Gene Symbol: Wnk3
Description: WNK lysine deficient protein kinase 3
Alias: Prkwnk3, Wnk3-ps, serine/threonine-protein kinase WNK3, WNK lysine deficient protein kinase 3, pseudogene, protein kinase lysine-deficient 3, protein kinase with no lysine 3
Species: mouse
Products:     Wnk3

Top Publications

  1. Kahle K, Rinehart J, de los Heros P, Louvi A, Meade P, Vazquez N, et al. WNK3 modulates transport of Cl- in and out of cells: implications for control of cell volume and neuronal excitability. Proc Natl Acad Sci U S A. 2005;102:16783-8 pubmed
    ..We show that WNK3, a member of the WNK family of serine-threonine kinases, colocalizes with NKCC1 and KCC1/2 in diverse Cl(-)-..
  2. Rinehart J, Kahle K, de los Heros P, Vazquez N, Meade P, Wilson F, et al. WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis. Proc Natl Acad Sci U S A. 2005;102:16777-82 pubmed
    ..Here, we reveal unique biochemical and functional properties of WNK3, a related member of the WNK kinase family...
  3. Yang D, Li Q, So I, Huang C, Ando H, Mizutani A, et al. IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway. J Clin Invest. 2011;121:956-65 pubmed publisher
    ..They also have implications for WNK/SPAK kinase-regulated processes involved in systemic fluid homeostasis, hypertension, and cystic fibrosis. ..
  4. Zeniya M, Sohara E, Kita S, Iwamoto T, Susa K, Mori T, et al. Dietary salt intake regulates WNK3-SPAK-NKCC1 phosphorylation cascade in mouse aorta through angiotensin II. Hypertension. 2013;62:872-8 pubmed publisher
    ..a low-salt diet and angiotensin II together did not increase phosphorylation of SPAK and NKCC1 in the aorta in WNK3 knockout mice, indicating that activation of the WNK-SPAK-NKCC1 phosphorylation cascade induced by a low-salt diet ..
  5. Zhao H, Nepomuceno R, Gao X, Foley L, Wang S, Begum G, et al. Deletion of the WNK3-SPAK kinase complex in mice improves radiographic and clinical outcomes in malignant cerebral edema after ischemic stroke. J Cereb Blood Flow Metab. 2017;37:550-563 pubmed publisher
    ..A WNK3-SPAK complex is highly expressed in brain, but its function in this organ remains unclear...
  6. Leng Q, Kahle K, Rinehart J, MacGregor G, Wilson F, Canessa C, et al. WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K+ channel ROMK1 (Kir1.1). J Physiol. 2006;571:275-86 pubmed
    The serine-threonine kinase WNK3 modulates Cl- transport into and out of cells through its regulation of SLC12A cation/Cl- cotransporters, implicating it as (one of) the long-sought Cl-/volume-sensitive kinase(s)...
  7. Lee A, Chen W, Stippec S, Self J, Yang F, Ding X, et al. Protein kinase WNK3 regulates the neuronal splicing factor Fox-1. Proc Natl Acad Sci U S A. 2012;109:16841-6 pubmed publisher
    We report an action of the protein kinase WNK3 on the neuronal mRNA splicing factor Fox-1. Fox-1 splices mRNAs encoding proteins important in synaptic transmission and membrane excitation...
  8. Mederle K, Mutig K, Paliege A, Carota I, Bachmann S, Castrop H, et al. Loss of WNK3 is compensated for by the WNK1/SPAK axis in the kidney of the mouse. Am J Physiol Renal Physiol. 2013;304:F1198-209 pubmed publisher
    b>WNK3 kinase is expressed throughout the nephron and acts as a positive regulator of NKCC2 and NCC in vitro. Here we addressed the in vivo relevance of WNK3 using WNK3-deficient mice...