Gene Symbol: Wnk3
Description: WNK lysine deficient protein kinase 3
Alias: Prkwnk3, Wnk3-ps, serine/threonine-protein kinase WNK3, WNK lysine deficient protein kinase 3, pseudogene, protein kinase lysine-deficient 3, protein kinase with no lysine 3
Kahle K, Rinehart J, de los Heros P, Louvi A, Meade P, Vazquez N, et al
. WNK3 modulates transport of Cl- in and out of cells: implications for control of cell volume and neuronal excitability. Proc Natl Acad Sci U S A. 2005;102:16783-8 pubmed
..We show that WNK3, a member of the WNK family of serine-threonine kinases, colocalizes with NKCC1 and KCC1/2 in diverse Cl(-)-..
Rinehart J, Kahle K, de los Heros P, Vazquez N, Meade P, Wilson F, et al
. WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis. Proc Natl Acad Sci U S A. 2005;102:16777-82 pubmed
..Here, we reveal unique biochemical and functional properties of WNK3, a related member of the WNK kinase family...
Yang D, Li Q, So I, Huang C, Ando H, Mizutani A, et al
. IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway. J Clin Invest. 2011;121:956-65 pubmed publisher
..They also have implications for WNK/SPAK kinase-regulated processes involved in systemic fluid homeostasis, hypertension, and cystic fibrosis. ..
Zeniya M, Sohara E, Kita S, Iwamoto T, Susa K, Mori T, et al
. Dietary salt intake regulates WNK3-SPAK-NKCC1 phosphorylation cascade in mouse aorta through angiotensin II. Hypertension. 2013;62:872-8 pubmed publisher
..a low-salt diet and angiotensin II together did not increase phosphorylation of SPAK and NKCC1 in the aorta in WNK3 knockout mice, indicating that activation of the WNK-SPAK-NKCC1 phosphorylation cascade induced by a low-salt diet ..
Zhao H, Nepomuceno R, Gao X, Foley L, Wang S, Begum G, et al
. Deletion of the WNK3-SPAK kinase complex in mice improves radiographic and clinical outcomes in malignant cerebral edema after ischemic stroke. J Cereb Blood Flow Metab. 2017;37:550-563 pubmed publisher
..A WNK3-SPAK complex is highly expressed in brain, but its function in this organ remains unclear...
Leng Q, Kahle K, Rinehart J, MacGregor G, Wilson F, Canessa C, et al
. WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K+ channel ROMK1 (Kir1.1). J Physiol. 2006;571:275-86 pubmed
The serine-threonine kinase WNK3 modulates Cl- transport into and out of cells through its regulation of SLC12A cation/Cl- cotransporters, implicating it as (one of) the long-sought Cl-/volume-sensitive kinase(s)...
Lee A, Chen W, Stippec S, Self J, Yang F, Ding X, et al
. Protein kinase WNK3 regulates the neuronal splicing factor Fox-1. Proc Natl Acad Sci U S A. 2012;109:16841-6 pubmed publisher
We report an action of the protein kinase WNK3 on the neuronal mRNA splicing factor Fox-1. Fox-1 splices mRNAs encoding proteins important in synaptic transmission and membrane excitation...
Mederle K, Mutig K, Paliege A, Carota I, Bachmann S, Castrop H, et al
. Loss of WNK3 is compensated for by the WNK1/SPAK axis in the kidney of the mouse. Am J Physiol Renal Physiol. 2013;304:F1198-209 pubmed publisher
b>WNK3 kinase is expressed throughout the nephron and acts as a positive regulator of NKCC2 and NCC in vitro. Here we addressed the in vivo relevance of WNK3 using WNK3-deficient mice...