Was

Summary

Gene Symbol: Was
Description: Wiskott-Aldrich syndrome
Alias: U42471, Wasp, wiskott-Aldrich syndrome protein homolog, Wiskott-Aldrich syndrome homolog
Species: mouse
Products:     Was

Top Publications

  1. Meyer Bahlburg A, Becker Herman S, Humblet Baron S, Khim S, Weber M, Bouma G, et al. Wiskott-Aldrich syndrome protein deficiency in B cells results in impaired peripheral homeostasis. Blood. 2008;112:4158-69 pubmed publisher
    ..syndrome (WAS), we used 3 distinct murine in vivo models to define the cell intrinsic requirements for WAS protein (WASp) in central versus peripheral B-cell development...
  2. Locci M, Draghici E, Marangoni F, Bosticardo M, Catucci M, Aiuti A, et al. The Wiskott-Aldrich syndrome protein is required for iNKT cell maturation and function. J Exp Med. 2009;206:735-42 pubmed publisher
    The Wiskott-Aldrich syndrome (WAS) protein (WASp) is a regulator of actin cytoskeleton in hematopoietic cells. Mutations of the WASp gene cause WAS...
  3. Blundell M, Bouma G, Metelo J, Worth A, Calle Y, Cowell L, et al. Phosphorylation of WASp is a key regulator of activity and stability in vivo. Proc Natl Acad Sci U S A. 2009;106:15738-43 pubmed publisher
    The Wiskott-Aldrich syndrome protein (WASp) is a key cytoskeletal regulator in hematopoietic cells...
  4. Westerberg L, Meelu P, Baptista M, Eston M, Adamovich D, Cotta de Almeida V, et al. Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes. J Exp Med. 2010;207:1145-52 pubmed publisher
    X-linked neutropenia (XLN) is caused by activating mutations in the Wiskott-Aldrich syndrome protein (WASP) that result in aberrant autoinhibition...
  5. Snapper S, Rosen F, Mizoguchi E, Cohen P, Khan W, Liu C, et al. Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation. Immunity. 1998;9:81-91 pubmed
    The Wiskott-Aldrich syndrome (WAS) is a human X-linked immunodeficiency resulting from mutations in a gene (WASP) encoding a cytoplasmic protein implicated in regulating the actin cytoskeleton...
  6. Shimizu M, Nikolov N, Ueno K, Ohta K, Siegel R, Yachie A, et al. Development of IgA nephropathy-like glomerulonephritis associated with Wiskott-Aldrich syndrome protein deficiency. Clin Immunol. 2012;142:160-6 pubmed publisher
    ..We found that WASp-deficient mice develop proliferative glomerulonephritis reminiscent of human IgA nephropathy (IgAN)...
  7. Andreansky S, Liu H, Turner S, McCullers J, Lang R, Rutschman R, et al. WASP- mice exhibit defective immune responses to influenza A virus, Streptococcus pneumoniae, and Mycobacterium bovis BCG. Exp Hematol. 2005;33:443-51 pubmed
    To quantify the immune response of WASP- mice to three different pathogens: influenza A virus, Streptococcus pneumoniae, and Mycobacterium bovis...
  8. Humblet Baron S, Sather B, Anover S, Becker Herman S, Kasprowicz D, Khim S, et al. Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis. J Clin Invest. 2007;117:407-18 pubmed
    Wiskott-Aldrich syndrome protein (WASp) is essential for optimal T cell activation. Patients with WAS exhibit both immunodeficiency and a marked susceptibility to systemic autoimmunity...
  9. Chellaiah M. Regulation of actin ring formation by rho GTPases in osteoclasts. J Biol Chem. 2005;280:32930-43 pubmed
    ..Wiscott-Aldrich syndrome protein (WASP) was observed in the actin ring of gelsolin null osteoclast...

More Information

Publications72

  1. Cannon J, Burkhardt J. Differential roles for Wiskott-Aldrich syndrome protein in immune synapse formation and IL-2 production. J Immunol. 2004;173:1658-62 pubmed
    Wiskott-Aldrich syndrome protein (WASP)-deficient T cells exhibit defects in IL-2 production that are widely believed to stem from primary defects in actin remodeling and immune synapse formation...
  2. Morales Tirado V, Sojka D, Katzman S, Lazarski C, Finkelman F, Urban J, et al. Critical requirement for the Wiskott-Aldrich syndrome protein in Th2 effector function. Blood. 2010;115:3498-507 pubmed publisher
    ..In T cells, the WAS protein (WASp) regulates actin polymerization and transcription, and plays a role in the dynamics of the immunologic synapse...
  3. Astrakhan A, Ochs H, Rawlings D. Wiskott-Aldrich syndrome protein is required for homeostasis and function of invariant NKT cells. J Immunol. 2009;182:7370-80 pubmed publisher
    ..The Wiskott-Aldrich Syndrome protein (WASp) serves as a crucial link between cellular stimuli and cytoskeletal rearrangements...
  4. Lacout C, Haddad E, Sabri S, Svinarchouk F, Garcon L, Capron C, et al. A defect in hematopoietic stem cell migration explains the nonrandom X-chromosome inactivation in carriers of Wiskott-Aldrich syndrome. Blood. 2003;102:1282-9 pubmed
    ..In this report, we show that marrow cells from WAS protein (WASP)-deficient mice also have a defect in chemotaxis...
  5. Strom T, Turner S, Andreansky S, Liu H, Doherty P, Srivastava D, et al. Defects in T-cell-mediated immunity to influenza virus in murine Wiskott-Aldrich syndrome are corrected by oncoretroviral vector-mediated gene transfer into repopulating hematopoietic cells. Blood. 2003;102:3108-16 pubmed
    ..We used a murine model created by knockout of the WAS protein gene (WASP) to evaluate the potential of gene therapy for WAS...
  6. de la Fuente M, Sasahara Y, Calamito M, Anton I, Elkhal A, Gallego M, et al. WIP is a chaperone for Wiskott-Aldrich syndrome protein (WASP). Proc Natl Acad Sci U S A. 2007;104:926-31 pubmed
    Wiskott-Aldrich syndrome protein (WASP) is in a complex with WASP-interacting protein (WIP). WASP levels, but not mRNA levels, were severely diminished in T cells from WIP(-/-) mice and were increased by introduction of WIP in these cells...
  7. Sato M, Ogihara K, Sawahata R, Sekikawa K, Kitani H. Impaired LPS-induced signaling in microglia overexpressing the Wiskott-Aldrich syndrome protein N-terminal domain. Int Immunol. 2007;19:901-11 pubmed
    Wiskott-Aldrich syndrome protein (WASP) plays important roles in TCR signaling, but its roles in signal transduction in innate immune cells have not been well characterized...
  8. Badour K, Zhang J, Shi F, Leng Y, Collins M, Siminovitch K. Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation. J Exp Med. 2004;199:99-112 pubmed
    Involvement of the Wiskott-Aldrich syndrome protein (WASp) in promoting cell activation requires its release from autoinhibitory structural constraints and has been attributed to WASp association with activated cdc42...
  9. Snapper S, Takeshima F, Anton I, Liu C, Thomas S, Nguyen D, et al. N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility. Nat Cell Biol. 2001;3:897-904 pubmed
    The Wiskott-Aldrich syndrome protein (WASP) family of molecules integrates upstream signalling events with changes in the actin cytoskeleton...
  10. Bouma G, Mendoza Naranjo A, Blundell M, De Falco E, Parsley K, Burns S, et al. Cytoskeletal remodeling mediated by WASp in dendritic cells is necessary for normal immune synapse formation and T-cell priming. Blood. 2011;118:2492-501 pubmed publisher
    ..have used a natural model of cytoskeletal dysfunction caused by deficiency of the Wiskott-Aldrich syndrome protein (WASp) to explore the contribution of the DC cytoskeleton to IS formation and to T-cell priming...
  11. Zhang J, Shehabeldin A, da Cruz L, Butler J, Somani A, McGavin M, et al. Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes. J Exp Med. 1999;190:1329-42 pubmed
    The Wiskott-Aldrich syndrome protein (WASp) has been implicated in modulation of lymphocyte activation and cytoskeletal reorganization...
  12. Calle Y, Jones G, Jagger C, Fuller K, Blundell M, Chow J, et al. WASp deficiency in mice results in failure to form osteoclast sealing zones and defects in bone resorption. Blood. 2004;103:3552-61 pubmed
    No defects related to deficiency of the Wiskott-Aldrich Syndrome protein (WASp) have been described in osteoclasts. Here we show that there are significant morphologic and functional abnormalities...
  13. Notarangelo L, Miao C, Ochs H. Wiskott-Aldrich syndrome. Curr Opin Hematol. 2008;15:30-6 pubmed
    ..Studies of Wiskott-Aldrich syndrome protein-deficient cell lines and wasp-knockout mice have paved the way for possible gene therapy...
  14. Chellaiah M, Kuppuswamy D, Lasky L, Linder S. Phosphorylation of a Wiscott-Aldrich syndrome protein-associated signal complex is critical in osteoclast bone resorption. J Biol Chem. 2007;282:10104-16 pubmed
    The activities of different kinases have been correlated to the phosphorylation of Wiscott-Aldrich syndrome protein (WASP) by studies in multiple cell systems...
  15. de Noronha S, Hardy S, Sinclair J, Blundell M, Strid J, Schulz O, et al. Impaired dendritic-cell homing in vivo in the absence of Wiskott-Aldrich syndrome protein. Blood. 2005;105:1590-7 pubmed
    ..Here we have used cells deficient in the Wiskott-Aldrich syndrome protein (WASp) to demonstrate the importance of dynamic remodeling of the actin cytoskeleton for these trafficking processes to ..
  16. Westerberg L, Greicius G, Snapper S, Aspenstrom P, Severinson E. Cdc42, Rac1, and the Wiskott-Aldrich syndrome protein are involved in the cytoskeletal regulation of B lymphocytes. Blood. 2001;98:1086-94 pubmed
    ..WAS is caused by a defective or a missing WAS protein (WASP). Signal mediators interleukin-4 (IL-4) and CD40 are important for actin-dependent morphology changes in B cells...
  17. Nikolov N, Shimizu M, Cleland S, Bailey D, Aoki J, STROM T, et al. Systemic autoimmunity and defective Fas ligand secretion in the absence of the Wiskott-Aldrich syndrome protein. Blood. 2010;116:740-7 pubmed publisher
    ..WAS), an X-linked primary immunodeficiency disorder caused by mutations in the gene encoding the WAS protein (WASp) with a high incidence of autoimmunity in affected patients...
  18. Maillard M, Cotta de Almeida V, Takeshima F, Nguyen D, Michetti P, Nagler C, et al. The Wiskott-Aldrich syndrome protein is required for the function of CD4(+)CD25(+)Foxp3(+) regulatory T cells. J Exp Med. 2007;204:381-91 pubmed
    ..from defective expression of the hematopoietic-specific cytoskeletal regulator Wiskott-Aldrich syndrome protein (WASP)...
  19. Sims T, Soos T, Xenias H, Dubin Thaler B, Hofman J, Waite J, et al. Opposing effects of PKCtheta and WASp on symmetry breaking and relocation of the immunological synapse. Cell. 2007;129:773-85 pubmed
    ..IS reformation is driven by the Wiscott Aldrich Syndrome protein (WASp)...
  20. Benesch S, Lommel S, Steffen A, Stradal T, Scaplehorn N, Way M, et al. Phosphatidylinositol 4,5-biphosphate (PIP2)-induced vesicle movement depends on N-WASP and involves Nck, WIP, and Grb2. J Biol Chem. 2002;277:37771-6 pubmed
    Wiskott-Aldrich syndrome protein (WASP)/Scar family proteins promote actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex...
  21. Morales Tirado V, Johannson S, Hanson E, Howell A, Zhang J, Siminovitch K, et al. Cutting edge: selective requirement for the Wiskott-Aldrich syndrome protein in cytokine, but not chemokine, secretion by CD4+ T cells. J Immunol. 2004;173:726-30 pubmed
    ..In this study, we demonstrate that the Wiskott-Aldrich syndrome protein (WASp) is an essential component of the cytokine secretory pathway in CD4(+) T cells...
  22. Cotta de Almeida V, Westerberg L, Maillard M, Onaldi D, Wachtel H, Meelu P, et al. Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development. Proc Natl Acad Sci U S A. 2007;104:15424-9 pubmed
    ..key features of immunodeficient patients with the Wiskott-Aldrich syndrome and Wiskott-Aldrich syndrome protein (WASP)-deficient mice, T cell development appears relatively normal...
  23. Snapper S, Meelu P, Nguyen D, Stockton B, Bozza P, Alt F, et al. WASP deficiency leads to global defects of directed leukocyte migration in vitro and in vivo. J Leukoc Biol. 2005;77:993-8 pubmed
    ..The Wiskott-Aldrich syndrome protein (WASP) regulates surface receptor signaling to the actin cytoskeleton in hematopoietic cells and thus plays a pivotal ..
  24. Jin Y, Mazza C, Christie J, Giliani S, Fiorini M, Mella P, et al. Mutations of the Wiskott-Aldrich Syndrome Protein (WASP): hotspots, effect on transcription, and translation and phenotype/genotype correlation. Blood. 2004;104:4010-9 pubmed
    ..WAS and XLT are caused by mutations of the Wiskott-Aldrich syndrome protein (WASP) gene which encodes a 502-amino acid protein, named WASP...
  25. Westerberg L, Larsson M, Hardy S, Fernandez C, Thrasher A, Severinson E. Wiskott-Aldrich syndrome protein deficiency leads to reduced B-cell adhesion, migration, and homing, and a delayed humoral immune response. Blood. 2005;105:1144-52 pubmed
    The Wiskott-Aldrich syndrome protein (WASp) is mutated in the severe immunodeficiency disease Wiskott-Aldrich syndrome (WAS). The function of B cells and the physiologic alterations in WAS remain unclear...
  26. Zhang H, Schaff U, Green C, Chen H, Sarantos M, Hu Y, et al. Impaired integrin-dependent function in Wiskott-Aldrich syndrome protein-deficient murine and human neutrophils. Immunity. 2006;25:285-95 pubmed
    ..suffered by WAS patients is consistent with defects in neutrophil (PMN) function, the consequences of WAS protein (WASp) deficiency on this innate immune cell have been unclear...
  27. Sato M, Iwaya R, Ogihara K, Sawahata R, Kitani H, Chiba J, et al. Intrabodies against the EVH1 domain of Wiskott-Aldrich syndrome protein inhibit T cell receptor signaling in transgenic mice T cells. FEBS J. 2005;272:6131-44 pubmed
    ..the cytosol of T lymphocytes and inhibited the function of the target molecule, Wiskott-Aldrich syndrome protein (WASP)...
  28. Nguyen D, Wurbel M, Goettel J, Eston M, Ahmed O, Marin R, et al. Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in mice. Gastroenterology. 2012;143:719-729.e2 pubmed publisher
    ..autoimmune sequelae, including colitis, develop in patients and mice deficient in Wiskott-Aldrich syndrome protein (WASP), a hematopoietic cell-specific intracellular signaling molecule that regulates the actin cytoskeleton...
  29. Recher M, Burns S, de la Fuente M, Volpi S, Dahlberg C, Walter J, et al. B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice. Blood. 2012;119:2819-28 pubmed publisher
    Wiskott Aldrich syndrome (WAS) is caused by mutations in the WAS gene that encodes for a protein (WASp) involved in cytoskeleton organization in hematopoietic cells...
  30. Zhang J, Shi F, Badour K, Deng Y, McGavin M, Siminovitch K. WASp verprolin homology, cofilin homology, and acidic region domain-mediated actin polymerization is required for T cell development. Proc Natl Acad Sci U S A. 2002;99:2240-5 pubmed
    All members of the Wiskott-Aldrich syndrome protein (WASp) family contain a carboxyl-terminal verprolin homology, cofilin homology, and acidic region (VCA) domain that binds and activates the Arp2/3 complex, thereby linking these proteins ..
  31. Westerberg L, de la Fuente M, Wermeling F, Ochs H, Karlsson M, Snapper S, et al. WASP confers selective advantage for specific hematopoietic cell populations and serves a unique role in marginal zone B-cell homeostasis and function. Blood. 2008;112:4139-47 pubmed publisher
    ..Here we demonstrate that expression of the cytoskeletal regulator WASP, mutated in the Wiskott-Aldrich syndrome, provides selective advantage for the development of naturally occurring ..
  32. Sato M, Sawahata R, Takenouchi T, Kitani H. Identification of Fyn as the binding partner for the WASP N-terminal domain in T cells. Int Immunol. 2011;23:493-502 pubmed publisher
    Wiskott-Aldrich syndrome protein (WASP) plays important roles in TCR signaling...
  33. Marangoni F, Trifari S, Scaramuzza S, Panaroni C, Martino S, Notarangelo L, et al. WASP regulates suppressor activity of human and murine CD4(+)CD25(+)FOXP3(+) natural regulatory T cells. J Exp Med. 2007;204:369-80 pubmed
    ..Therefore, we investigated the effect of WAS protein (WASP) deficiency on the distribution and suppressor function of nTreg cells...
  34. Adriani M, Aoki J, Horai R, Thornton A, Konno A, Kirby M, et al. Impaired in vitro regulatory T cell function associated with Wiskott-Aldrich syndrome. Clin Immunol. 2007;124:41-8 pubmed
    ..WAS protein (WASp)-deficient mice are also immunodeficient and can develop autoimmune disease...
  35. Bouma G, Burns S, Thrasher A. Impaired T-cell priming in vivo resulting from dysfunction of WASp-deficient dendritic cells. Blood. 2007;110:4278-84 pubmed
    ..To exclude environmental confounders as a result of WAS protein (WASp) deficiency, we studied migration and priming activity of WAS KO DCs in vivo after adoptive transfer into wild-type ..
  36. Badour K, McGavin M, Zhang J, Freeman S, Vieira C, Filipp D, et al. Interaction of the Wiskott-Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells. Proc Natl Acad Sci U S A. 2007;104:1593-8 pubmed
    The Wiskott-Aldrich syndrome protein (WASp) plays a major role in coupling T cell antigen receptor (TCR) stimulation to induction of actin cytoskeletal changes required for T cell activation...
  37. Westerberg L, Dahlberg C, Baptista M, Moran C, Detre C, Keszei M, et al. Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function. Blood. 2012;119:3966-74 pubmed publisher
    The Wiskott-Aldrich syndrome protein (WASP) is a key cytoskeletal regulator of hematopoietic cells. Although WASP-knockout (WKO) mice have aberrant B-cell cytoskeletal responses, B-cell development is relatively normal...
  38. Becker Herman S, Meyer Bahlburg A, Schwartz M, Jackson S, Hudkins K, Liu C, et al. WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity. J Exp Med. 2011;208:2033-42 pubmed publisher
    ..Whereas this defect leads to autoantibody production in WAS protein-deficient (WASp(-/-)) mice without overt disease, chimeric mice in which only the B cell lineage lacks WASp exhibit severe ..
  39. Labno C, Lewis C, You D, Leung D, Takesono A, Kamberos N, et al. Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP. Curr Biol. 2003;13:1619-24 pubmed
    ..to antigen presenting cells (APCs) induces localized activation of Cdc42 and Wiskott-Aldrich Syndrome protein (WASP) at the immune synapse...
  40. Pulecio J, Tagliani E, Scholer A, Prete F, Fetler L, Burrone O, et al. Expression of Wiskott-Aldrich syndrome protein in dendritic cells regulates synapse formation and activation of naive CD8+ T cells. J Immunol. 2008;181:1135-42 pubmed
    The Wiskott-Aldrich syndrome protein (WASp) is a key regulator of actin polimerization in hematopoietic cells...
  41. Dovas A, Gevrey J, Grossi A, Park H, Abou Kheir W, Cox D. Regulation of podosome dynamics by WASp phosphorylation: implication in matrix degradation and chemotaxis in macrophages. J Cell Sci. 2009;122:3873-82 pubmed publisher
    ..Wiskott-Aldrich Syndrome protein (WASp), an effector of the RhoGTPase Cdc42 and a Src family kinase substrate, regulates macrophage podosome formation...
  42. Liu C, Miller H, Hui K, Grooman B, Bolland S, Upadhyaya A, et al. A balance of Bruton's tyrosine kinase and SHIP activation regulates B cell receptor cluster formation by controlling actin remodeling. J Immunol. 2011;187:230-9 pubmed publisher
    ..This study suggests a novel feedback loop between BCR signaling and the actin cytoskeleton. ..
  43. Gallego M, de la Fuente M, Anton I, Snapper S, Fuhlbrigge R, Geha R. WIP and WASP play complementary roles in T cell homing and chemotaxis to SDF-1alpha. Int Immunol. 2006;18:221-32 pubmed
    ..The actin cytoskeleton plays a central role in lymphocyte adhesion and motility. Wiskott-Aldrich syndrome protein (WASP), the product of the gene mutated in Wiskott-Aldrich syndrome, and its partner, the Wiskott-Aldrich syndrome ..
  44. Suetsugu S, Tezuka T, Morimura T, Hattori M, Mikoshiba K, Yamamoto T, et al. Regulation of actin cytoskeleton by mDab1 through N-WASP and ubiquitination of mDab1. Biochem J. 2004;384:1-8 pubmed
    ..In the present paper, we show that mDab1 associates with N-WASP (neuronal Wiskott-Aldrich syndrome protein) in vitro and in brains of embryonic mice...
  45. Vignal E, De Toledo M, Comunale F, Ladopoulou A, Gauthier Rouviere C, Blangy A, et al. Characterization of TCL, a new GTPase of the rho family related to TC10 andCcdc42. J Biol Chem. 2000;275:36457-64 pubmed
    ..GDP-bound TCL protein directly interacts with Cdc42/Rac interacting binding domains, such as those found in PAK and WASP. Despite its overall similarity to TC10 and Cdc42, the constitutively active TCL mutant displays distinct ..
  46. Krawczyk C, Oliveira dos Santos A, Sasaki T, Griffiths E, Ohashi P, Snapper S, et al. Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells. Immunity. 2002;16:331-43 pubmed
    ..Intriguingly, TCR-induced cell adhesion and aggregation of integrins occurs independent of WASP. Whereas LFA-1 and actin caps colocalize in wasp(-/-) T cells in response to TCR stimulation, loss of WASP ..
  47. Mani M, Venkatasubrahmanyam S, Sanyal M, Levy S, Butte A, Weinberg K, et al. Wiskott-Aldrich syndrome protein is an effector of Kit signaling. Blood. 2009;114:2900-8 pubmed publisher
    ..In this study, we provide evidence that Kit signals through Wiskott-Aldrich syndrome protein (WASP), the central hematopoietic actin nucleation-promoting factor and regulator of the cytoskeleton...
  48. Zhang J, Diehl G, Littman D. Relief of preintegration inhibition and characterization of additional blocks for HIV replication in primary mouse T cells. PLoS ONE. 2008;3:e2035 pubmed publisher
    ..The pathways involved in HIV replication appear to be PKCtheta-, CARMA1-, and WASp-independent. Treatment with Cyclosporin A (CsA) further relieved the pre-integration block...
  49. Falet H, Marchetti M, Hoffmeister K, Massaad M, Geha R, Hartwig J. Platelet-associated IgAs and impaired GPVI responses in platelets lacking WIP. Blood. 2009;114:4729-37 pubmed publisher
    The role of the Wiskott-Aldrich syndrome protein (WASp) in platelet function is unclear because platelets that lack WASp function normally...
  50. Lexmond W, Goettel J, Lyons J, Jacobse J, Deken M, Lawrence M, et al. FOXP3+ Tregs require WASP to restrain Th2-mediated food allergy. J Clin Invest. 2016;126:4030-4044 pubmed publisher
    ..Here, we have shown that WAS patients and mice deficient in WAS protein (WASP) frequently develop IgE-mediated reactions to common food allergens...
  51. Legg J, Bompard G, Dawson J, Morris H, Andrew N, Cooper L, et al. N-WASP involvement in dorsal ruffle formation in mouse embryonic fibroblasts. Mol Biol Cell. 2007;18:678-87 pubmed
    The Wiskott-Aldrich syndrome protein (WASP) family activates the Arp2/3 complex leading to the formation of new actin filaments...
  52. Mace E, Zhang J, Siminovitch K, Takei F. Elucidation of the integrin LFA-1-mediated signaling pathway of actin polarization in natural killer cells. Blood. 2010;116:1272-9 pubmed publisher
    ..localization of actin-associated proteins in wild-type, talin-deficient, and Wiskott-Aldrich Syndrome protein (WASP)-deficient NK cells bound to beads coated with the LFA-1 ligand intercellular adhesion molecule-1 (ICAM-1)...
  53. Prislovsky A, Strom T. Increased uptake by splenic red pulp macrophages contributes to rapid platelet turnover in WASP(-) mice. Exp Hematol. 2013;41:789-98 pubmed publisher
    ..We show that rapid clearance of ¹¹¹In-labeled murine WASP(-) platelets correlates with enhanced splenic uptake...
  54. Shcherbina A, Cooley J, Lutskiy M, Benarafa C, Gilbert G, REMOLD O DONNELL E. WASP plays a novel role in regulating platelet responses dependent on alphaIIbbeta3 integrin outside-in signalling. Br J Haematol. 2010;148:416-27 pubmed publisher
    ..The responsible gene encodes WAS protein (WASP), which functions in leucocytes as an actin filament nucleating agent -yet- actin filament nucleation proceeds ..
  55. Solomon S, Rajasekaran N, Jeisy Walder E, Snapper S, Illges H. A crucial role for macrophages in the pathology of K/B x N serum-induced arthritis. Eur J Immunol. 2005;35:3064-73 pubmed
    ..Mast cell degranulation was seen in arthritogenic serum-treated mice even in the absence of macrophages, possibly suggesting that mast cell ..
  56. Krawczyk C, Bachmaier K, Sasaki T, Jones R, Snapper S, Bouchard D, et al. Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells. Immunity. 2000;13:463-73 pubmed
    ..Wiscott Aldrich Syndrome protein (WASP) was found to be essential for deregulated proliferation and membrane receptor reorganization of cbl-b mutant T ..
  57. Le Bras S, Massaad M, Koduru S, Kumar L, Oyoshi M, Hartwig J, et al. WIP is critical for T cell responsiveness to IL-2. Proc Natl Acad Sci U S A. 2009;106:7519-24 pubmed publisher
    The Wiskott-Aldrich syndrome (WAS) interacting protein (WIP) stabilizes the WAS protein (WASP), the product of the gene mutated in WAS...
  58. Boczkowska M, Rebowski G, Petoukhov M, Hayes D, Svergun D, Dominguez R. X-ray scattering study of activated Arp2/3 complex with bound actin-WCA. Structure. 2008;16:695-704 pubmed publisher
    ..We have engineered a stable activated complex consisting of Arp2/3 complex, the WCA activator region of N-WASP, and one actin monomer, and studied its structure in solution by small angle X-ray scattering (SAXS)...
  59. Wu Y, Spencer S, Lasky L. Tyrosine phosphorylation regulates the SH3-mediated binding of the Wiskott-Aldrich syndrome protein to PSTPIP, a cytoskeletal-associated protein. J Biol Chem. 1998;273:5765-70 pubmed
    ..of hematopoietic cells from affected individuals reveals that mutations in the Wiskott-Aldrich syndrome protein (WASP) result in structural and functional abnormalities in the cell cortex, consistent with the suggestion that WASP is ..
  60. Volpi S, Santori E, Abernethy K, Mizui M, Dahlberg C, Recher M, et al. N-WASP is required for B-cell-mediated autoimmunity in Wiskott-Aldrich syndrome. Blood. 2016;127:216-20 pubmed publisher
    ..Mice with conditional deficiency of Was in B lymphocytes (B/WcKO) have revealed a critical role for WAS protein (WASP) expression in B lymphocytes in the maintenance of immune homeostasis...
  61. Majstoravich S, Zhang J, Nicholson Dykstra S, Linder S, Friedrich W, Siminovitch K, et al. Lymphocyte microvilli are dynamic, actin-dependent structures that do not require Wiskott-Aldrich syndrome protein (WASp) for their morphology. Blood. 2004;104:1396-403 pubmed
    ..from Wiskott-Aldrich syndrome (WAS) patient, we find no such deficiency in either mouse or human WAS protein (WASp)-deficient lymphocytes...
  62. Dehring D, Clarke F, Ricart B, Huang Y, Gomez T, Williamson E, et al. Hematopoietic lineage cell-specific protein 1 functions in concert with the Wiskott-Aldrich syndrome protein to promote podosome array organization and chemotaxis in dendritic cells. J Immunol. 2011;186:4805-18 pubmed publisher
    ..HS1 interacts with Wiskott-Aldrich syndrome protein (WASp), another key actin-regulatory protein, through mutual binding to WASp-interacting protein...
  63. Prete F, Catucci M, Labrada M, Gobessi S, Castiello M, Bonomi E, et al. Wiskott-Aldrich syndrome protein-mediated actin dynamics control type-I interferon production in plasmacytoid dendritic cells. J Exp Med. 2013;210:355-74 pubmed publisher
    Mutations in Wiskott-Aldrich syndrome (WAS) protein (WASp), a regulator of actin dynamics in hematopoietic cells, cause WAS, an X-linked primary immunodeficiency characterized by recurrent infections and a marked predisposition to develop ..