Gene Symbol: Xin
Description: xin actin-binding repeat containing 1
Alias: AI415219, Cmya1, xin actin-binding repeat-containing protein 1, Xin alpha, cardiomyopathy associated 1, cardiomyopathy-associated protein 1, mXin alpha
Species: mouse
Products:     Xin

Top Publications

  1. Sinn H, Balsamo J, Lilien J, Lin J. Localization of the novel Xin protein to the adherens junction complex in cardiac and skeletal muscle during development. Dev Dyn. 2002;225:1-13 pubmed
    ..we demonstrated that chick embryos treated with antisense oligonucleotides against a striated muscle-specific Xin exhibit abnormal cardiac morphogenesis (Wang et al...
  2. Jung Ching Lin J, Gustafson Wagner E, Sinn H, Choi S, Jaacks S, Wang D, et al. Structure, Expression, and Function of a Novel Intercalated Disc Protein, Xin. J Med Sci. 2005;25:215-222 pubmed
    ..The human homologue of mXin? (named Cmya1) was mapped to chromosome 3p21.2-p21.3 by radiation hybrid analysis and recently to 3p22...
  3. Choi S, Gustafson Wagner E, Wang Q, Harlan S, Sinn H, Lin J, et al. The intercalated disk protein, mXinalpha, is capable of interacting with beta-catenin and bundling actin filaments [corrected]. J Biol Chem. 2007;282:36024-36 pubmed
    ..on mXinalpha was mapped to amino acids 535-636, which overlaps with the known actin-binding domains composed of the Xin repeats...
  4. Wang D, Reiter R, Lin J, Wang Q, Williams H, Krob S, et al. Requirement of a novel gene, Xin, in cardiac morphogenesis. Development. 1999;126:1281-94 pubmed
    A novel gene, Xin, from chick (cXin) and mouse (mXin) embryonic hearts, may be required for cardiac morphogenesis and looping...
  5. Gustafson Wagner E, Sinn H, Chen Y, Wang D, Reiter R, Lin J, et al. Loss of mXinalpha, an intercalated disk protein, results in cardiac hypertrophy and cardiomyopathy with conduction defects. Am J Physiol Heart Circ Physiol. 2007;293:H2680-92 pubmed
    ..In the mouse, there are two homologous genes, mXinalpha and mXinbeta. The human homolog of mXinalpha, Cmya1, maps to chromosomal region 3p21.2-21.3, near a dilated cardiomyopathy with conduction defect-2 locus...
  6. Feng H, Wang Q, Reiter R, Lin J, Lin J, Jin J. Localization and function of Xin? in mouse skeletal muscle. Am J Physiol Cell Physiol. 2013;304:C1002-12 pubmed publisher
    The Xin repeat-containing proteins were originally found in the intercalated discs of cardiac muscle with implicated roles in cardiac development and function...
  7. Fouillade C, Baron Menguy C, Domenga Denier V, Thibault C, Takamiya K, Huganir R, et al. Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature. Arterioscler Thromb Vasc Biol. 2013;33:76-86 pubmed publisher
    ..Notch3-regulated transcriptome provides potential for modulating myogenic response in the cerebrovasculature. ..
  8. Sharma P, Abbasi C, Lazic S, Teng A, Wang D, Dubois N, et al. Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function. Nat Commun. 2015;6:8391 pubmed publisher
    ..Our data demonstrate that the membrane protein Tmem65 is an intercalated disc protein that interacts with and functionally regulates ventricular Cx43. ..
  9. Wang Q, Lu T, Adams E, Lin J, Lin J. Intercalated disc protein, mXin?, suppresses p120-catenin-induced branching phenotype via its interactions with p120-catenin and cortactin. Arch Biochem Biophys. 2013;535:91-100 pubmed publisher
    The Xin repeat-containing proteins, Xin? (Xirp1) and Xin? (Xirp2), localize to the intercalated discs (ICDs) of mammalian hearts...

Scientific Experts

More Information


  1. Wang Q, Lin J, Chan S, Lin J. The Xin repeat-containing protein, mXin?, initiates the maturation of the intercalated discs during postnatal heart development. Dev Biol. 2013;374:264-80 pubmed publisher
    ..and mXin?) of human cardiomyopathy-associated (CMYA)/Xin actin-binding repeat-containing protein (XIRP) genes (CMYA1/XIRP1 and CMYA3/XIRP2, respectively) encode proteins localized to ICDs...
  2. Wang D, Hu X, Lin J, Kitten G, Solursh M, Lin J. Differential displaying of mRNAs from the atrioventricular region of developing chicken hearts at stages 15 and 21. Front Biosci. 1996;1:a1-15 pubmed
    ..From these data, we demonstrate that the differential display method together with the whole-mount in situ hybridization could be an effective means for the isolation of novel and differentially expressed genes. ..
  3. Hawke T, Atkinson D, Kanatous S, van der Ven P, Goetsch S, Garry D. Xin, an actin binding protein, is expressed within muscle satellite cells and newly regenerated skeletal muscle fibers. Am J Physiol Cell Physiol. 2007;293:C1636-44 pubmed
    b>Xin is a muscle-specific actin binding protein of which its role and regulation within skeletal muscle is not well understood...
  4. Otten J, van der Ven P, Vakeel P, Eulitz S, Kirfel G, Brandau O, et al. Complete loss of murine Xin results in a mild cardiac phenotype with altered distribution of intercalated discs. Cardiovasc Res. 2010;85:739-50 pubmed publisher
    b>Xin is a striated muscle-specific F-actin binding protein that has been implicated in cardiomyopathies. In cardiomyocytes, Xin is localized at intercalated discs (IDs)...
  5. Grosskurth S, Bhattacharya D, Wang Q, Lin J. Emergence of Xin demarcates a key innovation in heart evolution. PLoS ONE. 2008;3:e2857 pubmed publisher
    The mouse Xin repeat-containing proteins (mXinalpha and mXinbeta) localize to the intercalated disc in the heart...
  6. Al Sajee D, Nissar A, Coleman S, Rebalka I, Chiang A, Wathra R, et al. Xin-deficient mice display myopathy, impaired contractility, attenuated muscle repair and altered satellite cell functionality. Acta Physiol (Oxf). 2015;214:248-60 pubmed publisher
    b>Xin is an F-actin-binding protein expressed during development of cardiac and skeletal muscle...
  7. Leber Y, Ruparelia A, Kirfel G, van der Ven P, Hoffmann B, Merkel R, et al. Filamin C is a highly dynamic protein associated with fast repair of myofibrillar microdamage. Hum Mol Genet. 2016;25:2776-2788 pubmed
    ..Analysis of cardiomyocytes from Xirp1 and Xirp2 deficient animals indicates that both Xin actin-binding repeat-containing proteins stabilize FLNc selectively in premyofibrils...
  8. Kebir S, Orfanos Z, Schuld J, Linhart M, Lamberz C, van der Ven P, et al. Sarcomeric lesions and remodeling proximal to intercalated disks in overload-induced cardiac hypertrophy. Exp Cell Res. 2016;348:95-105 pubmed publisher
    ..Filamin C (FlnC) and Xin actin-binding repeat-containing proteins (XIRPs) are multi-adapters localizing in IDs of higher vertebrates...
  9. Molt S, B├╝hrdel J, Yakovlev S, Schein P, Orfanos Z, Kirfel G, et al. Aciculin interacts with filamin C and Xin and is essential for myofibril assembly, remodeling and maintenance. J Cell Sci. 2014;127:3578-92 pubmed publisher
    Filamin C (FLNc) and Xin actin-binding repeat-containing proteins (XIRPs) are multi-adaptor proteins that are mainly expressed in cardiac and skeletal muscles and which play important roles in the assembly and repair of myofibrils and ..