Vrk1

Summary

Gene Symbol: Vrk1
Description: vaccinia related kinase 1
Alias: 51PK, serine/threonine-protein kinase VRK1, serine/threonine-protein kinase 51PK
Species: mouse
Products:     Vrk1

Top Publications

  1. Nichols R, Traktman P. Characterization of three paralogous members of the Mammalian vaccinia related kinase family. J Biol Chem. 2004;279:7934-46 pubmed
    ..vvB1 plays an essential role in viral DNA replication, and Boyle and Traktman have demonstrated that VRK1 enzymes complement the replication defect of a temperature-sensitive viral mutant defective in vvB1 (Boyle, K...
  2. Boyle K, Traktman P. Members of a novel family of mammalian protein kinases complement the DNA-negative phenotype of a vaccinia virus ts mutant defective in the B1 kinase. J Virol. 2004;78:1992-2005 pubmed
    ..We therefore sought to determine whether the human and mouse VRK1 enzymes (hVRK1 and mVRK1, respectively) could complement a B1 deficiency in vivo...
  3. Kang T, Park D, Choi Y, Kim K, Yoon H, Kim K. Mitotic histone H3 phosphorylation by vaccinia-related kinase 1 in mammalian cells. Mol Cell Biol. 2007;27:8533-46 pubmed
    ..We show that histone H3 is phosphorylated by vaccinia-related kinase 1 (VRK1). Direct phosphorylation of Thr3 and Ser10 in H3 by VRK1 both in vitro and in vivo was observed...
  4. Wiebe M, Nichols R, Molitor T, Lindgren J, Traktman P. Mice deficient in the serine/threonine protein kinase VRK1 are infertile due to a progressive loss of spermatogonia. Biol Reprod. 2010;82:182-93 pubmed publisher
    The VRK1 protein kinase has been implicated as a pro-proliferative factor...
  5. Schober C, Aydiner F, Booth C, Seli E, Reinke V. The kinase VRK1 is required for normal meiotic progression in mammalian oogenesis. Mech Dev. 2011;128:178-90 pubmed publisher
    The kinase VRK1 has been implicated in mitotic and meiotic progression in invertebrate species, but whether it mediates these events during mammalian gametogenesis is not completely understood...
  6. Vega F, Gonzalo P, Gaspar M, Lazo P. Expression of the VRK (vaccinia-related kinase) gene family of p53 regulators in murine hematopoietic development. FEBS Lett. 2003;544:176-80 pubmed
    ..VRK proteins are upstream regulators of several transcription factors. VRK1 phosphorylates p53 in Thr-18 within the region of binding to mdm2 preventing their interaction...
  7. Choi Y, Park C, Kim W, Ling H, Kang A, Chang M, et al. Vaccinia-related kinase 1 is required for the maintenance of undifferentiated spermatogonia in mouse male germ cells. PLoS ONE. 2010;5:e15254 pubmed publisher
    Vaccinia-related kinase 1 (VRK1) is a crucial protein kinase for mitotic regulation. VRK1 is known to play a role in germ cell development, and its deficiency results in sterility...
  8. Vinograd Byk H, Sapir T, Cantarero L, Lazo P, Zeligson S, Lev D, et al. The spinal muscular atrophy with pontocerebellar hypoplasia gene VRK1 regulates neuronal migration through an amyloid-β precursor protein-dependent mechanism. J Neurosci. 2015;35:936-42 pubmed publisher
    ..We previously identified a nonsense mutation in Vaccinia-related kinase 1 (VRK1), R358X, as a cause of SMA-PCH...
  9. Zelko I, Kobayashi R, Honkakoski P, Negishi M. Molecular cloning and characterization of a novel nuclear protein kinase in mice. Arch Biochem Biophys. 1998;352:31-6 pubmed
    ..This 51-kDa protein kinase, designated 51PK, is 40% identical to the 34-kDa protein kinase encoded by the vaccinia virus B1 gene and 25% identical to the ..

More Information

Publications13

  1. Park C, Choi B, Jeong M, Kim S, Kim W, Song Y, et al. Protein kinase C? regulates vaccinia-related kinase 1 in DNA damage-induced apoptosis. Mol Biol Cell. 2011;22:1398-408 pubmed publisher
    Vaccinia-related kinase 1 (VRK1) is a novel serine/threonine kinase that plays an important role in cell proliferation. However, little is known about the upstream regulators of VRK1 activity...
  2. Quiel A, Jürgen B, Greinacher A, Lassen S, Wörl R, Witt S, et al. Sensitive detection of idiotypic platelet-reactive alloantibodies by an electrical protein chip. Biosens Bioelectron. 2012;36:207-11 pubmed publisher
    ..With this electrical chip assay it is possible to detect antibodies against HPA-1a, HPA-5b and HLA with high sensitivity and specificity in less than half the duration of the MAIPA protocol with similar intra- and interassay variance. ..
  3. Choi Y, Lim J, Jeong M, Kim K. HnRNP A1 phosphorylated by VRK1 stimulates telomerase and its binding to telomeric DNA sequence. Nucleic Acids Res. 2012;40:8499-518 pubmed
    ..Here, we identified hnRNP A1 as a novel substrate for vaccinia-related kinase 1 (VRK1), a cell cycle regulating kinase...
  4. Kim J, Choi Y, Chang S, Kim K, Je J. Defective folliculogenesis in female mice lacking Vaccinia-related kinase 1. Sci Rep. 2012;2:468 pubmed publisher
    The Vaccinia-related kinase 1(VRK1), which is generally implicated in modulating cell cycle, plays important roles in mammalian gametogenesis...