Gene Symbol: Vim
Description: vimentin
Alias: vimentin
Species: mouse
Products:     Vim

Top Publications

  1. Lepekhin E, Eliasson C, Berthold C, Berezin V, Bock E, Pekny M. Intermediate filaments regulate astrocyte motility. J Neurochem. 2001;79:617-25 pubmed
    ..following brain or spinal cord injury is impaired in mice deficient in glial fibrillary acidic protein and vimentin. These mice lack IFs in reactive astrocytes that are normally pivotal in the wound repair process...
  2. Goto H, Tanabe K, Manser E, Lim L, Yasui Y, Inagaki M. Phosphorylation and reorganization of vimentin by p21-activated kinase (PAK). Genes Cells. 2002;7:91-7 pubmed
    Intermediate filament (IF) is one of the three major cytoskeletal filaments. Vimentin is the most widely expressed IF protein component...
  3. Li B, Zheng Y, Sano Y, Taniguchi H. Evidence for mesenchymal-epithelial transition associated with mouse hepatic stem cell differentiation. PLoS ONE. 2011;6:e17092 pubmed publisher
    ..epithelial markers such as Cytokeratin18 and E-cadherin increase, while expression of mesenchymal markers such as vimentin and N-cadherin decreased. On the other hand, in freshly isolated hepatic stem cells, the majority of cells (65...
  4. Wilhelmsson U, Faiz M, de Pablo Y, Sjöqvist M, Andersson D, Widestrand A, et al. Astrocytes negatively regulate neurogenesis through the Jagged1-mediated Notch pathway. Stem Cells. 2012;30:2320-9 pubmed publisher
    ..of neural progenitor cells when cocultured with astrocytes lacking glial fibrillary acidic protein (GFAP) and vimentin (GFAP(-/-) Vim(-/-) )...
  5. Goto H, Yasui Y, Kawajiri A, Nigg E, Terada Y, Tatsuka M, et al. Aurora-B regulates the cleavage furrow-specific vimentin phosphorylation in the cytokinetic process. J Biol Chem. 2003;278:8526-30 pubmed
    ..We previously demonstrated the possible existence of a protein kinase that phosphorylates at least Ser-72 on vimentin, the most widely expressed intermediate filament protein, in the cleavage furrow-specific manner...
  6. Menet V, Prieto M, Privat A, Gimenez y Ribotta M. Axonal plasticity and functional recovery after spinal cord injury in mice deficient in both glial fibrillary acidic protein and vimentin genes. Proc Natl Acad Sci U S A. 2003;100:8999-9004 pubmed
    ..We generated mice knock-out for glial fibrillary acidic protein and vimentin, the major proteins of the astrocyte cytoskeleton, which are upregulated in reactive astrocytes...
  7. Perlson E, Hanz S, Ben Yaakov K, Segal Ruder Y, Seger R, Fainzilber M. Vimentin-dependent spatial translocation of an activated MAP kinase in injured nerve. Neuron. 2005;45:715-26 pubmed
    ..nerve axoplasm upon nerve injury, concomitantly with the production of soluble forms of the intermediate filament vimentin by local translation and calpain cleavage in axoplasm...
  8. Eliasson C, Sahlgren C, Berthold C, Stakeberg J, Celis J, Betsholtz C, et al. Intermediate filament protein partnership in astrocytes. J Biol Chem. 1999;274:23996-4006 pubmed
    ..Astrocytes may express three types of intermediate filament proteins: glial fibrillary acidic protein (GFAP), vimentin, and nestin...
  9. Jing R, Wilhelmsson U, Goodwill W, Li L, Pan Y, Pekny M, et al. Synemin is expressed in reactive astrocytes in neurotrauma and interacts differentially with vimentin and GFAP intermediate filament networks. J Cell Sci. 2007;120:1267-77 pubmed
    ..contain synemin and three other intermediate filament (IF) proteins: glial fibrillary acidic protein (GFAP), vimentin and nestin...

More Information


  1. Colucci Guyon E, Gimenez y Ribotta M, Maurice T, Babinet C, Privat A. Cerebellar defect and impaired motor coordination in mice lacking vimentin. Glia. 1999;25:33-43 pubmed
    b>Vimentin belongs to the family of intermediate filament (IF) proteins...
  2. Ding M, Eliasson C, Betsholtz C, Hamberger A, Pekny M. Altered taurine release following hypotonic stress in astrocytes from mice deficient for GFAP and vimentin. Brain Res Mol Brain Res. 1998;62:77-81 pubmed
    ..type mice were compared with cells from mice deficient for either glial fibrillary acidic protein (GFAP-/-) or vimentin (vimentin-/-) and with astrocytes from mice deficient for both proteins (GFAP-/-vim-/-)...
  3. Rasin M, Gazula V, Breunig J, Kwan K, Johnson M, Liu Chen S, et al. Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors. Nat Neurosci. 2007;10:819-27 pubmed
    ..Thus, by regulating RGC adhesion and polarity, Numb and Numbl are required for the tissue architecture of neurogenic niches and the cerebral cortex. ..
  4. Barberis L, Pasquali C, Bertschy Meier D, Cuccurullo A, Costa C, Ambrogio C, et al. Leukocyte transmigration is modulated by chemokine-mediated PI3Kgamma-dependent phosphorylation of vimentin. Eur J Immunol. 2009;39:1136-46 pubmed publisher
    ..Among the proteins analyzed, the intermediate filament vimentin was found as a downstream effector of the PI3Kgamma signaling pathway...
  5. Galou M, Colucci Guyon E, Ensergueix D, Ridet J, Gimenez y Ribotta M, Privat A, et al. Disrupted glial fibrillary acidic protein network in astrocytes from vimentin knockout mice. J Cell Biol. 1996;133:853-63 pubmed
    ..during development and in reactive astrocytes has revealed an intricate relationship with the expression of vimentin, another intermediate filament protein widely expressed in embryonic development...
  6. Ekmark Lewén S, Lewén A, Israelsson C, Li G, Farooque M, Olsson Y, et al. Vimentin and GFAP responses in astrocytes after contusion trauma to the murine brain. Restor Neurol Neurosci. 2010;28:311-21 pubmed publisher
    ..The aims for this study were to compare the temporal and spatial expression pattern of vimentin- and glial fibrillary acidic protein (GFAP) in a weight drop model of mild cerebral contusion injury in the rat...
  7. Burgstaller G, Gregor M, Winter L, Wiche G. Keeping the vimentin network under control: cell-matrix adhesion-associated plectin 1f affects cell shape and polarity of fibroblasts. Mol Biol Cell. 2010;21:3362-75 pubmed publisher
    ..mature FAs and their derivative fibronectin fibril-aligned fibrillar adhesions (FbAs) serve as docking sites for vimentin intermediate filaments (IFs) in a plectin isoform 1f (P1f)-dependent manner...
  8. Macauley S, Pekny M, Sands M. The role of attenuated astrocyte activation in infantile neuronal ceroid lipofuscinosis. J Neurosci. 2011;31:15575-85 pubmed publisher
    ..We hypothesized that preventing GFAP and vimentin upregulation in reactive astrocytes will alter the CNS disease...
  9. Nakazawa T, Takeda M, Lewis G, Cho K, Jiao J, Wilhelmsson U, et al. Attenuated glial reactions and photoreceptor degeneration after retinal detachment in mice deficient in glial fibrillary acidic protein and vimentin. Invest Ophthalmol Vis Sci. 2007;48:2760-8 pubmed
    ..astrocytes and Müller cells) to retinal injury in mice that lack glial fibrillary acidic protein (GFAP) and vimentin (GFAP-/-Vim-/-) and to determine the role of glial cells in retinal detachment (RD)-induced photoreceptor ..
  10. Bornheim R, Muller M, Reuter U, Herrmann H, Bussow H, Magin T. A dominant vimentin mutant upregulates Hsp70 and the activity of the ubiquitin-proteasome system, and causes posterior cataracts in transgenic mice. J Cell Sci. 2008;121:3737-46 pubmed publisher
    b>Vimentin is the main intermediate filament (IF) protein of mesenchymal cells and tissues. Unlike other IF-/- mice, vimentin-/- mice provided no evidence of an involvement of vimentin in the development of a specific disease...
  11. Nieminen M, Henttinen T, Merinen M, Marttila Ichihara F, Eriksson J, Jalkanen S. Vimentin function in lymphocyte adhesion and transcellular migration. Nat Cell Biol. 2006;8:156-62 pubmed
    ..The initiation of this process was markedly reduced in vimentin-deficient (vim(-/-)) PBMCs and endothelial cells...
  12. Cho K, Yang L, Lu B, Feng Ma H, Huang X, Pekny M, et al. Re-establishing the regenerative potential of central nervous system axons in postnatal mice. J Cell Sci. 2005;118:863-72 pubmed
    ..These results suggest that an early postnatal downregulation of Bcl-2 and post-traumatic reactive gliosis are two important elements of axon regenerative failure in the CNS. ..
  13. Ando S, Tanabe K, Gonda Y, Sato C, Inagaki M. Domain- and sequence-specific phosphorylation of vimentin induces disassembly of the filament structure. Biochemistry. 1989;28:2974-9 pubmed
    ..stoichiometric phosphorylation by either cAMP-dependent protein kinase or protein kinase C induces disassembly of vimentin filaments [Inagaki, M., Nishi, Y., Nishizawa, K., Matsuyama, M., & Sato, C...
  14. Takemura M, Gomi H, Colucci Guyon E, Itohara S. Protective role of phosphorylation in turnover of glial fibrillary acidic protein in mice. J Neurosci. 2002;22:6972-9 pubmed
    ..cultured astrocytes indicated that the Hm3-GFAP encoded by Gfap(hm3) was unstable particularly in the absence of vimentin, another IF protein...
  15. Tolstonog G, Shoeman R, Traub U, Traub P. Role of the intermediate filament protein vimentin in delaying senescence and in the spontaneous immortalization of mouse embryo fibroblasts. DNA Cell Biol. 2001;20:509-29 pubmed
    Because knockout of the vimentin gene in mice did not produce an immediately obvious, overt, or lethal specific phenotype, the conjecture was made that the mutation affects some subtle cellular functions whose loss manifests itself only ..
  16. Andrae J, Bongcam Rudloff E, Hansson I, Lendahl U, Westermark B, Nister M. A 1.8kb GFAP-promoter fragment is active in specific regions of the embryonic CNS. Mech Dev. 2001;107:181-5 pubmed
    ..The results indicate that GFAP activity is regulated in a region-specific manner during central nervous system (CNS) development and that the gene is turned on in different cell types independently. ..
  17. Jackson B, Grund C, Schmid E, Burki K, Franke W, Illmensee K. Formation of cytoskeletal elements during mouse embryogenesis. Intermediate filaments of the cytokeratin type and desmosomes in preimplantation embryos. Differentiation. 1980;17:161-79 pubmed
  18. McCall M, Gregg R, Behringer R, Brenner M, Delaney C, Galbreath E, et al. Targeted deletion in astrocyte intermediate filament (Gfap) alters neuronal physiology. Proc Natl Acad Sci U S A. 1996;93:6361-6 pubmed
    ..These mice therefore represent a direct demonstration that a primary defect in astrocytes influences neuronal physiology. ..
  19. Terzi F, Henrion D, Colucci Guyon E, Federici P, Babinet C, Levy B, et al. Reduction of renal mass is lethal in mice lacking vimentin. Role of endothelin-nitric oxide imbalance. J Clin Invest. 1997;100:1520-8 pubmed
    ..Disruption, by homologous recombination, of the gene encoding vimentin, a class III intermediate filament protein mainly expressed in vascular cells, was reported to result in ..
  20. Li Z, Mericskay M, Agbulut O, Butler Browne G, Carlsson L, Thornell L, et al. Desmin is essential for the tensile strength and integrity of myofibrils but not for myogenic commitment, differentiation, and fusion of skeletal muscle. J Cell Biol. 1997;139:129-44 pubmed
    ..The lack of desmin was not compensated by an upregulation of vimentin in these mice either during development or regeneration...
  21. Mamber C, Kamphuis W, Haring N, Peprah N, Middeldorp J, Hol E. GFAP? expression in glia of the developmental and adolescent mouse brain. PLoS ONE. 2012;7:e52659 pubmed publisher
    ..During development, GFAP? is expressed by radial glia, as denoted by the co-expression of markers like vimentin and nestin. GFAP? is also expressed in other astrocytic populations during development...
  22. Colucci Guyon E, Portier M, Dunia I, Paulin D, Pournin S, Babinet C. Mice lacking vimentin develop and reproduce without an obvious phenotype. Cell. 1994;79:679-94 pubmed
    To address the biological role of vimentin in the context of the living organism, we have introduced a null mutation of the vimentin gene into the germ line of mice...
  23. Lu Y, Iandiev I, Hollborn M, Körber N, Ulbricht E, Hirrlinger P, et al. Reactive glial cells: increased stiffness correlates with increased intermediate filament expression. FASEB J. 2011;25:624-31 pubmed publisher of dissociated single glial cells in wild-type mice, mice lacking glial fibrillary acidic protein and vimentin (GFAP(-/-)Vim(-/-)) in which glial cells are consequently devoid of IFs, and normal Long-Evans rats...
  24. Potokar M, Stenovec M, Gabrijel M, Li L, Kreft M, Grilc S, et al. Intermediate filaments attenuate stimulation-dependent mobility of endosomes/lysosomes in astrocytes. Glia. 2010;58:1208-19 pubmed publisher astrocytes, derived from either wild-type (WT) mice or mice deficient in glial fibrillary acidic protein and vimentin (GFAP(-/-)Vim(-/-)), the latter lacking astrocyte IFs...
  25. Levin E, Acharya N, Sedeyn J, Venkataraman V, D Andrea M, Wang H, et al. Neuronal expression of vimentin in the Alzheimer's disease brain may be part of a generalized dendritic damage-response mechanism. Brain Res. 2009;1298:194-207 pubmed publisher, we used single- and double-label immunohistochemistry to investigate the relationship between neuronal vimentin expression and local brain pathology...
  26. Bultje R, Castaneda Castellanos D, Jan L, Jan Y, Kriegstein A, Shi S. Mammalian Par3 regulates progenitor cell asymmetric division via notch signaling in the developing neocortex. Neuron. 2009;63:189-202 pubmed publisher
    ..These results reveal a critical molecular pathway underlying asymmetric cell division of radial glial progenitors in the mammalian neocortex. ..
  27. Pawlisz A, Mutch C, Wynshaw Boris A, Chenn A, Walsh C, Feng Y. Lis1-Nde1-dependent neuronal fate control determines cerebral cortical size and lamination. Hum Mol Genet. 2008;17:2441-55 pubmed publisher
    ..Our data suggest that maintaining the shape and cell-cell interactions of radial glial neuroepithelial progenitors by the Lis1-Nde1 complex is essential for their self renewal during the early phase of corticogenesis. ..
  28. Pekny M, Johansson C, Eliasson C, Stakeberg J, Wallen A, Perlmann T, et al. Abnormal reaction to central nervous system injury in mice lacking glial fibrillary acidic protein and vimentin. J Cell Biol. 1999;145:503-14 pubmed
    ..and express high levels of the intermediate filament (IF) proteins glial fibrillary acidic protein (GFAP), vimentin, and nestin...
  29. Ivaska J, Vuoriluoto K, Huovinen T, Izawa I, Inagaki M, Parker P. PKCepsilon-mediated phosphorylation of vimentin controls integrin recycling and motility. EMBO J. 2005;24:3834-45 pubmed
    ..b>Vimentin, an intermediate filament protein upregulated upon epithelial cell transformation, is shown here to be a proximal ..
  30. Foley J, Dann P, Hong J, Cosgrove J, Dreyer B, Rimm D, et al. Parathyroid hormone-related protein maintains mammary epithelial fate and triggers nipple skin differentiation during embryonic breast development. Development. 2001;128:513-25 pubmed
    ..Finally, PTHrP signaling regulates the epidermal and mesenchymal expression of LEF1 and (&bgr;)-catenin, suggesting that these changes in cell fate involve an interaction between the PTHrP and Wnt signaling pathways. ..
  31. Shime H, Ohnishi T, Nagao K, Oka K, Takao T, Horiguchi Y. Association of Pasteurella multocida toxin with vimentin. Infect Immun. 2002;70:6460-3 pubmed
    ..This protein was identified as vimentin by peptide mass fingerprinting...
  32. Larsson A, Wilhelmsson U, Pekna M, Pekny M. Increased cell proliferation and neurogenesis in the hippocampal dentate gyrus of old GFAP(-/-)Vim(-/-) mice. Neurochem Res. 2004;29:2069-73 pubmed
    ..and increase their expression of the intermediate filament proteins glial fibrillary acidic protein (GFAP) and vimentin. Studies of mice deficient in astrocytic intermediate filaments have provided insights into the function of ..
  33. Eckes B, Colucci Guyon E, Smola H, Nodder S, Babinet C, Krieg T, et al. Impaired wound healing in embryonic and adult mice lacking vimentin. J Cell Sci. 2000;113 ( Pt 13):2455-62 pubmed
    It is generally assumed that the vimentin intermediate filament network present in most mesenchymally-derived cells is in part responsible for the strength and integrity of these cells, and necessary for any tissue movements that require ..
  34. Gerashchenko M, Chernoivanenko I, Moldaver M, Minin A. Dynein is a motor for nuclear rotation while vimentin IFs is a "brake". Cell Biol Int. 2009;33:1057-64 pubmed publisher
    ..We used a vimentin-null cell line, MFT-16, which shows extensive nuclear rotation to study the phenomenon in detail...
  35. Spurny R, Gregor M, Castañón M, Wiche G. Plectin deficiency affects precursor formation and dynamics of vimentin networks. Exp Cell Res. 2008;314:3570-80 pubmed publisher
    ..One of the most important binding partners of plectin in fibroblasts is the intermediate filament subunit protein vimentin. Previous studies have demonstrated that vimentin networks are highly dynamic structures whose assembly and ..
  36. Eckes B, Dogic D, Colucci Guyon E, Wang N, Maniotis A, Ingber D, et al. Impaired mechanical stability, migration and contractile capacity in vimentin-deficient fibroblasts. J Cell Sci. 1998;111 ( Pt 13):1897-907 pubmed
    Loss of a vimentin network due to gene disruption created viable mice that did not differ overtly from wild-type littermates...
  37. Ha B, King J. Localization of gp130 in the developing and adult mouse cerebellum. J Chem Neuroanat. 2000;19:129-41 pubmed
    ..The present description of the differential spatial and temporal distribution of gp130 provides an initial step in defining specific cellular populations that are potential targets of IL-6 type cytokines during cerebellar ontogeny. ..
  38. Tao H, Shimizu M, Kusumoto R, Ono K, Noji S, Ohuchi H. A dual role of FGF10 in proliferation and coordinated migration of epithelial leading edge cells during mouse eyelid development. Development. 2005;132:3217-30 pubmed
  39. Lian N, Lin T, Liu W, Wang W, Li L, Sun S, et al. Transforming growth factor ? suppresses osteoblast differentiation via the vimentin activating transcription factor 4 (ATF4) axis. J Biol Chem. 2012;287:35975-84 pubmed publisher
    ATF4 is an osteoblast-enriched transcription factor of the leucine zipper family. We recently identified that vimentin, a leucine zipper-containing intermediate filament protein, suppresses ATF4-dependent osteocalcin (Ocn) transcription ..
  40. Eiraku M, Tohgo A, Ono K, Kaneko M, Fujishima K, Hirano T, et al. DNER acts as a neuron-specific Notch ligand during Bergmann glial development. Nat Neurosci. 2005;8:873-80 pubmed
    ..Thus, DNER mediates neuron-glia interaction and promotes morphological differentiation of Bergmann glia through Deltex-dependent Notch signaling. ..
  41. Wang X, Tolstonog G, Shoeman R, Traub P. Selective binding of specific mouse genomic DNA fragments by mouse vimentin filaments in vitro. DNA Cell Biol. 1996;15:209-25 pubmed
    Mouse vimentin intermediate filaments (IFs) reconstituted in vitro were analyzed for their capacity to select certain DNA sequences from a mixture of about 500-bp-long fragments of total mouse genomic DNA...
  42. Schietke R, Bröhl D, Wedig T, Mücke N, Herrmann H, Magin T. Mutations in vimentin disrupt the cytoskeleton in fibroblasts and delay execution of apoptosis. Eur J Cell Biol. 2006;85:1-10 pubmed
    To get new insights into the function of the intermediate filament (IF) protein vimentin in cell physiology, we generated two mutant cDNAs, one with a point mutation in the consensus motif in coil1A (R113C) and one with the complete ..
  43. Ojala J, Pikkarainen T, Elmberger G, Tryggvason K. Progressive reactive lymphoid connective tissue disease and development of autoantibodies in scavenger receptor A5-deficient mice. Am J Pathol. 2013;182:1681-95 pubmed publisher
    ..These disturbances are reminiscent of those found in many human autoimmune connective tissue disorders, which suggests that defects in fibroblast SCARA5 can underlie some forms of autoimmune disease. ..
  44. Li W, Xiong Y, Shang C, Twu K, Hang C, Yang J, et al. Brg1 governs distinct pathways to direct multiple aspects of mammalian neural crest cell development. Proc Natl Acad Sci U S A. 2013;110:1738-43 pubmed publisher
    ..Our findings reveal an important role for Brg1 and its downstream pathways in the survival, differentiation, and migration of the multipotent NCCs critical for mammalian cardiovascular development. ..
  45. VanDussen K, Samuelson L. Mouse atonal homolog 1 directs intestinal progenitors to secretory cell rather than absorptive cell fate. Dev Biol. 2010;346:215-23 pubmed publisher
    ..Thus, Math1 is a key effector directing multipotential precursors to adopt secretory and not absorptive cell fate. ..
  46. Scherholz P, de Souza P, Spadacci Morena D, Katz S. Vimentin is synthesized by mouse vascular trophoblast giant cells from embryonic day 7.5 onwards and is a characteristic factor of these cells. Placenta. 2013;34:518-25 pubmed publisher
    ..Although we previously showed vimentin in mouse antimesometrial TGC at embryonic days (E) 8.5-10...
  47. Wessels A, van den Hoff M, Adamo R, Phelps A, Lockhart M, Sauls K, et al. Epicardially derived fibroblasts preferentially contribute to the parietal leaflets of the atrioventricular valves in the murine heart. Dev Biol. 2012;366:111-24 pubmed publisher
  48. Chandramouli A, Simundza J, PINDERHUGHES A, Hiremath M, Droguett G, Frendewey D, et al. Ltbp1L is focally induced in embryonic mammary mesenchyme, demarcates the ductal luminal lineage and is upregulated during involution. Breast Cancer Res. 2013;15:R111 pubmed publisher
    ..We hypothesize that Ltbp1 functions in a mechanosensory capacity to establish and maintain ductal luminal cell fate, support and detect ductal distension, trigger irreversible involution, and facilitate nipple sphincter function. ..
  49. Ando S, Nakao K, Gohara R, Takasaki Y, Suehiro K, Oishi Y. Morphological analysis of glutaraldehyde-fixed vimentin intermediate filaments and assembly-intermediates by atomic force microscopy. Biochim Biophys Acta. 2004;1702:53-65 pubmed
    Atomic force microscopy (AFM) was used to study the morphology of vimentin intermediate filaments (IFs) and their assembly intermediates...
  50. Aoki K, Osumi Yamashita N, Ninomiya Y, Eto K. Differential expression of N-CAM, vimentin and MAP1B during initial pathfinding of olfactory receptor neurons in the mouse embryo. Anat Embryol (Berl). 1995;192:211-20 pubmed
    ..In the present study, expression of neuronal markers (vimentin and MAP1B) and N-CAM was immunohistochemically investigated in the development of the olfactory system in mouse ..
  51. Katoh Fukui Y, Owaki A, Toyama Y, Kusaka M, Shinohara Y, Maekawa M, et al. Mouse Polycomb M33 is required for splenic vascular and adrenal gland formation through regulating Ad4BP/SF1 expression. Blood. 2005;106:1612-20 pubmed
    ..In agreement with these observations, chromatin immunoprecipitation assays with adrenocortical Y-1 cells revealed direct binding of the M33-containing PcG to the Ad4BP/SF1 gene locus. ..
  52. Bidkar M, Vassallo R, Luckey D, Smart M, Mouapi K, Taneja V. Cigarette Smoke Induces Immune Responses to Vimentin in both, Arthritis-Susceptible and -Resistant Humanized Mice. PLoS ONE. 2016;11:e0162341 pubmed publisher
    ..In this study, we determined whether the response to a known autoantigen, Vimentin (Vim) is shared epitope specific and how CS influences this response using transgenic-mice carrying RA-..
  53. Tsunekawa Y, Britto J, Takahashi M, Polleux F, Tan S, Osumi N. Cyclin D2 in the basal process of neural progenitors is linked to non-equivalent cell fates. EMBO J. 2012;31:1879-92 pubmed publisher
    ..We demonstrate that Cyclin D2 is also expressed in the developing human cortex within similar domains, thus indicating that its role as a fate determinant is ancient and conserved. ..
  54. Formstone C, Moxon C, Murdoch J, Little P, Mason I. Basal enrichment within neuroepithelia suggests novel function(s) for Celsr1 protein. Mol Cell Neurosci. 2010;44:210-22 pubmed publisher
    ..Together, these data raise compelling new questions concerning the role of Celsr1 during neural development. ..
  55. van Berlo J, Kanisicak O, Maillet M, Vagnozzi R, Karch J, Lin S, et al. c-kit+ cells minimally contribute cardiomyocytes to the heart. Nature. 2014;509:337-41 pubmed publisher
    ..008. By contrast, c-kit(+) cells amply generated cardiac endothelial cells. Thus, endogenous c-kit(+) cells can generate cardiomyocytes within the heart, although probably at a functionally insignificant level. ..
  56. Dave J, Bayless K. Vimentin as an integral regulator of cell adhesion and endothelial sprouting. Microcirculation. 2014;21:333-44 pubmed publisher
    ..b>Vimentin, a major type III intermediate filament protein is expressed in endothelial and other mesenchymal cells...
  57. Dvoriantchikova G, Tao W, Pappas S, Gaidosh G, Tse D, Ivanov D, et al. Molecular Profiling of the Developing Lacrimal Gland Reveals Putative Role of Notch Signaling in Branching Morphogenesis. Invest Ophthalmol Vis Sci. 2017;58:1098-1109 pubmed publisher
    ..Our data also supports the hypothesis that NOTCH signaling regulates branching morphogenesis in the developing lacrimal gland by suppressing cleft formation. ..
  58. Sugiyama Y, Koike T, Shiojiri N. Developmental changes of cell adhesion molecule expression in the fetal mouse liver. Anat Rec (Hoboken). 2010;293:1698-710 pubmed publisher
    ..These results suggest that each cell adhesion molecule may play an important role during development in hepatic histogenesis, including hepatoblast/hepatocyte-stellate cell interactions, hemopoiesis, and bile duct morphogenesis. ..
  59. Arora H, Boulberdaa M, Qureshi R, Bitirim V, Messadeq N, Dolle P, et al. Prokineticin receptor 1 is required for mesenchymal-epithelial transition in kidney development. FASEB J. 2016;30:2733-40 pubmed publisher
    ..Arora, H., Boulberdaa, M., Qureshi, R., Bitirim, V., Messadeq, N., Dolle, P., Nebigil, C. G. Prokineticin receptor 1 is required for mesenchymal-epithelial transition in kidney development. ..
  60. Shen X, Xi G, Wai C, Clemmons D. The coordinate cellular response to insulin-like growth factor-I (IGF-I) and insulin-like growth factor-binding protein-2 (IGFBP-2) is regulated through vimentin binding to receptor tyrosine phosphatase β (RPTPβ). J Biol Chem. 2015;290:11578-90 pubmed publisher
    ..Proteomic experiments revealed that IGF-I stimulated the intermediate filament protein vimentin to bind to RPTPβ, and knockdown of vimentin resulted in failure of IGFBP-2 and IGF-I to stimulate RPTPβ ..
  61. Gimenez y Ribotta M, Langa F, Menet V, Privat A. Comparative anatomy of the cerebellar cortex in mice lacking vimentin, GFAP, and both vimentin and GFAP. Glia. 2000;31:69-83 pubmed
    In the cerebellum of adult mammals, glial fibrillary acidic protein (GFAP) and vimentin (VIM) are coexpressed in Golgi epithelial cells (GEC), also known as Bergmann glia...
  62. Qu X, Lam E, Doughman Y, Chen Y, Chou Y, Lam M, et al. Cited2, a coactivator of HNF4alpha, is essential for liver development. EMBO J. 2007;26:4445-56 pubmed
    ..Taken together, this study suggests that fetal liver defects in mice lacking Cited2 result, at least in part, from its defective coactivation function for HNF4alpha. ..
  63. Kim I, Ramakrishna S, Gusarova G, Yoder H, Costa R, Kalinichenko V. The forkhead box m1 transcription factor is essential for embryonic development of pulmonary vasculature. J Biol Chem. 2005;280:22278-86 pubmed
    ..In summary, development of mouse lungs depends on the Foxm1 transcription factor, which regulates expression of genes essential for mesenchyme proliferation, extracellular matrix remodeling, and vasculogenesis. ..
  64. Lin L, Chen J, Richardson J, Parada L. Mice lacking neurofibromin develop gastric hyperplasia. Am J Physiol Gastrointest Liver Physiol. 2009;297:G751-61 pubmed publisher
    ..These mice provide a useful model to study the pathogenesis of GI lesions in a subset of patients with NF1 and to investigate the role of the Nf1 gene in the development of GI neoplasms. ..
  65. Youssef K, Lapouge G, Bouvrée K, Rorive S, Brohée S, Appelstein O, et al. Adult interfollicular tumour-initiating cells are reprogrammed into an embryonic hair follicle progenitor-like fate during basal cell carcinoma initiation. Nat Cell Biol. 2012;14:1282-94 pubmed publisher
    ..Deletion of ?-catenin in adult SmoM2-expressing cells prevents EHFP reprogramming and tumour initiation. Finally, human basal cell carcinomas also express genes of the Wnt signalling and EHFP signatures...
  66. Greene S, Gunaratne P, Hammond S, Rosen J. A putative role for microRNA-205 in mammary epithelial cell progenitors. J Cell Sci. 2010;123:606-18 pubmed publisher
    ..Additionally, in normal mouse MECs, high expression of miR-205 was observed in stem-cell-enriched cell populations isolated by FACS using established cell-surface markers. ..
  67. Ando S, Tokui T, Yamauchi T, Sugiura H, Tanabe K, Inagaki M. Evidence that Ser-82 is a unique phosphorylation site on vimentin for Ca2(+)-calmodulin-dependent protein kinase II. Biochem Biophys Res Commun. 1991;175:955-62 pubmed
    We identified the sites on vimentin that are phosphorylated by Ca2(+)-calmodulin-dependent protein kinase II (CaM-kinase II)...
  68. Lund N, Henrion D, Tiede P, Ziche M, Schunkert H, Ito W. Vimentin expression influences flow dependent VASP phosphorylation and regulates cell migration and proliferation. Biochem Biophys Res Commun. 2010;395:401-6 pubmed publisher
    ..Recent studies indicate that the intermediate filament vimentin is necessary for endothelial cell morphogenesis e.g. in the context of leukocyte transmigration...
  69. Matsuoka R, Chivatakarn O, Badea T, SAMUELS I, Cahill H, Katayama K, et al. Class 5 transmembrane semaphorins control selective Mammalian retinal lamination and function. Neuron. 2011;71:460-73 pubmed publisher
    ..These findings define a set of ligands and receptors required for the establishment of inner retinal lamination and function. ..
  70. Nakanishi K, Maruyama M, Shibata T, Morishima N. Identification of a caspase-9 substrate and detection of its cleavage in programmed cell death during mouse development. J Biol Chem. 2001;276:41237-44 pubmed
    ..g. during development. We have identified vimentin as the first example of a caspase-9 substrate that is not a downstream procaspase...