Vegfa

Summary

Gene Symbol: Vegfa
Description: vascular endothelial growth factor A
Alias: Vegf, Vpf, vascular endothelial growth factor A, vascular permeability factor
Species: mouse
Products:     Vegfa

Top Publications

  1. Cesca F, Yabe A, Spencer Dene B, Scholz Starke J, Medrihan L, Maden C, et al. Kidins220/ARMS mediates the integration of the neurotrophin and VEGF pathways in the vascular and nervous systems. Cell Death Differ. 2012;19:194-208 pubmed publisher
    ..membrane spanning) as a main player in the modulation of neurotrophin and vascular endothelial growth factor (VEGF) signaling in vivo, and a primary determinant for neuronal and cardiovascular development...
  2. Benedito R, Rocha S, Woeste M, Zamykal M, Radtke F, Casanovas O, et al. Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling. Nature. 2012;484:110-4 pubmed publisher
    ..Previous work has uncovered that the VEGF and Notch pathways are tightly linked...
  3. Reinert R, Kantz J, Misfeldt A, Poffenberger G, Gannon M, Brissova M, et al. Tamoxifen-Induced Cre-loxP Recombination Is Prolonged in Pancreatic Islets of Adult Mice. PLoS ONE. 2012;7:e33529 pubmed publisher
    ..Therefore, investigators developing experimental approaches using Tm-inducible systems should consider both maximal recombination efficiency and the length of time that Tm-induced Cre-loxP recombination occurs...
  4. Kim J, Evans C, Weidemann A, Takeda N, Lee Y, Stockmann C, et al. Loss of fibroblast HIF-1α accelerates tumorigenesis. Cancer Res. 2012;72:3187-95 pubmed publisher
    ..promoter to create mice in which key hypoxia regulatory genes, including VHL, HIF-1α, HIF-2α, and VEGF-A, were knocked out specifically in tumor stromal fibroblasts...
  5. Lu X, Ji Y, Zhang L, Zhang Y, Zhang S, An Y, et al. Resistance to obesity by repression of VEGF gene expression through induction of brown-like adipocyte differentiation. Endocrinology. 2012;153:3123-32 pubmed publisher
    ..Vascular endothelial growth factor (VEGF)-A is the founding member of the VEGF family and has been found highly expressed in adipose tissue...
  6. Kurihara T, Westenskow P, Bravo S, Aguilar E, Friedlander M. Targeted deletion of Vegfa in adult mice induces vision loss. J Clin Invest. 2012;122:4213-7 pubmed publisher
    ..Here, we show that conditionally knocking out Vegfa in adult mouse retinal pigmented epithelial (RPE) cells, which regulate retinal homeostasis, rapidly leads to ..
  7. Yang Y, Zhang Y, Cao Z, Ji H, Yang X, Iwamoto H, et al. Anti-VEGF- and anti-VEGF receptor-induced vascular alteration in mouse healthy tissues. Proc Natl Acad Sci U S A. 2013;110:12018-23 pubmed publisher
    Systemic therapy with anti-VEGF drugs such as bevacizumab is widely used for treatment of human patients with various solid tumors. However, systemic impacts of such drugs in host healthy vasculatures remain poorly understood...
  8. Fantin A, Herzog B, Mahmoud M, Yamaji M, Plein A, Denti L, et al. Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis. Development. 2014;141:556-62 pubmed publisher
    Neuropilin 1 (NRP1) is a receptor for class 3 semaphorins and vascular endothelial growth factor (VEGF) A and is essential for cardiovascular development...
  9. Parker M, Xu P, Li X, Vander Kooi C. Structural basis for selective vascular endothelial growth factor-A (VEGF-A) binding to neuropilin-1. J Biol Chem. 2012;287:11082-9 pubmed publisher
    Neuropilin-1 (Nrp1) is an essential receptor for angiogenesis that binds to VEGF-A. Nrp1 binds directly to VEGF-A with high affinity, but the nature of their selective binding has remained unclear...

More Information

Publications94

  1. Ueta T, Inoue T, Yuda K, Furukawa T, Yanagi Y, Tamaki Y. Intense physiological light upregulates vascular endothelial growth factor and enhances choroidal neovascularization via peroxisome proliferator-activated receptor ? coactivator-1? in mice. Arterioscler Thromb Vasc Biol. 2012;32:1366-71 pubmed publisher
    ..Toxicity of intense light to facilitate the development of neovascular age-related macular degeneration has been a health concern although the mechanism remains unclear...
  2. Cai Q, Brissova M, Reinert R, Pan F, Brahmachary P, Jeansson M, et al. Enhanced expression of VEGF-A in ? cells increases endothelial cell number but impairs islet morphogenesis and ? cell proliferation. Dev Biol. 2012;367:40-54 pubmed publisher
    ..tet-operon-angiogenic factor transgene) to increase the ? cell production of vascular endothelial growth factor-A (VEGF-A), angiopoietin-1 (Ang1), or angiopoietin-2 (Ang2) during islet cell differentiation and islet development...
  3. Liu F, Lou Y, Wu J, Ruan Q, Xie A, Guo F, et al. Upregulation of microRNA-210 regulates renal angiogenesis mediated by activation of VEGF signaling pathway under ischemia/perfusion injury in vivo and in vitro. Kidney Blood Press Res. 2012;35:182-91 pubmed publisher
    ..CD31 immunostaining indicated a significant increase of microvessels in the ischemic region. VEGF and VEGFR2 expression were increased in renal I/R at both the mRNA and protein levels which were detected by qRT-..
  4. Kim M, Park H, Seol J, Jang J, Cho Y, Kim K, et al. VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodelling during pregnancy. EMBO Mol Med. 2013;5:1415-30 pubmed publisher
    ..Decidual angiogenesis is mainly regulated through VEGF-A secreted from the progesterone receptor (PR)-expressing decidual stromal cells which are largely distributed in ..
  5. Liu J, Copland D, Horie S, Wu W, Chen M, Xu Y, et al. Myeloid cells expressing VEGF and arginase-1 following uptake of damaged retinal pigment epithelium suggests potential mechanism that drives the onset of choroidal angiogenesis in mice. PLoS ONE. 2013;8:e72935 pubmed publisher
    ..Accumulating macrophages from retina and peripheral blood were activated at the site of injury, displaying enhanced VEGF expression, and notably prior to exaggerated VEGF expression from RPE, or earliest stages of angiogenesis...
  6. Argaw A, Asp L, Zhang J, Navrazhina K, Pham T, Mariani J, et al. Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease. J Clin Invest. 2012;122:2454-68 pubmed publisher
    ..Inactivation of astrocytic Vegfa expression reduced BBB breakdown, decreased lymphocyte infiltration and neuropathology in inflammatory and ..
  7. Lu N, Sargent K, Clopton D, Pohlmeier W, Brauer V, McFee R, et al. Loss of vascular endothelial growth factor A (VEGFA) isoforms in the testes of male mice causes subfertility, reduces sperm numbers, and alters expression of genes that regulate undifferentiated spermatogonia. Endocrinology. 2013;154:4790-802 pubmed publisher
    b>Vascular endothelial growth factor A (VEGFA) isoform treatment has been demonstrated to alter spermatogonial stem cell homeostasis...
  8. Willenborg S, Lucas T, Van Loo G, Knipper J, Krieg T, Haase I, et al. CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair. Blood. 2012;120:613-25 pubmed publisher
    ..reporter mouse model with conditional mouse mutants defective in myeloid cell-restricted CCR2 signaling or VEGF-A synthesis, we show herein that among the large number of inflammatory CCR2(+)Ly6C(+) macrophages that dominate ..
  9. Reinert R, Brissova M, Shostak A, Pan F, Poffenberger G, Cai Q, et al. Vascular endothelial growth factor-a and islet vascularization are necessary in developing, but not adult, pancreatic islets. Diabetes. 2013;62:4154-64 pubmed publisher
    Pancreatic islets are highly vascularized mini-organs, and vascular endothelial growth factor (VEGF)-A is a critical factor in the development of islet vascularization...
  10. Rao S, Chun C, Fan J, Kofron J, Yang M, Hegde R, et al. A direct and melanopsin-dependent fetal light response regulates mouse eye development. Nature. 2013;494:243-6 pubmed publisher
    ..neuron number, limits hypoxia and, as a consequence, holds local expression of vascular endothelial growth factor (VEGFA) in check...
  11. Foxton R, Finkelstein A, Vijay S, Dahlmann Noor A, Khaw P, Morgan J, et al. VEGF-A is necessary and sufficient for retinal neuroprotection in models of experimental glaucoma. Am J Pathol. 2013;182:1379-90 pubmed publisher
    b>Vascular endothelial growth factor A (VEGF-A) is a validated therapeutic target in several angiogenic- and vascular permeability-related pathological conditions, including certain cancers and potentially blinding diseases, such as age-..
  12. He L, Marneros A. Macrophages are essential for the early wound healing response and the formation of a fibrovascular scar. Am J Pathol. 2013;182:2407-17 pubmed publisher
    ..express the proangiogenic factor IL-1? strongly, whereas retinal pigment epithelial cells are the main source of VEGF-A...
  13. Feliers D, Duraisamy S, Barnes J, Ghosh Choudhury G, Kasinath B. Translational regulation of vascular endothelial growth factor expression in renal epithelial cells by angiotensin II. Am J Physiol Renal Physiol. 2005;288:F521-9 pubmed
    ..We investigated whether ANG II regulated vascular endothelial growth factor (VEGF) synthesis in proximal tubular epithelial (MCT) cells...
  14. Konopatskaya O, Churchill A, Harper S, Bates D, Gardiner T. VEGF165b, an endogenous C-terminal splice variant of VEGF, inhibits retinal neovascularization in mice. Mol Vis. 2006;12:626-32 pubmed
    ..These conditions are initiated and sustained by hypoxia dependent vascular endothelial growth factor (VEGF) expression in the eye...
  15. Brockington A, Heath P, Holden H, Kasher P, Bender F, Claes F, et al. Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGFdelta/delta mouse model of amyotrophic lateral sclerosis. BMC Genomics. 2010;11:203 pubmed publisher
    Vascular endothelial growth factor (VEGF) is an endothelial cell mitogen that stimulates vasculogenesis. It has also been shown to act as a neurotrophic factor in vitro and in vivo...
  16. Huss W, Hanrahan C, Barrios R, Simons J, Greenberg N. Angiogenesis and prostate cancer: identification of a molecular progression switch. Cancer Res. 2001;61:2736-43 pubmed
    ..adhesion molecule-1 (PECAM1/CD31), hypoxia-induced factor-1alpha (HIF-1alpha), vascular endothelial growth factor (VEGF), and the cognate receptors VEGFR1 and VEGFR2 were characterized...
  17. Becker P, Waltenberger J, Yachechko R, Mirzapoiazova T, Sham J, Lee C, et al. Neuropilin-1 regulates vascular endothelial growth factor-mediated endothelial permeability. Circ Res. 2005;96:1257-65 pubmed
    Neuropilin-1 (Npn-1) is a cell surface receptor that binds vascular endothelial growth factor (VEGF), a potent mediator of endothelial permeability, chemotaxis, and proliferation...
  18. Hong Y, Lange Asschenfeldt B, Velasco P, Hirakawa S, Kunstfeld R, Brown L, et al. VEGF-A promotes tissue repair-associated lymphatic vessel formation via VEGFR-2 and the alpha1beta1 and alpha2beta1 integrins. FASEB J. 2004;18:1111-3 pubmed
    Vascular endothelial growth factor-A (VEGF-A) is strongly up-regulated in wounded cutaneous tissue and promotes repair-associated angiogenesis. However, little is known about its role in lymphatic regeneration of the healing skin...
  19. Pettersson A, Nagy J, Brown L, Sundberg C, Morgan E, Jungles S, et al. Heterogeneity of the angiogenic response induced in different normal adult tissues by vascular permeability factor/vascular endothelial growth factor. Lab Invest. 2000;80:99-115 pubmed
    b>Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) is an angiogenic cytokine with potential for the treatment of tissue ischemia...
  20. Lichtenberger B, Tan P, Niederleithner H, Ferrara N, Petzelbauer P, Sibilia M. Autocrine VEGF signaling synergizes with EGFR in tumor cells to promote epithelial cancer development. Cell. 2010;140:268-79 pubmed publisher
    It is established that tumor cell-derived VEGF acts on endothelial cells to promote angiogenesis and tumor growth...
  21. Bryan B, Walshe T, Mitchell D, Havumaki J, Saint Geniez M, MAHARAJ A, et al. Coordinated vascular endothelial growth factor expression and signaling during skeletal myogenic differentiation. Mol Biol Cell. 2008;19:994-1006 pubmed
    ..controlled by hypoxia-driven transcriptional up-regulation and secretion of vascular endothelial growth factor (VEGF) and its binding to the endothelial cell tyrosine receptor kinases, VEGFR1 and VEGFR2...
  22. Gale N, Yancopoulos G. Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development. Genes Dev. 1999;13:1055-66 pubmed
  23. Regan C, Li W, Boucher D, Spatz S, Su M, Kuida K. Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects. Proc Natl Acad Sci U S A. 2002;99:9248-53 pubmed
    ..Moreover, the inability of Erk5-deficient mice to form a complex vasculature suggests that Erk5 may play an important role in controlling angiogenesis. ..
  24. Beck B, Driessens G, Goossens S, Youssef K, Kuchnio A, Caauwe A, et al. A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumours. Nature. 2011;478:399-403 pubmed publisher
    ..Conditional deletion of Vegfa in tumour epithelial cells caused tumours to regress, whereas VEGF overexpression by tumour epithelial cells ..
  25. Ruiz de Almodovar C, Fabre P, Knevels E, Coulon C, Segura I, Haddick P, et al. VEGF mediates commissural axon chemoattraction through its receptor Flk1. Neuron. 2011;70:966-78 pubmed publisher
    ..Here we show that the prototypic angiogenic factor VEGF is secreted by the floor plate and is a chemoattractant for commissural axons in vitro and in vivo...
  26. Nowak D, Amin E, Rennel E, Hoareau Aveilla C, Gammons M, Damodoran G, et al. Regulation of vascular endothelial growth factor (VEGF) splicing from pro-angiogenic to anti-angiogenic isoforms: a novel therapeutic strategy for angiogenesis. J Biol Chem. 2010;285:5532-40 pubmed publisher
    Vascular endothelial growth factor (VEGF) is produced either as a pro-angiogenic or anti-angiogenic protein depending upon splice site choice in the terminal, eighth exon...
  27. Lee S, Chen T, Barber C, Jordan M, Murdock J, Desai S, et al. Autocrine VEGF signaling is required for vascular homeostasis. Cell. 2007;130:691-703 pubmed
    Vascular endothelial growth factor (VEGF) is essential for developmental and pathological angiogenesis...
  28. Tham E, Wang J, Piehl F, Weber G. Upregulation of VEGF-A without angiogenesis in a mouse model of dilated cardiomyopathy caused by mitochondrial dysfunction. J Histochem Cytochem. 2002;50:935-44 pubmed
    ..We have studied the expression of members of the vascular endothelial growth factor (VEGF) and the angiopoietin families and their receptors in mice lacking the mitochondrial transcription factor A...
  29. Vieira J, Schwarz Q, Ruhrberg C. Selective requirements for NRP1 ligands during neurovascular patterning. Development. 2007;134:1833-43 pubmed
    ..We conclude that NRP1 contributes to both neuronal and vascular patterning by preferentially relaying SEMA3A signals in peripheral axons and VEGF164 signals in blood vessels. ..
  30. Weidemann A, Kerdiles Y, Knaup K, Rafie C, Boutin A, Stockmann C, et al. The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice. J Clin Invest. 2009;119:3373-83 pubmed publisher
    ..and their negative regulator von Hippel-Lindau (VHL) as well as astrocyte-specific deletion of the HIF target gene Vegf. We found that loss of the hypoxic response in astrocytes does not cause anemia in mice but is necessary for ..
  31. Raab S, Beck H, Gaumann A, Yuce A, Gerber H, Plate K, et al. Impaired brain angiogenesis and neuronal apoptosis induced by conditional homozygous inactivation of vascular endothelial growth factor. Thromb Haemost. 2004;91:595-605 pubmed
    Vascular endothelial growth factor (VEGF) is essential for the differentiation of the primitive embryonic vascular system and has been implicated in the vascularization of organs...
  32. Hellstrom M, Gerhardt H, Kalén M, Li X, Eriksson U, Wolburg H, et al. Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis. J Cell Biol. 2001;153:543-53 pubmed
    ..5 and persisted throughout development. From E 13.5, vascular endothelial growth factor-A (VEGF-A) and other genes responsive to metabolic stress became upregulated, suggesting that the abnormal microvessel ..
  33. Xu B, Qu X, Gu S, Doughman Y, Watanabe M, Dunwoodie S, et al. Cited2 is required for fetal lung maturation. Dev Biol. 2008;317:95-105 pubmed publisher
    ..We propose that the Cited2-Tcfap2c complex controls lung maturation by regulating Cebpa expression. Understanding the function of this complex may provide novel therapeutic strategies for patients with respiratory distress syndromes. ..
  34. Ferrara N, Carver Moore K, Chen H, Dowd M, Lu L, O Shea K, et al. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature. 1996;380:439-42 pubmed
    ..The endothelial cell-specific mitogen vascular endothelial growth factor (VEGF) is a major mediator of pathological angiogenesis...
  35. Thurston G, Suri C, Smith K, McClain J, Sato T, Yancopoulos G, et al. Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. Science. 1999;286:2511-4 pubmed
    Angiopoietin-1 (Ang1) and vascular endothelial growth factor (VEGF) are endothelial cell-specific growth factors...
  36. Tee M, Jaffe R. A precursor form of vascular endothelial growth factor arises by initiation from an upstream in-frame CUG codon. Biochem J. 2001;359:219-26 pubmed
    Vascular endothelial growth factor (VEGF) is a mitogen in physiological and pathological angiogenesis...
  37. Inoue M, Hager J, Ferrara N, Gerber H, Hanahan D. VEGF-A has a critical, nonredundant role in angiogenic switching and pancreatic beta cell carcinogenesis. Cancer Cell. 2002;1:193-202 pubmed
    ..Signaling through VEGF receptor tyrosine kinases is a well-established component of angiogenic regulation...
  38. Hutter R, Carrick F, Valdiviezo C, Wolinsky C, Rudge J, Wiegand S, et al. Vascular endothelial growth factor regulates reendothelialization and neointima formation in a mouse model of arterial injury. Circulation. 2004;110:2430-5 pubmed
    ..Vascular endothelial growth factor (VEGF), a potent endothelial mitogen, has been advocated for accelerating endothelial repair and preventing intimal ..
  39. Roberts A, Arbogast L, Friedman C, Cohn D, KAUMAYA P, Danforth D. Neutralization of endogenous vascular endothelial growth factor depletes primordial follicles in the mouse ovary. Biol Reprod. 2007;76:218-23 pubmed
    ..b>Vascular endothelial growth factor A (VEGFA) is a major regulator of vascular physiology in the ovary...
  40. Detmar M, Brown L, Schön M, Elicker B, Velasco P, Richard L, et al. Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice. J Invest Dermatol. 1998;111:1-6 pubmed
    Vascular endothelial growth factor (VEGF) has been implicated in the pathologic angiogenesis observed in psoriasis and other chronic inflammatory skin diseases that are characterized by enhanced expression of VEGF by epidermal ..
  41. Kim B, Tang Q, Biswas P, Xu J, Schiffelers R, Xie F, et al. Inhibition of ocular angiogenesis by siRNA targeting vascular endothelial growth factor pathway genes: therapeutic strategy for herpetic stromal keratitis. Am J Pathol. 2004;165:2177-85 pubmed
    ..siRNAs targeting either VEGFA, VEGFR1, VEGFR2, or a mix of the three were shown to significantly inhibit neovascularization induced by CpG when ..
  42. Liu Z, Xu J, Colvin J, Ornitz D. Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18. Genes Dev. 2002;16:859-69 pubmed
    ..Signaling to multiple FGFRs positions FGF18 to coordinate chondrogenesis in the growth plate with osteogenesis in cortical and trabecular bone. ..
  43. Ivkovic S, Yoon B, Popoff S, Safadi F, Libuda D, Stephenson R, et al. Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development. 2003;130:2779-91 pubmed
    ..These defects are linked to decreased expression of vascular endothelial growth factor (VEGF) in the hypertrophic zones of Ctgf mutants...
  44. Onesto C, Berra E, Grepin R, Pages G. Poly(A)-binding protein-interacting protein 2, a strong regulator of vascular endothelial growth factor mRNA. J Biol Chem. 2004;279:34217-26 pubmed
    Expression of vascular endothelial growth factor (VEGF) is tightly regulated, particularly at the level of its mRNA stability, which is essentially mediated through the 3'-untranslated region (3'-UTR) of VEGF mRNA...
  45. Shweiki D, Itin A, Neufeld G, Gitay Goren H, Keshet E. Patterns of expression of vascular endothelial growth factor (VEGF) and VEGF receptors in mice suggest a role in hormonally regulated angiogenesis. J Clin Invest. 1993;91:2235-43 pubmed
    Vascular endothelial growth factor (VEGF) is a secreted endothelial cell-specific mitogen...
  46. Yano K, Brown L, Detmar M. Control of hair growth and follicle size by VEGF-mediated angiogenesis. J Clin Invest. 2001;107:409-17 pubmed
    ..aimed to quantify the cyclic changes of perifollicular vascularization and to characterize the biological role of VEGF for hair growth, angiogenesis, and follicle cycling...
  47. Oosthuyse B, Moons L, Storkebaum E, Beck H, Nuyens D, Brusselmans K, et al. Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Nat Genet. 2001;28:131-8 pubmed
    ..the binding of hypoxia-inducible factors to the hypoxia-response element in the vascular endothelial growth factor (Vegf) promotor...
  48. Bertuccio C, Veron D, Aggarwal P, Holzman L, Tufro A. Vascular endothelial growth factor receptor 2 direct interaction with nephrin links VEGF-A signals to actin in kidney podocytes. J Biol Chem. 2011;286:39933-44 pubmed publisher
    ..b>Vascular endothelial growth factor A (VEGF-A) is a required growth factor produced and secreted by podocytes...
  49. Ciais D, Cherradi N, Bailly S, Grenier E, Berra E, Pouyssegur J, et al. Destabilization of vascular endothelial growth factor mRNA by the zinc-finger protein TIS11b. Oncogene. 2004;23:8673-80 pubmed
    Vascular endothelial growth factor (VEGF) is an angiogenic cytokine, which plays a major role in tumor angiogenesis...
  50. Saint Geniez M, Kurihara T, Sekiyama E, Maldonado A, D Amore P. An essential role for RPE-derived soluble VEGF in the maintenance of the choriocapillaris. Proc Natl Acad Sci U S A. 2009;106:18751-6 pubmed publisher
    Clinical and experimental observations indicate a role for VEGF secreted by the retinal pigment epithelium (RPE) in the maintenance of the choriocapillaris (CC)...
  51. Liu Y, Lui E, Friedman S, Li L, Ye T, Chen Y, et al. PTK787/ZK22258 attenuates stellate cell activation and hepatic fibrosis in vivo by inhibiting VEGF signaling. Lab Invest. 2009;89:209-21 pubmed publisher
    ..PTK/ZK significantly inhibited vascular endothelial growth factor (VEGF) expression, as well as VEGF-simulated cell proliferation and phosphorylation of Akt in activated HSCs...
  52. Saint Geniez M, Maharaj A, Walshe T, Tucker B, Sekiyama E, Kurihara T, et al. Endogenous VEGF is required for visual function: evidence for a survival role on müller cells and photoreceptors. PLoS ONE. 2008;3:e3554 pubmed publisher
    Vascular endothelial growth factor (VEGF) is well known for its role in normal and pathologic neovascularization...
  53. Kamba T, Tam B, Hashizume H, Haskell A, Sennino B, Mancuso M, et al. VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature. Am J Physiol Heart Circ Physiol. 2006;290:H560-76 pubmed
    Unlike during development, blood vessels in the adult are generally thought not to require VEGF for normal function...
  54. Schwarz Q, Gu C, Fujisawa H, Sabelko K, Gertsenstein M, Nagy A, et al. Vascular endothelial growth factor controls neuronal migration and cooperates with Sema3A to pattern distinct compartments of the facial nerve. Genes Dev. 2004;18:2822-34 pubmed
    ..These observations demonstrate, for the first time, that VEGF contributes to neuronal patterning in vivo, and that different compartments of one cell can be co-ordinately ..
  55. Nico B, Mangieri D, Crivellato E, Longo V, De Giorgis M, Capobianco C, et al. HIF activation and VEGF overexpression are coupled with ZO-1 up-phosphorylation in the brain of dystrophic mdx mouse. Brain Pathol. 2007;17:399-406 pubmed
    ..factor-1alpha (HIF-1alpha) and we correlated it with the expression of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor-2 (VEGFR-2) and of the endothelial tight junction proteins zonula ..
  56. Loureiro R, Maharaj A, Dankort D, Muller W, D Amore P. ErbB2 overexpression in mammary cells upregulates VEGF through the core promoter. Biochem Biophys Res Commun. 2005;326:455-65 pubmed
    The angiogenic molecule, vascular endothelial growth factor (VEGF), is a critical regulator of normal and pathologic angiogenesis...
  57. Zelzer E, McLean W, Ng Y, Fukai N, Reginato A, Lovejoy S, et al. Skeletal defects in VEGF(120/120) mice reveal multiple roles for VEGF in skeletogenesis. Development. 2002;129:1893-904 pubmed
    Angiogenesis is an essential component of skeletal development and VEGF signaling plays an important if not pivotal role in this process...
  58. Nagy J, Vasile E, Feng D, Sundberg C, Brown L, Detmar M, et al. Vascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis. J Exp Med. 2002;196:1497-506 pubmed
    b>Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF, VEGF-A) is a multifunctional cytokine with important roles in pathological angiogenesis...
  59. Lambrechts D, Storkebaum E, Morimoto M, Del Favero J, Desmet F, Marklund S, et al. VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death. Nat Genet. 2003;34:383-94 pubmed
    ..We recently reported that reduced expression of Vegfa causes ALS-like motoneuron degeneration in Vegfa(delta/delta) mice...
  60. Ng Y, Rohan R, Sunday M, deMello D, D Amore P. Differential expression of VEGF isoforms in mouse during development and in the adult. Dev Dyn. 2001;220:112-21 pubmed
    Vascular endothelial growth factor (VEGF), a factor that is critical for development of the vascular system in mouse embryos, exists as at least three isoforms, VEGF120, VEGF164, and VEGF188...
  61. Jeansson M, Gawlik A, Anderson G, Li C, Kerjaschki D, Henkelman M, et al. Angiopoietin-1 is essential in mouse vasculature during development and in response to injury. J Clin Invest. 2011;121:2278-89 pubmed publisher
    ..These findings redefine our understanding of the biological roles of angiopoietin-1: it is dispensable in quiescent vessels but has a powerful ability to modulate the vascular response after injury. ..
  62. Olfert I, Howlett R, Tang K, Dalton N, Gu Y, Peterson K, et al. Muscle-specific VEGF deficiency greatly reduces exercise endurance in mice. J Physiol. 2009;587:1755-67 pubmed publisher
    Vascular endothelial growth factor (VEGF) is required for vasculogenesis and angiogenesis during embryonic and early postnatal life...
  63. Cuddihy A, Ge S, Zhu J, Jang J, Chidgey A, Thurston G, et al. VEGF-mediated cross-talk within the neonatal murine thymus. Blood. 2009;113:2723-31 pubmed publisher
    ..that is organized as primitive, dense networks of capillaries dependent on vascular endothelial growth factor (VEGF)...
  64. Zelzer E, Mamluk R, Ferrara N, Johnson R, Schipani E, Olsen B. VEGFA is necessary for chondrocyte survival during bone development. Development. 2004;131:2161-71 pubmed
    To directly examine the role of vascular endothelial growth factor (VEGFA) in cartilage development, we conditionally knocked out Vegfa in chondrocytes, using the Col2a1 promoter to drive expression of Cre recombinase...
  65. Ruiz de Almodovar C, Coulon C, Salin P, Knevels E, Chounlamountri N, Poesen K, et al. Matrix-binding vascular endothelial growth factor (VEGF) isoforms guide granule cell migration in the cerebellum via VEGF receptor Flk1. J Neurosci. 2010;30:15052-66 pubmed publisher
    Vascular endothelial growth factor (VEGF) regulates angiogenesis, but also has important, yet poorly characterized roles in neuronal wiring...
  66. Carmeliet P, Ng Y, Nuyens D, Theilmeier G, Brusselmans K, Cornelissen I, et al. Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188. Nat Med. 1999;5:495-502 pubmed
  67. Yamamoto H, Yun E, Gerber H, Ferrara N, Whitsett J, Vu T. Epithelial-vascular cross talk mediated by VEGF-A and HGF signaling directs primary septae formation during distal lung morphogenesis. Dev Biol. 2007;308:44-53 pubmed
    ..Selective inactivation of the Vegf-A gene in respiratory epithelium results in an almost complete absence of pulmonary capillaries, demonstrating the ..
  68. Gerber H, Hillan K, Ryan A, Kowalski J, Keller G, Rangell L, et al. VEGF is required for growth and survival in neonatal mice. Development. 1999;126:1149-59 pubmed
    We employed two independent approaches to inactivate the angiogenic protein VEGF in newborn mice: inducible, Cre-loxP- mediated gene targeting, or administration of mFlt(1-3)-IgG, a soluble VEGF receptor chimeric protein...
  69. Inada M, Wang Y, Byrne M, Rahman M, Miyaura C, Lopez Otin C, et al. Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification. Proc Natl Acad Sci U S A. 2004;101:17192-7 pubmed
    ..Cartilaginous growth plate abnormalities persisted in adult mice and phenocopied defects observed in human hereditary chondrodysplasias. Our findings demonstrate a unique role of Mmp13 in skeletal development. ..
  70. Maharaj A, Walshe T, Saint Geniez M, Venkatesha S, Maldonado A, Himes N, et al. VEGF and TGF-beta are required for the maintenance of the choroid plexus and ependyma. J Exp Med. 2008;205:491-501 pubmed publisher
    Although the role of vascular endothelial growth factor (VEGF) in developmental and pathological angiogenesis is well established, its function in the adult is less clear...
  71. Maes C, Carmeliet P, Moermans K, Stockmans I, Smets N, Collen D, et al. Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188. Mech Dev. 2002;111:61-73 pubmed
    Vascular endothelial growth factor (VEGF)-mediated angiogenesis is an important part of bone formation...
  72. Miquerol L, Langille B, Nagy A. Embryonic development is disrupted by modest increases in vascular endothelial growth factor gene expression. Development. 2000;127:3941-6 pubmed
    Previous work has shown that heterozygocity for a null mutation of the VEGF-A gene, resulting in a 50% reduction in VEGF-A expression, is embryonic lethal at embroyonic day (E) 9.5 in mice...
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    b>VEGF and TGF-beta1 are potent angiogenesis inducers with opposing effects on endothelial cells. TGF-beta1 induces apoptosis; VEGF protects endothelial cells from apoptosis...
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    ..recently demonstrated that the very long 5'-untranslated region (5'-UTR) of the vascular endothelial growth factor (VEGF) mRNA contains two independent internal ribosome entry sites (IRES A and B)...
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    b>Vascular endothelial growth factor A (VEGFA) plays a pivotal role in the first steps of endothelial and haematopoietic development in the yolk sac, as well as in the establishment of the cardiovascular system of the embryo...
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    ..the hypoxia responsive transcription factor HIF-1alpha, its negative regulator VHL, and a known downstream target, VEGF. We find that activation of HIF-1alpha is essential for myeloid cell infiltration and activation in vivo through a ..
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    ..physiological adaptation to increased metabolic demand, possibly dependent on vascular endothelial growth factor (VEGF), the increased expression of which is a known early response to exercise...
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    ..Here we explored different mechanisms by which VEGF, a pleiotropic factor known to possess multiple activities vis-à-vis blood vessels and neurons, may affect adult ..
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    ..In vivo ablation of VEGF-A expression by pancreas-specific inactivation of floxed Vegfa alleles results in reduced endothelial development and in excessive acinar differentiation...
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    ..Vascular endothelial growth factor-A (VEGF-A) in islets is essential for maintaining normal islet blood vessels...
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    We previously demonstrated that vascular endothelial growth factor (VEGF) expression in the murine lung increases local CD11c+MHCII+ DC number and activation...
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    ..NO synthase (eNOS) is essential for increased vascular permeability induced by vascular endothelial growth factor (VEGF). However, the molecular mechanisms by which NO modulates endothelial permeability remain elusive...
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    ..endothelial cells (HMEC) stimulated by the endothelial cell mitogen vascular endothelial growth factor (VEGF)...