Gene Symbol: Vrk2
Description: vaccinia related kinase 2
Alias: 2810003O05Rik, AI447698, serine/threonine-protein kinase VRK2, vaccinia virus BIR kinase related kinase 2
Agoulnik A, Lu B, Zhu Q, Truong C, Ty M, Arango N, et al
. A novel gene, Pog, is necessary for primordial germ cell proliferation in the mouse and underlies the germ cell deficient mutation, gcd. Hum Mol Genet. 2002;11:3047-53 pubmed
..Thus, in addition to being necessary for PGC proliferation, Pog may have a wider significance in early embryonic development. ..
Vega F, Gonzalo P, Gaspar M, Lazo P. Expression of the VRK (vaccinia-related kinase) gene family of p53 regulators in murine hematopoietic development. FEBS Lett. 2003;544:176-80 pubmed
..b>VRK2 is expressed at lower levels than VRK1 and VRK3 in the mouse embryo...
Nichols R, Traktman P. Characterization of three paralogous members of the Mammalian vaccinia related kinase family. J Biol Chem. 2004;279:7934-46 pubmed
..and Traktman, P. (2004) J. Virol. 78, 1992-2005). This mammalian kinase family comprises three members, VRK1, VRK2, and VRK3...
Wang S, Yehya N, Schadt E, Wang H, Drake T, Lusis A. Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity. PLoS Genet. 2006;2:e15 pubmed
..These data have implications on the potential effects of sex on the genetic regulation of other complex traits. ..
Blanco S, Santos C, Lazo P. Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1. Mol Cell Biol. 2007;27:7273-83 pubmed
..This activation of TAK1-JIP1-JNK is suppressed by vaccinia-related kinase 2 (VRK2). VRK2A is able to interact with TAK1 by its C-terminal region, forming stable complexes...
Quiel A, Jürgen B, Greinacher A, Lassen S, Wörl R, Witt S, et al
. Sensitive detection of idiotypic platelet-reactive alloantibodies by an electrical protein chip. Biosens Bioelectron. 2012;36:207-11 pubmed publisher
..With this electrical chip assay it is possible to detect antibodies against HPA-1a, HPA-5b and HLA with high sensitivity and specificity in less than half the duration of the MAIPA protocol with similar intra- and interassay variance. ..