Vdac1

Summary

Gene Symbol: Vdac1
Description: voltage-dependent anion channel 1
Alias: AL033343, Vdac5, mVDAC1, mVDAC5, voltage-dependent anion-selective channel protein 1, outer mitochondrial membrane protein porin 1, plasmalemmal porin, voltage-dependent anion-selective channel protein 5
Species: mouse
Products:     Vdac1

Top Publications

  1. Anflous Pharayra K, Cai Z, Craigen W. VDAC1 serves as a mitochondrial binding site for hexokinase in oxidative muscles. Biochim Biophys Acta. 2007;1767:136-42 pubmed
    ..that mitochondria-bound hexokinase activity is significantly reduced in oxidative muscles (heart and soleus) in vdac1(-/-) mice. The activity data were supported by western blot analysis using HK2 specific antibody...
  2. Sampson M, Lovell R, Craigen W. The murine voltage-dependent anion channel gene family. Conserved structure and function. J Biol Chem. 1997;272:18966-73 pubmed
    ..Two human VDAC cDNAs have been described previously, and we recently reported the isolation of mouse VDAC1 and VDAC2 cDNAs, as well as a third novel VDAC cDNA, designated VDAC3...
  3. Weeber E, Levy M, Sampson M, Anflous K, Armstrong D, Brown S, et al. The role of mitochondrial porins and the permeability transition pore in learning and synaptic plasticity. J Biol Chem. 2002;277:18891-7 pubmed
    ..These results demonstrate a dynamic functional role for mitochondrial porins and the permeability transition pore in learning and synaptic plasticity. ..
  4. Abu Hamad S, Arbel N, Calo D, Arzoine L, Israelson A, Keinan N, et al. The VDAC1 N-terminus is essential both for apoptosis and the protective effect of anti-apoptotic proteins. J Cell Sci. 2009;122:1906-16 pubmed publisher
    ..Here, we demonstrate that the N-terminal domain of VDAC1 controls the release of cytochrome c, apoptosis and the regulation of apoptosis by anti-apoptotic proteins such as ..
  5. Ujwal R, Cascio D, Colletier J, Faham S, Zhang J, Toro L, et al. The crystal structure of mouse VDAC1 at 2.3 A resolution reveals mechanistic insights into metabolite gating. Proc Natl Acad Sci U S A. 2008;105:17742-7 pubmed publisher
    ..We report the crystal structure of a beta-barrel eukaryotic membrane protein, the murine VDAC1 (mVDAC1) at 2.3 A resolution, revealing a high-resolution image of its architecture formed by 19 beta-strands...
  6. Buettner R, Papoutsoglou G, Scemes E, Spray D, Dermietzel R. Evidence for secretory pathway localization of a voltage-dependent anion channel isoform. Proc Natl Acad Sci U S A. 2000;97:3201-6 pubmed
    ..Thus, our data provide unique genetic evidence in favor of a multitopological localization of a mitochondrial porin. ..
  7. Anflous K, Armstrong D, Craigen W. Altered mitochondrial sensitivity for ADP and maintenance of creatine-stimulated respiration in oxidative striated muscles from VDAC1-deficient mice. J Biol Chem. 2001;276:1954-60 pubmed
    ..The mouse vdac1 gene has been disrupted by gene targeting, and the resulting mutant mice have been examined for defects in muscle ..
  8. Choudhary O, Ujwal R, Kowallis W, Coalson R, Abramson J, Grabe M. The electrostatics of VDAC: implications for selectivity and gating. J Mol Biol. 2010;396:580-92 pubmed publisher
    ..from electrostatics calculations carried out on the recently determined high-resolution structure of murine VDAC1 (mVDAC1)...
  9. Weis V, Knowles B, Choi E, Goldstein A, Williams J, Manning E, et al. Loss of MYO5B in mice recapitulates Microvillus Inclusion Disease and reveals an apical trafficking pathway distinct to neonatal duodenum. Cell Mol Gastroenterol Hepatol. 2016;2:131-157 pubmed
    ..However, the diarrheal pathology after MYO5B loss is due to deficits in transporter presentation at the apical membrane in duodenal enterocytes. ..

More Information

Publications67

  1. Choudhary O, Paz A, Adelman J, Colletier J, Abramson J, Grabe M. Structure-guided simulations illuminate the mechanism of ATP transport through VDAC1. Nat Struct Mol Biol. 2014;21:626-32 pubmed publisher
    ..To understand ATP permeation through VDAC, we solved the crystal structure of mouse VDAC1 (mVDAC1) in the presence of ATP, revealing a low-affinity binding site...
  2. Geula S, Naveed H, Liang J, Shoshan Barmatz V. Structure-based analysis of VDAC1 protein: defining oligomer contact sites. J Biol Chem. 2012;287:2179-90 pubmed publisher
    ..Oligomeric assembly of VDAC1 was shown to be coupled to apoptosis induction, with oligomerization increasing substantially upon apoptosis ..
  3. Briones R, Weichbrodt C, Paltrinieri L, Mey I, Villinger S, Giller K, et al. Voltage Dependence of Conformational Dynamics and Subconducting States of VDAC-1. Biophys J. 2016;111:1223-1234 pubmed publisher
    ..These voltage-dependent protein changes include asymmetric barrel distortion, its interaction with the membrane, and significant displacement of N-? amino acids. ..
  4. Sun Y, Vashisht A, Tchieu J, Wohlschlegel J, Dreier L. Voltage-dependent anion channels (VDACs) recruit Parkin to defective mitochondria to promote mitochondrial autophagy. J Biol Chem. 2012;287:40652-60 pubmed publisher
    ..We hypothesize that VDACs serve as mitochondrial docking sites to recruit Parkin from the cytosol to defective mitochondria. ..
  5. Imada S, Yamamoto M, Tanaka K, Seiwa C, Watanabe K, Kamei Y, et al. Hypothermia-induced increase of oligodendrocyte precursor cells: Possible involvement of plasmalemmal voltage-dependent anion channel 1. J Neurosci Res. 2010;88:3457-66 pubmed publisher
    ..possible involvement of the G?13-Rho GTPase Cdc42-ERK1/2 signaling cascade and voltage-dependent anion channel 1 (VDAC1), which associate or dissociate with G?13 protein at 37°C and 31.5°C, respectively...
  6. Levavasseur F, Miyadera H, Sirois J, Tremblay M, Kita K, Shoubridge E, et al. Ubiquinone is necessary for mouse embryonic development but is not essential for mitochondrial respiration. J Biol Chem. 2001;276:46160-4 pubmed
    ..These findings indicate that UQ is necessary for vertebrate embryonic development but suggest that mitochondrial respiration is not the function for which UQ is essential when DMQ is present. ..
  7. Rardin M, Wiley S, Murphy A, Pagliarini D, Dixon J. Dual specificity phosphatases 18 and 21 target to opposing sides of the mitochondrial inner membrane. J Biol Chem. 2008;283:15440-50 pubmed publisher
    ..This work rigorously demonstrates the unique location of two highly similar DSPs on opposing sides of the mitochondrial inner membrane...
  8. Abu Hamad S, Zaid H, Israelson A, Nahon E, Shoshan Barmatz V. Hexokinase-I protection against apoptotic cell death is mediated via interaction with the voltage-dependent anion channel-1: mapping the site of binding. J Biol Chem. 2008;283:13482-90 pubmed publisher
    ..We have previously shown that HK-I decreases murine VDAC1 (mVDAC1) channel conductance, inhibits cytochrome c release, and protects against apoptotic cell death...
  9. Zhou H, Zhang Y, Hu S, Shi C, Zhu P, Ma Q, et al. Melatonin protects cardiac microvasculature against ischemia/reperfusion injury via suppression of mitochondrial fission-VDAC1-HK2-mPTP-mitophagy axis. J Pineal Res. 2017;63: pubmed publisher
    ..protein 1 (Drp1)-dependent mitochondrial fission, which subsequently induced voltage-dependent anion channel 1 (VDAC1) oligomerization, hexokinase 2 (HK2) liberation, mitochondrial permeability transition pore (mPTP) opening, PINK1/..
  10. Manczak M, Reddy P. Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease. Hum Mol Genet. 2012;21:5131-46 pubmed publisher
    The purpose of our study was to determine the relationship between voltage-dependent anion channel 1 protein (VDAC1) and amyloid beta (A?) and phosphorylated tau in Alzheimer's disease (AD)...
  11. Powell K, Davies J, Taylor E, Wride M, Votruba M. Mitochondrial localization and ocular expression of mutant Opa3 in a mouse model of 3-methylglutaconicaciduria type III. Invest Ophthalmol Vis Sci. 2011;52:4369-80 pubmed publisher
    ..Opa3 accumulates in the lens. The results may reflect a slow turnover of Opa3 protein in vivo and may be important in normal lens physiology. ..
  12. Engl G, Florian S, Tranebjærg L, Rapaport D. Alterations in expression levels of deafness dystonia protein 1 affect mitochondrial morphology. Hum Mol Genet. 2012;21:287-99 pubmed publisher
    ..Taken together, these results suggest that alterations in the levels of DDP1 can affect the morphology of mitochondria and thus shed new light on the pathogenic mechanisms of DDON. ..
  13. Zhou H, Hu S, Jin Q, Shi C, Zhang Y, Zhu P, et al. Mff-Dependent Mitochondrial Fission Contributes to the Pathogenesis of Cardiac Microvasculature Ischemia/Reperfusion Injury via Induction of mROS-Mediated Cardiolipin Oxidation and HK2/VDAC1 Disassociation-Involved mPTP Opening. J Am Heart Assoc. 2017;6: pubmed publisher
  14. Ben Hail D, Shoshan Barmatz V. VDAC1-interacting anion transport inhibitors inhibit VDAC1 oligomerization and apoptosis. Biochim Biophys Acta. 2016;1863:1612-23 pubmed publisher
    ..The voltage-dependent anion channel 1 (VDAC1), an OMM protein, is central to mitochondria-mediated apoptosis...
  15. Jones S, Zachara N, Ngoh G, Hill B, Teshima Y, Bhatnagar A, et al. Cardioprotection by N-acetylglucosamine linkage to cellular proteins. Circulation. 2008;117:1172-82 pubmed publisher
    ..O-GlcNAc signaling represents a unique endogenously recruitable mechanism of cardioprotection that may involve direct modification of mitochondrial proteins critical for survival such as voltage-dependent anion channel. ..
  16. Noskov S, Rostovtseva T, Bezrukov S. ATP transport through VDAC and the VDAC-tubulin complex probed by equilibrium and nonequilibrium MD simulations. Biochemistry. 2013;52:9246-56 pubmed publisher
    ..simulations, we established the thermodynamic and kinetic components governing ATP transport across the VDAC1 channel...
  17. Arzoine L, Zilberberg N, Ben Romano R, Shoshan Barmatz V. Voltage-dependent anion channel 1-based peptides interact with hexokinase to prevent its anti-apoptotic activity. J Biol Chem. 2009;284:3946-55 pubmed publisher
    ..Now, we demonstrate that synthetic peptides corresponding to the VDAC1 N-terminal region and selected sequences bound specifically, in a concentration- and time-dependent manner, to ..
  18. Morohaku K, Phuong N, Selvaraj V. Developmental expression of translocator protein/peripheral benzodiazepine receptor in reproductive tissues. PLoS ONE. 2013;8:e74509 pubmed publisher
  19. Tan W, Naniche N, Bogush A, Pedrini S, Trotti D, Pasinelli P. Small peptides against the mutant SOD1/Bcl-2 toxic mitochondrial complex restore mitochondrial function and cell viability in mutant SOD1-mediated ALS. J Neurosci. 2013;33:11588-98 pubmed publisher
    ..mutSOD1-G93A cells and mice, the newly exposed BH3 domain in Bcl-2 alters the normal interaction between Bcl-2 and VDAC1 thus reducing permeability of the outer mitochondrial membrane...
  20. Krauskopf A, Eriksson O, Craigen W, Forte M, Bernardi P. Properties of the permeability transition in VDAC1(-/-) mitochondria. Biochim Biophys Acta. 2006;1757:590-5 pubmed
    ..labeled a approximately 32 kDa protein that was identified as isoform 1 of the voltage-dependent anion channel (VDAC1) [A.M. Cesura, E. Pinard, R. Schubenel, V. Goetschy, A. Friedlein, H. Langen, P. Polcic, M.A. Forte, P...
  21. Sabirov R, Sheiko T, Liu H, Deng D, Okada Y, Craigen W. Genetic demonstration that the plasma membrane maxianion channel and voltage-dependent anion channels are unrelated proteins. J Biol Chem. 2006;281:1897-904 pubmed
    ..The channel activity is similar in VDAC1/VDAC3-double-deficient cells and in double-deficient cells with the VDAC2 protein depleted by RNA interference...
  22. Arif T, Krelin Y, Shoshan Barmatz V. Reducing VDAC1 expression induces a non-apoptotic role for pro-apoptotic proteins in cancer cell differentiation. Biochim Biophys Acta. 2016;1857:1228-1242 pubmed publisher
    ..We found that treating glioblastoma (GBM) tumors with siRNA against VDAC1, a mitochondrial protein found at the crossroads of metabolic and survival pathways and involved in apoptosis, ..
  23. Stary C, Sun X, Ouyang Y, Li L, Giffard R. miR-29a differentially regulates cell survival in astrocytes from cornu ammonis 1 and dentate gyrus by targeting VDAC1. Mitochondrion. 2016;30:248-54 pubmed publisher
    ..A reciprocal change was observed in the mitochondrial voltage dependent cation channel-1 (VDAC1), a regulator of mitochondria and target of miR-29a...
  24. Yu Z, Liu N, Wang Y, Li X, Wang X. Identification of neuroglobin-interacting proteins using yeast two-hybrid screening. Neuroscience. 2012;200:99-105 pubmed publisher
    ..Our findings provide molecular targets for investigating protein interaction-based biological functions and neuroprotective mechanisms of Ngb. ..
  25. Sheldon K, Maldonado E, Lemasters J, Rostovtseva T, Bezrukov S. Phosphorylation of voltage-dependent anion channel by serine/threonine kinases governs its interaction with tubulin. PLoS ONE. 2011;6:e25539 pubmed publisher
    ..Our findings suggest a novel functional link between serine/threonine kinase signaling pathways, mitochondrial respiration, and the highly dynamic microtubule network which is characteristic of cancerogenesis and cell proliferation...
  26. Sampson M, Lovell R, Davison D, Craigen W. A novel mouse mitochondrial voltage-dependent anion channel gene localizes to chromosome 8. Genomics. 1996;36:192-6 pubmed
    ..The deduced MVDAC3 protein is approximately 70% identical to the previously isolated MVDAC1 and MVDAC2 proteins. The MVDAC3 gene was mapped by an interspecies backcross panel to mouse chromosome 8...
  27. Ben Hail D, Begas Shvartz R, Shalev M, Shteinfer Kuzmine A, Gruzman A, Reina S, et al. Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction. J Biol Chem. 2016;291:24986-25003 pubmed
    ..The outer mitochondrial membrane protein voltage-dependent anion channel 1 (VDAC1) is a convergence point for a variety of cell survival and death signals, including apoptosis...
  28. Teijido O, Ujwal R, Hillerdal C, Kullman L, Rostovtseva T, Abramson J. Affixing N-terminal ?-helix to the wall of the voltage-dependent anion channel does not prevent its voltage gating. J Biol Chem. 2012;287:11437-45 pubmed publisher
    ..The three-dimensional structure of VDAC1 reveals a channel formed by 19 ?-strands and an N-terminal ?-helix located near the midpoint of the pore...
  29. Gatliff J, East D, Crosby J, Abeti R, Harvey R, Craigen W, et al. TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control. Autophagy. 2014;10:2279-96 pubmed publisher
    ..Independent of cholesterol regulation, the modulation of mitophagy by TSPO is instead dependent on VDAC1 (voltage-dependent anion channel 1), to which TSPO binds, reducing mitochondrial coupling and promoting an ..
  30. Watanabe M, Funakoshi T, Unuma K, Aki T, Uemura K. Activation of the ubiquitin-proteasome system against arsenic trioxide cardiotoxicity involves ubiquitin ligase Parkin for mitochondrial homeostasis. Toxicology. 2014;322:43-50 pubmed publisher
    ..Ubiquitination of the voltage-dependent anion channel1 (VDAC1), a substrate of Parkin, was also proved by immunoprecipitation...
  31. Wiley S, Murphy A, Ross S, van der Geer P, Dixon J. MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity. Proc Natl Acad Sci U S A. 2007;104:5318-23 pubmed
    ..Cardiac mitochondria isolated from mitoNEET-null mice demonstrate a reduced oxidative capacity, suggesting that mito- NEET is an important iron-containing protein involved in the control of maximal mitochondrial respiratory rates. ..
  32. Kumada T, Yamanaka Y, Kitano A, Shibata M, Awaya T, Kato T, et al. Ttyh1, a Ca(2+)-binding protein localized to the endoplasmic reticulum, is required for early embryonic development. Dev Dyn. 2010;239:2233-45 pubmed publisher
    ..Our findings indicate that Ttyh1 plays an indispensable role during mitosis in early embryogenesis, possibly by maintaining Ca(2+) homeostasis in the ER. ..
  33. Shoshan Barmatz V, Keinan N, Abu Hamad S, Tyomkin D, Aram L. Apoptosis is regulated by the VDAC1 N-terminal region and by VDAC oligomerization: release of cytochrome c, AIF and Smac/Diablo. Biochim Biophys Acta. 2010;1797:1281-91 pubmed publisher
    ..In this study, the functions played by the N-terminal region of VDAC1 and by VDAC1 oligomerization in the release of cytochrome c, Smac/Diablo and apoptosis-inducing factor (AIF) and ..
  34. Wu S, Sampson M, Decker W, Craigen W. Each mammalian mitochondrial outer membrane porin protein is dispensable: effects on cellular respiration. Biochim Biophys Acta. 1999;1452:68-78 pubmed
    ..Deletion of the yeast VDAC1 gene leads to conditional lethality that can be partially or completely complemented by the mammalian VDAC genes...
  35. Ujwal R, Cascio D, Chaptal V, Ping P, Abramson J. Crystal packing analysis of murine VDAC1 crystals in a lipidic environment reveals novel insights on oligomerization and orientation. Channels (Austin). 2009;3:167-70 pubmed
    ..We recently determined the structure of the murine VDAC1 (mVDAC1) at 2.3 A resolution crystallized in a native-like bilayer environment...
  36. Shoshan Barmatz V, Zakar M, Rosenthal K, Abu Hamad S. Key regions of VDAC1 functioning in apoptosis induction and regulation by hexokinase. Biochim Biophys Acta. 2009;1787:421-30 pubmed publisher
    ..Here, we demonstrate that the HK-VDAC1 interaction can be disrupted by mutating VDAC1 and by VDAC1-based peptides, consequently leading to diminished HK ..
  37. Martinez Caballero S, Dejean L, Kinnally M, Oh K, Mannella C, Kinnally K. Assembly of the mitochondrial apoptosis-induced channel, MAC. J Biol Chem. 2009;284:12235-45 pubmed publisher
    ..formation in isolated mitochondria containing Bax and/or Bak with a time course of minutes and does not require VDAC1 or VDAC3...
  38. Rostovtseva T, Antonsson B, Suzuki M, Youle R, Colombini M, Bezrukov S. Bid, but not Bax, regulates VDAC channels. J Biol Chem. 2004;279:13575-83 pubmed
    ..We speculate that by decreasing the probability of VDAC opening, Bid reduces metabolite exchange between mitochondria and the cytosol, leading to mitochondrial dysfunction. ..
  39. Narendra D, Kane L, Hauser D, Fearnley I, Youle R. p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both. Autophagy. 2010;6:1090-106 pubmed
    ..Although VDAC1 (but not VDAC2) is ubiquitinated following mitochondrial depolarization, we find VDAC1 cannot fully account for ..
  40. Odegaard J, Lee M, Sogawa Y, Bertholet A, Locksley R, Weinberg D, et al. Perinatal Licensing of Thermogenesis by IL-33 and ST2. Cell. 2016;166:841-854 pubmed publisher
    ..Together, these data suggest that IL-33 and ST2 function as a developmental switch to license thermogenesis during the perinatal period. PAPERCLIP. ..
  41. Guan K, Zheng Z, Song T, He X, Xu C, Zhang Y, et al. MAVS regulates apoptotic cell death by decreasing K48-linked ubiquitination of voltage-dependent anion channel 1. Mol Cell Biol. 2013;33:3137-49 pubmed publisher
    ..Here, we show that MAVS binds to voltage-dependent anion channel 1 (VDAC1) and induces apoptosis by caspase-3 activation, which is independent of its role in innate immunity...
  42. Ha S, Park S, Han C, Nguyen M, Kim S. Cellular adaptation to anthrax lethal toxin-induced mitochondrial cholesterol enrichment, hyperpolarization, and reactive oxygen species generation through downregulating MLN64 in macrophages. Mol Cell Biol. 2012;32:4846-60 pubmed publisher
    ..This study demonstrates for the first time that MLN64 plays a key role in LeTx/caspase-1-induced mitochondrial dysfunction...
  43. Hyde B, Liesa M, Elorza A, Qiu W, Haigh S, Richey L, et al. The mitochondrial transporter ABC-me (ABCB10), a downstream target of GATA-1, is essential for erythropoiesis in vivo. Cell Death Differ. 2012;19:1117-26 pubmed publisher
    ..Altogether, our findings demonstrate that ABC-me is essential for erythropoiesis in vivo...
  44. Okada S, O Neal W, Huang P, Nicholas R, Ostrowski L, Craigen W, et al. Voltage-dependent anion channel-1 (VDAC-1) contributes to ATP release and cell volume regulation in murine cells. J Gen Physiol. 2004;124:513-26 pubmed
    ..However, the observation that VDAC-1 knockout cells released a significant amount of ATP suggests that other molecules also play a role in this function. ..
  45. Israelson A, Zaid H, Abu Hamad S, Nahon E, Shoshan Barmatz V. Mapping the ruthenium red-binding site of the voltage-dependent anion channel-1. Cell Calcium. 2008;43:196-204 pubmed
    ..Binding of RuR to bilayer-reconstituted mVDAC1 and the resulting channel closure was inhibited upon mutation of specific VDAC1 residues...
  46. Zaid H, Abu Hamad S, Israelson A, Nathan I, Shoshan Barmatz V. The voltage-dependent anion channel-1 modulates apoptotic cell death. Cell Death Differ. 2005;12:751-60 pubmed
    ..Binding of HK-I to mitochondria expressing E72Q-mVDAC1, as compared to native VDAC1, was decreased by approximately 70% and rendered insensitive to DCCD...
  47. Baghel M, Thakur M. Differential proteome profiling in the hippocampus of amnesic mice. Hippocampus. 2017;27:845-859 pubmed publisher
    ..analysis revealed that majority of identified proteins exhibit common association with Actg1 cytoskeleton and Vdac1 energy transporter protein...
  48. Baines C, Kaiser R, Sheiko T, Craigen W, Molkentin J. Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death. Nat Cell Biol. 2007;9:550-5 pubmed
    ..Mitochondria from Vdac1-, Vdac3-, and Vdac1-Vdac3-null mice exhibited a Ca(2+)- and oxidative stress-induced MPT that was ..
  49. Yehezkel G, Abu Hamad S, Shoshan Barmatz V. An N-terminal nucleotide-binding site in VDAC1: involvement in regulating mitochondrial function. J Cell Physiol. 2007;212:551-61 pubmed
    ..The predicated NBS of murine VDAC1 (mVDAC1) was mutated by replacing two glycine residues with alanines or a conserved lysine residue with a serine...
  50. De Marchi U, Szabo I, Cereghetti G, Hoxha P, Craigen W, Zoratti M. A maxi-chloride channel in the inner membrane of mammalian mitochondria. Biochim Biophys Acta. 2008;1777:1438-48 pubmed publisher
    ..Its identification with porin is therefore to be excluded. It most likely coincides instead with the "maxi-chloride channel" characterized in the plasma membrane of various cell types. ..
  51. Mertins B, Psakis G, Grosse W, Back K, Salisowski A, Reiss P, et al. Flexibility of the N-terminal mVDAC1 segment controls the channel's gating behavior. PLoS ONE. 2012;7:e47938 pubmed publisher
    ..Through engineering of two double-cysteine mVDAC1 variants we achieved fixing of the N-terminal segment at the bottom and midpoint of the pore...
  52. Israelson A, Arbel N, Da Cruz S, Ilieva H, Yamanaka K, Shoshan Barmatz V, et al. Misfolded mutant SOD1 directly inhibits VDAC1 conductance in a mouse model of inherited ALS. Neuron. 2010;67:575-87 pubmed publisher
    ..antibodies, we now demonstrate that misfolded mutant SOD1 binds directly to the voltage-dependent anion channel (VDAC1), an integral membrane protein imbedded in the outer mitochondrial membrane...
  53. Martin J, Balmer M, Rajendran S, Maurhofer O, Dufour J, St Pierre M. Nutritional stress exacerbates hepatic steatosis induced by deletion of the histidine nucleotide-binding (Hint2) mitochondrial protein. Am J Physiol Gastrointest Liver Physiol. 2016;310:G497-509 pubmed publisher
    ..The absence of Hint2 deregulates the posttranslational modification of several mitochondrial proteins, which impedes the adaptation to episodes of nutritional stress. ..
  54. Manczak M, Sheiko T, Craigen W, Reddy P. Reduced VDAC1 protects against Alzheimer's disease, mitochondria, and synaptic deficiencies. J Alzheimers Dis. 2013;37:679-90 pubmed publisher
    The objective of this study was to elucidate the effect of VDAC1 on Alzheimer's disease (AD)-related genes, mitochondrial activity, and synaptic viability...
  55. Danial N, Gramm C, Scorrano L, Zhang C, Krauss S, Ranger A, et al. BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature. 2003;424:952-6 pubmed
    ..This combination of proteomics, genetics and physiology indicates an unanticipated role for BAD in integrating pathways of glucose metabolism and apoptosis. ..
  56. Smorodchenko A, Rupprecht A, Sarilova I, Ninnemann O, Bräuer A, Franke K, et al. Comparative analysis of uncoupling protein 4 distribution in various tissues under physiological conditions and during development. Biochim Biophys Acta. 2009;1788:2309-19 pubmed publisher
    ..UCP4 preferential expression in neurons and its developmental expression pattern under physiological conditions may indicate a specific protein function, e.g. in neuronal cell differentiation. ..
  57. Sampson M, Lovell R, Craigen W. Isolation, characterization, and mapping of two mouse mitochondrial voltage-dependent anion channel isoforms. Genomics. 1996;33:283-8 pubmed
    ..Here, the isolation of two mouse VDAC cDNAs (VDAC5 and VDAC6) is described...
  58. Kotarsky H, Tabasum I, Mannisto S, Heikinheimo M, Hansson S, Fellman V. BCS1L is expressed in critical regions for neural development during ontogenesis in mice. Gene Expr Patterns. 2007;7:266-73 pubmed
    ..The predominant expression of BCS1L in this region, together with its presence in peripheral ganglia from E13 onwards, indicates a role for BCS1L in the development of neural structures. ..