Vrk2

Summary

Gene Symbol: Vrk2
Description: vaccinia related kinase 2
Alias: 2810003O05Rik, AI447698, serine/threonine-protein kinase VRK2, vaccinia virus BIR kinase related kinase 2
Species: mouse
Products:     Vrk2

Top Publications

  1. Agoulnik A, Lu B, Zhu Q, Truong C, Ty M, Arango N, et al. A novel gene, Pog, is necessary for primordial germ cell proliferation in the mouse and underlies the germ cell deficient mutation, gcd. Hum Mol Genet. 2002;11:3047-53 pubmed
    ..Thus, in addition to being necessary for PGC proliferation, Pog may have a wider significance in early embryonic development. ..
  2. Vega F, Gonzalo P, Gaspar M, Lazo P. Expression of the VRK (vaccinia-related kinase) gene family of p53 regulators in murine hematopoietic development. FEBS Lett. 2003;544:176-80 pubmed
    ..b>VRK2 is expressed at lower levels than VRK1 and VRK3 in the mouse embryo...
  3. Nichols R, Traktman P. Characterization of three paralogous members of the Mammalian vaccinia related kinase family. J Biol Chem. 2004;279:7934-46 pubmed
    ..and Traktman, P. (2004) J. Virol. 78, 1992-2005). This mammalian kinase family comprises three members, VRK1, VRK2, and VRK3...
  4. Wang S, Yehya N, Schadt E, Wang H, Drake T, Lusis A. Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity. PLoS Genet. 2006;2:e15 pubmed
    ..These data have implications on the potential effects of sex on the genetic regulation of other complex traits. ..
  5. Blanco S, Santos C, Lazo P. Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1. Mol Cell Biol. 2007;27:7273-83 pubmed
    ..This activation of TAK1-JIP1-JNK is suppressed by vaccinia-related kinase 2 (VRK2). VRK2A is able to interact with TAK1 by its C-terminal region, forming stable complexes...
  6. Quiel A, Jürgen B, Greinacher A, Lassen S, Wörl R, Witt S, et al. Sensitive detection of idiotypic platelet-reactive alloantibodies by an electrical protein chip. Biosens Bioelectron. 2012;36:207-11 pubmed publisher
    ..With this electrical chip assay it is possible to detect antibodies against HPA-1a, HPA-5b and HLA with high sensitivity and specificity in less than half the duration of the MAIPA protocol with similar intra- and interassay variance. ..