Gene Symbol: Vrk3
Description: vaccinia related kinase 3
Alias: AI428238, inactive serine/threonine-protein kinase VRK3, serine/threonine-protein kinase VRK3, serine/threonine-protein pseudokinase VRK3
Species: mouse
Products:     Vrk3

Top Publications

  1. Quiel A, Jürgen B, Greinacher A, Lassen S, Wörl R, Witt S, et al. Sensitive detection of idiotypic platelet-reactive alloantibodies by an electrical protein chip. Biosens Bioelectron. 2012;36:207-11 pubmed publisher
    ..With this electrical chip assay it is possible to detect antibodies against HPA-1a, HPA-5b and HLA with high sensitivity and specificity in less than half the duration of the MAIPA protocol with similar intra- and interassay variance. ..
  2. Song H, Kim W, Choi J, Kim S, Lee D, Park C, et al. Stress-induced nuclear translocation of CDK5 suppresses neuronal death by downregulating ERK activation via VRK3 phosphorylation. Sci Rep. 2016;6:28634 pubmed publisher
    ..kinase 5 (CDK5) activation stimulates neuroprotective signaling via phosphorylation of vaccinia-related kinase 3 (VRK3) at Ser 108...
  3. Kang T, Kim K. VRK3-mediated inactivation of ERK signaling in adult and embryonic rodent tissues. Biochim Biophys Acta. 2008;1783:49-58 pubmed
    Vaccinia-related kinase 3 (VRK3), previously characterized as a direct activator of vaccinia H1-related (VHR) phosphatase, inactivates extracellular signal-regulated kinase (ERK) in the nucleus of neuronal cells...
  4. Kang M, Choi T, Ryu H, Lee D, Lee S, Choi S, et al. Autism-like behavior caused by deletion of vaccinia-related kinase 3 is improved by TrkB stimulation. J Exp Med. 2017;214:2947-2966 pubmed publisher
    ..However, the neuronal function of VRK3 is still unknown despite its etiological potential in human autism spectrum disorder (ASD)...
  5. Vega F, Gonzalo P, Gaspar M, Lazo P. Expression of the VRK (vaccinia-related kinase) gene family of p53 regulators in murine hematopoietic development. FEBS Lett. 2003;544:176-80 pubmed
    ..VRK2 is expressed at lower levels than VRK1 and VRK3 in the mouse embryo. VRK genes play a role during embryonic development of hematopoiesis.
  6. Nichols R, Traktman P. Characterization of three paralogous members of the Mammalian vaccinia related kinase family. J Biol Chem. 2004;279:7934-46 pubmed
    ..2004) J. Virol. 78, 1992-2005). This mammalian kinase family comprises three members, VRK1, VRK2, and VRK3. We have annotated the gene structure for the members of this family and have characterized the enzyme activity and ..
  7. Park C, Ryu H, Kim S, Lee D, Song H, Kim K. Presumed pseudokinase VRK3 functions as a BAF kinase. Biochim Biophys Acta. 2015;1853:1738-48 pubmed publisher
    Vaccinia-related kinase 3 (VRK3) is known as a pseudokinase that is catalytically inactive due to changes in motifs that are essential for kinase activity...
  8. Park N, Song J, Jeong S, Thi Tran T, Ko H, Kim E. Vaccinia-related kinase 3 (VRK3) sets the circadian period and amplitude by affecting the subcellular localization of clock proteins in mammalian cells. Biochem Biophys Res Commun. 2017;487:320-326 pubmed publisher
    ..Taken together, these data suggest that VRK3 plays a role in setting the amplitude and period length of circadian rhythms in mammalian cells.
  9. Rennie P, Bruchovsky N, Akakura K, Goldenberg S, Otal N, Akakura S, et al. Effect of tumour progression on the androgenic regulation of the androgen receptor, TRPM-2 and YPT1 genes in the Shionogi carcinoma. J Steroid Biochem Mol Biol. 1994;50:31-40 pubmed

More Information


  1. Angata T, Kerr S, Greaves D, Varki N, Crocker P, Varki A. Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia. J Biol Chem. 2002;277:24466-74 pubmed