Genomes and Genes
Gene Symbol: wa3
Description: protein phosphatase 1, regulatory (inhibitor) subunit 13 like
Alias: AV260376, IASPP, Nkip1, wa3, relA-associated inhibitor, NFkB interacting protein 1, PPP1R13B-like protein, inhibitor of ASPP protein, ppp1r13l, protein iASPP
- Laska M, Lowe S, Zender L, Hearn S, Vogel U, Jensen U, et al. Enforced expression of PPP1R13L increases tumorigenesis and invasion through p53-dependent and p53-independent mechanisms. Mol Carcinog. 2009;48:832-42 pubmed publisherb>PPP1R13L was initially identified as a protein that binds to the NF-kappaB subunit p65/RelA and inhibits its transcriptional activity. It also binds p53 and inhibits its action...
- Toonen J, Liang L, Sidjanin D. Waved with open eyelids 2 (woe2) is a novel spontaneous mouse mutation in the protein phosphatase 1, regulatory (inhibitor) subunit 13 like (Ppp1r13l) gene. BMC Genet. 2012;13:76 pubmed publisher..The goals of this study were to phenotypically characterize the woe2 mice and to identify the gene harboring the mutation responsible for the woe2 phenotype...
- Notari M, Hu Y, Sutendra G, DedeiÄ‡ Z, Lu M, Dupays L, et al. iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death. Proc Natl Acad Sci U S A. 2015;112:E973-81 pubmed publisher..5. iASPP-deficient mice with exon 8 deletion (Ppp1r13l(Î”8/Î”8)) die of sudden cardiac death, displaying features of ARVC...
- Dedeic Z, Sutendra G, Hu Y, Chung K, Slee E, White M, et al. Cell autonomous role of iASPP deficiency in causing cardiocutaneous disorders. Cell Death Differ. 2018;25:1289-1303 pubmed publisher..Previous studies showed that inhibitor of Apoptosis Stimulating p53 Protein (iASPP) regulates desmosome integrity at cell-cell junctions and transcription in the nucleus, and its deficiency causes ..