WAVE2

Summary

Gene Symbol: WAVE2
Description: WAS protein family, member 2
Alias: AW742646, D4Ertd13e, WAVE2, WASP family protein member 2, protein WAVE-2, wiskott-Aldrich syndrome protein family member 2
Species: mouse

Top Publications

  1. ncbi A WAVE2-Abi1 complex mediates CSF-1-induced F-actin-rich membrane protrusions and migration in macrophages
    Wassim Abou Kheir
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York City, NY 10461, USA
    J Cell Sci 118:5369-79. 2005
  2. ncbi WAVE2 regulates meiotic spindle stability, peripheral positioning and polar body emission in mouse oocytes
    Shao Chen Sun
    Chungbuk National University Cheongju, Korea
    Cell Cycle 10:1853-60. 2011
  3. ncbi WAVE2 is required for directed cell migration and cardiovascular development
    Daisuke Yamazaki
    Department of Biochemistry, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Mianato ku, Tokyo 108 8639, Japan
    Nature 424:452-6. 2003
  4. ncbi Characterization of the WAVE1 knock-out mouse: implications for CNS development
    John P Dahl
    Department of Molecular Genetics, Wyeth Research, Princeton, New Jersey 08543, USA
    J Neurosci 23:3343-52. 2003
  5. pmc Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation
    Anika Steffen
    German Research Centre for Biotechnology, Department of Cell Biology, Braunschweig, Germany
    EMBO J 23:749-59. 2004
  6. pmc WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility
    Catherine Yan
    Center for Blood Research, 200 Longwood Avenue, Boston, MA 02115, USA
    EMBO J 22:3602-12. 2003
  7. doi WAVE2-Abi2 complex controls growth cone activity and regulates the multipolar-bipolar transition as well as the initiation of glia-guided migration
    Min Jue Xie
    Division of Cell Biology and Neuroscience, Department of Morphological and Physiological Sciences, Faculty of Medical Sciences, University of Fukui, Fukui 910 1193, Japan
    Cereb Cortex 23:1410-23. 2013
  8. doi Wasf2: a novel target of intermittent parathyroid hormone administration
    Maki Uyama
    Department of Biochemistry and Molecular Biology, Graduate School of Dental Medicine, Hokkaido University, Sapporo 060 8586, Japan
    Int J Mol Med 31:1243-7. 2013
  9. doi Role of nucleation-promoting factors in mouse early embryo development
    Qiao Chu Wang
    College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China
    Microsc Microanal 19:559-64. 2013
  10. pmc Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival
    Rupalatha Maddala
    Department of Ophthalmology, Duke University School of Medicine, Durham, NC 27710, USA
    Dev Biol 360:30-43. 2011

Research Grants

  1. Molecular Cloning of the Wilms tumor Gene from 7p15-21
    Khalid Sossey Alaoui; Fiscal Year: 2004

Scientific Experts

  • Khalid Sossey-Alaoui
  • Josephine M Enciso
  • Shao Chen Sun
  • Tadaomi Takenawa
  • Shiro Suetsugu
  • Daisuke Yamazaki
  • Khalid Sossey Alaoui
  • Nam Hyung Kim
  • Xiang Shun Cui
  • Qiao Chu Wang
  • Jun Liu
  • Hideki Yamaguchi
  • Takunori Ogaeri
  • Hiroaki Miki
  • Koji Eto
  • Min Jue Xie
  • Maki Uyama
  • Sina Mohammadi
  • Hong Lin Liu
  • Xiao Xin Dai
  • Xing Duan
  • Teng Wang
  • Fei Wang
  • Wah Ing Goh
  • Shusaku Kurisu
  • Yong Nan Xu
  • Yong Xun Jin
  • Patrycja M Dubielecka
  • Hiroshi Yamashita
  • Rupalatha Maddala
  • Arthur Millius
  • Hiromitsu Nakauchi
  • Wassim Abou-Kheir
  • Hang Dinh
  • Klemens Rottner
  • Osamu Nakanishi
  • Christopher M Danson
  • Beth Isaac
  • Dianne Cox
  • Jeremy R Stuart
  • Noriko Hirao
  • Hyun Ju Kim
  • Wassim Abou Kheir
  • Seung P Kwak
  • Anika Steffen
  • Kiyohito Mizutani
  • Kazuhiro Kawamura
  • Tsukasa Oikawa
  • Jurgen Wehland
  • Takeshi Endo
  • Catherine Yan
  • Juana Magdalena
  • Peng Sun
  • John P Dahl
  • Hiroyuki Nakagawa
  • Munekazu Komada
  • Kazuki Kuroda
  • Chen Chi Wang
  • Masamitsu Kawanami
  • Takaki Miyata
  • Akira Sakakibara
  • Ralph R Isberg
  • Makoto Sato
  • Tokuichi Iguchi
  • Yuichiro Oka
  • Koh ichi Nagata
  • Masato Tamura
  • Hong Zhao
  • Hideshi Yagi
  • Wei Wei Gao
  • Ai Mei Chou
  • Kim Buay Lim
  • Thankiah Sudhaharan
  • Xi Jun Yin
  • Qing ling Wang
  • Wenyu Bu
  • Sohail Ahmed
  • Kai Ping Sem
  • Xiaoling Xiong
  • Bharesh K Chauhan
  • Leszek Kotula
  • Anna Chorzalska
  • Ponugoti V Rao
  • Theresia E Stradal
  • Seung Eun Lee
  • Kathrin I Ladwein
  • Ying hua Li
  • Michael L Robinson
  • Yi Zheng
  • Kathryn V Anderson

Detail Information

Publications36

  1. ncbi A WAVE2-Abi1 complex mediates CSF-1-induced F-actin-rich membrane protrusions and migration in macrophages
    Wassim Abou Kheir
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York City, NY 10461, USA
    J Cell Sci 118:5369-79. 2005
    ..We found that WAVE2 was the predominant isoform to be expressed in primary macrophages and in cells derived from the murine monocyte/..
  2. ncbi WAVE2 regulates meiotic spindle stability, peripheral positioning and polar body emission in mouse oocytes
    Shao Chen Sun
    Chungbuk National University Cheongju, Korea
    Cell Cycle 10:1853-60. 2011
    ..In the present study, the role of WASP family member WAVE2 in mouse oocyte asymmetric division was investigated...
  3. ncbi WAVE2 is required for directed cell migration and cardiovascular development
    Daisuke Yamazaki
    Department of Biochemistry, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Mianato ku, Tokyo 108 8639, Japan
    Nature 424:452-6. 2003
    b>WAVE2, a protein related to Wiskott-Aldrich syndrome protein, is crucial for Rac-induced membrane ruffling, which is important in cell motility...
  4. ncbi Characterization of the WAVE1 knock-out mouse: implications for CNS development
    John P Dahl
    Department of Molecular Genetics, Wyeth Research, Princeton, New Jersey 08543, USA
    J Neurosci 23:3343-52. 2003
    ..Our data indicate that WAVE1, although important for the general development of the CNS, is not essential for the formation and extension of neuritic processes...
  5. pmc Sra-1 and Nap1 link Rac to actin assembly driving lamellipodia formation
    Anika Steffen
    German Research Centre for Biotechnology, Department of Cell Biology, Braunschweig, Germany
    EMBO J 23:749-59. 2004
    ..we show that the specifically Rac1-associated protein-1 (Sra-1) and Nck-associated protein 1 (Nap1) interact with WAVE2 and Abi-1 (e3B1) in resting cells or upon Rac activation...
  6. pmc WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility
    Catherine Yan
    Center for Blood Research, 200 Longwood Avenue, Boston, MA 02115, USA
    EMBO J 22:3602-12. 2003
    The Wiskott-Aldrich syndrome related protein WAVE2 is implicated in the regulation of actin-cytoskeletal reorganization downstream of the small Rho GTPase, Rac...
  7. doi WAVE2-Abi2 complex controls growth cone activity and regulates the multipolar-bipolar transition as well as the initiation of glia-guided migration
    Min Jue Xie
    Division of Cell Biology and Neuroscience, Department of Morphological and Physiological Sciences, Faculty of Medical Sciences, University of Fukui, Fukui 910 1193, Japan
    Cereb Cortex 23:1410-23. 2013
    ..These growth cone activities are regulated by Abl kinase and Cdk5 via WAVE2-Abi2 through the phosphorylation of tyrosine 150 and serine 137 of WAVE2...
  8. doi Wasf2: a novel target of intermittent parathyroid hormone administration
    Maki Uyama
    Department of Biochemistry and Molecular Biology, Graduate School of Dental Medicine, Hokkaido University, Sapporo 060 8586, Japan
    Int J Mol Med 31:1243-7. 2013
    ....
  9. doi Role of nucleation-promoting factors in mouse early embryo development
    Qiao Chu Wang
    College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China
    Microsc Microanal 19:559-64. 2013
    During mitosis nucleation-promoting factors (NPFs) bind to the Arp2/3 complex and activate actin assembly. JMY and WAVE2 are two critical members of the NPFs...
  10. pmc Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival
    Rupalatha Maddala
    Department of Ophthalmology, Duke University School of Medicine, Durham, NC 27710, USA
    Dev Biol 360:30-43. 2011
    ....
  11. pmc mDia1 and WAVE2 proteins interact directly with IRSp53 in filopodia and are involved in filopodium formation
    Wah Ing Goh
    Institute of Medical Biology, 8A Biomedical Grove, Immunos, Singapore 138655
    J Biol Chem 287:4702-14. 2012
    ..The Src homology 3 domain of IRSp53 binds to the actin regulators Mena, Eps8, WAVE1, WAVE2, mDia1, and mDia2. We show that mDia1 and WAVE2 synergize with IRSp53 to form filopodia...
  12. doi Degradation of actin nucleators affects cortical polarity of aged mouse oocytes
    Shao Chen Sun
    Department of Animal Sciences, Chungbuk National University, Cheongju, Chungbuk, South Korea
    Fertil Steril 97:984-90. 2012
    ..To investigate the molecular mechanism of mouse oocyte polarity loss during aging...
  13. pmc Nucleation promoting factors regulate the expression and localization of Arp2/3 complex during meiosis of mouse oocytes
    Jun Liu
    College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China
    PLoS ONE 7:e52277. 2012
    ..In the present work, we identified that the nucleation promoting factors (NPFs) JMY and WAVE2 were necessary for the expression and localization of Arp2/3 complex in mouse oocytes...
  14. pmc Cdc42 interacts with the exocyst complex to promote phagocytosis
    Sina Mohammadi
    Howard Hughes Medical Institute, Tufts University School of Medicine, Boston, MA 02111, USA
    J Cell Biol 200:81-93. 2013
    ..Furthermore, disruption of exocyst function through Exo70 depletion led to a defect in large particle internalization, thereby establishing a functional role for the exocyst complex during phagocytosis...
  15. pmc Essential role for Abi1 in embryonic survival and WAVE2 complex integrity
    Patrycja M Dubielecka
    Laboratory of Cell Signaling, New York Blood Center, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 108:7022-7. 2011
    Abl interactor 1 (Abi1) plays a critical function in actin cytoskeleton dynamics through participation in the WAVE2 complex...
  16. pmc WAVE2 forms a complex with PKA and is involved in PKA enhancement of membrane protrusions
    Hiroshi Yamashita
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo, Kyoto 606 8502, Japan
    J Biol Chem 286:3907-14. 2011
    ..Here, we show that PKA forms a complex with WAVE2 (Wiskott-Aldrich syndrome protein family verprolin-homologous protein 2) in MDA-MB-231 breast cancer cells and ..
  17. pmc Endothelial cell migration during murine yolk sac vascular remodeling occurs by means of a Rac1 and FAK activation pathway in vivo
    Josephine M Enciso
    Division of Neonatology, Department of Pediatrics, University of California, Los Angeles, Los Angeles, California, USA
    Dev Dyn 239:2570-83. 2010
    ....
  18. doi The actin polymerization regulator WAVE2 is required for early bone marrow repopulation by hematopoietic stem cells
    Takunori Ogaeri
    Division of Stem Cell Therapy, Center for Stem Cell and Regenerative Medicine, The Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Stem Cells 27:1120-9. 2009
    ..We here showed that CD34(-/low)c-Kit(+)Sca-1(+)lineage(-) HSCs (CD34(-)KSL HSCs) express WAVE2 but neither WAVE1 nor WAVE3...
  19. pmc Neutrophils establish rapid and robust WAVE complex polarity in an actin-dependent fashion
    Arthur Millius
    Department of Biochemistry, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158, USA
    Curr Biol 19:253-9. 2009
    ..Under these conditions, the WAVE complex no longer polarizes, despite the presence of strong external gradients. Thus, actin polymer and the WAVE complex reciprocally interact during polarization...
  20. doi Regulation of WAVE1 expression in macrophages at multiple levels
    Hang Dinh
    Arthritis and Inflammation Research Centre and CRC for Chronic Inflammatory Diseases, University of Melbourne, Department of Medicine, The Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    J Leukoc Biol 84:1483-91. 2008
    ..b>WAVE2 but not WAVE1 has been considered significant for macrophage function...
  21. pmc Membrane targeting of WAVE2 is not sufficient for WAVE2-dependent actin polymerization: a role for IRSp53 in mediating the interaction between Rac and WAVE2
    Wassim Abou-Kheir
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Cell Sci 121:379-90. 2008
    ..53 (IRSp53) or a complex of proteins containing Abelson interactor protein 1 (Abi1) mediates the interaction of WAVE2 and Rac...
  22. pmc Phosphorylation of WAVE2 by MAP kinases regulates persistent cell migration and polarity
    Christopher M Danson
    Department of Biochemistry, Faculty of Medical and Veterinary Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK
    J Cell Sci 120:4144-54. 2007
    ..been implicated in the stimulus-dependent generation of lamellipodia at the leading edge of migrating cells, with WAVE2 in particular implicated in the formation of peripheral ruffles and chemotactic migration...
  23. ncbi Small GTPase Rah/Rab34 is associated with membrane ruffles and macropinosomes and promotes macropinosome formation
    Peng Sun
    Department of Biology, Faculty of Science, and Graduate School of Science and Technology, Chiba University, Yayoicho, Inageku, Japan
    J Biol Chem 278:4063-71. 2003
    ..Rah-promoted macropinosome formation was retarded by dominant-negative mutants of Rac1 and WAVE2, which are essential for membrane ruffling...
  24. pmc Involvement of the Arp2/3 complex and Scar2 in Golgi polarity in scratch wound models
    Juana Magdalena
    School of Biosciences, University of Birmingham, Edgbaston, United Kingdom
    Mol Biol Cell 14:670-84. 2003
    ..Furthermore, in NIH 3T3 cells, Scar2 and the Arp2/3 complex appear to be involved in the establishment and maintenance of Golgi polarity during directed migration...
  25. ncbi IRSp53 is colocalised with WAVE2 at the tips of protruding lamellipodia and filopodia independently of Mena
    Hiroyuki Nakagawa
    Department of Cell Biology, Institute of Molecular Biology, Austrian Academy of Sciences, Billrothstrasse 11, Salzburg A 5020, Austria
    J Cell Sci 116:2577-83. 2003
    The insulin receptor tyrosine kinase substrate p53 (IRSp53) links Rac and WAVE2 and has been implicated in lamellipodia protrusion. Recently, however, IRSp53 has been reported to bind to both Cdc42 and Mena to induce filopodia...
  26. ncbi Genomic organization and expression profile of the human and mouse WAVE gene family
    Khalid Sossey-Alaoui
    Department of Cancer Genetics, Roswell Park Cancer Institute, 110 C and V Building, Elm and Carlton Streets, Buffalo, New York 14263, USA
    Mamm Genome 14:314-22. 2003
    ..During our analysis of the human gene map, we also noted that WAVE2 maps to Chr region lp35-36, which frequently undergoes loss of heterozygosity and deletion in advanced stage ..
  27. ncbi FBP11 regulates nuclear localization of N-WASP and inhibits N-WASP-dependent microspike formation
    Kiyohito Mizutani
    Department of Biochemistry, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokane dai, Minato ku, Tokyo 108 8639, Japan
    Biochem Biophys Res Commun 313:468-74. 2004
    ..These results indicate that FBP11 regulates localization of N-WASP, thus negatively regulating the function of N-WASP in the cytoplasm...
  28. ncbi PtdIns(3,4,5)P3 binding is necessary for WAVE2-induced formation of lamellipodia
    Tsukasa Oikawa
    Department of Biochemistry, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Nat Cell Biol 6:420-6. 2004
    ..Here, we report that WAVE2 binds to PtdIns(3,4,5)P(3) through its basic domain...
  29. ncbi N-WASP and WAVE2 acting downstream of phosphatidylinositol 3-kinase are required for myogenic cell migration induced by hepatocyte growth factor
    Kazuhiro Kawamura
    Department of Biology, Faculty of Science, Graduate School of Science and Technology, Chiba University, Yayoicho, Inageku, Chiba 263 8522, Japan
    J Biol Chem 279:54862-71. 2004
    ..Endogenous N-WASP and WAVE2 were concentrated in the lamellipodia at the leading edge of the migrating cells...
  30. ncbi Rac-WAVE2 signaling is involved in the invasive and metastatic phenotypes of murine melanoma cells
    Shusaku Kurisu
    Department of Biochemistry, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Oncogene 24:1309-19. 2005
    ..We show that WAVEs, especially WAVE2, are essential for invasion and metastasis of melanoma cells...
  31. ncbi WAVE1 is required for oligodendrocyte morphogenesis and normal CNS myelination
    Hyun Ju Kim
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 26:5849-59. 2006
    ..Together, these data demonstrate a role for WAVE1 in oligodendrocyte morphogenesis and myelination...
  32. ncbi c-Abl interacts with the WAVE2 signaling complex to induce membrane ruffling and cell spreading
    Jeremy R Stuart
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Biol Chem 281:31290-7. 2006
    The Wiskott-Aldrich syndrome-related protein WAVE2 promotes Arp2/3-dependent actin polymerization downstream of Rho-GTPase activation...
  33. ncbi NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation
    Noriko Hirao
    School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192 0392, Japan
    FEBS Lett 580:6464-70. 2006
    ..Previous studies showed that Abi-1 promotes c-Abl-mediated phosphorylation of Mammalian Enabled (Mena) and WAVE2. In addition to Abi-1, mammals possess Abi-2 and NESH (Abi-3)...
  34. ncbi Effect of WAVE2 phosphorylation on activation of the Arp2/3 complex
    Osamu Nakanishi
    Department of Biochemistry, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokane dai, Tokyo 108 8639, Japan
    J Biochem 141:319-25. 2007
    ..The WAVE family comprises three proteins, namely, WAVE1, WAVE2 and WAVE3...
  35. ncbi The WAVE2/Abi1 complex differentially regulates megakaryocyte development and spreading: implications for platelet biogenesis and spreading machinery
    Koji Eto
    Laboratory of Stem Cell Therapy, Center for Experimental Medicine, The Institute of Medical Science, University of Tokyo, Japan
    Blood 110:3637-47. 2007
    ..While MKs and platelets principally express WAVE1 and WAVE2, which are associated with Abi1, the physiologic significance of WAVE isoforms remains undefined...
  36. ncbi IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling
    H Miki
    Department of Biochemistry, Institute of Medical Science, University of Tokyo, and CREST, Japan Science and Technology Corporation
    Nature 408:732-5. 2000
    ..From studies of ectopic expression, we found that IRSp53 is essential for Rac to induce membrane ruffling, probably because it recruits WAVE, which stimulates actin polymerization mediated by the Arp2/3 complex...

Research Grants2

  1. Molecular Cloning of the Wilms tumor Gene from 7p15-21
    Khalid Sossey Alaoui; Fiscal Year: 2004
    ..Understanding the nature of the genetic events which allow these cells to escape their normal growth regulation may also provide an opportunity for therapeutic intervention. ..