Washc5

Summary

Gene Symbol: Washc5
Description: WASH complex subunit 5
Alias: AL022848, C76463, E430025E21Rik, Kiaa0196, mKIAA0196, strumpellin, WASH complex subunit 5, WASH complex subunit strumpellin
Species: mouse
Products:     Washc5

Top Publications

  1. Harbour M, Breusegem S, Antrobus R, Freeman C, Reid E, Seaman M. The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics. J Cell Sci. 2010;123:3703-17 pubmed publisher
    ..One of the retromer-interacting proteins, strumpellin, is mutated in hereditary spastic paraplegia, a progressive length-dependent axonopathy...
  2. Bartuzi P, Billadeau D, Favier R, Rong S, Dekker D, Fedoseienko A, et al. CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL. Nat Commun. 2016;7:10961 pubmed publisher
    ..Furthermore, a mutation in the WASH component KIAA0196 (strumpellin) is associated with hypercholesterolaemia in humans...
  3. Wang F, Zhang L, Zhang G, Wang Z, Cui X, Kim N, et al. WASH complex regulates Arp2/3 complex for actin-based polar body extrusion in mouse oocytes. Sci Rep. 2014;4:5596 pubmed publisher
    ..Here, we examined the functions of two important subunits of a WASH complex, WASH1 and Strumpellin, during mouse oocyte meiosis...
  4. Tyrrell B, Woodham E, Spence H, Strathdee D, Insall R, Machesky L. Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour. Pigment Cell Melanoma Res. 2016;29:559-71 pubmed publisher
    ..Loss of one of the two subunits WASH or strumpellin in mice is lethal, but little is known about their role in mammals in vivo...