weaver

Summary

Gene Symbol: weaver
Description: potassium inwardly-rectifying channel, subfamily J, member 6
Alias: BIR1, GIRK2, KATP2, KCNJ7, Kir3.2, weaver, G protein-activated inward rectifier potassium channel 2, G-protein-coupled inward rectifier K+ channel 2-1, G-protein-coupled inward rectifier K+ channel 2-A, G-protein-coupled inward rectifier K+ channel 2-B, G-protein-coupled inward rectifier K+ channel 2-C, GIRK-2, inward rectifier K(+) channel Kir3.2, potassium channel, inwardly rectifying subfamily J member 6, potassium inwardly-rectifying channel J6
Species: mouse
Products:     weaver

Top Publications

  1. Simon J, Ghetti B. Topographic distribution of dopamine uptake, choline uptake, choline acetyltransferase, and GABA uptake in the striata of weaver mutant mice. Neurochem Res. 1992;17:431-6 pubmed
    ..DA) uptake, choline uptake, choline acetyltransferase (ChAT) activity and GABA uptake within the striata of weaver mutant mice and control mice was determined...
  2. Chou H, Ogawa N, Asanuma M, Hirata H, Mori A. Dopamine deficiency in the weaver mutant mouse: an animal model of olivopontocerebellar atrophy. Res Commun Chem Pathol Pharmacol. 1991;74:117-20 pubmed
    The dopamine system in weaver mutant mice, a model of cerebellar atrophy, was studied...
  3. Yao W, Zhong J, Rosen C, Hock J, Lee W. Igf-I and postnatal growth of weaver mutant mice. Endocrine. 2005;26:117-25 pubmed
    ..The weaver (wv) mutant mouse is a commonly used model for studying hereditary cerebellar ataxia and provides us with an ..
  4. Mitrovic I, Margeta Mitrovic M, Bader S, Stoffel M, Jan L, Basbaum A. Contribution of GIRK2-mediated postsynaptic signaling to opiate and alpha 2-adrenergic analgesia and analgesic sex differences. Proc Natl Acad Sci U S A. 2003;100:271-6 pubmed
    ..Here, we used mice lacking the GIRK2 channel subunit to assess the relative contribution of these two effector systems to nociceptive processing in ..
  5. Lesage F, Duprat F, Fink M, Guillemare E, Coppola T, Lazdunski M, et al. Cloning provides evidence for a family of inward rectifier and G-protein coupled K+ channels in the brain. FEBS Lett. 1994;353:37-42 pubmed
    ..These results provide the first evidence that the GIRK family, as the IRK family, is composed of multiple genes with members specifically expressed in the nervous system. ..
  6. Inanobe A, Horio Y, Fujita A, Tanemoto M, Hibino H, Inageda K, et al. Molecular cloning and characterization of a novel splicing variant of the Kir3.2 subunit predominantly expressed in mouse testis. J Physiol. 1999;521 Pt 1:19-30 pubmed
    1. One of the features of weaver mutant mice is male infertility, which suggests that Kir3.2, a G-protein-gated inwardly rectifying K+ channel subunit, may be involved in spermatogenesis. Therefore, we have characterized the Kir3...
  7. Torrecilla M, Marker C, Cintora S, Stoffel M, Williams J, Wickman K. G-protein-gated potassium channels containing Kir3.2 and Kir3.3 subunits mediate the acute inhibitory effects of opioids on locus ceruleus neurons. J Neurosci. 2002;22:4328-34 pubmed
    ..We conclude that the acute opioid inhibition of LC neurons is mediated primarily by the activation of G-protein-gated potassium channels and that the cAMP-dependent cation conductance does not contribute significantly to this effect. ..
  8. Blednov Y, Stoffel M, Alva H, Harris R. A pervasive mechanism for analgesia: activation of GIRK2 channels. Proc Natl Acad Sci U S A. 2003;100:277-82 pubmed
    ..By using GIRK2-null mutant mice, we found marked reduction or complete elimination of the antinociceptive (hot plate test) ..
  9. Lesage F, Guillemare E, Fink M, Duprat F, Heurteaux C, Fosset M, et al. Molecular properties of neuronal G-protein-activated inwardly rectifying K+ channels. J Biol Chem. 1995;270:28660-7 pubmed
    ..Krapivinsky, L., and Clapham, D. E. (1995) Nature 374, 135-141). We report the cloning of a mouse GIRK2 splice variant, noted mGIRK2A...
  10. Berlin S, Tsemakhovich V, Castel R, Ivanina T, Dessauer C, Keren Raifman T, et al. Two distinct aspects of coupling between G?(i) protein and G protein-activated K+ channel (GIRK) revealed by fluorescently labeled G?(i3) protein subunits. J Biol Chem. 2011;286:33223-35 pubmed publisher
    ..Our findings support the notion that G?(i/o) actively regulates GIRK. Although regulation of I(basal) is a function of G?(i)(GDP), our new findings indicate that regulation of kinetics of I(evoked) is mediated by G?(i)(GTP). ..

Detail Information

Publications100

  1. Simon J, Ghetti B. Topographic distribution of dopamine uptake, choline uptake, choline acetyltransferase, and GABA uptake in the striata of weaver mutant mice. Neurochem Res. 1992;17:431-6 pubmed
    ..DA) uptake, choline uptake, choline acetyltransferase (ChAT) activity and GABA uptake within the striata of weaver mutant mice and control mice was determined...
  2. Chou H, Ogawa N, Asanuma M, Hirata H, Mori A. Dopamine deficiency in the weaver mutant mouse: an animal model of olivopontocerebellar atrophy. Res Commun Chem Pathol Pharmacol. 1991;74:117-20 pubmed
    The dopamine system in weaver mutant mice, a model of cerebellar atrophy, was studied...
  3. Yao W, Zhong J, Rosen C, Hock J, Lee W. Igf-I and postnatal growth of weaver mutant mice. Endocrine. 2005;26:117-25 pubmed
    ..The weaver (wv) mutant mouse is a commonly used model for studying hereditary cerebellar ataxia and provides us with an ..
  4. Mitrovic I, Margeta Mitrovic M, Bader S, Stoffel M, Jan L, Basbaum A. Contribution of GIRK2-mediated postsynaptic signaling to opiate and alpha 2-adrenergic analgesia and analgesic sex differences. Proc Natl Acad Sci U S A. 2003;100:271-6 pubmed
    ..Here, we used mice lacking the GIRK2 channel subunit to assess the relative contribution of these two effector systems to nociceptive processing in ..
  5. Lesage F, Duprat F, Fink M, Guillemare E, Coppola T, Lazdunski M, et al. Cloning provides evidence for a family of inward rectifier and G-protein coupled K+ channels in the brain. FEBS Lett. 1994;353:37-42 pubmed
    ..These results provide the first evidence that the GIRK family, as the IRK family, is composed of multiple genes with members specifically expressed in the nervous system. ..
  6. Inanobe A, Horio Y, Fujita A, Tanemoto M, Hibino H, Inageda K, et al. Molecular cloning and characterization of a novel splicing variant of the Kir3.2 subunit predominantly expressed in mouse testis. J Physiol. 1999;521 Pt 1:19-30 pubmed
    1. One of the features of weaver mutant mice is male infertility, which suggests that Kir3.2, a G-protein-gated inwardly rectifying K+ channel subunit, may be involved in spermatogenesis. Therefore, we have characterized the Kir3...
  7. Torrecilla M, Marker C, Cintora S, Stoffel M, Williams J, Wickman K. G-protein-gated potassium channels containing Kir3.2 and Kir3.3 subunits mediate the acute inhibitory effects of opioids on locus ceruleus neurons. J Neurosci. 2002;22:4328-34 pubmed
    ..We conclude that the acute opioid inhibition of LC neurons is mediated primarily by the activation of G-protein-gated potassium channels and that the cAMP-dependent cation conductance does not contribute significantly to this effect. ..
  8. Blednov Y, Stoffel M, Alva H, Harris R. A pervasive mechanism for analgesia: activation of GIRK2 channels. Proc Natl Acad Sci U S A. 2003;100:277-82 pubmed
    ..By using GIRK2-null mutant mice, we found marked reduction or complete elimination of the antinociceptive (hot plate test) ..
  9. Lesage F, Guillemare E, Fink M, Duprat F, Heurteaux C, Fosset M, et al. Molecular properties of neuronal G-protein-activated inwardly rectifying K+ channels. J Biol Chem. 1995;270:28660-7 pubmed
    ..Krapivinsky, L., and Clapham, D. E. (1995) Nature 374, 135-141). We report the cloning of a mouse GIRK2 splice variant, noted mGIRK2A...
  10. Berlin S, Tsemakhovich V, Castel R, Ivanina T, Dessauer C, Keren Raifman T, et al. Two distinct aspects of coupling between G?(i) protein and G protein-activated K+ channel (GIRK) revealed by fluorescently labeled G?(i3) protein subunits. J Biol Chem. 2011;286:33223-35 pubmed publisher
    ..Our findings support the notion that G?(i/o) actively regulates GIRK. Although regulation of I(basal) is a function of G?(i)(GDP), our new findings indicate that regulation of kinetics of I(evoked) is mediated by G?(i)(GTP). ..
  11. Blednov Y, Stoffel M, Chang S, Harris R. Potassium channels as targets for ethanol: studies of G-protein-coupled inwardly rectifying potassium channel 2 (GIRK2) null mutant mice. J Pharmacol Exp Ther. 2001;298:521-30 pubmed
    ..Selective enhancement of GIRK2 function by intoxicating concentrations of ethanol was recently shown for recombinant homomeric and heteromeric ..
  12. Inanobe A, Nakagawa A, Kurachi Y. Conformational changes underlying pore dilation in the cytoplasmic domain of mammalian inward rectifier K+ channels. PLoS ONE. 2013;8:e79844 pubmed publisher
    ..These results suggest that the G protein association triggers pore dilation at the cytoplasmic domain in functional channels, and the pore-constituting structural elements contribute differently to these conformational changes. ..
  13. Pravetoni M, Wickman K. Behavioral characterization of mice lacking GIRK/Kir3 channel subunits. Genes Brain Behav. 2008;7:523-31 pubmed publisher
    ..GIRK1(-/-) mice and GIRK2(-/-) mice, however, showed elevated motor activity and delayed habituation to an open field...
  14. Costa A, Stasko M, Stoffel M, Scott McKean J. G-protein-gated potassium (GIRK) channels containing the GIRK2 subunit are control hubs for pharmacologically induced hypothermic responses. J Neurosci. 2005;25:7801-4 pubmed
    ..G-protein-gated potassium (GIRK) channels, we investigated the hypothermic response to several of these agents on Girk2 null mutant mice...
  15. Pegan S, Arrabit C, Zhou W, Kwiatkowski W, Collins A, Slesinger P, et al. Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification. Nat Neurosci. 2005;8:279-87 pubmed
    ..1(L) that is important for modulating inward rectification. Taken together, these results suggest the cytoplasmic domains of Kir channels undergo structural changes to modulate gating and inward rectification. ..
  16. Marker C, Stoffel M, Wickman K. Spinal G-protein-gated K+ channels formed by GIRK1 and GIRK2 subunits modulate thermal nociception and contribute to morphine analgesia. J Neurosci. 2004;24:2806-12 pubmed
    ..We detected GIRK1 (G-protein-gated inwardly rectifying K+ channel subunit 1) and GIRK2 subunits, but not GIRK3, in the superficial layers of the dorsal horn...
  17. Adelbrecht C, Murer M, Lauritzen I, Lesage F, Ladzunski M, Agid Y, et al. An immunocytochemical study of a G-protein-gated inward rectifier K+ channel (GIRK2) in the weaver mouse mesencephalon. Neuroreport. 1997;8:969-74 pubmed
    ..inward rectifier K+ channel (GIRK2) is responsible for inducing cell death in the cerebellum of homozygous weaver (wv/wv) mutant mice. These mice also display a progressive, massive loss of mesencephalic dopaminergic neurones...
  18. Joshi K, Shen L, Michaeli A, Salter M, Thibault Messier G, Hashmi S, et al. Infantile spasms in down syndrome: Rescue by knockdown of the GIRK2 channel. Ann Neurol. 2016;80:511-21 pubmed publisher
    ..the Kcnj6 gene that encodes the GABAB R-coupled G protein-coupled inward rectifying potassium channel subunit 2 (GIRK2) channel...
  19. Bahjaoui Bouhaddi M, Padilla F, Nicolet M, Cifuentes Diaz C, Fellmann D, Mege R. Localized deposition of M-cadherin in the glomeruli of the granular layer during the postnatal development of mouse cerebellum. J Comp Neurol. 1997;378:180-95 pubmed
    ..M-cadherin was undetectable in the cerebella of the weaver and staggerer mutants, lacking granule cells, and therefore mature glomeruli and puncta adherentia...
  20. Kobayashi T, Ikeda K, Ichikawa T, Abe S, Togashi S, Kumanishi T. Molecular cloning of a mouse G-protein-activated K+ channel (mGIRK1) and distinct distributions of three GIRK (GIRK1, 2 and 3) mRNAs in mouse brain. Biochem Biophys Res Commun. 1995;208:1166-73 pubmed
  21. Ehler E, van Leeuwen F, Collard J, Salinas P. Expression of Tiam-1 in the developing brain suggests a role for the Tiam-1-Rac signaling pathway in cell migration and neurite outgrowth. Mol Cell Neurosci. 1997;9:1-12 pubmed
    ..function of Tiam-1 in neuronal migration and neurite extension, we examined the pattern of Tiam-1 expression in weaver mice, in which cerebellar granule cells fail to migrate to their final position and subsequently die...
  22. Bolivar V, Danilchuk W, Fentress J. Separation of activation and pattern in grooming development of weaver mice. Behav Brain Res. 1996;75:49-58 pubmed
    The effects of environmental conditions and age on grooming behavior were examined in weaver mutant mice and control littermates...
  23. Bakalian A, Kopmels B, Messer A, Fradelizi D, Delhaye Bouchaud N, Wollman E, et al. Peripheral macrophage abnormalities in mutant mice with spinocerebellar degeneration. Res Immunol. 1992;143:129-39 pubmed
    ..Hyperexpression of IL1 beta mRNA was present in the cerebellar mutants nodding and nervous, but not in weaver. A similar phenomenon was found, but to a lesser extent, in the spinal mutants dystonia musculorum, wobbler and ..
  24. Bayer S, Wills K, Triarhou L, Verina T, Thomas J, Ghetti B. Selective vulnerability of late-generated dopaminergic neurons of the substantia nigra in weaver mutant mice. Proc Natl Acad Sci U S A. 1995;92:9137-40 pubmed
    In homozygous weaver (wv/wv) mutant mice, nearly 50% of the dopaminergic substantia nigra neurons degenerate by postnatal day 20...
  25. Ellisor D, Rieser C, Voelcker B, Machan J, Zervas M. Genetic dissection of midbrain dopamine neuron development in vivo. Dev Biol. 2012;372:249-62 pubmed publisher
    ..By placing Wnt1, Fgf8, and En1/2 in the context of their temporal requirement for MbDA neuron development, we further deciphered the developmental program underpinning MbDA neuron progenitors. ..
  26. Eicher E, Beamer W. New mouse dw allele: genetic location and effects on lifespan and growth hormone levels. J Hered. 1980;71:187-90 pubmed
    ..Linkage experiments designed to assign the dw gene, together with another gene weaver (wv), were successful in that both were found to be on chromosome 16...
  27. Lalonde R, Strazielle C. Spontaneous and induced mouse mutations with cerebellar dysfunctions: behavior and neurochemistry. Brain Res. 2007;1140:51-74 pubmed
    ..Rora(sg) (staggerer), nr (nervous), Agtpbp1(pcd) (Purkinje cell degeneration), Reln(rl) (reeler), and Girk2(Wv) (Weaver) are spontaneous mutations with cerebellar atrophy, ataxia, and deficits in motor coordination tasks requiring ..
  28. Seregaza Z, Roubertoux P, Jamon M, Soumireu Mourat B. Mouse models of cognitive disorders in trisomy 21: a review. Behav Genet. 2006;36:387-404 pubmed
    ..This review confirms the crucial but not exclusive contribution of the D21S17-ETS2 region encompassing 16 genes to cognitive disorders. ..
  29. Fukaya M, Yamada K, Nagashima M, Tanaka K, Watanabe M. Down-regulated expression of glutamate transporter GLAST in Purkinje cell-associated astrocytes of reeler and weaver mutant cerebella. Neurosci Res. 1999;34:165-75 pubmed
    ..Here we investigated the expression and localization in the reeler and weaver mutant cerebella with disorganized cytoarchitecture and disrupted synaptic circuitry...
  30. Matsui K, Masui A, Kato N, Adachi K. Levels of somatostatin and cholecystokinin in the brain of ataxic mutant mice. Life Sci. 1993;53:333-40 pubmed
    ..were investigated in three types of genetically-determined ataxic mutant mice: rolling mouse Nagoya (RMN), weaver, and Purkinje cell degeneration (PCD) mice. The cerebellar pathology in each of these types differs...
  31. Reader T, Hebert C, Ase A, Le Marec N. Distribution of serotonin, its metabolites and 5-HT transporters in the neostriatum of Lurcher and weaver mutant mice. Neurochem Int. 2001;39:169-77 pubmed
    ..in the neostriatum (caudate putamen) of wild type (+/+) mice and heterozygous (wv/+) and homozygous (wv/wv) weaver, as well as in heterozygous Lurcher (Lc/+) mutants...
  32. Savy C, Martin Martinelli E, Simon A, Duyckaerts C, Verney C, Adelbrecht C, et al. Altered development of dopaminergic cells in the retina of weaver mice. J Comp Neurol. 1999;412:656-68 pubmed
    Postnatal degeneration of dopaminergic (DA) cells is known to occur in mesencephalic nuclei of mutant weaver mice, whereas retinal DA content is reported to be unchanged in the adult animal...
  33. Liss B, Neu A, Roeper J. The weaver mouse gain-of-function phenotype of dopaminergic midbrain neurons is determined by coactivation of wvGirk2 and K-ATP channels. J Neurosci. 1999;19:8839-48 pubmed
    The phenotype of substantia nigra (SN) neurons in homozygous weaver (wv/wv) mice was studied by combining patch-clamp and single-cell RT-multiplex PCR techniques in midbrain slices of 14-d-old mice...
  34. Sotelo C. Cerebellar synaptogenesis: what we can learn from mutant mice. J Exp Biol. 1990;153:225-49 pubmed
    ..In weaver and in the central ectopia of reeler, Purkinje cells form innumerable dendritic spines, despite the absence of ..
  35. Aryal P, Dvir H, Choe S, Slesinger P. A discrete alcohol pocket involved in GIRK channel activation. Nat Neurosci. 2009;12:988-95 pubmed publisher
    ..By contrast, alcohols inhibited constitutively open channels, such as IRK1 or GIRK2 engineered to strongly bind PIP(2)...
  36. Ponomarev I, Schafer G, Blednov Y, Williams R, Iyer V, Harris R. Convergent analysis of cDNA and short oligomer microarrays, mouse null mutants and bioinformatics resources to study complex traits. Genes Brain Behav. 2004;3:360-8 pubmed
    ..Mice lacking a functional copy of G protein-gated potassium channel subunit 2 (Girk2) show a decrease in the aversive effects of ethanol, whereas preproenkephalin (Penk) null mutant mice show the ..
  37. Cabraja M, Bäurle J. Vestibular ganglion neurons survive hair cell defects in jerker, shaker, and Varitint-waddler mutants and downregulate calretinin expression. J Comp Neurol. 2007;504:418-26 pubmed
    ..calretinin (Calr) were quantified stereologically in the cerebellar mutants purkinje cell degeneration (pcd/pcd), weaver (wv/wv), and Lurcher (Lc/+), and in the vestibular mutants jerker (je/je), shaker-1 (sh/sh), and Varitint-waddler (..
  38. Gao W, Liu X, Hatten M. The weaver gene encodes a nonautonomous signal for CNS neuronal differentiation. Cell. 1992;68:841-54 pubmed
    In the neurological mutant mouse weaver, CNS precursor cells in the external germinal layer (EGL) of the cerebellar cortex proliferate normally, but fail to differentiate and die in the proliferative zone...
  39. Armstrong C, Hawkes R. Selective Purkinje cell ectopia in the cerebellum of the weaver mouse. J Comp Neurol. 2001;439:151-61 pubmed
    ..In the adult weaver (wv/wv) mouse, the zebrin II expression pattern in the cerebellar vermis is abnormal, consistent with the absence ..
  40. Mallet J, Huchet M, Pougeois R, Changeux J. Anatomical, physiological and biochemical studies on the cerebellum from mutant mice. III. Protein differences associated with the weaver, staggerer and nervous mutations. Brain Res. 1976;103:291-312 pubmed
    The protein composition of subcellular fractions of the cerebella of normal and weaver, staggerer and nervous mutant mice and of X-irradiated rats are studied by polyacrylamide gel electrophoresis in sodium dodecyl sulphate...
  41. Lalonde R, Strazielle C. Behavioral effects of neonatal lesions on the cerebellar system. Int J Dev Neurosci. 2015;43:58-65 pubmed publisher
    ..pathology are impaired in motor functions during the neonatal period, including Grid2(Lc), Rora(sg), Dab1(scm), Girk2(Wv), Lmx1a(dr-sst), Myo5a(dn), Inpp4a(wbl), and Cacna1a(rol) mice as well as shaker and dystonic rats...
  42. Marron Fernandez de Velasco E, Zhang L, N Vo B, Tipps M, Farris S, Xia Z, et al. GIRK2 splice variants and neuronal G protein-gated K+ channels: implications for channel function and behavior. Sci Rep. 2017;7:1639 pubmed publisher
    ..While most neuronal GIRK channels are formed by GIRK1 and GIRK2 subunits, distinct GIRK2 isoforms generated by alternative splicing have been identified...
  43. Tong Y, Wei J, Zhang S, Strong J, Dlouhy S, Hodes M, et al. The weaver mutation changes the ion selectivity of the affected inwardly rectifying potassium channel GIRK2. FEBS Lett. 1996;390:63-8 pubmed
    The weaver mutation in mice has recently been identified as a single base-pair mutation in the Girk2 gene, which encodes a G-protein-activated inwardly rectifying potassium channel, GIRK2...
  44. Grüsser C, Grüsser Cornehls U. Improvement in motor performance of Weaver mutant mice following lesions of the cerebellum. Behav Brain Res. 1998;97:189-94 pubmed
    In Weaver mutants (B6CBA wv/wv) cerebellar granule cells degenerate almost completely postnatally. A partial loss of Purkinje cells (PC) and a degeneration of dopaminergic cells in the substantia nigra have also been found...
  45. Bolger T, Yao T. Intracellular trafficking of histone deacetylase 4 regulates neuronal cell death. J Neurosci. 2005;25:9544-53 pubmed
    ..Finally, an increase of nuclear HDAC4 in granule neurons is also observed in weaver mice, which harbor a mutation that promotes CGN apoptosis...
  46. Goldowitz D, Mullen R. Granule cell as a site of gene action in the weaver mouse cerebellum: evidence from heterozygous mutant chimeras. J Neurosci. 1982;2:1474-85 pubmed
    Experimental mouse chimeras were used to determine the site(s) of gene action in the weaver mutant cerebellum...
  47. Bare D, Ghetti B, Richter J. The tyrosine kinase inhibitor genistein increases endogenous dopamine release from normal and weaver mutant mouse striatal slices. J Neurochem. 1995;65:2096-104 pubmed
    ..We have previously described alterations in basal and evoked DA release from the striatum of the weaver (wv/wv) mutant mouse, and genotypic differences in fractional release were also observed with genistein ..
  48. Bäurle J, Grüsser Cornehls U. Calbindin D-28k in the lateral vestibular nucleus of mutant mice as a tool to reveal Purkinje cell plasticity. Neurosci Lett. 1994;167:85-8 pubmed
    ..In PCD an almost complete loss of CaBP+ fibres and terminals in the dLVN compared to the wildtype and the Weaver mutant was present...
  49. Fragioudaki K, Kouvelas E, Cristiani R, Giompres P, Bagnoli P, Mitsacos A. Expression of amino acid receptors and neural peptides in the weaver mouse brain. Brain Res. 2007;1140:132-52 pubmed
    ..of kainate and GABA(A) receptor subunits and the pre-proenkephalin and prodynorphin peptides in the brain of weaver mouse (a genetic model of dopamine deficiency) and (ii) immunocytochemistry in order to study the somatostatin-..
  50. Dewar K, Paquet M, Sequeira A. Apparent dopamine D1 and D2 receptors in the weaver mutant mouse: receptor binding and coupling to adenylyl cyclase. J Neural Transm (Vienna). 1999;106:487-97 pubmed
    b>Weaver mutant mice have a selective degeneration of the nigrostriatal dopamine pathway arising between 7-21 days after birth...
  51. Wang W, Whorton M, MacKinnon R. Quantitative analysis of mammalian GIRK2 channel regulation by G proteins, the signaling lipid PIP2 and Na+ in a reconstituted system. elife. 2014;3:e03671 pubmed publisher
    ..In this study, the mammalian GIRK2 channel has been purified and reconstituted in planar lipid membranes and effects of G?, G??, PIP2 and Na(+) ..
  52. Richter J, Bare D, Yu H, Ghetti B, Simon J. Dopamine transporter-dependent and -independent endogenous dopamine release from weaver mouse striatum in vitro. J Neurochem. 1995;64:191-8 pubmed
    The weaver mutant mouse (wv/wv) has an approximately 70% loss of nigrostriatal dopamine (DA) neurons, but the fractional DA release evoked by amphetamine (but not a high potassium level) has been shown to be greater from striatal slices ..
  53. Bjerregaard A, Jørgensen O. Ontogeny of the cell adhesion molecule L1 in the cerebellum of weaver and reeler mutant mice. Neurochem Res. 1994;19:789-93 pubmed
    The ontogeny of cell adhesion molecule L1 in cerebellum was quantitatively assessed in weaver and reeler mutant mice and in heterozygous litter-mate controls...
  54. Signorini S, Liao Y, Duncan S, Jan L, Stoffel M. Normal cerebellar development but susceptibility to seizures in mice lacking G protein-coupled, inwardly rectifying K+ channel GIRK2. Proc Natl Acad Sci U S A. 1997;94:923-7 pubmed
    ..suggested by the recent finding that a point mutation in the pore region of GIRK2 (G156S) is responsible for the weaver (wv) phenotype...
  55. Eisenman L, Gallagher E, Hawkes R. Regionalization defects in the weaver mouse cerebellum. J Comp Neurol. 1998;394:431-44 pubmed
    ..Zebrin II expression has been examined in the weaver (wv) mouse cerebellum...
  56. Triarhou L, Sola C, Palacios J, Mengod G. MAP2 and GAP-43 expression in normal and weaver mouse cerebellum: correlative immunohistochemical and in situ hybridization studies. Arch Histol Cytol. 1998;61:233-42 pubmed
    ..probes, we examined the cellular localization of MAP2, GAP-43 and their mRNAs in the cerebellum of control and weaver (wv/wv) mutant mice, which exhibit massive granule cell death...
  57. Schwartz N, Szabo M, Verina T, Wei J, Dlouhy S, Won L, et al. Hypothalamic-pituitary-gonadal axis in the mutant weaver mouse. Neuroendocrinology. 1998;68:374-85 pubmed
    The weaver (wv) mutant mouse manifests severe locomotor defects, a deficiency in granule cells of the cerebellum, and cellular deficits in the midbrain dopaminergic system...
  58. Hablitz L, Molzof H, Paul J, Johnson R, Gamble K. Suprachiasmatic nucleus function and circadian entrainment are modulated by G protein-coupled inwardly rectifying (GIRK) channels. J Physiol. 2014;592:5079-92 pubmed publisher
    ..We show that GIRK current and GIRK2 protein expression are greater during the day...
  59. Koyrakh L, Lujan R, Colon J, Karschin C, Kurachi Y, Karschin A, et al. Molecular and cellular diversity of neuronal G-protein-gated potassium channels. J Neurosci. 2005;25:11468-78 pubmed
    ..In the substantia nigra, GIRK2 was the principal subunit, and it was found primarily in dendrites of neurons in the substantia nigra pars ..
  60. Roffler Tarlov S, Graybiel A. Weaver mutation has differential effects on the dopamine-containing innervation of the limbic and nonlimbic striatum. Nature. 1984;307:62-6 pubmed
    ..report here evidence that the mesolimbic and nigrostriatal systems are differentially affected in the mutant mouse weaver, and in particular that dopamine is severely depleted in the dorsal striatum of weaver but relatively spared in ..
  61. Millonig J, Millen K, Hatten M. A high-density molecular genetic map around the weaver locus. Mamm Genome. 1996;7:616-8 pubmed
  62. Coscia E, Fentress J. Neurological dysfunction expressed in the grooming behavior of developing weaver mutant mice. Behav Genet. 1993;23:533-41 pubmed
    The present study provides the first quantitative developmental analysis of movement in the weaver (wv/wv) mutant mouse...
  63. Guatteo E, Bengtson C, Bernardi G, Mercuri N. Voltage-gated calcium channels mediate intracellular calcium increase in weaver dopaminergic neurons during stimulation of D2 and GABAB receptors. J Neurophysiol. 2004;92:3368-74 pubmed
    The weaver (wv) mutation affects the pore-forming region of the inwardly rectifying potassium channel (GIRK) leading to degeneration of cerebellar granule and midbrain dopaminergic neurons...
  64. Krug F, Bäurle J, Grüsser Cornehls U. Enlargement of GAD-immunopositive terminals in the lateral vestibular nucleus (LVN) of weaver mutant mice. Histol Histopathol. 1995;10:105-9 pubmed
    Reorganization of cerebellar circuitry due to specific cell loss in Weaver mutants causes physiological and morphological alterations in the terminal domains of the GABAergic cerebellar corticovestibular projections...
  65. Marti J, Wills K, Ghetti B, Bayer S. Evidence that the loss of Purkinje cells and deep cerebellar nuclei neurons in homozygous weaver is not related to neurogenetic patterns. Int J Dev Neurosci. 2001;19:599-610 pubmed
    To determine whether the neurogenetic patterns of Purkinje cells and deep cerebellar nuclei neurons were normal in weaver homozygotes and whether the degeneration of those neuronal types was linked to their time of origin, [3H] thymidine ..
  66. Mitsacos A, Tomiyama M, Stasi K, Giompres P, Kouvelas E, Cortes R, et al. [3H]CNQX and NMDA-sensitive [3H]glutamate binding sites and AMPA receptor subunit RNA transcripts in the striatum of normal and weaver mutant mice and effects of ventral mesencephalic grafts. Cell Transplant. 1999;8:11-23 pubmed
    Levels of excitatory amino acid receptors were studied in the weaver mouse model of DA deficiency after unilateral intrastriatal transplantation of E12+/+ mesencephalic cell suspensions...
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    Most cerebellar granule neurons in weaver mice undergo premature apoptosis during the first 3 postnatal weeks, subsequently leading to severe ataxia...
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    ..Otx2 is restricted to ventral tegmental area (VTA) neurons that are prevalently complementary to those expressing Girk2 and glycosylated active form of the dopamine transporter (Dat)...
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    Neurons exhibiting D2 receptor-like immunoreactivity were investigated in the substantia nigra pars compacta of weaver mice at the light and electron microscope levels using immunocytochemical techniques...
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    ..In addition, we show that calbindin-, GIRK2-, and calretinin-expressing MbDA neuron subtypes are derived from Wnt1-expressing progenitors marked over a broad ..
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    ..we show that, in DA neurons of mice, the low coupling efficiency reflects the selective expression of heteromeric GIRK2/3 channels and is dynamically modulated by a member of the regulator of G protein signaling (RGS) protein family...
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    ..identified by positional cloning of the spontaneous mouse mutants motor endplate disease, tottering, lethargic and weaver. The phenotypes of four allelic mutations identified in the sodium channel gene Scn8a range from ataxia and muscle ..
  73. Liss B, Bruns R, Roeper J. Alternative sulfonylurea receptor expression defines metabolic sensitivity of K-ATP channels in dopaminergic midbrain neurons. EMBO J. 1999;18:833-46 pubmed
    ..In contrast to wild-type, surviving dopaminergic SN neurons of homozygous weaver mouse exclusively expressed SUR1 + Kir6.2 during the active period of dopaminergic neurodegeneration...
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    ..In the mouse mutant weaver, Id mRNA was only seen in granule cells that have reached their normal positions in the IGL...
  76. Stotz E, Palacios J, Landwehrmeyer B, Norton J, Ghetti B, Simon J, et al. Alterations in dopamine and serotonin uptake systems in the striatum of the weaver mutant mouse. J Neural Transm Gen Sect. 1994;97:51-64 pubmed
    In the striatum of the homozygous weaver mutant mouse (wv/wv), dopamine content, uptake and tyrosine hydroxylase activity are decreased compared to wild-type (+/+) mice...
  77. Bayer S, Wills K, Triarhou L, Thomas J, Ghetti B. Systematic differences in time of dopaminergic neuron origin between normal mice and homozygous weaver mutants. Exp Brain Res. 1995;105:200-8 pubmed
    ..hydroxylase and [3H]thymidine autoradiography were combined in wild-type mice and in mice homozygous for the weaver mutant gene (wv) to see whether the neurogenetic patterns of midbrain dopaminergic neurons was normal in the ..
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    The dopamine system in weaver mutant mice (B6CBA-Aw-J/A background) was studied...
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    ..cell degeneration (pcd), and to a lesser extent reeler and wobbler, but was absent in the neurological mutants weaver, jimpy, and motor end plate disease (medH)...
  80. Marti J, Wills K, Ghetti B, Bayer S. Regional differences in the Purkinje cells settled pattern: a comparative autoradiographic study in control and homozygous weaver mice. Exp Neurol. 2002;175:168-81 pubmed
    To determine whether Purkinje cells located in the vermis and the lateral hemispheres of weaver mice homozygotes are distributed according to precise neurogenetic gradients, [3H]thymidine autoradiography was applied on sections of ..
  81. Cabin D, McKee Johnson J, Matesic L, Wiltshire T, Rue E, Mjaatvedt A, et al. Physical and comparative mapping of distal mouse chromosome 16. 5 p5. Genome Res. 1998;8:940-50 pubmed
    ..Comparison of this physical map with that of the corresponding region on Chr. 21 shows conservation not only of gene order but of size in the 3 Mb from Cbr1 to Ets2; distal to Ets2, the human map is expanded. ..
  82. Airaksinen M, Thoenen H, Meyer M. Vulnerability of midbrain dopaminergic neurons in calbindin-D28k-deficient mice: lack of evidence for a neuroprotective role of endogenous calbindin in MPTP-treated and weaver mice. Eur J Neurosci. 1997;9:120-7 pubmed
    ..mice treated with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and in a calbindin-deficient weaver strain (homozygous for weaver and the calbindin null mutation)...
  83. Ryo Y, Miyawaki A, Furuichi T, Mikoshiba K. Expression of the metabotropic glutamate receptor mGluR1 alpha and the ionotropic glutamate receptor GluR1 in the brain during the postnatal development of normal mouse and in the cerebellum from mutant mice. J Neurosci Res. 1993;36:19-32 pubmed
    ..Both receptors are expressed to a fair degree in weaver mutant cerebellum despite granule cell degeneration...
  84. Reeves R, Crowley M, Lorenzon N, Pavan W, Smeyne R, Goldowitz D. The mouse neurological mutant weaver maps within the region of chromosome 16 that is homologous to human chromosome 21. Genomics. 1989;5:522-6 pubmed
    Utilizing the backcross C57BL/6 wv/wv x (C57BL/6 wv/wv x MOLD/Rk), the mouse neurological mutation weaver (wv) was mapped less than 1 cM proximal to Ets-2 and Mx on mouse chromosome 16 (0.96 +/- 0.1% recombination)...
  85. Sotelo C. Anatomical, physiological and biochemical studies of the cerebellum from mutant mice. II. Morphological study of cerebellar cortical neurons and circuits in the weaver mouse. Brain Res. 1975;94:19-44 pubmed
    The vermis of the homozygous weaver mice has been examined with Golgi and electron microscopic techniques...