Gene Symbol: Vsig4
Description: V-set and immunoglobulin domain containing 4
Alias: A530061A11, BC025105, CRIg, Z39IG, V-set and immunoglobulin domain-containing protein 4, complement receptor of the immunoglobulin superfamily
Species: mouse
Products:     Vsig4

Top Publications

  1. Kim D, Miwa T, Kimura Y, Schwendener R, van Lookeren Campagne M, Song W. Deficiency of decay-accelerating factor and complement receptor 1-related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg. Blood. 2008;112:1109-19 pubmed publisher
    ..Antibody blocking or gene ablation of the newly identified complement receptor CRIg, but not complement receptor 3 (CR3), rescued DAF/Crry-deficient platelets from complement-dependent elimination...
  2. Vogt L, Schmitz N, Kurrer M, Bauer M, Hinton H, Behnke S, et al. VSIG4, a B7 family-related protein, is a negative regulator of T cell activation. J Clin Invest. 2006;116:2817-26 pubmed
    ..We have identified a previously unknown function for B7 family-related protein V-set and Ig domain-containing 4 (VSIG4)...
  3. Helmy K, Katschke K, Gorgani N, Kljavin N, Elliott J, Diehl L, et al. CRIg: a macrophage complement receptor required for phagocytosis of circulating pathogens. Cell. 2006;124:915-27 pubmed
    ..Here we report the identification and characterization of a Complement Receptor of the Immunoglobulin superfamily, CRIg, that binds complement fragments C3b and iC3b...
  4. Yuan X, Yang B, Dong Y, Yamamura A, Fu W. CRIg, a tissue-resident macrophage specific immune checkpoint molecule, promotes immunological tolerance in NOD mice, via a dual role in effector and regulatory T cells. elife. 2017;6: pubmed publisher
    ..These mechanisms are mediated by the complement receptor of immunoglobulin family (CRIg)...
  5. Kim K, Choi B, Song K, Cha K, Kim Y, Lee H, et al. CRIg signals induce anti-intracellular bacterial phagosome activity in a chloride intracellular channel 3-dependent manner. Eur J Immunol. 2013;43:667-78 pubmed publisher
    ..Complement receptor of the immunoglobulin (CRIg), a C3b receptor, binds to C3b on opsonized bacteria and facilitates clearance of the bacteria by promoting their ..
  6. Gorgani N, He J, Katschke K, Helmy K, Xi H, Steffek M, et al. Complement receptor of the Ig superfamily enhances complement-mediated phagocytosis in a subpopulation of tissue resident macrophages. J Immunol. 2008;181:7902-8 pubmed
    ..of resident peritoneal macrophages characterized by high expression of complement receptor of the Ig superfamily (CRIg), a recently discovered complement C3 receptor...
  7. Li J, Diao B, Guo S, Huang X, Yang C, Feng Z, et al. VSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism. Nat Commun. 2017;8:1322 pubmed publisher
    ..Here we show that V-set immunoglobulin-domain-containing 4 (VSIG4), a B7 family-related protein that is expressed by resting macrophages, inhibits macrophage activation in response ..
  8. Tanaka M, Nagai T, Usami M, Hasui K, Takao S, Matsuyama T. Phenotypic and functional profiles of CRIg (Z39Ig)-expressing macrophages in the large intestine. Innate Immun. 2012;18:258-67 pubmed publisher
    ..In this study, we showed that a complement receptor of the Ig superfamily (CRIg, also known as Z39Ig), a receptor for complement fragments (C3b and iC3b), was expressed on a subset of intestinal M in murine and ..
  9. Li Y, Wang Y, Wang D, Hou W, Zhang Y, Li M, et al. Costimulatory molecule VSIG4 exclusively expressed on macrophages alleviates renal tubulointerstitial injury in VSIG4 KO mice. J Nephrol. 2014;27:29-36 pubmed publisher
    ..The costimulatory molecule V-set and immunoglobulin domain-containing protein-4 (VSIG4), which is exclusively expressed on macrophages, is capable of inhibiting the T cell response...

More Information


  1. Qiao Q, Teng X, Wang N, Lu R, Guo L, Zhang X, et al. A novel CRIg-targeted complement inhibitor protects cells from complement damage. FASEB J. 2014;28:4986-99 pubmed publisher
    ..In addition, complement receptor of the immunoglobulin superfamily (CRIg) has been demonstrated to inhibit AP and, more notably, still specifically binds to ..
  2. Miwa T, Zhou L, Kimura Y, Kim D, Bhandoola A, Song W. Complement-dependent T-cell lymphopenia caused by thymocyte deletion of the membrane complement regulator Crry. Blood. 2009;113:2684-94 pubmed publisher
    ..Thus, Crry is essential for mature T-cell survival in the periphery but not for lymphogenesis in the thymus. The observation that the thymus is a complement-privileged site may have implications for complement-based antitumor therapies. ..
  3. Kim K, Choi B, Kim Y, Han C, Oh H, Lee D, et al. Extracellular stimulation of VSIG4/complement receptor Ig suppresses intracellular bacterial infection by inducing autophagy. Autophagy. 2016;12:1647-59 pubmed publisher
    b>VSIG4/CRIg (V-set and immunoglobulin domain containing 4) is a transmembrane receptor of the immunoglobulin superfamily that is expressed specifically on macrophages and mature dendritic cells...
  4. He J, Katschke K, Gribling P, Suto E, Lee W, Diehl L, et al. CRIg mediates early Kupffer cell responses to adenovirus. J Leukoc Biol. 2013;93:301-6 pubmed publisher
    ..KCs, the macrophage population responsible for early uptake and elimination of many blood-borne pathogens, express CRIg, a complement receptor for C3 proteins...
  5. Liao Y, Guo S, Chen Y, Cao D, Xu H, Yang C, et al. VSIG4 expression on macrophages facilitates lung cancer development. Lab Invest. 2014;94:706-15 pubmed publisher
    ..The protein V-set and Ig domain-containing 4 (VSIG4), a novel B7 family-related macrophage protein that has the capacity to inhibit T-cell activation, has a potential ..
  6. Li Y, Wang Y, Li M, Zhang Y, Li F, Wang Z, et al. [Effects of costimulatory molecule VSIG4 exclusively expression in macrophage on renal interstitial fibrosis]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2010;26:522-4 pubmed
    To investigate the relationship between costimulatory molecule VSIG4 expression in macrophage and mice renal interstitial fibrosis.
  7. Jung K, Seo S, Choi I. Endogenous VSIG4 negatively regulates the helper T cell-mediated antibody response. Immunol Lett. 2015;165:78-83 pubmed publisher
    b>VSIG4 acts as a co-inhibitory ligand to negatively regulate T cell proliferation and cytokine production, and its expression is restricted to macrophages...
  8. Zeng Z, Surewaard B, Wong C, Geoghegan J, Jenne C, Kubes P. CRIg Functions as a Macrophage Pattern Recognition Receptor to Directly Bind and Capture Blood-Borne Gram-Positive Bacteria. Cell Host Microbe. 2016;20:99-106 pubmed publisher
    ..Circulating S. aureus were captured by KCs in a manner dependent on the macrophage complement receptor CRIg, but the process was independent of complement...
  9. Katschke K, Helmy K, Steffek M, Xi H, Yin J, Lee W, et al. A novel inhibitor of the alternative pathway of complement reverses inflammation and bone destruction in experimental arthritis. J Exp Med. 2007;204:1319-25 pubmed
    ..Previously, we have shown that human complement receptor of the immunoglobulin superfamily (CRIg) is a selective inhibitor of the AP of complement...