Wee2

Summary

Gene Symbol: Wee2
Description: WEE1 homolog 2 (S. pombe)
Alias: Gm1065, Wee1B, wee1-like protein kinase 2, mWee1B, wee1-like protein kinase 1B, wee1B kinase
Species: mouse
Products:     Wee2

Top Publications

  1. Han S, Chen R, Paronetto M, Conti M. Wee1B is an oocyte-specific kinase involved in the control of meiotic arrest in the mouse. Curr Biol. 2005;15:1670-6 pubmed
    ..Unlike the widely expressed Wee1 and Myt1, mWee1B mRNA and its protein are expressed only in oocytes, and mRNA downregulation by RNAi injection in vitro or ..
  2. Oh J, Han S, Conti M. Wee1B, Myt1, and Cdc25 function in distinct compartments of the mouse oocyte to control meiotic resumption. J Cell Biol. 2010;188:199-207 pubmed publisher
    ..Down-regulation of either Wee1B or Myt1 causes partial meiotic resumption, and oocytes reenter the cell cycle only when both proteins are down-..
  3. Oh J, Susor A, Conti M. Protein tyrosine kinase Wee1B is essential for metaphase II exit in mouse oocytes. Science. 2011;332:462-5 pubmed publisher
    ..Cdc2 inactivation by Wee1B-mediated phosphorylation is necessary for arrest of the oocyte at G2-prophase, but it is unclear whether this ..
  4. Su Y, Sugiura K, Sun F, Pendola J, Cox G, Handel M, et al. MARF1 regulates essential oogenic processes in mice. Science. 2012;335:1496-9 pubmed publisher
    ..Therefore MARF1, by suppressing levels of specific transcripts, is an essential regulator of important oogenic processes leading to female fertility and the development of healthy offspring. ..
  5. Nakanishi M, Ando H, Watanabe N, Kitamura K, Ito K, Okayama H, et al. Identification and characterization of human Wee1B, a new member of the Wee1 family of Cdk-inhibitory kinases. Genes Cells. 2000;5:839-47 pubmed
    ..We identified human Wee1B by searching a sequence database. The predicted human Wee1B protein comprises 561 amino acids...
  6. Liu C, Liu Y, Liu Y, Wu D, Luan Z, Wang E, et al. Ser 15 of WEE1B is a potential PKA phosphorylation target in G2/M transition in one-cell stage mouse embryos. Mol Med Rep. 2013;7:1929-37 pubmed publisher
    ..WEE1 homolog 2 (WEE2, also known as WEE1B) was first identified in Xenopus laevis and more recently in humans and mice, and is responsible for ..