Vldlr

Summary

Gene Symbol: Vldlr
Description: very low density lipoprotein receptor
Alias: AA408956, AI451093, AW047288, very low-density lipoprotein receptor, VLDL receptor, VLDL-R
Species: mouse
Products:     Vldlr

Top Publications

  1. Uchida T, Baba A, Pérez Martínez F, Hibi T, Miyata T, Luque J, et al. Downregulation of functional Reelin receptors in projection neurons implies that primary Reelin action occurs at early/premigratory stages. J Neurosci. 2009;29:10653-62 pubmed publisher
    ..It is thus strongly suggested that Reelin exerts critical actions on migrating projection neurons at their early/premigratory stages en route to their final destinations, in the developing cerebral cortex and cerebellum. ..
  2. Hashimoto Torii K, Torii M, Sarkisian M, Bartley C, Shen J, Radtke F, et al. Interaction between Reelin and Notch signaling regulates neuronal migration in the cerebral cortex. Neuron. 2008;60:273-84 pubmed publisher
    ..Finally, our in vitro biochemical studies show that Reelin signaling inhibits Notch ICD degradation via Dab1. Together, our results indicate that neuronal migration in the developing cerebral cortex requires a Reelin-Notch interaction. ..
  3. Chen Y, Hu Y, Moiseyev G, Zhou K, Chen D, Ma J. Photoreceptor degeneration and retinal inflammation induced by very low-density lipoprotein receptor deficiency. Microvasc Res. 2009;78:119-27 pubmed publisher
    Our previous studies have shown that very low-density lipoprotein receptor (VLDLR) is a negative regulator of the Wnt pathway...
  4. HOE H, Rebeck G. Regulation of ApoE receptor proteolysis by ligand binding. Brain Res Mol Brain Res. 2005;137:31-9 pubmed
    Two brain receptors for apolipoprotein E (apoE), the apoE receptor 2 (apoEr2) and the very low density lipoprotein receptor (VLDLr), are important in neuronal migration during development...
  5. Li C, Huang Z, Kingsley R, Zhou X, Li F, Parke D, et al. Biochemical alterations in the retinas of very low-density lipoprotein receptor knockout mice: an animal model of retinal angiomatous proliferation. Arch Ophthalmol. 2007;125:795-803 pubmed
    To identify and characterize biochemical alterations in the retinas of very low-density lipoprotein receptor (VLDLr) knockout mice in an animal model of retinal angiomatous proliferation...
  6. Assadi A, Zhang G, Beffert U, McNeil R, Renfro A, Niu S, et al. Interaction of reelin signaling and Lis1 in brain development. Nat Genet. 2003;35:270-6 pubmed
    ..Reln encodes an extracellular protein that regulates layer formation by interacting with VLDLR and ApoER2 (Lrp8) receptors, thereby phosphorylating the Dab1 signaling molecule...
  7. Poirier S, Mayer G, Benjannet S, Bergeron E, Marcinkiewicz J, Nassoury N, et al. The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2. J Biol Chem. 2008;283:2363-72 pubmed
    ..These include the very low density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2) implicated in neuronal development and lipid ..
  8. Hong C, Duit S, Jalonen P, Out R, Scheer L, Sorrentino V, et al. The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2. J Biol Chem. 2010;285:19720-6 pubmed publisher
    ..Here we demonstrate that Idol also targets two closely related LDLR family members, VLDLR and ApoE receptor 2 (ApoER2), proteins implicated in both neuronal development and lipid metabolism...
  9. Frykman P, Brown M, Yamamoto T, Goldstein J, Herz J. Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor. Proc Natl Acad Sci U S A. 1995;92:8453-7 pubmed
    ..We conclude that the VLDL receptor is not required for VLDL clearance from plasma or for ovulation in mice.

More Information

Publications85

  1. Trotter J, Klein M, Jinwal U, Abisambra J, Dickey C, Tharkur J, et al. ApoER2 function in the establishment and maintenance of retinal synaptic connectivity. J Neurosci. 2011;31:14413-23 pubmed publisher
    ..Mice deficient in another Reelin receptor, very low-density lipoprotein receptor (VLDLR), had normal rod bipolar morphology but altered A-II amacrine dendritic development...
  2. Xia C, Lu E, Liu H, Du X, Beutler B, Gong X. The role of Vldlr in intraretinal angiogenesis in mice. Invest Ophthalmol Vis Sci. 2011;52:6572-9 pubmed publisher
    ..2239C>T, in the very-low-density lipoprotein receptor (Vldlr) gene...
  3. Jossin Y, Gui L, Goffinet A. Processing of Reelin by embryonic neurons is important for function in tissue but not in dissociated cultured neurons. J Neurosci. 2007;27:4243-52 pubmed
  4. Hua J, Guerin K, Chen J, Michan S, Stahl A, Krah N, et al. Resveratrol inhibits pathologic retinal neovascularization in Vldlr(-/-) mice. Invest Ophthalmol Vis Sci. 2011;52:2809-16 pubmed publisher
    ..Very low-density lipoprotein receptor mutant mice (Vldlr(-/-)) exhibit critical features of MacTel such as retinal neovascularization and photoreceptor degeneration...
  5. Heckenlively J, Hawes N, Friedlander M, Nusinowitz S, Hurd R, Davisson M, et al. Mouse model of subretinal neovascularization with choroidal anastomosis. Retina. 2003;23:518-22 pubmed
    ..On genetic analysis, homozygosity of the Vldlr mutation always segregated with the retinal angiogenesis, whereas normal and heterozygous mice had no ..
  6. Trommsdorff M, Gotthardt M, Hiesberger T, Shelton J, Stockinger W, Nimpf J, et al. Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2. Cell. 1999;97:689-701 pubmed
    ..Here, we report the requirement for two other proteins, cell surface receptors termed very low density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2)...
  7. Bock H, Herz J. Reelin activates SRC family tyrosine kinases in neurons. Curr Biol. 2003;13:18-26 pubmed
    ..of the Reelin signal to migrating embryonic neurons requires binding to the very-low-density lipoprotein receptor (VLDLR) and the apolipoprotein E receptor-2 (apoER2)...
  8. Weeber E, Beffert U, Jones C, Christian J, Forster E, Sweatt J, et al. Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning. J Biol Chem. 2002;277:39944-52 pubmed
    ..Mice lacking either the VLDL receptor or the apoER2 show contextual fear conditioning deficits...
  9. Shan L, Pang L, Zhang R, Murgolo N, Lan H, Hedrick J. PCSK9 binds to multiple receptors and can be functionally inhibited by an EGF-A peptide. Biochem Biophys Res Commun. 2008;375:69-73 pubmed publisher
    ..In addition to LDLR, we show that PCSK9 also binds directly to ApoER2 and mouse VLDLR. Importantly, binding of PCSK9 to either LDLR or mouse VLDLR was effectively inhibited by EGF-A while binding to ..
  10. Magdaleno S, Keshvara L, Curran T. Rescue of ataxia and preplate splitting by ectopic expression of Reelin in reeler mice. Neuron. 2002;33:573-86 pubmed
    ..These results indicate that Reelin does not function simply as a positional signal. Rather, it appears to participate in multiple events critical for neuronal migration and cell positioning. ..
  11. Yagyu H, Lutz E, Kako Y, Marks S, Hu Y, Choi S, et al. Very low density lipoprotein (VLDL) receptor-deficient mice have reduced lipoprotein lipase activity. Possible causes of hypertriglyceridemia and reduced body mass with VLDL receptor deficiency. J Biol Chem. 2002;277:10037-43 pubmed
    Although very low density lipoprotein (VLDL) receptor (VLDLr) knockout mice have been reported to have no lipoprotein abnormalities, they develop less adipose tissue than control mice when fed a high calorie diet...
  12. Hiesberger T, Trommsdorff M, Howell B, Goffinet A, Mumby M, Cooper J, et al. Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation. Neuron. 1999;24:481-9 pubmed
    ..of the Reelin signal by migrating neurons involves two neuronal cell surface proteins, the very low density lipoprotein receptor (VLDLR) and the apoE receptor 2 (ApoER2) as well as a cytosolic adaptor protein, Disabled-1 (Dab1)...
  13. Hu W, Jiang A, Liang J, Meng H, Chang B, Gao H, et al. Expression of VLDLR in the retina and evolution of subretinal neovascularization in the knockout mouse model's retinal angiomatous proliferation. Invest Ophthalmol Vis Sci. 2008;49:407-15 pubmed publisher
    Very-low-density lipoprotein receptor (VLDLR) in knockout mice (vldlr(-/-)) has been reported to induce subretinal neovascularization...
  14. McKenzie J, Fruttiger M, Abraham S, Lange C, Stone J, Gandhi P, et al. Apelin is required for non-neovascular remodeling in the retina. Am J Pathol. 2012;180:399-409 pubmed publisher
    ..effect in two models of neovascular pathology [laser-induced choroidal neovascularization and the very low density lipoprotein receptor (Vldlr)-knockout mouse]...
  15. Jiang A, Hu W, Meng H, Gao H, Qiao X. Loss of VLDL receptor activates retinal vascular endothelial cells and promotes angiogenesis. Invest Ophthalmol Vis Sci. 2009;50:844-50 pubmed publisher
    The very low-density lipoprotein receptor (VLDLR) knockout (vldlr(-/-)) mouse has been identified as a model for retinal angiomatous proliferation with subretinal neovascularization (SNV) evolving from retinal vessels...
  16. Hack I, Hellwig S, Junghans D, Brunne B, Bock H, Zhao S, et al. Divergent roles of ApoER2 and Vldlr in the migration of cortical neurons. Development. 2007;134:3883-91 pubmed
    Reelin, its lipoprotein receptors [very low density lipoprotein receptor (Vldlr) and apolipoprotein E receptor 2 (ApoER2; also known as Lrp8)], and the cytoplasmic adaptor protein disabled 1 (Dab1) are important for the correct formation ..
  17. Blake S, Strasser V, Andrade N, Duit S, Hofbauer R, Schneider W, et al. Thrombospondin-1 binds to ApoER2 and VLDL receptor and functions in postnatal neuronal migration. EMBO J. 2008;27:3069-80 pubmed publisher
    Apolipoprotein E receptor 2 (ApoER2), very low-density lipoprotein receptor (VLDLR), and Dab1 are the main components of the Reelin signalling cascade. Reelin is the sole ligand defined so far in signalling through this pathway...
  18. Andrade N, Komnenovic V, Blake S, Jossin Y, Howell B, Goffinet A, et al. ApoER2/VLDL receptor and Dab1 in the rostral migratory stream function in postnatal neuronal migration independently of Reelin. Proc Natl Acad Sci U S A. 2007;104:8508-13 pubmed
    ..Here we show that ApoER2 and possibly very-low-density lipoprotein receptor (VLDLR) and their intracellular adapter protein Dab1 are involved in chain formation most likely independent of Reelin...
  19. Beffert U, Durudas A, Weeber E, Stolt P, Giehl K, Sweatt J, et al. Functional dissection of Reelin signaling by site-directed disruption of Disabled-1 adaptor binding to apolipoprotein E receptor 2: distinct roles in development and synaptic plasticity. J Neurosci. 2006;26:2041-52 pubmed
    ..Together, these findings emphasize the complexity of Reelin signaling in the adult brain, which likely requires multiple adaptor protein interactions with the intracellular domain of Apoer2. ..
  20. Perez Garcia C, Tissir F, Goffinet A, Meyer G. Reelin receptors in developing laminated brain structures of mouse and human. Eur J Neurosci. 2004;20:2827-32 pubmed
    ..The target cells for reelin express the cytoplasmic adapter protein Dab1, which binds to the reelin receptors VLDLR and ApoER2...
  21. Sakai K, Tiebel O, Ljungberg M, Sullivan M, Lee H, Terashima T, et al. A neuronal VLDLR variant lacking the third complement-type repeat exhibits high capacity binding of apoE containing lipoproteins. Brain Res. 2009;1276:11-21 pubmed publisher
    Very-low-density lipoprotein receptor (VLDLR) is a multi ligand apolipoprotein E (apoE) receptor and is involved in brain development through Reelin signaling. Different forms of VLDLR can be generated by alternative splicing...
  22. Khialeeva E, Lane T, Carpenter E. Disruption of reelin signaling alters mammary gland morphogenesis. Development. 2011;138:767-76 pubmed publisher
  23. Leemhuis J, Bouché E, Frotscher M, Henle F, Hein L, Herz J, et al. Reelin signals through apolipoprotein E receptor 2 and Cdc42 to increase growth cone motility and filopodia formation. J Neurosci. 2010;30:14759-72 pubmed publisher
    ..Our data link the observation that defects in Rho GTPases and Reelin signaling are responsible for developmental defects leading to neurological and psychiatric disorders. ..
  24. Rossel M, Loulier K, Feuillet C, Alonso S, Carroll P. Reelin signaling is necessary for a specific step in the migration of hindbrain efferent neurons. Development. 2005;132:1175-85 pubmed
    ..However, examination of mice lacking both reelin receptors, ApoER2 and VLDLR, did not reveal the same phenotype, suggesting involvement of an additional reelin-binding receptor...
  25. Qiao L, Zou C, van der Westhuyzen D, Shao J. Adiponectin reduces plasma triglyceride by increasing VLDL triglyceride catabolism. Diabetes. 2008;57:1824-33 pubmed publisher
    ..Skeletal muscle LPL activity and mRNA levels of LPL and VLDL receptor (VLDLr) were also increased in Ad-mACRP30-treated mice...
  26. Weiss K, Johanssen C, Tielsch A, Herz J, Deller T, Frotscher M, et al. Malformation of the radial glial scaffold in the dentate gyrus of reeler mice, scrambler mice, and ApoER2/VLDLR-deficient mice. J Comp Neurol. 2003;460:56-65 pubmed
    ..and in mutant mice lacking the Reelin receptors apolipoprotein receptor 2 (ApoER2) and/or the very low density lipoprotein receptor (VLDLR), known to transmit the Reelin signal via Dab1...
  27. Bovenschen N, Mertens K, Hu L, Havekes L, van Vlijmen B. LDL receptor cooperates with LDL receptor-related protein in regulating plasma levels of coagulation factor VIII in vivo. Blood. 2005;106:906-12 pubmed
    ..We propose that LDLR acts in concert with LRP in regulating plasma levels of FVIII in vivo. This represents a previously unrecognized link between LDLR and hemostasis. ..
  28. Huynh H, Wei W, Wan Y. mTOR Inhibition Subdues Milk Disorder Caused by Maternal VLDLR Loss. Cell Rep. 2017;19:2014-2025 pubmed publisher
    ..Here, we report that maternal and offspring VLDLRs play opposite roles in osteoclastogenesis and bone resorption. VLDLR deletion in the offspring augments osteoclast differentiation by enhancing RANKL signaling, leading to ..
  29. Dumanis S, Chamberlain K, Jin Sohn Y, Jin Lee Y, GUENETTE S, Suzuki T, et al. FE65 as a link between VLDLR and APP to regulate their trafficking and processing. Mol Neurodegener. 2012;7:9 pubmed publisher
    ..In the present study, we tested whether FE65 can interact with another ApoE receptor, VLDLR, thereby altering its trafficking and processing, and whether FE65 can serve as a linker between APP and VLDLR...
  30. Herrick T, Cooper J. High affinity binding of Dab1 to Reelin receptors promotes normal positioning of upper layer cortical plate neurons. Brain Res Mol Brain Res. 2004;126:121-8 pubmed
    ..Dab1 and the Reelin receptors VLDLR and ApoER2 are expressed by neurons whose migrations are coordinated by Reelin...
  31. Kysenius K, Huttunen H. Stress-induced upregulation of VLDL receptor alters Wnt-signaling in neurons. Exp Cell Res. 2016;340:238-47 pubmed publisher
    ..of neuronal stressors cobalt chloride, thapsigargin and rotenone increased very-low-density lipoprotein receptor (VLDLR) mRNA and protein expression in CGN suggesting a conserved pathway for stress-induced upregulation of VLDLR in ..
  32. Jo H, Choe S, Shin K, Jang H, Lee J, Seong J, et al. Endoplasmic reticulum stress induces hepatic steatosis via increased expression of the hepatic very low-density lipoprotein receptor. Hepatology. 2013;57:1366-77 pubmed publisher
    ..stimulates hepatic steatosis through increased expression of the hepatic very low-density lipoprotein receptor (VLDLR)...
  33. Kwok S, Singh Bist A, Natu V, Kraemer F. Dietary regulation of the very low density lipoprotein receptor in mouse heart and fat. Horm Metab Res. 1997;29:524-9 pubmed
    ..As opposed to the LDL receptor, the VLDL receptor is expressed primarily in muscle and adipose tissue...
  34. Kobayashi K, Oka K, Forte T, Ishida B, Teng B, Ishimura Oka K, et al. Reversal of hypercholesterolemia in low density lipoprotein receptor knockout mice by adenovirus-mediated gene transfer of the very low density lipoprotein receptor. J Biol Chem. 1996;271:6852-60 pubmed
    ..We have used the technique of adenovirus-mediated gene transfer to study the in vivo function of the very low density lipoprotein receptor (VLDLR) in low density lipoprotein receptor (LDLR) knockout mice...
  35. Cariboni A, Rakic S, Liapi A, Maggi R, Goffinet A, Parnavelas J. Reelin provides an inhibitory signal in the migration of gonadotropin-releasing hormone neurons. Development. 2005;132:4709-18 pubmed
    ..Mutants lacking the reelin receptors ApoER2 and Vldlr, and scrambler mice lacking Dab1, showed a normal complement of GnRH neurons in the hypothalamus, confirming that ..
  36. Krüger M, Zhao S, Chai X, Brunne B, Bouché E, Bock H, et al. Role for Reelin-induced cofilin phosphorylation in the assembly of sympathetic preganglionic neurons in the murine intermediolateral column. Eur J Neurosci. 2010;32:1611-7 pubmed publisher
    ..The results extend our previous studies on cortical neurons in which Reelin in the marginal zone was found to stabilize the leading processes of migrating neurons and terminate the migration process. ..
  37. van der Hoogt C, Berbee J, Espirito Santo S, Gerritsen G, Krom Y, van der Zee A, et al. Apolipoprotein CI causes hypertriglyceridemia independent of the very-low-density lipoprotein receptor and apolipoprotein CIII in mice. Biochim Biophys Acta. 2006;1761:213-20 pubmed
    ..Since the very-low-density lipoprotein receptor (VLDLr) and apoCIII are potent modifiers of LPL activity, our current aim was to study whether the lipolysis-inhibiting ..
  38. Bodea G, Spille J, Abe P, Andersson A, Acker Palmer A, Stumm R, et al. Reelin and CXCL12 regulate distinct migratory behaviors during the development of the dopaminergic system. Development. 2014;141:661-73 pubmed publisher
  39. Bovenschen N, van Dijk K, Havekes L, Mertens K, van Vlijmen B. Clearance of coagulation factor VIII in very low-density lipoprotein receptor knockout mice. Br J Haematol. 2004;126:722-5 pubmed
    ..Besides LRP, FVIII also interacts with very low-density lipoprotein receptor (VLDLR) in vitro...
  40. Yip Y, Capriotti C, Magdaleno S, Benhayon D, Curran T, Nakajima K, et al. Components of the reelin signaling pathway are expressed in the spinal cord. J Comp Neurol. 2004;470:210-9 pubmed
    The Reelin signaling pathway in the brain involves the binding of Reelin to very-low-density lipoprotein receptors (VLDLR) and apolipoprotein E receptor 2 (ApoER2)...
  41. Fredriksson K, Mishra A, Lam J, Mushaben E, Cuento R, Meyer K, et al. The very low density lipoprotein receptor attenuates house dust mite-induced airway inflammation by suppressing dendritic cell-mediated adaptive immune responses. J Immunol. 2014;192:4497-509 pubmed publisher
    The very low density lipoprotein receptor (VLDLR) is a member of the low-density lipoprotein receptor family that binds multiple ligands and plays a key role in brain development...
  42. Hirota Y, Kubo K, Katayama K, Honda T, Fujino T, Yamamoto T, et al. Reelin receptors ApoER2 and VLDLR are expressed in distinct spatiotemporal patterns in developing mouse cerebral cortex. J Comp Neurol. 2015;523:463-78 pubmed publisher
    ..the formation of the layered neocortex via its receptors, apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR)...
  43. Pehrson J, Changolkar L, Costanzi C, Leu N. Mice without macroH2A histone variants. Mol Cell Biol. 2014;34:4523-33 pubmed publisher
    ..MacroH2A-dependent gene regulation changes substantially in postnatal development and can be strongly affected by fasting. We propose that macroH2As produce adaptive changes to gene expression, which in the liver focus on metabolism. ..
  44. Gafvels M, Paavola L, Boyd C, Nolan P, Wittmaack F, Chawla A, et al. Cloning of a complementary deoxyribonucleic acid encoding the murine homolog of the very low density lipoprotein/apolipoprotein-E receptor: expression pattern and assignment of the gene to mouse chromosome 19. Endocrinology. 1994;135:387-94 pubmed
    ..of a complementary DNA for the mouse homolog of the very low density lipoprotein (VLDL)/apolipoprotein-E receptor (VLDLR), the deduced amino acid sequence of the protein, and the mapping of the gene encoding the receptor to mouse ..
  45. Qiu F, Matlock G, Chen Q, Zhou K, Du Y, Wang X, et al. Therapeutic Effects of PPARα Agonist on Ocular Neovascularization in Models Recapitulating Neovascular Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2017;58:5065-5075 pubmed publisher
    ..Laser-induced choroidal NV (CNV) in rats and very low-density lipoprotein receptor knockout (Vldlr-/-) mice received daily intraperitoneal injections of Feno-FA or vehicle...
  46. Rebustini I, Hayashi T, Reynolds A, Dillard M, Carpenter E, Hoffman M. miR-200c regulates FGFR-dependent epithelial proliferation via Vldlr during submandibular gland branching morphogenesis. Development. 2012;139:191-202 pubmed publisher
    ..We discovered that miR-200c targets the very low density lipoprotein receptor (Vldlr) and its ligand reelin, which unexpectedly regulate FGFR-dependent epithelial proliferation...
  47. Fish K, Krucker T. Functional consequences of hippocampal neuronal ectopia in the apolipoprotein E receptor-2 knockout mouse. Neurobiol Dis. 2008;32:391-401 pubmed publisher
    ..However, the presence of these two layers alters the spatiotemporal pattern of hippocampal activity, which may explain why ApoER2 knockout mice have selective cognitive dysfunctions that are revealed only under challenging conditions. ..
  48. Tiebel O, Oka K, Robinson K, Sullivan M, Martinez J, Nakamuta M, et al. Mouse very low-density lipoprotein receptor (VLDLR): gene structure, tissue-specific expression and dietary and developmental regulation. Atherosclerosis. 1999;145:239-51 pubmed
    The very low density lipoprotein receptor (VLDLR) is a multifunctional apolipoprotein (apo) E receptor that shares a common structural feature as well as some ligand specificity to apo E with members of the low density lipoprotein ..
  49. Spies T, DeMars R. Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter. Nature. 1991;351:323-4 pubmed
    ..No similar effect was observed in 721.174 mutant cells, in which a homozygous deletion includes PSF among several other closely linked genes. At least one of these genes may therefore also be required for PSF function. ..
  50. Rahman T, Taha A, Song B, Orr S, Liu Z, Chen C, et al. The very low density lipoprotein receptor is not necessary for maintaining brain polyunsaturated fatty acid concentrations. Prostaglandins Leukot Essent Fatty Acids. 2010;82:141-5 pubmed publisher
    ..Our study tested whether the very low density lipoprotein receptor (VLDLr) is necessary for maintaining brain PUFA and cholesterol concentrations...
  51. Hevner R, Shi L, Justice N, Hsueh Y, Sheng M, Smiga S, et al. Tbr1 regulates differentiation of the preplate and layer 6. Neuron. 2001;29:353-66 pubmed
    ..These results show that Tbr1 is a common genetic determinant for the differentiation of early-born glutamatergic neocortical neurons and provide insights into the functions of these neurons as regulators of cortical development. ..
  52. Roubtsova A, Chamberland A, Marcinkiewicz J, Essalmani R, Fazel A, Bergeron J, et al. PCSK9 deficiency unmasks a sex- and tissue-specific subcellular distribution of the LDL and VLDL receptors in mice. J Lipid Res. 2015;56:2133-42 pubmed publisher
    ..In contrast, in KO female mice, the LDLR is more abundant at the cell surface enterocytes, as is the VLDL receptor (VLDLR) at the cell surface of adipocytes...
  53. Hellwig S, Hack I, Zucker B, Brunne B, Junghans D. Reelin together with ApoER2 regulates interneuron migration in the olfactory bulb. PLoS ONE. 2012;7:e50646 pubmed publisher
    ..Reelin and components of its signaling cascade, the lipoprotein receptors ApoER2 and Vldlr and the intracellular adapter protein Dab1 are pivotal for a correct layer formation during corticogenesis...
  54. Qiao L, Yoo H, Madon A, Kinney B, Hay W, Shao J. Adiponectin enhances mouse fetal fat deposition. Diabetes. 2012;61:3199-207 pubmed publisher
    ..Together, our study indicates that adiponectin enhances fetal fat deposition and plays an important role in maternal obesity-induced high birth weight. ..
  55. Chen Y, Hu Y, Lu K, Flannery J, Ma J. Very low density lipoprotein receptor, a negative regulator of the wnt signaling pathway and choroidal neovascularization. J Biol Chem. 2007;282:34420-8 pubmed
    ..b>Very low density lipoprotein receptor gene knock-out (Vldlr(-/-)) mice have been shown to develop subretinal neovascularization (NV) ..
  56. Nguyen A, Tao H, Metrione M, Hajri T. Very low density lipoprotein receptor (VLDLR) expression is a determinant factor in adipose tissue inflammation and adipocyte-macrophage interaction. J Biol Chem. 2014;289:1688-703 pubmed publisher
    ..Previously, we have shown that very low density lipoprotein receptor (VLDLR) is virtually absent in preadipocytes but is strongly induced during adipogenesis and ..
  57. Xia C, Lu E, Zeng J, Gong X. Deletion of LRP5 in VLDLR knockout mice inhibits retinal neovascularization. PLoS ONE. 2013;8:e75186 pubmed publisher
    ..of the low-density lipoprotein receptor-related protein 5 (LRP5) and the very low-density lipoprotein receptor (VLDLR) mutant mice indicate that LRP5 mediates a pro-angiogenic signal while VLDLR mediates an anti-angiogenic signal in ..
  58. Du Y, Yang M, Wei W, Huynh H, Herz J, Saghatelian A, et al. Macrophage VLDL receptor promotes PAFAH secretion in mother's milk and suppresses systemic inflammation in nursing neonates. Nat Commun. 2012;3:1008 pubmed publisher
    ..b>VLDL receptor deletion significantly impairs the expression of phospholipase A2 group 7 (Pla2g7) in macrophages, which ..
  59. Vaillend C, Poirier R, Laroche S. Genes, plasticity and mental retardation. Behav Brain Res. 2008;192:88-105 pubmed publisher
  60. de Haan W, Out R, Berbee J, van der Hoogt C, van Dijk K, Van Berkel T, et al. Apolipoprotein CI inhibits scavenger receptor BI and increases plasma HDL levels in vivo. Biochem Biophys Res Commun. 2008;377:1294-8 pubmed publisher
    ..We conclude that apoCI is a novel inhibitor of SR-BI in vitro and increases HDL levels in vivo. ..
  61. Deane R, Sagare A, Hamm K, Parisi M, Lane S, Finn M, et al. apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. J Clin Invest. 2008;118:4002-13 pubmed publisher
    ..apoE4 redirected the rapid clearance of free Abeta40/42 from the LDL receptor-related protein 1 (LRP1) to the VLDL receptor (VLDLR), which internalized apoE4 and Abeta-apoE4 complexes at the BBB more slowly than LRP1...
  62. Lighthouse J, Zhang L, Hsieh J, Rosenquist T, Holdener B. MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm. Dev Dyn. 2011;240:577-88 pubmed publisher
    ..Combined, our results provide evidence that MESD functions as a general LRP chaperone and suggest that the Mesd phenotype results from both signaling and endocytic defects resulting from misfolding of multiple LRP receptors...
  63. Tao H, Hajri T. Very low density lipoprotein receptor promotes adipocyte differentiation and mediates the proadipogenic effect of peroxisome proliferator-activated receptor gamma agonists. Biochem Pharmacol. 2011;82:1950-62 pubmed publisher
    b>Very low density lipoprotein receptor (VLDLR) is a member of the low density receptor family, expressed mostly in adipose tissue, heart, and skeletal muscles...
  64. Barr A, Fish K, Markou A. The reelin receptors VLDLR and ApoER2 regulate sensorimotor gating in mice. Neuropharmacology. 2007;52:1114-23 pubmed
    ..is known, however, about the involvement of the two receptors for reelin, Very-Low-Density Lipoprotein Receptor (VLDLR) and Apolipoprotein E Receptor 2 (ApoER2), on pre-cognitive processes of relevance to deficits seen in ..
  65. Jones C, Hammer R, Li W, Cohen J, Hobbs H, Herz J. Normal sorting but defective endocytosis of the low density lipoprotein receptor in mice with autosomal recessive hypercholesterolemia. J Biol Chem. 2003;278:29024-30 pubmed
    ..Taken together, these results are consistent with ARH playing a critical and specific role in LDLR endocytosis in the liver. ..
  66. Perman J, Boström P, Lindbom M, Lidberg U, Ståhlman M, Hagg D, et al. The VLDL receptor promotes lipotoxicity and increases mortality in mice following an acute myocardial infarction. J Clin Invest. 2011;121:2625-40 pubmed publisher
    ..accumulation of lipids in HL-1 cardiomyocytes and mouse hearts is dependent on expression of the VLDL receptor (VLDLR)...
  67. Sun Y, Liu C, SanGiovanni J, Evans L, Tian K, Zhang B, et al. Nuclear receptor RORα regulates pathologic retinal angiogenesis by modulating SOCS3-dependent inflammation. Proc Natl Acad Sci U S A. 2015;112:10401-6 pubmed publisher
    ..in both oxygen-induced retinopathy and another angiogenic model of very-low-density lipoprotein receptor (Vldlr)-deficient (Vldlr (-/-) ) mice with spontaneous subretinal neovascularization, whereas a RORα agonist worsened ..
  68. McEvilly R, de Diaz M, Schonemann M, Hooshmand F, Rosenfeld M. Transcriptional regulation of cortical neuron migration by POU domain factors. Science. 2002;295:1528-32 pubmed
  69. Epifano O, Liang L, Dean J. Mouse Zp1 encodes a zona pellucida protein homologous to egg envelope proteins in mammals and fish. J Biol Chem. 1995;270:27254-8 pubmed
  70. Lutter S, Xie S, Tatin F, Makinen T. Smooth muscle-endothelial cell communication activates Reelin signaling and regulates lymphatic vessel formation. J Cell Biol. 2012;197:837-49 pubmed publisher
  71. Schnaufer C, Breer H, Fleischer J. Outgrowing olfactory axons contain the Reelin receptor VLDLR and navigate through the Reelin-rich cribriform mesenchyme. Cell Tissue Res. 2009;337:393-406 pubmed publisher
    ..Importantly, these axons were found to be endowed with the Reelin receptor very-low-density lipoprotein receptor (VLDLR)...
  72. Luque J, Morante Oria J, Fairen A. Localization of ApoER2, VLDLR and Dab1 in radial glia: groundwork for a new model of reelin action during cortical development. Brain Res Dev Brain Res. 2003;140:195-203 pubmed
    ..Here we provide evidence that the reelin receptor machinery, including the lipoprotein receptors ApoER2 and VLDLR along with the cytoplasmic adaptor protein Dab1, is located in radial glia precursors whose processes span the ..
  73. Gao Y, Shen W, Lu B, Zhang Q, Hu Y, Chen Y. Upregulation of hepatic VLDLR via PPAR? is required for the triglyceride-lowering effect of fenofibrate. J Lipid Res. 2014;55:1622-33 pubmed publisher
    The liver and the VLDL receptor (VLDLR) play major roles in TG and VLDL metabolism. However, the exact role of liver VLDLR is not well known because of the absence of or difficulty in detecting VLDLR in the liver...
  74. Leeb C, Eresheim C, Nimpf J. Clusterin is a ligand for apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR) and signals via the Reelin-signaling pathway. J Biol Chem. 2014;289:4161-72 pubmed publisher
    ..Here we report, that clusterin binds to apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR) and is internalized by cells expressing either one of these receptors...
  75. Palmesino E, Rousso D, Kao T, Klar A, Laufer E, Uemura O, et al. Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling. PLoS Biol. 2010;8:e1000446 pubmed publisher
    ..Together, these observations point to identical transcription factors that control motor axon guidance and soma migration and reveal the molecular hierarchy of myotopic organisation. ..
  76. Akopians A, Babayan A, Beffert U, Herz J, Basbaum A, Phelps P. Contribution of the Reelin signaling pathways to nociceptive processing. Eur J Neurosci. 2008;27:523-37 pubmed publisher
    The reeler gene encodes Reelin, a secreted glycoprotein that binds to the very-low-density lipoprotein receptor (Vldlr) and apolipoprotein E receptor 2 (Apoer 2), and induces Src- and Fyn-mediated tyrosine phosphorylation of the ..