wa3

Summary

Gene Symbol: wa3
Description: protein phosphatase 1, regulatory (inhibitor) subunit 13 like
Alias: AV260376, IASPP, Nkip1, wa3, relA-associated inhibitor, NFkB interacting protein 1, PPP1R13B-like protein, inhibitor of ASPP protein, ppp1r13l, protein iASPP
Species: mouse
Products:     wa3

Top Publications

  1. Herron B, Rao C, Liu S, Laprade L, Richardson J, Olivieri E, et al. A mutation in NFkB interacting protein 1 results in cardiomyopathy and abnormal skin development in wa3 mice. Hum Mol Genet. 2005;14:667-77 pubmed
    ..A C-terminal fragment of this protein was previously identified as the RelA associated inhibitor (RAI)...
  2. Sullivan A, Lu X. ASPP: a new family of oncogenes and tumour suppressor genes. Br J Cancer. 2007;96:196-200 pubmed
    The apoptosis stimulating proteins of p53 (ASPP) family consists of three members, ASPP1, ASPP2 and iASPP. They bind to proteins that are key players in controlling apoptosis (p53, Bcl-2 and RelA/p65) and cell growth (APCL, PP1)...
  3. Chikh A, Matin R, Senatore V, Hufbauer M, Lavery D, Raimondi C, et al. iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia. EMBO J. 2011;30:4261-73 pubmed publisher
    b>iASPP, an inhibitory member of the ASPP (apoptosis stimulating protein of p53) family, is an evolutionarily conserved inhibitor of p53 which is frequently upregulated in human cancers...
  4. Notari M, Hu Y, Koch S, Lu M, Ratnayaka I, Zhong S, et al. Inhibitor of apoptosis-stimulating protein of p53 (iASPP) prevents senescence and is required for epithelial stratification. Proc Natl Acad Sci U S A. 2011;108:16645-50 pubmed publisher
    Inhibitor of apoptosis-stimulating protein of p53 (iASPP) is the most ancient member of the ASPP family of proteins and an evolutionarily conserved inhibitor of p53. iASPP is also a binding partner and negative regulator of p65RelA...
  5. Laska M, Vogel U, Jensen U, Nexø B. p53 and PPP1R13L (alias iASPP or RAI) form a feedback loop to regulate genotoxic stress responses. Biochim Biophys Acta. 2010;1800:1231-40 pubmed publisher
    b>PPP1R13L gene has been found to be over-expressed in variety of cancers and its expression in p53 wild-type background is sufficient to promote tumor growth in vivo...
  6. Liu X, Li F, Zhao S, Luo Y, Kang J, Zhao H, et al. MicroRNA-124-mediated regulation of inhibitory member of apoptosis-stimulating protein of p53 family in experimental stroke. Stroke. 2013;44:1973-80 pubmed publisher
    ..microRNA mechanism that downregulation of inhibitory member of the apoptosis-stimulating proteins of p53 family (iASPP) by the brain-specific microRNA-124 (miR-124) promotes neuronal death after cerebral ischemia...
  7. Morris E, Cerundolo L, Lu M, Verrill C, Fritzsche F, White M, et al. Nuclear iASPP may facilitate prostate cancer progression. Cell Death Dis. 2014;5:e1492 pubmed publisher
    ..Here we identify inhibitor of apoptosis-stimulating protein of p53 (iASPP), a common cellular regulator of p53 and p63, as an important player of PCa progression...
  8. Yi H, Huang Y, Yang F, Liu W, He S, Hu X. MicroRNA-182 aggravates cerebral ischemia injury by targeting inhibitory member of the ASPP family (iASPP). Arch Biochem Biophys. 2017;620:52-58 pubmed publisher
    ..present study, we demonstrate a crucial role of miR-182 in down-regulating inhibitory member of the ASPP family (iASPP) expression and promoting cerebral ischemia injury...
  9. Choy L, Yeo J, Tse V, Chan S, Tse G. Cardiac disease and arrhythmogenesis: Mechanistic insights from mouse models. Int J Cardiol Heart Vasc. 2016;12:1-10 pubmed
    ..Mouse models can serve as useful systems in which to explore how protein defects contribute to arrhythmias and direct future therapy. ..

More Information

Publications13

  1. Laska M, Lowe S, Zender L, Hearn S, Vogel U, Jensen U, et al. Enforced expression of PPP1R13L increases tumorigenesis and invasion through p53-dependent and p53-independent mechanisms. Mol Carcinog. 2009;48:832-42 pubmed publisher
    b>PPP1R13L was initially identified as a protein that binds to the NF-kappaB subunit p65/RelA and inhibits its transcriptional activity. It also binds p53 and inhibits its action...
  2. Toonen J, Liang L, Sidjanin D. Waved with open eyelids 2 (woe2) is a novel spontaneous mouse mutation in the protein phosphatase 1, regulatory (inhibitor) subunit 13 like (Ppp1r13l) gene. BMC Genet. 2012;13:76 pubmed publisher
    ..The goals of this study were to phenotypically characterize the woe2 mice and to identify the gene harboring the mutation responsible for the woe2 phenotype...
  3. Notari M, Hu Y, Sutendra G, Dedeić Z, Lu M, Dupays L, et al. iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death. Proc Natl Acad Sci U S A. 2015;112:E973-81 pubmed publisher
    ..5. iASPP-deficient mice with exon 8 deletion (Ppp1r13l(Δ8/Δ8)) die of sudden cardiac death, displaying features of ARVC...
  4. Dedeic Z, Sutendra G, Hu Y, Chung K, Slee E, White M, et al. Cell autonomous role of iASPP deficiency in causing cardiocutaneous disorders. Cell Death Differ. 2018;25:1289-1303 pubmed publisher
    ..Previous studies showed that inhibitor of Apoptosis Stimulating p53 Protein (iASPP) regulates desmosome integrity at cell-cell junctions and transcription in the nucleus, and its deficiency causes ..