. C-terminal sequences direct cyclin D1-CRM1 binding. J Biol Chem. 2004;279:56061-6 pubmed
    GSK-3beta-dependent phosphorylation of cyclin D1 at a conserved C-terminal residue, Thr-286, promotes CRM1-dependent cyclin D1 nuclear export...
  9. Barnfield P, Zhang X, Thanabalasingham V, Yoshida M, Hui C. Negative regulation of Gli1 and Gli2 activator function by Suppressor of fused through multiple mechanisms. Differentiation. 2005;73:397-405 pubmed
    ..While Su(fu) itself is not subject to CRM1-dependent regulation, Su(fu) sequesters Gli1 in the cytoplasm mostly through a mechanism that depends on the ..
  10. Pradet Balade B, Girard C, Boulon S, Paul C, Azzag K, Bordonné R, et al. CRM1 controls the composition of nucleoplasmic pre-snoRNA complexes to licence them for nucleolar transport. EMBO J. 2011;30:2205-18 pubmed publisher
    Transport of C/D snoRNPs to nucleoli involves nuclear export factors. In particular, CRM1 binds nascent snoRNPs, but its precise role remains unknown...
  11. Saito S, Çiğdem S, Okuwaki M, Nagata K. Leukemia-Associated Nup214 Fusion Proteins Disturb the XPO1-Mediated Nuclear-Cytoplasmic Transport Pathway and Thereby the NF-?B Signaling Pathway. Mol Cell Biol. 2016;36:1820-35 pubmed publisher
    ..We found that SET-Nup214 and DEK-Nup214 interact with exportin-1 (XPO1)/CRM1 and nuclear RNA export factor 1 (NXF1)/TAP, which mediate leucine-rich nuclear export signal (NES)-dependent ..
  12. Samuels A, Klinken S, Ingley E. Liar, a novel Lyn-binding nuclear/cytoplasmic shuttling protein that influences erythropoietin-induced differentiation. Blood. 2009;113:3845-56 pubmed publisher
    ..These results show that Liar is a novel Lyn-interacting molecule that plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation. ..
  13. Cai X, Liu X. Inhibition of Thr-55 phosphorylation restores p53 nuclear localization and sensitizes cancer cells to DNA damage. Proc Natl Acad Sci U S A. 2008;105:16958-63 pubmed publisher
    ..In this study, we report that Thr-55 phosphorylation induces the association of p53 with the nuclear export factor CRM1, leading to p53 nuclear export...
  14. Chen L, Moore J, Samathanam C, Shao C, Cobos E, Miller M, et al. CRM1-dependent p53 nuclear accumulation in lung lesions of a bitransgenic mouse lung tumor model. Oncol Rep. 2011;26:223-8 pubmed publisher
    The p53 tumor suppressor gene plays an essential role in tumorigenesis, and the chromosomal region maintenance 1 (CRM1) has been suggested to export p53 protein from the nucleus to the cytoplasm...
  15. Tomoda K, Kubota Y, Arata Y, Mori S, Maeda M, Tanaka T, et al. The cytoplasmic shuttling and subsequent degradation of p27Kip1 mediated by Jab1/CSN5 and the COP9 signalosome complex. J Biol Chem. 2002;277:2302-10 pubmed
    ..Nuclear-cytoplasmic translocation plays an important role because leptomycin B (LMB), a chemical inhibitor of CRM1-dependent nuclear export, prevents p27 degradation mediated by Jab1/CSN5...
  16. Pickard B, Hodsman A, Fraher L, Watson P. Type 1 parathyroid hormone receptor (PTH1R) nuclear trafficking: regulation of PTH1R nuclear-cytoplasmic shuttling by importin-alpha/beta and chromosomal region maintenance 1/exportin 1. Endocrinology. 2007;148:2282-9 pubmed
    ..To address the nuclear export of PTH1R, interactions between PTH1R and chromosomal region maintenance 1 (CRM1) were investigated...
  17. Evsikov A, de Vries W, Peaston A, Radford E, Fancher K, Chen F, et al. Systems biology of the 2-cell mouse embryo. Cytogenet Genome Res. 2004;105:240-50 pubmed
    ..These results provide a foundation for understanding molecular control at the onset of mammalian development. ..
  18. Fernandez L A, Northcott P, Dalton J, Fraga C, Ellison D, Angers S, et al. YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation. Genes Dev. 2009;23:2729-41 pubmed publisher
    ..Post-irradiation, YAP1 was found in newly growing tumor cells. These findings implicate YAP1 as a new Shh effector that may be targeted by medulloblastoma therapies aimed at eliminating medulloblastoma recurrence. ..
  19. Crochiere M, Baloglu E, Klebanov B, Donovan S, Del Alamo D, Lee M, et al. A method for quantification of exportin-1 (XPO1) occupancy by Selective Inhibitor of Nuclear Export (SINE) compounds. Oncotarget. 2016;7:1863-77 pubmed publisher
    ..that inhibit nuclear export through covalent binding to cysteine 528 (Cys528) in the cargo-binding pocket of Exportin 1 (XPO1/CRM1) and promote cancer cell death...
  20. Li J, Shiraki T, Igarashi K. Transcription-independent role of Bach1 in mitosis through a nuclear exporter Crm1-dependent mechanism. FEBS Lett. 2012;586:448-54 pubmed publisher
    ..Despite its role in transcription, Bach1 is predominantly exported to the cytoplasm in a Crm1-dependent manner, but the functional role of its cytoplasmic retention is still unclear...
  21. Gao C, Li X, Lam M, Liu Y, Chakraborty S, Kao H. CRM1 mediates nuclear export of HDAC7 independently of HDAC7 phosphorylation and association with 14-3-3s. FEBS Lett. 2006;580:5096-104 pubmed
    b>CRM1, 14-3-3 proteins, and CaMK play important roles in trafficking of HDAC7, but the interplay between these proteins in this process is not clearly understood...
  22. Elinav H, Wu Y, Coskun A, Hryckiewicz K, Kemler I, Hu Y, et al. Human CRM1 augments production of infectious human and feline immunodeficiency viruses from murine cells. J Virol. 2012;86:12053-68 pubmed publisher
    ..In contrast, the overexpression of mouse CRM1 (mCRM1) minimally affected HIV-1 and FIV production and did not antagonize hCRM1...
  23. Panasyuk G, Nemazanyy I, Zhyvoloup A, Bretner M, Litchfield D, Filonenko V, et al. Nuclear export of S6K1 II is regulated by protein kinase CK2 phosphorylation at Ser-17. J Biol Chem. 2006;281:31188-201 pubmed
    ..We also provide evidence that nuclear export of S6K1 is mediated by a CRM1-dependent mechanism...
  24. Agassandian M, Chen B, Pulijala R, Kaercher L, Glasser J, Mallampalli R. Calcium-calmodulin kinase I cooperatively regulates nucleocytoplasmic shuttling of CCT? by accessing a nuclear export signal. Mol Biol Cell. 2012;23:2755-69 pubmed publisher
    ..290-299), a sequence that displays similarities to a canonical nuclear export signal (NES) that also binds CRM1/exportin 1. Expression of a CFP-CCT? mutant lacking residues 290-299 in cells results in cytosolically retained enzyme...
  25. Nagamori I, Yomogida K, Adams P, Sassone Corsi P, Nojima H. Transcription factors, cAMP-responsive element modulator (CREM) and Tisp40, act in concert in postmeiotic transcriptional regulation. J Biol Chem. 2006;281:15073-81 pubmed
    ..Finally, we demonstrate that the Tisp40DeltaTM-CREMtau heterodimer acts as a recruiter of HIRA, a histone chaperone, to CRE. Taken together, we propose that Tisp40 is an important transcriptional regulator during spermiogenesis. ..
  26. Suarez Sanchez R, Aguilar A, Wagstaff K, Velez G, Azuara Medina P, Gomez P, et al. Nucleocytoplasmic shuttling of the Duchenne muscular dystrophy gene product dystrophin Dp71d is dependent on the importin ?/? and CRM1 nuclear transporters and microtubule motor dynein. Biochim Biophys Acta. 2014;1843:985-1001 pubmed publisher
    ..the nucleus and cytoplasm mediated by the conventional nuclear transporters, importin (IMP) ?/? and the exportin CRM1. Binding was confirmed in cells using pull-downs, while in vitro binding assays showed direct, high affinity (..
  27. Hilton L, White M, Quarmby L. The NIMA-related kinase NEK1 cycles through the nucleus. Biochem Biophys Res Commun. 2009;389:52-6 pubmed publisher
    ..Our data suggest that NEK1 is a candidate to transduce messages from the ciliary-basal body region to the regulation of nuclear gene expression. ..
  28. Oka M, Asally M, Yasuda Y, Ogawa Y, Tachibana T, Yoneda Y. The mobile FG nucleoporin Nup98 is a cofactor for Crm1-dependent protein export. Mol Biol Cell. 2010;21:1885-96 pubmed publisher
    ..Here, we show that Nup98 plays an important role in Crm1-mediated nuclear protein export...
  29. Thomas M, Lischka P, Müller R, Stamminger T. The cellular DExD/H-box RNA-helicases UAP56 and URH49 exhibit a CRM1-independent nucleocytoplasmic shuttling activity. PLoS ONE. 2011;6:e22671 pubmed publisher
    ..Here, we demonstrate that UAP56 and URH49 exhibit an intrinsic CRM1-independent nucleocytoplasmic shuttling activity...
  30. Aligeti M, Behrens R, Pocock G, Schindelin J, Dietz C, Eliceiri K, et al. Cooperativity among Rev-associated nuclear export signals regulates HIV-1 gene expression and is a determinant of virus species tropism. J Virol. 2014;88:14207-21 pubmed publisher
    ..of the chromosomal region maintenance 1 (mCRM1) nuclear export receptor and rescued by the expression of human CRM1 (hCRM1)...
  31. Corum D, Tsichlis P, Muise Helmericks R. AKT3 controls mitochondrial biogenesis and autophagy via regulation of the major nuclear export protein CRM-1. FASEB J. 2014;28:395-407 pubmed publisher
    ..This correlates with an ~1.5-fold decrease in mitochondrial Cox IV expression. Our studies suggest that Akt3 is a regulator of mitochondrial dynamics in the vasculature via regulation of CRM-1-dependent nuclear export. ..
  32. Cong F, Varmus H. Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of beta-catenin. Proc Natl Acad Sci U S A. 2004;101:2882-7 pubmed
    ..Our results suggest that Axin functions as a molecular chaperone for beta-catenin and that nuclear-cytoplasmic shuttling of Axin regulates the nuclear-cytoplasmic distribution of beta-catenin. ..
  33. Kim J, Shen S, Dietz K, He Y, Howell O, Reynolds R, et al. HDAC1 nuclear export induced by pathological conditions is essential for the onset of axonal damage. Nat Neurosci. 2010;13:180-9 pubmed publisher
    ..Together these data identify nuclear export of HDAC1 as a critical event for impaired mitochondrial transport in damaged neurons. ..
  34. Monecke T, Haselbach D, Voß B, Russek A, Neumann P, Thomson E, et al. Structural basis for cooperativity of CRM1 export complex formation. Proc Natl Acad Sci U S A. 2013;110:960-5 pubmed publisher
    ..The highly versatile exportin chromosome region maintenance 1 (CRM1) is essential for nuclear depletion of numerous structurally and functionally unrelated protein and ..
  35. Custódio N, Antoniou M, Carmo Fonseca M. Abundance of the largest subunit of RNA polymerase II in the nucleus is regulated by nucleo-cytoplasmic shuttling. Exp Cell Res. 2006;312:2557-67 pubmed
    ..over-expressed RNA Pol II LS was predominantly hypophosphorylated, soluble and accumulated in the cytoplasm in a CRM1-dependent manner...
  36. Nakrieko K, Vespa A, Mason D, Irvine T, D Souza S, Dagnino L. Modulation of integrin-linked kinase nucleo-cytoplasmic shuttling by ILKAP and CRM1. Cell Cycle. 2008;7:2157-66 pubmed
    ..In addition, nuclear ILK can be rapidly exported into the cytoplasm through a CRM1-dependent pathway, and its export is enhanced by the type 2C protein phosphatase ILKAP...
  37. Stipanovich A, Valjent E, Matamales M, Nishi A, Ahn J, Maroteaux M, et al. A phosphatase cascade by which rewarding stimuli control nucleosomal response. Nature. 2008;453:879-84 pubmed publisher
    ..Mutation of Ser 97 profoundly alters behavioural effects of drugs of abuse and decreases motivation for food, underlining the functional importance of this signalling cascade. ..
  38. Eilers A, Sundwall E, Lin M, Sullivan A, Ayer D. A novel heterodimerization domain, CRM1, and 14-3-3 control subcellular localization of the MondoA-Mlx heterocomplex. Mol Cell Biol. 2002;22:8514-26 pubmed
    ..Mondo conserved regions (MCRs) II and III contribute to cytoplasmic localization of MondoA-Mlx by functioning as a CRM1-dependent nuclear export signal and as a novel binding site for 14-3-3 family members, respectively...
  39. Knauer S, Carra G, Stauber R. Nuclear export is evolutionarily conserved in CVC paired-like homeobox proteins and influences protein stability, transcriptional activation, and extracellular secretion. Mol Cell Biol. 2005;25:2573-82 pubmed
    ..Complementary experimental approaches demonstrated that PLC-HDP family members are exported by the Crm1 pathway and contain an evolutionary conserved leucine-rich nuclear export signal...
  40. Leskov K, Araki S, Lavik J, Gomez J, Gama V, Gonos E, et al. CRM1 protein-mediated regulation of nuclear clusterin (nCLU), an ionizing radiation-stimulated, Bax-dependent pro-death factor. J Biol Chem. 2011;286:40083-90 pubmed publisher
    ..nCLU accumulation was regulated by CRM1 because binding between CRM1 and nCLU proteins was significantly diminished by leptomycin B (LMB), and nuclear ..
  41. Dölker N, Blanchet C, Voß B, Haselbach D, Kappel C, Monecke T, et al. Structural determinants and mechanism of mammalian CRM1 allostery. Structure. 2013;21:1350-60 pubmed publisher
    Proteins carrying nuclear export signals cooperatively assemble with the export factor CRM1 and the effector protein RanGTP...
  42. Bodendorf U, Cziepluch C, Jauniaux J, Rommelaere J, Salome N. Nuclear export factor CRM1 interacts with nonstructural proteins NS2 from parvovirus minute virus of mice. J Virol. 1999;73:7769-79 pubmed
    ..the NS2 proteins from the parvovirus minute virus of mice (MVM) and rat as well as mouse homologues of the human CRM1 protein, a member of the importin-beta family recently identified as an essential nuclear export factor...
  43. Buck M, Zhang L, Halasz N, Hunter T, Chojkier M. Nuclear export of phosphorylated C/EBPbeta mediates the inhibition of albumin expression by TNF-alpha. EMBO J. 2001;20:6712-23 pubmed
    ..The cytoplasmic localization and association of C/EBPbeta-PSer239 with CRM1 (exportin-1) in TNF-alpha-treated hepatocytes was inhibited by leptomycin B, a blocker of CRM1 activity...
  44. Taagepera S, McDonald D, Loeb J, Whitaker L, McElroy A, Wang J, et al. Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase. Proc Natl Acad Sci U S A. 1998;95:7457-62 pubmed
    ..Taken together, these results demonstrate that c-Abl shuttles continuously between the nucleus and the cytoplasm and that the rate of nuclear import and export can be modulated by the adherence status of fibroblastic cells. ..
  45. Rousselet A. Inhibiting Crm1 causes the formation of excess acentriolar spindle poles containing NuMA and B23, but does not affect centrosome numbers. Biol Cell. 2009;101:679-93 pubmed publisher
    ..Migration of B23 to the poles is under the control of exportin Crm1. B23 at the centrosome plays a role in the control centrosome duplication...
  46. Ivanova I, Dagnino L. Activation of p38- and CRM1-dependent nuclear export promotes E2F1 degradation during keratinocyte differentiation. Oncogene. 2007;26:1147-54 pubmed
    ..in differentiating keratinocytes involves its ubiquitination, as well as proteasomal degradation subsequent to CRM1-dependent nuclear export...
  47. Suzuki H, Tashiro S, Hira S, Sun J, Yamazaki C, Zenke Y, et al. Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1. EMBO J. 2004;23:2544-53 pubmed
    ..This region functioned as a heme-regulated NES dependent on the exporter Crm1. These results extend the regulatory roles for heme in protein sorting, and suggest that Bach1 transduces metabolic ..
  48. Fuchs S, Resch K, Thiel C, Ulbrich M, Platzer M, Jockusch H, et al. Comparative transcription map of the wobbler critical region on mouse chromosome 11 and the homologous region on human chromosome 2p13-14. BMC Genet. 2002;3:14 pubmed
    ..The possibility arises that there might be hitherto unknown effects of mutations, in addition to structural changes of the mRNA or regulatory abnormalities. ..
  49. Phillips R, Ramos S, Blackshear P. Members of the tristetraprolin family of tandem CCCH zinc finger proteins exhibit CRM1-dependent nucleocytoplasmic shuttling. J Biol Chem. 2002;277:11606-13 pubmed
    ..This type of leucine-rich nuclear export signal interacts with the nuclear export receptor CRM1; abrogation of CRM1 activity resulted in nuclear accumulation of TTP, CMG1, and TIS11D...
  50. Mihalas B, Western P, Loveland K, McLaughlin E, Holt J. Changing expression and subcellular distribution of karyopherins during murine oogenesis. Reproduction. 2015;150:485-96 pubmed publisher
    ..Of the KPNAs examined (Kpna1, Kpna2, Kpna3, Kpna4, Kpna6, Kpna7, Kpnb1, Ipo5 and Xpo1), all were expressed in the embryonic ovary with up-regulation of protein levels concomitant with meiotic entry for ..
  51. Hilditch Maguire P, Trettel F, Passani L, Auerbach A, Persichetti F, MacDonald M. Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles. Hum Mol Genet. 2000;9:2789-97 pubmed
    ..Thus, organelles that require huntingtin to function suggest roles for the protein in RNA biogenesis, trafficking and iron homeostasis to be explored in HD pathogenesis. ..
  52. Yue Y, Coskun A, Jawanda N, Auer J, Sutton R. Differential interaction between human and murine Crm1 and lentiviral Rev proteins. Virology. 2018;513:1-10 pubmed publisher
    ..In human, Rev binds to the Rev-response element and human (h) Crm1, facilitating nuclear export of RRE-containing viral RNAs...