Gene Symbol: Vmp1
Description: vacuole membrane protein 1
Alias: 3110098I04Rik, 4930579A11Rik, AI787464, Tango5, Tmem49, mir-21a, ni-2, vacuole membrane protein 1, NF-E2 induceble protein-2, protein ni-2, transmembrane protein 49
Lo Ré A, Fernández Barrena M, Almada L, Mills L, Elsawa S, Lund G, et al
. Novel AKT1-GLI3-VMP1 pathway mediates KRAS oncogene-induced autophagy in cancer cells. J Biol Chem. 2012;287:25325-34 pubmed publisher
..both in vitro and in vivo evidence of a novel signaling pathway whereby the oncogene KRAS induces the expression of VMP1, a molecule needed for the formation of the authophagosome and capable of inducing autophagy, even under nutrient-..
Ropolo A, Grasso D, Pardo R, Sacchetti M, Archange C, Lo Re A, et al
. The pancreatitis-induced vacuole membrane protein 1 triggers autophagy in mammalian cells. J Biol Chem. 2007;282:37124-33 pubmed
..We have previously characterized the vacuole membrane protein 1 (VMP1) gene, which is highly activated in acute pancreatitis, a disease associated with morphological ..
Grasso D, Ropolo A, Lo Re A, Boggio V, Molejón M, Iovanna J, et al
. Zymophagy, a novel selective autophagy pathway mediated by VMP1-USP9x-p62, prevents pancreatic cell death. J Biol Chem. 2011;286:8308-24 pubmed publisher
..We have coined the term "zymophagy" to refer to this process. The autophagy-related protein VMP1, the ubiquitin-protease USP9x, and the ubiquitin-binding protein p62 mediate zymophagy...
Hu S, Ren G, Liu J, Zhao Z, Yu Y, Su R, et al
. MicroRNA expression and regulation in mouse uterus during embryo implantation. J Biol Chem. 2008;283:23473-84 pubmed publisher
..Furthermore, we showed that Reck was the target gene of miR-21. Our data suggest that miR-21 may play a key role during embryo implantation. ..
Itakura E, Mizushima N. p62 Targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding. J Cell Biol. 2011;192:17-27 pubmed publisher
..p62 colocalizes with upstream autophagy factors such as ULK1 and VMP1 even when autophagosome formation is blocked by wortmannin or FIP200 knockout...
Loncle C, Molejon M, Lac S, Tellechea J, Lomberk G, Gramatica L, et al
. The pancreatitis-associated protein VMP1, a key regulator of inducible autophagy, promotes Kras(G12D)-mediated pancreatic cancer initiation. Cell Death Dis. 2016;7:e2295 pubmed publisher
..In this study we demonstrate a novel role for vacuole membrane protein 1 (VMP1), a pancreatitis-associated protein critical for inducible autophagy, in the regulation of Kras-..
Zhao Y, Chen Y, Miao G, Zhao H, Qu W, Li D, et al
. The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation. Mol Cell. 2017;67:974-989.e6 pubmed publisher
..Here, we demonstrated that the ER-localized metazoan-specific autophagy protein EPG-3/VMP1 controls ER-IM contacts...