Gene Symbol: Vav3
Description: vav 3 oncogene
Alias: A530094I06Rik, AA986410, Idd18.1, guanine nucleotide exchange factor VAV3, VAV-3
Species: mouse
Products:     Vav3

Top Publications

  1. Pearce A, McCarty O, Calaminus S, Vigorito E, Turner M, Watson S. Vav family proteins are required for optimal regulation of PLCgamma2 by integrin alphaIIbbeta3. Biochem J. 2007;401:753-61 pubmed
    ..of Vav family proteins in filopodia and lamellipodia formation on fibrinogen using platelets deficient in Vav1 and Vav3. Wild-type mouse platelets undergo a limited degree of spreading on fibrinogen, characterized by the formation of ..
  2. Cella M, Fujikawa K, Tassi I, Kim S, Latinis K, Nishi S, et al. Differential requirements for Vav proteins in DAP10- and ITAM-mediated NK cell cytotoxicity. J Exp Med. 2004;200:817-23 pubmed
    ..It is also possible that two other Vav family molecules, Vav2 and Vav3, are involved in NK cell activation...
  3. Bhavsar P, Vigorito E, Turner M, Ridley A. Vav GEFs regulate macrophage morphology and adhesion-induced Rac and Rho activation. Exp Cell Res. 2009;315:3345-58 pubmed publisher
  4. Sindrilaru A, Peters T, Schymeinsky J, Oreshkova T, Wang H, Gompf A, et al. Wound healing defect of Vav3-/- mice due to impaired {beta}2-integrin-dependent macrophage phagocytosis of apoptotic neutrophils. Blood. 2009;113:5266-76 pubmed publisher
    ..We here provide first evidence for a role of Vav3 for beta(2)-integrins-mediated macrophage functions during wound healing...
  5. Chang K, Sanchez Aguilera A, Shen S, Sengupta A, Madhu M, Ficker A, et al. Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival. Blood. 2012;120:800-11 pubmed publisher
    ..We show that genetic deficiency of the guanine nucleotide exchange factor Vav3 delays leukemogenesis by p190-BCR-ABL and phenocopies the effect of Rac2 deficiency, a downstream ..
  6. Sauzeau V, Sevilla M, Rivas Elena J, de Alava E, Montero M, Lopez Novoa J, et al. Vav3 proto-oncogene deficiency leads to sympathetic hyperactivity and cardiovascular dysfunction. Nat Med. 2006;12:841-5 pubmed
    ..Here we identify Vav3, a GDP-GTP exchange factor that stimulates Rho and Rac GTPases, as an essential factor regulating the homeostasis ..
  7. Aoki K, Nakamura T, Fujikawa K, Matsuda M. Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells. Mol Biol Cell. 2005;16:2207-17 pubmed
    ..Depletion of Vav2 and Vav3 by RNA interference significantly inhibited both Rac1/Cdc42 activation and the formation of short processes leading ..
  8. Faccio R, Teitelbaum S, Fujikawa K, Chappel J, Zallone A, Tybulewicz V, et al. Vav3 regulates osteoclast function and bone mass. Nat Med. 2005;11:284-90 pubmed
    ..Here we identify Vav3, a Rho family guanine nucleotide exchange factor, as essential for stimulated osteoclast activation and bone ..
  9. Fujikawa K, Miletic A, Alt F, Faccio R, Brown T, Hoog J, et al. Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells. J Exp Med. 2003;198:1595-608 pubmed
    ..alone is sufficient for normal lymphocyte development, our data also reveal lineage-specific roles for Vav2 and Vav3, with the first demonstration that Vav3 plays a critical compensatory function in T cells...

More Information


  1. Gakidis M, Cullere X, Olson T, Wilsbacher J, Zhang B, Moores S, et al. Vav GEFs are required for beta2 integrin-dependent functions of neutrophils. J Cell Biol. 2004;166:273-82 pubmed
    ..Using Vav1/Vav3-deficient neutrophils (Vav1/3ko), we show that Vav proteins are required for multiple beta2 integrin-dependent ..
  2. Miletic A, Graham D, Montgrain V, Fujikawa K, Kloeppel T, Brim K, et al. Vav proteins control MyD88-dependent oxidative burst. Blood. 2007;109:3360-8 pubmed
    ..MyD88-dependent activation of Rac2, NADPH oxidase, and ROI production using mice deficient in Vav1, Vav2, and Vav3. Vav proteins are also required for p38 MAPK activation and for normal regulation of proinflammatory cytokine ..
  3. Rahaman S, Swat W, Febbraio M, Silverstein R. Vav family Rho guanine nucleotide exchange factors regulate CD36-mediated macrophage foam cell formation. J Biol Chem. 2011;286:7010-7 pubmed publisher
    ..These studies for the first time link CD36 and Vavs in a signaling pathway required for macrophage foam cell formation. ..
  4. Quevedo C, Sauzeau V, Menacho Márquez M, Castro Castro A, Bustelo X. Vav3-deficient mice exhibit a transient delay in cerebellar development. Mol Biol Cell. 2010;21:1125-39 pubmed publisher
    b>Vav3 is a guanosine diphosphate/guanosine triphosphate exchange factor for Rho/Rac GTPases that has been involved in functions related to the hematopoietic system, bone formation, cardiovascular regulation, angiogenesis, and axon guidance...
  5. Graham D, Akilesh H, Gmyrek G, Piccio L, Gilfillan S, Sim J, et al. ITAM signaling in dendritic cells controls T helper cell priming by regulating MHC class II recycling. Blood. 2010;116:3208-18 pubmed publisher
    ..We propose a novel mechanism for control of T helper cell priming. ..
  6. Pearce A, Senis Y, Billadeau D, Turner M, Watson S, Vigorito E. Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen. J Biol Chem. 2004;279:53955-62 pubmed
    ..Vav1, Vav2, and Vav3 play a crucial role in the regulation of phospholipase C gamma (PLC gamma) isoforms by immuno-tyrosine-based ..
  7. Moores S, Selfors L, Fredericks J, Breit T, Fujikawa K, Alt F, et al. Vav family proteins couple to diverse cell surface receptors. Mol Cell Biol. 2000;20:6364-73 pubmed
    ..However, it is not known whether the recently identified isoforms Vav2 and Vav3, which are broadly expressed, can couple with similar classes of receptors, nor is it known whether all Vav ..
  8. Sauzeau V, Sevilla M, Montero M, Bustelo X. The Rho/Rac exchange factor Vav2 controls nitric oxide-dependent responses in mouse vascular smooth muscle cells. J Clin Invest. 2010;120:315-30 pubmed publisher
  9. Hall A, Gakidis M, Glogauer M, Wilsbacher J, Gao S, Swat W, et al. Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis. Immunity. 2006;24:305-16 pubmed
    ..phagocytosis mediated by integrin and Fcgamma receptors (FcgammaR), whereas the genetic deletion of Vav1 and Vav3 only prevents integrin-mediated phagocytosis through the complement receptor alpha(M)beta(2)...
  10. Hunter S, Zhuang G, Brantley Sieders D, Swat W, Cowan C, Chen J. Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesis. Mol Cell Biol. 2006;26:4830-42 pubmed
    ..Here we report the identification of Vav2 and Vav3 as guanine nucleotide exchange factors (GEFs) that link the EphA2 receptor to Rho family GTPase activation and ..
  11. Vigorito E, Gambardella L, Colucci F, McAdam S, Turner M. Vav proteins regulate peripheral B-cell survival. Blood. 2005;106:2391-8 pubmed
    ..Vav proteins thus regulate an NF-kappaB-dependent survival signal in naive B cells and are required for NF-kappaB function after BCR cross-linking. ..
  12. Utomo A, Cullere X, Glogauer M, Swat W, Mayadas T. Vav proteins in neutrophils are required for FcgammaR-mediated signaling to Rac GTPases and nicotinamide adenine dinucleotide phosphate oxidase component p40(phox). J Immunol. 2006;177:6388-97 pubmed, studies in neutrophils isolated from mice deficient in Vav or Rac isoforms demonstrate a critical role for Vav3 in Rac2-dependent activation of the NADPH oxidase following FcgammaR clustering...
  13. Sauzeau V, Jerkic M, Lopez Novoa J, Bustelo X. Loss of Vav2 proto-oncogene causes tachycardia and cardiovascular disease in mice. Mol Biol Cell. 2007;18:943-52 pubmed
    ..Experiments using knockout mice have indicated that the three Vav proteins present in mammals (Vav1, Vav2, and Vav3) are essential for proper signaling responses in hematopoietic cells...
  14. Cowan C, Shao Y, Sahin M, Shamah S, Lin M, Greer P, et al. Vav family GEFs link activated Ephs to endocytosis and axon guidance. Neuron. 2005;46:205-17 pubmed
    ..These findings suggest an important role for Vav family GEFs as regulators of ligand-receptor endocytosis and determinants of repulsive signaling during axon guidance. ..
  15. Sauzeau V, Horta Junior J, Riolobos A, Fernandez G, Sevilla M, López D, et al. Vav3 is involved in GABAergic axon guidance events important for the proper function of brainstem neurons controlling cardiovascular, respiratory, and renal parameters. Mol Biol Cell. 2010;21:4251-63 pubmed publisher
    b>Vav3 is a phosphorylation-dependent activator of Rho/Rac GTPases that has been implicated in hematopoietic, bone, cerebellar, and cardiovascular roles...
  16. Sauzeau V, Carvajal Gonzalez J, Riolobos A, Sevilla M, Menacho Márquez M, Román A, et al. Transcriptional factor aryl hydrocarbon receptor (Ahr) controls cardiovascular and respiratory functions by regulating the expression of the Vav3 proto-oncogene. J Biol Chem. 2011;286:2896-909 pubmed publisher
    ..We recently described that Vav3, an activator of Rho/Rac GTPases, is an Ahr transcriptional target in embryonic fibroblasts...
  17. Lawson C, Donald S, Anderson K, Patton D, Welch H. P-Rex1 and Vav1 cooperate in the regulation of formyl-methionyl-leucyl-phenylalanine-dependent neutrophil responses. J Immunol. 2011;186:1467-76 pubmed publisher
    ..lacking both P-Rex1 and Vav1 than those lacking the entire P-Rex family, the entire Vav family, or both P-Rex1 and Vav3. P-Rex1/Vav1 (P1V1) double-deficient cells also showed the strongest reduction in fMLF-stimulated activation of ..
  18. Graham D, Stephenson L, Lam S, Brim K, Lee H, Bautista J, et al. An ITAM-signaling pathway controls cross-presentation of particulate but not soluble antigens in dendritic cells. J Exp Med. 2007;204:2889-97 pubmed
  19. Menacho Márquez M, García Escudero R, Ojeda V, Abad A, Delgado P, Costa C, et al. The Rho exchange factors Vav2 and Vav3 favor skin tumor initiation and promotion by engaging extracellular signaling loops. PLoS Biol. 2013;11:e1001615 pubmed publisher
    ..Using genetically engineered mice, we show here that Vav2 and Vav3 favor cooperatively the initiation and promotion phases of skin tumors...
  20. Luft V, Reinhard J, Shibuya M, Fischer K, Faissner A. The guanine nucleotide exchange factor Vav3 regulates differentiation of progenitor cells in the developing mouse retina. Cell Tissue Res. 2015;359:423-440 pubmed publisher
    ..Here, we report that the guanine nucleotide exchange factor Vav3, a regulator of Rho-GTPases, is involved in retinal development...
  21. Ruiz S, Santos E, Bustelo X. The use of knockout mice reveals a synergistic role of the Vav1 and Rasgrf2 gene deficiencies in lymphomagenesis and metastasis. PLoS ONE. 2009;4:e8229 pubmed publisher
    ..They also suggest that the inactivation of Vav1 function may represent an inadequate strategy to treat T-cell lymphomas, especially those associated with low levels of Rasgrf2 gene expression. ..
  22. Gmyrek G, Akilesh H, Graham D, Fuchs A, Yang L, Miller M, et al. Loss of DAP12 and FcR? drives exaggerated IL-12 production and CD8(+) T cell response by CCR2(+) Mo-DCs. PLoS ONE. 2013;8:e76145 pubmed publisher
    ..Our data suggest a novel cross-talk between DC-ITAM and GM-CSF signaling pathways, which controls Mo-DC differentiation, IL-12 production, and CD8(+) T cell responses. ..
  23. Dumont C, Corsoni Tadrzak A, Ruf S, de Boer J, Williams A, Turner M, et al. Rac GTPases play critical roles in early T-cell development. Blood. 2009;113:3990-8 pubmed publisher
    ..Furthermore, we found a similar novel phenotype in the absence of Vav1, Vav2, and Vav3, which function as guanine nucleotide exchange factors for Rac1 and Rac2...
  24. Keilhoff G, Wiegand S, Fansa H. Vav deficiency impedes peripheral nerve regeneration in mice. Restor Neurol Neurosci. 2012;30:463-79 pubmed publisher
    ..all of these processes; therefore, activators of the cytoskeleton such as Rho GTPases and RhoGEFS such as Vav2 and Vav3 represent attractive targets for therapeutic intervention...
  25. Park Y, Drazba J, Vasanji A, Egelhoff T, Febbraio M, Silverstein R. Oxidized LDL/CD36 interaction induces loss of cell polarity and inhibits macrophage locomotion. Mol Biol Cell. 2012;23:3057-68 pubmed
    ..Activation of the Vav-Rac-myosin II pathway by oxidant stress may induce trapping of macrophages at sites of chronic inflammation such as atherosclerotic plaque. ..
  26. Ahronian L, Zhu L, Chen Y, Chu H, Klimstra D, Lewis B. A novel KLF6-Rho GTPase axis regulates hepatocellular carcinoma cell migration and dissemination. Oncogene. 2016;35:4653-62 pubmed publisher
    ..coupled to deep sequencing, we identified novel transcriptional targets of KLF6 in HCC cells including VAV3, a known activator of the RAC1 small GTPase...
  27. Graham D, Robertson C, Bautista J, Mascarenhas F, Diacovo M, Montgrain V, et al. Neutrophil-mediated oxidative burst and host defense are controlled by a Vav-PLCgamma2 signaling axis in mice. J Clin Invest. 2007;117:3445-52 pubmed
    ..Taken together, our data indicate that integrin-dependent signals generated during neutrophil adhesion contribute to the activation of NADPH oxidase by a variety of distinct effector pathways, all of which require Vav. ..
  28. Hale C, Dietz K, Varela J, Wood C, Zirlin B, Leverich L, et al. Essential role for vav Guanine nucleotide exchange factors in brain-derived neurotrophic factor-induced dendritic spine growth and synapse plasticity. J Neurosci. 2011;31:12426-36 pubmed publisher
  29. Utomo A, Hirahashi J, Mekala D, Asano K, Glogauer M, Cullere X, et al. Requirement for Vav proteins in post-recruitment neutrophil cytotoxicity in IgG but not complement C3-dependent injury. J Immunol. 2008;180:6279-87 pubmed
    ..Thus, FcgammaR signaling through the Vav and Rac proteins in neutrophils is critical for stimulating immune complex disease while Vav- and Rac-independent pathways promote Mac-1/complement C3-dependent functions...
  30. Zhu S, Zhao C, Wu Y, Yang Q, Shao A, Wang T, et al. Identification of a Vav2-dependent mechanism for GDNF/Ret control of mesolimbic DAT trafficking. Nat Neurosci. 2015;18:1084-93 pubmed publisher
    ..Our data demonstrate that Vav2 is a determinant of DAT trafficking in vivo and contributes to the maintenance of DA homeostasis in limbic DA neuron terminals. ..
  31. Fujikawa K, Iwata T, Inoue K, Akahori M, Kadotani H, Fukaya M, et al. VAV2 and VAV3 as candidate disease genes for spontaneous glaucoma in mice and humans. PLoS ONE. 2010;5:e9050 pubmed publisher
    ..Here we demonstrate that deficiency of Vav2 and Vav3, guanine nucleotides exchange factors for Rho guanosine triphosphatases, leads to an ocular phenotype similar to ..
  32. Pan D, Amison R, Riffo Vasquez Y, Spina D, Cleary S, Wakelam M, et al. P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation. Blood. 2015;125:1146-58 pubmed publisher
    ..recruitment into the peritoneum was more severely impaired in P-Rex1(-/-) Vav1(-/-) (P1V1) or P-Rex1(-/-) Vav3(-/-) (P1V3) mice than in P-Rex null or Vav null mice, suggesting cooperation between P-Rex and Vav Rac-GEFs in this ..
  33. Johannesson M, Olsson L, Lindqvist A, Moller S, Koczan D, Wester Rosenlöf L, et al. Gene expression profiling of arthritis using a QTL chip reveals a complex gene regulation of the Cia5 region in mice. Genes Immun. 2005;6:575-83 pubmed
    ..We conclude the QTL-chip strategy to be valuable in the selection of candidate genes to be prioritized for further investigation...
  34. Kant S, Swat W, Zhang S, Zhang Z, Neel B, Flavell R, et al. TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway. Genes Dev. 2011;25:2069-78 pubmed publisher
    ..We show that this pathway is essential for full MAP kinase activation during the response to TNF. Moreover, this MLK pathway contributes to inflammation in vivo. ..
  35. Carvajal Gonzalez J, Mulero Navarro S, Roman A, Sauzeau V, Merino J, Bustelo X, et al. The dioxin receptor regulates the constitutive expression of the vav3 proto-oncogene and modulates cell shape and adhesion. Mol Biol Cell. 2009;20:1715-27 pubmed publisher
    ..The cytoskeleton alterations of AhR-/- cells were due to down-regulation of constitutive Vav3 expression, a guanosine diphosphate/guanosine triphosphate exchange factor for Rho/Rac GTPases and a novel ..
  36. Fraser H, Dendrou C, Healy B, Rainbow D, Howlett S, Smink L, et al. Nonobese diabetic congenic strain analysis of autoimmune diabetes reveals genetic complexity of the Idd18 locus and identifies Vav3 as a candidate gene. J Immunol. 2010;184:5075-84 pubmed publisher
    ..diabetes (Idd)18 interval to a region on chromosome 3 that includes the immunologically relevant candidate gene, Vav3. To test the candidacy of Vav3, we developed a novel congenic strain that enabled the resolution of Idd18 to a 604-..
  37. Brantley Sieders D, Zhuang G, Vaught D, Freeman T, Hwang Y, Hicks D, et al. Host deficiency in Vav2/3 guanine nucleotide exchange factors impairs tumor growth, survival, and angiogenesis in vivo. Mol Cancer Res. 2009;7:615-23 pubmed publisher
    ..Although Vav1 expression is restricted to the immune system, Vav2 and Vav3 are expressed in several tissues, including highly vascularized organs...
  38. Charvet C, Canonigo A, Bécart S, Maurer U, Miletic A, Swat W, et al. Vav1 promotes T cell cycle progression by linking TCR/CD28 costimulation to FOXO1 and p27kip1 expression. J Immunol. 2006;177:5024-31 pubmed
    ..These defects were more pronounced in Vav1/Vav3 double-deficient T cells, suggesting partial redundancy between Vav1 and Vav3...
  39. Menacho Márquez M, Nogueiras R, Fabbiano S, Sauzeau V, Al Massadi O, Dieguez C, et al. Chronic sympathoexcitation through loss of Vav3, a Rac1 activator, results in divergent effects on metabolic syndrome and obesity depending on diet. Cell Metab. 2013;18:199-211 pubmed publisher
    ..issue, we utilized genetically engineered mice showing chronic sympathoexcitation and hypertension due to lack of Vav3, a Rac1 activator. Here, we report that these animals develop metabolic syndrome under chow diet...
  40. Malhotra S, Kovats S, Zhang W, Coggeshall K. B cell antigen receptor endocytosis and antigen presentation to T cells require Vav and dynamin. J Biol Chem. 2009;284:24088-97 pubmed publisher
    ..We have identified a pathway supporting BCR internalization that includes the Vav1 and/or Vav3 isoforms and the GTPase dynamin...
  41. Robles Valero J, Lorenzo Martín L, Menacho Márquez M, Fernández Pisonero I, Abad A, Camos M, et al. A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia. Cancer Cell. 2017;32:608-623.e9 pubmed publisher
    ..The downregulation of Vav1 is essential for the pathogenesis of human T-ALL of the TLX+ clinical subtype, further underscoring the suppressor role of this pathway. ..
  42. Trenkle T, McClelland M, Adlkofer K, Welsh J. Major transcript variants of VAV3, a new member of the VAV family of guanine nucleotide exchange factors. Gene. 2000;245:139-49 pubmed
    b>VAV3 is a new member of the VAV oncogene family with a strong homology to VAV and VAV2...
  43. Liu J, Seno H, Miletic A, Mills J, Swat W, Stappenbeck T. Vav proteins are necessary for correct differentiation of mouse cecal and colonic enterocytes. J Cell Sci. 2009;122:324-34 pubmed publisher
    ..Loss of Vav protein expression in triple-knockout mice (Vav1(-/-);Vav2(-/-);Vav3(-/-)) resulted in defective expansion of microtubule cytoskeletons, a significant decrease in cell height and ..
  44. Stephenson L, Miletic A, Kloeppel T, Kusin S, Swat W. Vav proteins regulate the plasma cell program and secretory Ig production. J Immunol. 2006;177:8620-5 pubmed
    ..These data indicate a previously unknown role for Vav as an upstream regulator of Blimp-1. ..
  45. Henderson R, Grys K, Vehlow A, de Bettignies C, Zachacz A, Henley T, et al. A novel Rac-dependent checkpoint in B cell development controls entry into the splenic white pulp and cell survival. J Exp Med. 2010;207:837-53 pubmed publisher
    ..Thus, these studies identify a novel developmental checkpoint that coincides with B cell positive selection. ..
  46. Fabbiano S, Menacho Márquez M, Sevilla M, Albarrán Juárez J, Zheng Y, Offermanns S, et al. Genetic dissection of the vav2-rac1 signaling axis in vascular smooth muscle cells. Mol Cell Biol. 2014;34:4404-19 pubmed publisher
    ..Finally, our results suggest that the therapeutic inhibition of Rac1 will be associated with extensive cardiovascular system-related side effects and identify pharmacological avenues to circumvent them. ..
  47. Damoulakis G, Gambardella L, Rossman K, Lawson C, Anderson K, Fukui Y, et al. P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils. J Cell Sci. 2014;127:2589-600 pubmed publisher
    ..These findings thus have broad implications for our understanding of GPCR signalling to Rho GTPases and the actin cytoskeleton. ..
  48. Dong Z, Davidson D, Pérez Quintero L, Kurosaki T, Swat W, Veillette A. The adaptor SAP controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cells. Immunity. 2012;36:974-85 pubmed publisher
    ..These data showed that SAP secures NK cell activation by a dichotomous molecular mechanism, which is required for conjugate formation. These findings may have implications for the role of SAP in other immune cell types. ..
  49. Glassmann A, Topka S, Wang Eckardt L, Anders S, Weisheit G, Endl E, et al. Basic molecular fingerprinting of immature cerebellar cortical inhibitory interneurons and their precursors. Neuroscience. 2009;159:69-82 pubmed publisher
    ..Together, these data support the notion that diversification of cerebellar inhibitory interneurons is highly regulative and subject to local signaling to postmigratory precursors. ..
  50. Liu Y, Mo J, Hu Q, Boivin G, Levin L, Yang D, et al. Targeted overexpression of vav3 oncogene in prostatic epithelium induces nonbacterial prostatitis and prostate cancer. Cancer Res. 2008;68:6396-406 pubmed publisher
    Our previous study revealed that Vav3 oncogene is overexpressed in human prostate cancer, activates androgen receptor (AR), and stimulates growth in prostate cancer cells...
  51. Boyle K, Gyori D, Sindrilaru A, Scharffetter Kochanek K, Taylor P, Mócsai A, et al. Class IA phosphoinositide 3-kinase β and δ regulate neutrophil oxidase activation in response to Aspergillus fumigatus hyphae. J Immunol. 2011;186:2978-89 pubmed publisher
    ..These results start to define the signaling network controlling neutrophil ROS responses to A. fumigatus hyphae. ..
  52. Acton S, Astarita J, Malhotra D, Lukacs Kornek V, Franz B, Hess P, et al. Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2. Immunity. 2012;37:276-89 pubmed publisher
    ..Thus, activation of CLEC-2 by PDPN rearranges the actin cytoskeleton in DCs to promote efficient motility along stromal surfaces. ..
  53. Chen K, Li W, Major J, Rahaman S, Febbraio M, Silverstein R. Vav guanine nucleotide exchange factors link hyperlipidemia and a prothrombotic state. Blood. 2011;117:5744-50 pubmed publisher
    ..We now show that the guanine nucleotide exchange factors Vav1 and Vav3 were tyrosine phosphorylated in platelets exposed to oxLDL...
  54. Janas M, Turner M. Interaction of Ras with p110? is required for thymic ?-selection in the mouse. J Immunol. 2011;187:4667-75 pubmed publisher
    ..Uncoupling Ras from p110? provides unambiguous identification of a Ras interaction required for thymic ?-selection. ..
  55. Fabbiano S, Menacho Márquez M, Robles Valero J, Pericacho M, Matesanz Marín A, García Macías C, et al. Immunosuppression-Independent Role of Regulatory T Cells against Hypertension-Driven Renal Dysfunctions. Mol Cell Biol. 2015;35:3528-46 pubmed publisher
    ..These results indicate that TREG cells constitute a first protective barrier against hypertension-driven tissue fibrosis and, in addition, suggest new therapeutic avenues to prevent hypertension-linked cardiorenal diseases. ..
  56. Li X, Utomo A, Cullere X, Choi M, Milner D, Venkatesh D, et al. The ?-glucan receptor Dectin-1 activates the integrin Mac-1 in neutrophils via Vav protein signaling to promote Candida albicans clearance. Cell Host Microbe. 2011;10:603-15 pubmed publisher
    ..Both Mac-1 activation and Dectin-1- and Mac-1-induced neutrophil effector functions require Vav1 and Vav3, exchange factors for RhoGTPases...
  57. Roth S, Bergmann H, Jaeger M, Yeroslaviz A, Neumann K, Koenig P, et al. Vav Proteins Are Key Regulators of Card9 Signaling for Innate Antifungal Immunity. Cell Rep. 2016;17:2572-2583 pubmed publisher
    ..Here, we identify Vav proteins as key activators of the Card9 pathway. Vav1, Vav2, and Vav3 cooperate downstream of Dectin-1, Dectin-2, and Mincle to engage Card9 for NF-?B control and proinflammatory gene ..
  58. Reeve J, Zou W, Liu Y, Maltzman J, Ross F, Teitelbaum S. SLP-76 couples Syk to the osteoclast cytoskeleton. J Immunol. 2009;183:1804-12 pubmed publisher
    ..Furthermore, in the absence of the adaptor protein, integrin-mediated phosphorylation of Vav3, the OC cytoskeleton-organizing guanine nucleotide exchange factor, is abrogated...