Wee1

Summary

Gene Symbol: Wee1
Description: WEE 1 homolog 1 (S. pombe)
Alias: Wee1A, wee1-like protein kinase, WEE1 tyrosine kinase, wee1A kinase
Species: mouse
Products:     Wee1

Top Publications

  1. Matsuo T, Yamaguchi S, Mitsui S, Emi A, Shimoda F, Okamura H. Control mechanism of the circadian clock for timing of cell division in vivo. Science. 2003;302:255-9 pubmed
    ..Among these genes, expression of wee1 was directly regulated by the molecular components of the circadian clockwork...
  2. Poon R, Chau M, Yamashita K, Hunter T. The role of Cdc2 feedback loop control in the DNA damage checkpoint in mammalian cells. Cancer Res. 1997;57:5168-78 pubmed
    ..Thus, the decrease in Cdc25C activity may in part account for the DNA damage-induced increase in Thr14/Tyr15 phosphorylation. ..
  3. Cichutek A, Brueckmann T, Seipel B, Hauser H, Schlaubitz S, Prawitt D, et al. Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1). Cytogenet Cell Genet. 2001;93:277-83 pubmed
    ..this genomic area has been studied for years, the exact order of genes/chromosome markers between D11S572 and the WEE1 gene locus remained unclear...
  4. Tanaka Y, Nanba Y, Park K, Mabuchi T, Suenaga Y, Shiraishi S, et al. Transcriptional repression of the mouse wee1 gene by TBP-related factor 2. Biochem Biophys Res Commun. 2007;352:21-8 pubmed
    ..We previously reported that TRF2 is involved in reduction of wee1 mRNA in genotoxin-treated chicken cells. In this study, we investigated the role of TRF2 in wee1 gene expression...
  5. Lou W, Zhang X, Hu X, Hu A. MicroRNA-219-5p Inhibits Morphine-Induced Apoptosis by Targeting Key Cell Cycle Regulator WEE1. Med Sci Monit. 2016;22:1872-9 pubmed
    BACKGROUND To identify the effects of microRNA (miR)-219-5p on morphine-induced apoptosis by targeting WEE1. MATERIAL AND METHODS Forty Balb/C mice (Toll-like receptor 9, TLR9 knockout) were randomly allocated to the experimental and ..
  6. Kitamura T, Suzuki H, Tamura T. Mouse Wee1 gene is repressed by Krüppel-like factor 3 (KLF3) via interaction with multiple upstream elements. Gene. 2012;492:361-7 pubmed publisher
    b>Wee1 protein kinase represses CDK1 required for G(2)/M transition. The mouse wee1 promoter contains multiple CACCC-boxes between -306 and +1 that can bind to Krüppel-like factor 3 (KLF3) transcriptional repressor...
  7. Hong K, Kim H, Kim S, Lim D, Park J, Kim S. Hypoxia induces Wee1 expression and attenuates hydrogen peroxide-induced endothelial damage in MS1 cells. Exp Mol Med. 2011;43:653-9 pubmed publisher
    ..The induction of Wee1 under hypoxia was confirmed both at the mRNA and protein levels...
  8. Oh J, Susor A, Conti M. Protein tyrosine kinase Wee1B is essential for metaphase II exit in mouse oocytes. Science. 2011;332:462-5 pubmed publisher
  9. Kim M, Lee J, Lee S. Transient suppression of nuclear Cdc2 activity in response to ionizing radiation. Oncol Rep. 2008;19:1323-9 pubmed
    ..The level of phosphorylated Wee1 and its activity were also markedly increased at 12 h after irradiation...

More Information

Publications18

  1. Honda R, Ohba Y, Yasuda H. 14-3-3 zeta protein binds to the carboxyl half of mouse wee1 kinase. Biochem Biophys Res Commun. 1997;230:262-5 pubmed
    To identify proteins which bind to mouse wee1 kinase, the yeast "two-hybrid" system was used with a mouse cDNA library. Using the carboxyl half of weel kinase, the 14-3-3 zeta protein was isolated...
  2. Honda R, Tanaka H, Ohba Y, Yasuda H. Mouse p87wee1 kinase is regulated by M-phase specific phosphorylation. Chromosome Res. 1995;3:300-8 pubmed
    We have cloned a mouse wee1 kinase cDNA (mwee1). The clone is 2258 bp in length and its open reading frame corresponds to 646 amino acid residues. The molecular weight of this kinase is 87 kDa in SDS-PAGE, which is about 1...
  3. Tominaga Y, Li C, Wang R, Deng C. Murine Wee1 plays a critical role in cell cycle regulation and pre-implantation stages of embryonic development. Int J Biol Sci. 2006;2:161-70 pubmed
    b>Wee1 kinase regulates the G2/M cell cycle checkpoint by phosphorylating and inactivating the mitotic cyclin-dependent kinase 1 (Cdk1). Loss of Wee1 in many systems, including yeast and drosophila, leads to premature mitotic entry...
  4. Müller M, Lutter D, Püschel A. Persistence of the cell-cycle checkpoint kinase Wee1 in SadA- and SadB-deficient neurons disrupts neuronal polarity. J Cell Sci. 2010;123:286-94 pubmed publisher
    b>Wee1 is well characterized as a cell-cycle checkpoint kinase that regulates the entry into mitosis in dividing cells...
  5. Park C, Kim Y, Jeon E, Cha K, Lee S, Lee K. Expression of wee1 and its related cell cycle components in mouse early stage follicles. Cells Tissues Organs. 2004;177:221-8 pubmed
    b>Wee1 is a kinase regulator of the M-phase promoting factor (a complex of cdc2 and cyclin B1). The present study was performed to determine the role(s) of wee1 in the early stages of mouse ovarian follicles...
  6. Wu C, Kirley S, Xiao H, Chuang Y, Chung D, Zukerberg L. Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers. Cancer Res. 2001;61:7325-32 pubmed
    ..Cables enhanced cdk2 tyrosine 15 phosphorylation by the Wee1 protein kinase, an inhibitory phosphorylation, which led to decreased cdk2 kinase activity...
  7. Wlodarczyk B, Craig J, Bennett G, Calvin J, Finnell R. Valproic acid-induced changes in gene expression during neurulation in a mouse model. Teratology. 1996;54:284-97 pubmed
    ..These results suggest that alterations in the expression of multiple genes are most likely responsible for valproic acid-induced neural tube defects. ..
  8. Vassilopoulos A, Tominaga Y, Kim H, Lahusen T, Li B, Yu H, et al. WEE1 murine deficiency induces hyper-activation of APC/C and results in genomic instability and carcinogenesis. Oncogene. 2015;34:3023-35 pubmed publisher
    The tyrosine kinase WEE1 controls the timing of entry into mitosis in eukaryotes and its genetic deletion leads to pre-implantation lethality in mice...
  9. Obi Ioka Y, Ushijima K, Kusama M, Ishikawa Kobayashi E, Fujimura A. Involvement of Wee1 in the circadian rhythm-dependent intestinal damage induced by docetaxel. J Pharmacol Exp Ther. 2013;347:242-8 pubmed publisher
    ..b>Wee1 expression is controlled by the clock gene complex, clock/bmal1, and contributes to cell-cycle progression...