Gene Symbol: Vps26a
Description: VPS26 retromer complex component A
Alias: AA407240, HB58, Vps26, vacuolar protein sorting-associated protein 26A, H beta 58, h58 protein, mVPS26, vacuolar protein sorting 26 homolog A, vacuole protein sorting 26, vesicle protein sorting 26A
Species: mouse
Products:     Vps26a

Top Publications

  1. Lee J, Radice G, Perkins C, Costantini F. Identification and characterization of a novel, evolutionarily conserved gene disrupted by the murine H beta 58 embryonic lethal transgene insertion. Development. 1992;115:277-88 pubmed
    ..Sequence analysis of H beta 58 cDNA clones revealed no homology between the 38 x 10(3) M(r) H beta 58 protein and other known proteins...
  2. Radice G, Lee J, Costantini F. H beta 58, an insertional mutation affecting early postimplantation development of the mouse embryo. Development. 1991;111:801-11 pubmed
    ..Embryos homozygous for the H beta 58 transgenic insertion developed normally through the early postimplantation, egg cylinder stage (day 6...
  3. Kim E, Lee Y, Lee H, Kim J, Song B, Huh J, et al. Implication of mouse Vps26b-Vps29-Vps35 retromer complex in sortilin trafficking. Biochem Biophys Res Commun. 2010;403:167-71 pubmed publisher
    ..In mammals, there are two different isoforms of Vps26, Vps26a and Vps26b, that localize to the endosome, and to the plasma membrane, respectively...
  4. Collins B, Skinner C, Watson P, Seaman M, Owen D. Vps29 has a phosphoesterase fold that acts as a protein interaction scaffold for retromer assembly. Nat Struct Mol Biol. 2005;12:594-602 pubmed
    ..The mVps29 and mVps26 subunits bind independently to mVps35 and together form a high-affinity heterotrimeric subcomplex...
  5. Gokool S, Tattersall D, Reddy J, Seaman M. Identification of a conserved motif required for Vps35p/Vps26p interaction and assembly of the retromer complex. Biochem J. 2007;408:287-95 pubmed
    ..is performed by the Vps35p/VPS35 (where Vps is vacuolar protein sorting) component, which together with Vps26p/VPS26 and Vps29p/VPS29, forms the cargo-selective subcomplex...
  6. Kim E, Lee J, Baek D, Lee S, Kim M, Kim S, et al. Identification of novel retromer complexes in the mouse testis. Biochem Biophys Res Commun. 2008;375:16-21 pubmed publisher
    ..b>Vps26a is known as a retromer component that plays an important role in embryonic development: however, its cell-type ..
  7. Bugarcic A, Zhe Y, Kerr M, Griffin J, Collins B, Teasdale R. Vps26A and Vps26B subunits define distinct retromer complexes. Traffic. 2011;12:1759-73 pubmed publisher
    ..Our group has recently identified a Vps26 paralogue, Vps26B, which is able to suppress the expression of Vps26A when exogenously expressed in mammalian cells and defines a distinct retromer complex (Vps26B-retromer) in vivo ..
  8. Helfer E, Harbour M, Henriot V, Lakisic G, Sousa Blin C, Volceanov L, et al. Endosomal recruitment of the WASH complex: active sequences and mutations impairing interaction with the retromer. Biol Cell. 2013;105:191-207 pubmed publisher
    ..The CSC is composed of three subunits, VPS35, VPS29 and VPS26. FAM21 directly binds the VPS35 subunit of the retromer CSC...
  9. Gallon M, Clairfeuille T, Steinberg F, Mas C, Ghai R, Sessions R, et al. A unique PDZ domain and arrestin-like fold interaction reveals mechanistic details of endocytic recycling by SNX27-retromer. Proc Natl Acad Sci U S A. 2014;111:E3604-13 pubmed publisher
    ..in the SNX27 PDZ domain engages a groove in the arrestin-like structure of the vacuolar protein sorting 26A (VPS26A) retromer subunit...

More Information


  1. Tang F, Erion J, Tian Y, Liu W, Yin D, Ye J, et al. VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease. J Neurosci. 2015;35:10613-28 pubmed publisher
    ..These results suggest that VPS35 deficiency or mutation promotes PD pathogenesis, and reveals a crucial pathway, VPS35-Lamp2a-α-synuclein, to prevent PD pathogenesis. ..
  2. Seaman M. Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer. J Cell Biol. 2004;165:111-22 pubmed
    ..We have localized mVPS26 to multivesicular body endosomes by electron microscopy, and through the use of CD8 reporter protein constructs ..
  3. Griffin C, Trejo J, Magnuson T. Genetic evidence for a mammalian retromer complex containing sorting nexins 1 and 2. Proc Natl Acad Sci U S A. 2005;102:15173-7 pubmed
    ..lethality when simultaneously targeted for deletion in mice, whereas others have shown that Hbeta58 (also known as mVps26), another retromer component, results in similar lethality when targeted for deletion...
  4. Muhammad A, Flores I, Zhang H, Yu R, Staniszewski A, Planel E, et al. Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation. Proc Natl Acad Sci U S A. 2008;105:7327-32 pubmed publisher
    ..By recapitulating features of the disease, these animal models suggest that retromer deficiency observed in late-onset Alzheimer's disease can contribute to disease pathogenesis. ..
  5. Fjorback A, Seaman M, Gustafsen C, Mehmedbasic A, Gokool S, Wu C, et al. Retromer binds the FANSHY sorting motif in SorLA to regulate amyloid precursor protein sorting and processing. J Neurosci. 2012;32:1467-80 pubmed publisher
    ..We have identified a sequence (FANSHY) in the cytoplasmic domain of sorLA that is recognized by the VPS26 subunit of the retromer complex...
  6. Harbour M, Breusegem S, Antrobus R, Freeman C, Reid E, Seaman M. The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics. J Cell Sci. 2010;123:3703-17 pubmed publisher
    ..that act together in endosome-to-Golgi retrieval; the cargo-selective complex is a trimer of VPS35, VPS29 and VPS26 that sorts cargo into tubules for retrieval to the Golgi...
  7. Zheng H, Tsukahara M, Liu E, Ye L, Xiong H, Noguchi S, et al. The novel helicase helG (DHX30) is expressed during gastrulation in mice and has a structure similar to a human DExH box helicase. Stem Cells Dev. 2015;24:372-83 pubmed publisher