Wnt10b

Summary

Gene Symbol: Wnt10b
Description: wingless-type MMTV integration site family, member 10B
Alias: Wnt12, protein Wnt-10b, wingless related MMTV integration site 10b, wnt-12
Species: mouse
Products:     Wnt10b

Top Publications

  1. Ross S, Hemati N, Longo K, Bennett C, Lucas P, Erickson R, et al. Inhibition of adipogenesis by Wnt signaling. Science. 2000;289:950-3 pubmed
    ..Disruption of Wnt signaling also causes transdifferentiation of myoblasts into adipocytes in vitro, highlighting the importance of this pathway not only in adipocyte differentiation but also in mesodermal cell fate determination. ..
  2. Davenport T, Jerome Majewska L, Papaioannou V. Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulnar mammary syndrome. Development. 2003;130:2263-73 pubmed
  3. Veltmaat J, Van Veelen W, Thiery J, Bellusci S. Identification of the mammary line in mouse by Wnt10b expression. Dev Dyn. 2004;229:349-56 pubmed
    ..We show here that a mammary line exists in the mouse embryo at embryonic day (E) 11.25 as a concise line of Wnt10b expression and a broader band of Wnt6 expression in the surface ectoderm, between the subaxillary and ..
  4. Bennett C, Ouyang H, Ma Y, Zeng Q, Gerin I, Sousa K, et al. Wnt10b increases postnatal bone formation by enhancing osteoblast differentiation. J Bone Miner Res. 2007;22:1924-32 pubmed
    Overexpression of Wnt10b from the osteocalcin promoter in transgenic mice increases postnatal bone mass...
  5. Zhou H, Mak W, Zheng Y, Dunstan C, Seibel M. Osteoblasts directly control lineage commitment of mesenchymal progenitor cells through Wnt signaling. J Biol Chem. 2008;283:1936-45 pubmed
    ..regulation of early adipogenic and osteoblastogenic transcription factors and with a reduction in Wnt7b and Wnt10b mRNA and beta-catenin protein levels in transgenic versus non-transgenic cultures...
  6. Veltmaat J, Relaix F, Le L, Kratochwil K, Sala F, Van Veelen W, et al. Gli3-mediated somitic Fgf10 expression gradients are required for the induction and patterning of mammary epithelium along the embryonic axes. Development. 2006;133:2325-35 pubmed
    ..We propose that the intra-somitic Fgf10 gradient, together with ventral elongation of the somites, determines the correct dorsoventral position of mammary epithelium along the flank. ..
  7. Reddy S, Andl T, Bagasra A, Lu M, Epstein D, Morrisey E, et al. Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis. Mech Dev. 2001;107:69-82 pubmed
    ..These results identify candidates for several key follicular signals and suggest that WNT and SHH signaling pathways interact to regulate hair follicle morphogenesis. ..
  8. Iwatsuki K, Liu H, Grónder A, Singer M, Lane T, Grosschedl R, et al. Wnt signaling interacts with Shh to regulate taste papilla development. Proc Natl Acad Sci U S A. 2007;104:2253-8 pubmed
    ..The elimination of Wnt/beta-catenin signaling in either Lef1 or Wnt10b knockout mice resulted in down-regulation of Shh expression...
  9. Liu F, Thirumangalathu S, Gallant N, Yang S, Stoick Cooper C, Reddy S, et al. Wnt-beta-catenin signaling initiates taste papilla development. Nat Genet. 2007;39:106-12 pubmed
    ..Thus, Wnt-beta-catenin signaling is critical for fungiform papilla and taste bud development. Altered regulation of this pathway may underlie evolutionary changes in taste papilla patterning. ..

More Information

Publications90

  1. Vertino A, Taylor Jones J, Longo K, Bearden E, Lane T, McGehee R, et al. Wnt10b deficiency promotes coexpression of myogenic and adipogenic programs in myoblasts. Mol Biol Cell. 2005;16:2039-48 pubmed
    ..during aging such that aspects of both differentiation programs are coexpressed in myoblasts due to decreased Wnt10b abundance...
  2. Bennett C, Longo K, Wright W, Suva L, Lane T, Hankenson K, et al. Regulation of osteoblastogenesis and bone mass by Wnt10b. Proc Natl Acad Sci U S A. 2005;102:3324-9 pubmed
    ..Activation of Wnt signaling by Wnt10b inhibits differentiation of preadipocytes and blocks adipose tissue development; however, the effect of Wnt10b on ..
  3. Bennett C, Ross S, Longo K, Bajnok L, Hemati N, Johnson K, et al. Regulation of Wnt signaling during adipogenesis. J Biol Chem. 2002;277:30998-1004 pubmed
    We have identified Wnt10b as a potent inhibitor of adipogenesis that must be suppressed for preadipocytes to differentiate in vitro...
  4. Bayle J, Fitch J, Jacobsen K, Kumar R, Lafyatis R, Lemaire R. Increased expression of Wnt2 and SFRP4 in Tsk mouse skin: role of Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis. J Invest Dermatol. 2008;128:871-81 pubmed
    ..Tsk skin showed increased mRNA levels of several genes involved in Wnt signaling, including Wnt2, Wnt9a, Wnt10b and Wnt11; Dapper homolog antagonist of beta-catenin (DACT1) and DACT2; Wnt-induced secreted protein 2; and ..
  5. Cygan J, Johnson R, McMahon A. Novel regulatory interactions revealed by studies of murine limb pattern in Wnt-7a and En-1 mutants. Development. 1997;124:5021-32 pubmed
    ..Unlike the normal AER, ectopic AER formation is dependent upon Wnt-7a activity, indicating that distinct genetic mechanisms may be involved in primary and secondary AER formation. ..
  6. Liu H, Mohamed O, Dufort D, Wallace V. Characterization of Wnt signaling components and activation of the Wnt canonical pathway in the murine retina. Dev Dyn. 2003;227:323-34 pubmed
  7. Suomalainen M, Thesleff I. Patterns of Wnt pathway activity in the mouse incisor indicate absence of Wnt/beta-catenin signaling in the epithelial stem cells. Dev Dyn. 2010;239:364-72 pubmed publisher
    ..We conclude that epithelial stem cells in the mouse incisors are not regulated directly by Wnt/beta-catenin signaling. ..
  8. Petersen C, Jheon A, Mostowfi P, Charles C, Ching S, Thirumangalathu S, et al. FGF signaling regulates the number of posterior taste papillae by controlling progenitor field size. PLoS Genet. 2011;7:e1002098 pubmed publisher
  9. Wen X, Cawthorn W, MacDougald O, Stupp S, Snead M, Zhou Y. The influence of Leucine-rich amelogenin peptide on MSC fate by inducing Wnt10b expression. Biomaterials. 2011;32:6478-86 pubmed publisher
    ..b>Wnt10b-mediated activation of canonical Wnt signaling has been shown to regulate mesenchymal stem cell fate...
  10. Hay E, Dieudonné F, Saidak Z, Marty C, Brun J, Da Nascimento S, et al. N-cadherin/wnt interaction controls bone marrow mesenchymal cell fate and bone mass during aging. J Cell Physiol. 2014;229:1765-75 pubmed publisher
    ..The reversed phenotype with age was associated with enhanced Wnt5a and Wnt10b expression in osteoblasts and a concomitant increase in BMSC osteogenic differentiation...
  11. Loureiro J. The Wnts. Curr Biol. 1999;9:R4 pubmed
  12. Sima J, Piao Y, Chen Y, Schlessinger D. Molecular dynamics of Dkk4 modulates Wnt action and regulates meibomian gland development. Development. 2016;143:4723-4735 pubmed
    ..Thus, the dynamic state of Dkk4 itself and its interaction with Lrp6 modulates Wnt function during MG development, with a novel limitation of Dkk4 action by proteolytic cleavage. ..
  13. Li J, Adams J, Calvi L, Lane T, DiPaolo R, Weitzmann M, et al. PTH expands short-term murine hemopoietic stem cells through T cells. Blood. 2012;120:4352-62 pubmed publisher
    ..ST-HSPCs by activating Wnt signaling in HSPCs and stromal cells (SCs) through T-cell production of the Wnt ligand Wnt10b. Attesting to the relevance of Wnt10b, iPTH fails to expand ST-HSPCs in mice with Wnt10b(-/-) T cells...
  14. Andl T, Reddy S, Gaddapara T, Millar S. WNT signals are required for the initiation of hair follicle development. Dev Cell. 2002;2:643-53 pubmed
    ..This phenotype indicates that activation of WNT signaling in the skin precedes, and is required for, localized expression of regulatory genes and initiation of hair follicle placode formation. ..
  15. Stevens J, Miranda Carboni G, Singer M, Brugger S, Lyons K, Lane T. Wnt10b deficiency results in age-dependent loss of bone mass and progressive reduction of mesenchymal progenitor cells. J Bone Miner Res. 2010;25:2138-47 pubmed publisher
    b>Wnt10b is a canonical Wnt ligand expressed in developing bone and has been linked to mesenchymal progenitor functions in mice and humans...
  16. Närhi K, Järvinen E, Birchmeier W, Taketo M, Mikkola M, Thesleff I. Sustained epithelial beta-catenin activity induces precocious hair development but disrupts hair follicle down-growth and hair shaft formation. Development. 2008;135:1019-28 pubmed publisher
    ..Our data suggest that BMPs are downstream of Wnt/beta-catenin and that their interplay may be a critical component in establishing correct patterning of hair follicles through the reaction-diffusion mechanism. ..
  17. Lefebvre S, Fliniaux I, Schneider P, Mikkola M. Identification of ectodysplasin target genes reveals the involvement of chemokines in hair development. J Invest Dermatol. 2012;132:1094-102 pubmed publisher
    ..Deficiency in cxcR3 resulted in decreased primary hair follicle density but otherwise normal hair development, indicating that chemokine signaling influences the patterning of primary hair placodes only. ..
  18. Abiola M, Favier M, Christodoulou Vafeiadou E, Pichard A, Martelly I, Guillet Deniau I. Activation of Wnt/beta-catenin signaling increases insulin sensitivity through a reciprocal regulation of Wnt10b and SREBP-1c in skeletal muscle cells. PLoS ONE. 2009;4:e8509 pubmed publisher
    ..signaling impact the balance between myogenic and adipogenic programs in myoblasts, partly due to the decrease of Wnt10b protein...
  19. Huh S, Närhi K, Lindfors P, Häärä O, Yang L, Ornitz D, et al. Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles. Genes Dev. 2013;27:450-8 pubmed publisher
  20. Cui C, Hashimoto T, Grivennikov S, Piao Y, Nedospasov S, Schlessinger D. Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation. Proc Natl Acad Sci U S A. 2006;103:9142-7 pubmed
    ..Thus, as an EDA target, LTbeta regulates the form of hair in developing hair follicles; and when EDA is defective, failure of LTbeta activation can account for part of the Ta phenotype. ..
  21. Närhi K, Tummers M, Ahtiainen L, Itoh N, Thesleff I, Mikkola M. Sostdc1 defines the size and number of skin appendage placodes. Dev Biol. 2012;364:149-61 pubmed
    ..Our data suggest that functions of Sostdc1 can be largely attributed to its ability to attenuate Wnt/?-catenin signaling. ..
  22. Terauchi M, Li J, Bedi B, Baek K, Tawfeek H, Galley S, et al. T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling. Cell Metab. 2009;10:229-40 pubmed publisher
    ..Here, we show that iPTH increases the production of Wnt10b by bone marrow CD8+ T cells and induces these lymphocytes to activate canonical Wnt signaling in preosteoblasts...
  23. Suzuki K, Yamaguchi Y, Villacorte M, Mihara K, Akiyama M, Shimizu H, et al. Embryonic hair follicle fate change by augmented beta-catenin through Shh and Bmp signaling. Development. 2009;136:367-72 pubmed publisher
    ..These results indicate the presence of growth factor signal cross-talk involving beta-catenin signaling, which regulates the HF fate. ..
  24. Ahtiainen L, Uski I, Thesleff I, Mikkola M. Early epithelial signaling center governs tooth budding morphogenesis. J Cell Biol. 2016;214:753-67 pubmed publisher
    ..These data functionally link the signaling center size to organ size and imply that the early signaling center is a prerequisite for budding morphogenesis. ..
  25. El Shahawy M, Reibring C, Neben C, Hallberg K, Marangoni P, Harfe B, et al. Cell fate specification in the lingual epithelium is controlled by antagonistic activities of Sonic hedgehog and retinoic acid. PLoS Genet. 2017;13:e1006914 pubmed publisher
    ..At developmental stages during which Wnt10b expression normally ceases and Shh becomes confined to taste bud cells, loss of SHH inputs causes the lingual ..
  26. Howard B, Panchal H, McCarthy A, Ashworth A. Identification of the scaramanga gene implicates Neuregulin3 in mammary gland specification. Genes Dev. 2005;19:2078-90 pubmed
  27. Gu B, Sun P, Yuan Y, Moraes R, Li A, Teng A, et al. Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation. J Cell Biol. 2009;185:811-26 pubmed publisher
  28. Dabdoub A, Donohue M, Brennan A, Wolf V, Montcouquiol M, Sassoon D, et al. Wnt signaling mediates reorientation of outer hair cell stereociliary bundles in the mammalian cochlea. Development. 2003;130:2375-84 pubmed
    ..We propose that Wnt signaling across the region of developing outer hair cells gives rise to planar polarity in the mammalian cochlea. ..
  29. Keil K, Mehta V, Abler L, Joshi P, Schmitz C, Vezina C. Visualization and quantification of mouse prostate development by in situ hybridization. Differentiation. 2012;84:232-9 pubmed publisher
    ..locus 1 (Nkx3-1), and two newly identified prostatic bud markers, wingless-related MMTV integration site 10b (Wnt10b) and ectodysplasin-A receptor (Edar)...
  30. Christiansen J, Dennis C, Wicking C, Monkley S, Wilkinson D, Wainwright B. Murine Wnt-11 and Wnt-12 have temporally and spatially restricted expression patterns during embryonic development. Mech Dev. 1995;51:341-50 pubmed
    ..Wnt-11 transcripts are also detected in limb bud mesenchyme from the time the bud is first visible. Wnt-12 is detected in the apical ectodermal ridge from 10.5 dpc. The implications of these expression patterns are discussed. ..
  31. Porntaveetus T, Ohazama A, Choi H, Herz J, Sharpe P. Wnt signaling in the murine diastema. Eur J Orthod. 2012;34:518-24 pubmed publisher
    ..this study we found that in the embryonic diastema, Wnt5a expression was observed in mesenchyme, whereas Wnt4 and Wnt10b were expressed in epithelium. The expression of Wnt6 and Wnt11 was found in both tissues...
  32. Jerome Majewska L, Jenkins G, Ernstoff E, Zindy F, Sherr C, Papaioannou V. Tbx3, the ulnar-mammary syndrome gene, and Tbx2 interact in mammary gland development through a p19Arf/p53-independent pathway. Dev Dyn. 2005;234:922-33 pubmed
  33. Ouji Y, Yoshikawa M, Shiroi A, Ishizaka S. Wnt-10b promotes differentiation of skin epithelial cells in vitro. Biochem Biophys Res Commun. 2006;342:28-35 pubmed
    ..These results suggest that Wnt-10b promotes the differentiation of MPSEC. ..
  34. Prochazka J, Prochazkova M, Du W, Spoutil F, Tureckova J, Hoch R, et al. Migration of Founder Epithelial Cells Drives Proper Molar Tooth Positioning and Morphogenesis. Dev Cell. 2015;35:713-24 pubmed publisher
    ..These results demonstrate the importance of intraepithelial cell migration in proper positioning of an initiating organ. ..
  35. Austin T, Solar G, Ziegler F, Liem L, Matthews W. A role for the Wnt gene family in hematopoiesis: expansion of multilineage progenitor cells. Blood. 1997;89:3624-35 pubmed
    ..We conclude that WNTs stimulate the survival/proliferation of hematopoietic progenitors, demonstrating that WNTs comprise a novel class of hematopoietic cell regulators. ..
  36. Suzuki Y, Ikeda K, Kawakami K. Regulatory role of Six1 in the development of taste papillae. Cell Tissue Res. 2010;339:513-25 pubmed publisher
    ..The number of primordia of fungiform papillae marked by Shh and Wnt10b appeared to increase in Six1 ( -/- )...
  37. Lippens S, Lefebvre S, Gilbert B, Sze M, Devos M, Verhelst K, et al. Keratinocyte-specific ablation of the NF-?B regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis. Cell Death Differ. 2011;18:1845-53 pubmed publisher
    ..In summary, our data indicate that EDAR-induced NF-?B levels are controlled by A20, which functions as a negative feedback regulator, to assure proper skin homeostasis and epidermal appendage development. ..
  38. Wagatsuma A. Adipogenic potential can be activated during muscle regeneration. Mol Cell Biochem. 2007;304:25-33 pubmed
    ..the expression pattern of adipogenic transcriptional factors, an adipocyte-terminal differentiation marker, and Wnt10b signaling molecules during muscle regeneration...
  39. Fox K, Colton L, Erickson P, Friedman J, Cha H, Keller P, et al. Regulation of cyclin D1 and Wnt10b gene expression by cAMP-responsive element-binding protein during early adipogenesis involves differential promoter methylation. J Biol Chem. 2008;283:35096-105 pubmed publisher
    Cyclin D1 expression is elevated and Wnt10b is repressed by cAMP during the first few hours of adipogenesis...
  40. St Jacques B, Dassule H, Karavanova I, Botchkarev V, Li J, Danielian P, et al. Sonic hedgehog signaling is essential for hair development. Curr Biol. 1998;8:1058-68 pubmed
    ..Expression of members of the Wnt, Hedgehog and bone morphogenetic protein families (Wnt10b, Sonic hedgehog (Shh) and Bmp2/Bmp4, respectively) in the epidermis correlates with the initiation of hair ..
  41. Ouji Y, Yoshikawa M, Moriya K, Nishiofuku M, Matsuda R, Ishizaka S. Wnt-10b, uniquely among Wnts, promotes epithelial differentiation and shaft growth. Biochem Biophys Res Commun. 2008;367:299-304 pubmed
    ..Our results suggest that Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. ..
  42. Liu F, Chu E, WATT B, Zhang Y, Gallant N, Andl T, et al. Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis. Dev Biol. 2008;313:210-24 pubmed
  43. Foronjy R, Imai K, Shiomi T, Mercer B, Sklepkiewicz P, Thankachen J, et al. The divergent roles of secreted frizzled related protein-1 (SFRP1) in lung morphogenesis and emphysema. Am J Pathol. 2010;177:598-607 pubmed publisher
    ..Thus, SFRP1 induction during tissue injury is unlikely to contribute to the repair response but rather is a participatory factor in the pathogenesis of emphysema and tissue destruction...
  44. Liu H, Grosse A, Iwatsuki K, Mishina Y, Gumucio D, Mistretta C. Separate and distinctive roles for Wnt5a in tongue, lingual tissue and taste papilla development. Dev Biol. 2012;361:39-56 pubmed publisher
  45. Lin C, Fisher A, Yin Y, Maruyama T, Veith G, Dhandha M, et al. The inductive role of Wnt-?-Catenin signaling in the formation of oral apparatus. Dev Biol. 2011;356:40-50 pubmed publisher
    ..We provide genetic evidence that disruption of either signaling pathway results in severe microglossia. Altogether, we demonstrate a dynamic role for Wnt-?-Catenin signaling in the development of the oral apparatus...
  46. Lu C, Wan Y, Cao J, Zhu X, Yu J, Zhou R, et al. Wnt-mediated reciprocal regulation between cartilage and bone development during endochondral ossification. Bone. 2013;53:566-74 pubmed publisher
  47. Aberg T, Wang X, Kim J, Yamashiro T, Bei M, Rice R, et al. Runx2 mediates FGF signaling from epithelium to mesenchyme during tooth morphogenesis. Dev Biol. 2004;270:76-93 pubmed
    ..We conclude that Runx2 mediates the functions of epithelial FGF signals regulating Fgf3 expression in the dental mesenchyme and that Fgf3 may be a direct target gene of Runx2. ..
  48. Adamson M, Dennis C, Delaney S, Christiansen J, Monkley S, Kozak C, et al. Isolation and genetic mapping of two novel members of the murine Wnt gene family, Wnt11 and Wnt12, and the mapping of Wnt5a and Wnt7a. Genomics. 1994;24:9-13 pubmed
    ..Using a PCR-based approach, we have isolated two novel members of the murine Wnt gene family, Wnt11 and Wnt12. These cDNAs display an amino acid sequence identity of between 38 and 49% with all other murine Wnts over the ..
  49. Rhee H, Polak L, Fuchs E. Lhx2 maintains stem cell character in hair follicles. Science. 2006;312:1946-9 pubmed
    ..Using gain- and loss-of-function studies, we uncovered a role for Lhx2 in maintaining the growth and undifferentiated properties of hair follicle progenitors. ..
  50. Ota K, Quint P, Ruan M, Pederson L, Westendorf J, Khosla S, et al. TGF-? induces Wnt10b in osteoclasts from female mice to enhance coupling to osteoblasts. Endocrinology. 2013;154:3745-52 pubmed publisher
    ..TGF-?1 increased osteoclast production of Wnt10b, but not BMP6 or S1P...
  51. Dassule H, McMahon A. Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth. Dev Biol. 1998;202:215-27 pubmed
    ..In this paper we have investigated the role of four epithelial signaling molecules, Bmp2, Shh, Wnt10a, and Wnt10b, in the early inductive cascades that govern tooth development...
  52. Nakatomi M, Hovorakova M, Gritli Linde A, Blair H, MacArthur K, Peterka M, et al. Evc regulates a symmetrical response to Shh signaling in molar development. J Dent Res. 2013;92:222-8 pubmed publisher
  53. Warner D, Smith H, Webb C, Greene R, Pisano M. Expression of Wnts in the developing murine secondary palate. Int J Dev Biol. 2009;53:1105-12 pubmed publisher
    ..The expression of 5 Wnt family members was found to be temporally regulated. Moreover, these Wnts had unique spatio-temporal patterns of expression which suggested possible roles in palatal ontogeny. ..
  54. Yang S, Andl T, Grachtchouk V, Wang A, Liu J, Syu L, et al. Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/beta3-catenin signaling. Nat Genet. 2008;40:1130-5 pubmed publisher
  55. Prochazkova M, Häkkinen T, Prochazka J, Spoutil F, Jheon A, Ahn Y, et al. FGF signaling refines Wnt gradients to regulate the patterning of taste papillae. Development. 2017;144:2212-2221 pubmed publisher
  56. Trischler J, Shiomi T, Turner D, Sklepkiewicz P, Goldklang M, Tanaka K, et al. Immune Modulation of the T Cell Response in Asthma through Wnt10b. Am J Respir Cell Mol Biol. 2016;54:584-93 pubmed publisher
    ..We hypothesized that Wnt10b plays a role in the modulation of the allergic airway response and affects T cell activation and polarization...
  57. Ramasamy S, Kusumbe A, Schiller M, Zeuschner D, Bixel M, Milia C, et al. Blood flow controls bone vascular function and osteogenesis. Nat Commun. 2016;7:13601 pubmed publisher
    ..We propose that blood flow and endothelial Notch signalling are key factors controlling ageing processes in the skeletal system. ..
  58. Sarkar L, Sharpe P. Expression of Wnt signalling pathway genes during tooth development. Mech Dev. 1999;85:197-200 pubmed
    ..Expression of Wnt-4, Wnt-6, and one Wnt receptor MFz6 was observed in the facial, oral and dental epithelium. Wnt10b was localised specifically to the presumptive dental epithelium...
  59. Cui C, Yin M, Sima J, Childress V, Michel M, Piao Y, et al. Involvement of Wnt, Eda and Shh at defined stages of sweat gland development. Development. 2014;141:3752-60 pubmed publisher
    ..Thus, sweat gland development shows a relay of regulatory steps initiated by Wnt/β-catenin - itself modulated by Dkk4 - with subsequent participation of Eda and Shh pathways. ..
  60. Ishikawa T, Tamai Y, Zorn A, Yoshida H, Seldin M, Nishikawa S, et al. Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis. Development. 2001;128:25-33 pubmed
    ..5 days post coitum. Fzd5 specifically synergized with Wnt2, Wnt5a and Wnt10b in ectopic axis induction assays in Xenopus embryos...
  61. Lekven A, Buckles G, Kostakis N, Moon R. Wnt1 and wnt10b function redundantly at the zebrafish midbrain-hindbrain boundary. Dev Biol. 2003;254:172-87 pubmed
    ..Further, wnt1 is part of a Wnt cluster conserved in all vertebrates comprising wnt1 and wnt10b, yet the function of wnt10b during embryogenesis has not been explored...
  62. Cho Y, Kim T, Hun Kim D, Hee Kim D, Jeong S, Kwon O. miR-148a is a downstream effector of X-box-binding protein 1 that silences Wnt10b during adipogenesis of 3T3-L1 cells. Exp Mol Med. 2016;48:e226 pubmed publisher
    b>Wnt10b, an endogenous inhibitor of adipogenesis, maintains preadipocytes in an undifferentiated state by suppressing adipogenic transcription factors...
  63. Lei M, Guo H, Qiu W, Lai X, Yang T, Widelitz R, et al. Modulating hair follicle size with Wnt10b/DKK1 during hair regeneration. Exp Dermatol. 2014;23:407-13 pubmed publisher
    ..Here, we showed that in response to prolonged ectopic Wnt10b-mediated ?-catenin activation, regenerating anagen hair follicles grew larger in size...
  64. Chen D, Jarrell A, Guo C, Lang R, Atit R. Dermal ?-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation. Development. 2012;139:1522-33 pubmed publisher
    ..These data reveal functional roles for dermal Wnt signaling/?-catenin in fibroblast proliferation and in the epidermal hair follicle initiation program. ..
  65. Longo K, Wright W, Kang S, Gerin I, Chiang S, Lucas P, et al. Wnt10b inhibits development of white and brown adipose tissues. J Biol Chem. 2004;279:35503-9 pubmed
    ..Activation of canonical Wnt signaling by Wnt10b inhibits differentiation of preadipocytes in vitro...
  66. Matsushita K, Wu Y, Pratt R, Dzau V. Deletion of angiotensin II type 2 receptor accelerates adipogenesis in murine mesenchymal stem cells via Wnt10b/beta-catenin signaling. Lab Invest. 2016;96:909-17 pubmed publisher
    ..We further examined the role of Wnt10b/beta-catenin signaling, which reportedly has an important inhibitory role in adipogenesis...
  67. Li L, Tam L, Liu L, Jin T, Ng D. Wnt-signaling mediates the anti-adipogenic action of lysophosphatidic acid through cross talking with the Rho/Rho associated kinase (ROCK) pathway. Biochem Cell Biol. 2011;89:515-21 pubmed publisher
    ..also resulted in significant but delayed upregulation of components of the canonical Wnt signaling, namely Wnt10b mRNA, ?-catenin protein, and mRNA expression of ?-catenin target genes, detectable at day 7, but not day 3...
  68. Li Y, Zhang K, Yang K, Ye J, Xing Y, Guo H, et al. Adenovirus-mediated Wnt10b overexpression induces hair follicle regeneration. J Invest Dermatol. 2013;133:42-8 pubmed publisher
    ..We previously reported that Wnt10b (wingless-type mouse mammary tumor virus integration site family member 10b) could promote the growth of hair ..
  69. Balciunaite G, Keller M, Balciunaite E, Piali L, Zuklys S, Mathieu Y, et al. Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice. Nat Immunol. 2002;3:1102-8 pubmed
    ..Wnt molecules therefore provide regulatory signals critical for thymic function. ..
  70. Cawthorn W, Bree A, Yao Y, Du B, Hemati N, Martinez Santibañez G, et al. Wnt6, Wnt10a and Wnt10b inhibit adipogenesis and stimulate osteoblastogenesis through a ?-catenin-dependent mechanism. Bone. 2012;50:477-89 pubmed publisher
    b>Wnt10b is an established regulator of mesenchymal stem cell (MSC) fate that inhibits adipogenesis and stimulates osteoblastogenesis, thereby impacting bone mass in vivo...
  71. Ouji Y, Yoshikawa M, Shiroi A, Ishizaka S. Wnt-10b secreted from lymphocytes promotes differentiation of skin epithelial cells. Biochem Biophys Res Commun. 2006;342:1063-9 pubmed
    ..These results suggest that Wnt-10b promotes the differentiation of MPSEC and may play an important role in hair follicle development by promoting differentiation of epithelial cells. ..
  72. Pederson L, Ruan M, Westendorf J, Khosla S, Oursler M. Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate. Proc Natl Acad Sci U S A. 2008;105:20764-9 pubmed publisher
    ..S1P induces osteoblast precursor recruitment and promotes mature cell survival. Wnt10b and BMP6 also were significantly increased in mature osteoclasts, whereas sclerostin levels decreased during ..
  73. Moore R, Dixon M, Smith R, Peters G, Dickson C. Complete nucleotide sequence of a milk-transmitted mouse mammary tumor virus: two frameshift suppression events are required for translation of gag and pol. J Virol. 1987;61:480-90 pubmed
    ..Direct evidence is presented for translational readthrough of both stop codons in an in vitro protein synthesis system...
  74. Tucker A, Headon D, Schneider P, Ferguson B, Overbeek P, Tschopp J, et al. Edar/Eda interactions regulate enamel knot formation in tooth morphogenesis. Development. 2000;127:4691-700 pubmed
    ..into a different shape, the enamel rope, showing altered expression of signalling factors (Shh, Fgf4, Bmp4 and Wnt10b)...
  75. Voutilainen M, Lindfors P, Trela E, Lönnblad D, Shirokova V, Elo T, et al. Ectodysplasin/NF-κB Promotes Mammary Cell Fate via Wnt/β-catenin Pathway. PLoS Genet. 2015;11:e1005676 pubmed publisher
    ..Using an ex vivo culture system, we show that suppression of canonical Wnt signalling leads to a dose-dependent inhibition of supernumerary placodes in K14-Eda tissue explants. ..
  76. Ohazama A, Courtney J, Tucker A, Naito A, Tanaka S, Inoue J, et al. Traf6 is essential for murine tooth cusp morphogenesis. Dev Dyn. 2004;229:131-5 pubmed
    ..Developmental Dynamics 229:131-135, 2004. ..
  77. Kang S, Bajnok L, Longo K, Petersen R, Hansen J, Kristiansen K, et al. Effects of Wnt signaling on brown adipocyte differentiation and metabolism mediated by PGC-1alpha. Mol Cell Biol. 2005;25:1272-82 pubmed
    ..b>Wnt10b blocks brown adipose tissue development and expression of UCP1 when expressed from the fatty acid binding protein ..
  78. Zhang Y, Tomann P, Andl T, Gallant N, Huelsken J, Jerchow B, et al. Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction. Dev Cell. 2009;17:49-61 pubmed publisher
    ..We show that maintenance of localized expression of Wnt10b and Wnt10a requires NF-kappaB signaling, providing a molecular explanation for the latter observation, and ..
  79. Miranda Carboni G, Krum S, Yee K, Nava M, Deng Q, Pervin S, et al. A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes Dev. 2008;22:3121-34 pubmed publisher
    Loss of the CDK inhibitor p27(KIP1) is widely linked with poor prognosis in human cancer. In Wnt10b-expressing mammary tumors, levels of p27(KIP1) were extremely low; conversely, Wnt10b-null mammary cells expressed high levels of this ..
  80. Cho Y, Kim D, Kwak S, Jeong S, Kwon O. X-box binding protein 1 enhances adipogenic differentiation of 3T3-L1 cells through the downregulation of Wnt10b expression. FEBS Lett. 2013;587:1644-9 pubmed publisher
    ..In this study, we demonstrated that XBP1 suppresses the expression of Wnt10b, an anti-adipogenic Wnt, during the differentiation of 3T3-L1 preadipocytes...
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    ..Furthermore, Bmp signaling appears to be a fundamental feature of DV patterning. ..