Vav1

Summary

Gene Symbol: Vav1
Description: vav 1 oncogene
Alias: Vav, vav-T, proto-oncogene vav, p95vav, vav oncogene
Species: mouse
Products:     Vav1

Top Publications

  1. Machide M, Mano H, Todokoro K. Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain. Oncogene. 1995;11:619-25 pubmed
    ..We found that the c-vav proto-oncogene product, Vav, is rapidly and transiently tyrosine-phosphorylated in response to erythropoietin and ..
  2. Schuebel K, Bustelo X, Nielsen D, Song B, Barbacid M, Goldman D, et al. Isolation and characterization of murine vav2, a member of the vav family of proto-oncogenes. Oncogene. 1996;13:363-71 pubmed
    ..vav2 shares 63% and 55% identity at the nucleic acid and amino acid levels, respectively, with vav, a proto-oncogene that plays an essential role in embryonic development and hematopoietic signal transduction...
  3. Vicente Manzanares M, Cruz Adalia A, Martín Cófreces N, Cabrero J, Dosil M, Alvarado Sánchez B, et al. Control of lymphocyte shape and the chemotactic response by the GTP exchange factor Vav. Blood. 2005;105:3026-34 pubmed
    ..In this report, we have analyzed the activation and subcellular localization of the hematopoietic GEF Vav in human peripheral blood lymphocytes stimulated with the chemokine stromal cell-derived factor-1 (SDF-1alpha)...
  4. Miletic A, Graham D, Sakata Sogawa K, Hiroshima M, Hamann M, Cemerski S, et al. Vav links the T cell antigen receptor to the actin cytoskeleton and T cell activation independently of intrinsic Guanine nucleotide exchange activity. PLoS ONE. 2009;4:e6599 pubmed publisher
    ..Here, we report that Vav1 assembles into signaling microclusters at TCR contact sites and is critical for TCR-initiated actin polymerization...
  5. Katzav S, Martin Zanca D, Barbacid M. vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells. EMBO J. 1989;8:2283-90 pubmed
    ..A novel human oncogene, designated vav, was generated by a genetic rearrangement during gene transfer assays. The vav oncogene directs the synthesis of a 3.0 kb mRNA from which we isolated a 2.8 kb-long complementary DNA copy...
  6. Miletic A, Graham D, Montgrain V, Fujikawa K, Kloeppel T, Brim K, et al. Vav proteins control MyD88-dependent oxidative burst. Blood. 2007;109:3360-8 pubmed
    ..of LPS-induced MyD88-dependent activation of Rac2, NADPH oxidase, and ROI production using mice deficient in Vav1, Vav2, and Vav3...
  7. Saveliev A, Vanes L, Ksionda O, Rapley J, Smerdon S, Rittinger K, et al. Function of the nucleotide exchange activity of vav1 in T cell development and activation. Sci Signal. 2009;2:ra83 pubmed publisher
    The guanine nucleotide exchange factor (GEF) Vav1 is essential for transducing T cell antigen receptor (TCR) signals and therefore plays a critical role in the development and activation of T cells...
  8. Bustelo X, Barbacid M. Tyrosine phosphorylation of the vav proto-oncogene product in activated B cells. Science. 1992;256:1196-9 pubmed
    ..One such protein is p95vav, the product of the vav proto-oncogene...
  9. Arana E, Vehlow A, Harwood N, Vigorito E, Henderson R, Turner M, et al. Activation of the small GTPase Rac2 via the B cell receptor regulates B cell adhesion and immunological-synapse formation. Immunity. 2008;28:88-99 pubmed publisher
    ..cells, Rac1 and Rac2, were activated rapidly downstream of Src-family kinases, guanine-nucleotide exchange factors Vav1 and Vav2, and phosphoinositide-3 kinase (PI3K) after BCR engagement...

More Information

Publications70

  1. Sauzeau V, Carvajal Gonzalez J, Riolobos A, Sevilla M, Menacho Márquez M, Román A, et al. Transcriptional factor aryl hydrocarbon receptor (Ahr) controls cardiovascular and respiratory functions by regulating the expression of the Vav3 proto-oncogene. J Biol Chem. 2011;286:2896-909 pubmed publisher
    ..Our data also reveal the presence of sympathoexcitation and new cardiorespiratory defects in Ahr(-/-) mice. ..
  2. Tanaka Y, So T, Lebedeva S, Croft M, Altman A. Impaired IL-4 and c-Maf expression and enhanced Th1-cell development in Vav1-deficient mice. Blood. 2005;106:1286-95 pubmed
    ..We report that Vav1-/- CD4+ T cells display deficient T-cell receptor (TCR)/CD28-induced IL-4 and c-Maf expression and, conversely, ..
  3. Doody G, Bell S, Vigorito E, Clayton E, McAdam S, Tooze R, et al. Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation. Nat Immunol. 2001;2:542-7 pubmed
    B and T lymphocytes develop normally in mice lacking the guanine nucleotide exchange factor Vav-2...
  4. Wells C, Bhavsar P, Evans I, Vigorito E, Turner M, Tybulewicz V, et al. Vav1 and Vav2 play different roles in macrophage migration and cytoskeletal organization. Exp Cell Res. 2005;310:303-10 pubmed
    ..Using mice deficient for Vav1, Vav2 and/or Vav3, overlapping and isoform-specific functions of the three Vav proteins have been described in ..
  5. Rahaman S, Swat W, Febbraio M, Silverstein R. Vav family Rho guanine nucleotide exchange factors regulate CD36-mediated macrophage foam cell formation. J Biol Chem. 2011;286:7010-7 pubmed publisher
    ..Although Vav family guanine nucleotide exchange factors impact processes highly relevant to atherogenesis and are involved in ..
  6. Gomez T, Hamann M, McCarney S, Savoy D, Lubking C, Heldebrant M, et al. Dynamin 2 regulates T cell activation by controlling actin polymerization at the immunological synapse. Nat Immunol. 2005;6:261-70 pubmed
    ..Moreover, Dyn2 interacted directly with the Rho family guanine nucleotide exchange factor Vav1, and this interaction was required for T cell activation...
  7. Korn T, Fischer K, Girkontaite I, Köllner G, Toyka K, Jung S. Vav1-deficient mice are resistant to MOG-induced experimental autoimmune encephalomyelitis due to impaired antigen priming. J Neuroimmunol. 2003;139:17-26 pubmed
    Mice that lack the guanine nucleotide exchange factor (GEF) Vav1 exhibit particular defects in antigen-triggered T cell activation but may have an autoreactive T cell repertoire due to impaired intra-thymic negative selection...
  8. Holsinger L, Graef I, Swat W, Chi T, Bautista D, Davidson L, et al. Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction. Curr Biol. 1998;8:563-72 pubmed
    ..We have studied the events underlying cap formation using mice bearing a null mutation in vav (vav-/-), a gene that encodes a guanine-nucleotide exchange factor for the GTPase Rac...
  9. Ruiz S, Santos E, Bustelo X. RasGRF2, a guanosine nucleotide exchange factor for Ras GTPases, participates in T-cell signaling responses. Mol Cell Biol. 2007;27:8127-42 pubmed
    ..The stimulation of this GTPase in T cells occurs primarily through the Vav1- and phospholipase C-gamma1-dependent activation of RasGRP1, a diacylglycerol-responsive Ras GDP/GTP exchange ..
  10. Swat W, Xavier R, Mizoguchi A, Mizoguchi E, Fredericks J, Fujikawa K, et al. Essential role for Vav1 in activation, but not development, of gammadelta T cells. Int Immunol. 2003;15:215-21 pubmed
    b>Vav1 is a guanine nucleotide exchange factor essential in the development and function of alphabeta lineage T cells...
  11. David R, Ma L, Ivetic A, Takesono A, Ridley A, Chai J, et al. T-cell receptor- and CD28-induced Vav1 activity is required for the accumulation of primed T cells into antigenic tissue. Blood. 2009;113:3696-705 pubmed publisher
    ..The guanine nucleotide exchange factor (GEF) Vav1 has an integral role in coupling TCR and CD28 to signaling pathways that regulate T-cell activation and migration...
  12. Ming W, Li S, Billadeau D, Quilliam L, Dinauer M. The Rac effector p67phox regulates phagocyte NADPH oxidase by stimulating Vav1 guanine nucleotide exchange activity. Mol Cell Biol. 2007;27:312-23 pubmed
    ..Previous studies suggest that Vav1 regulates NADPH oxidase activity elicited by the chemoattractant formyl-Met-Leu-Phe (fMLP)...
  13. Krawczyk C, Bachmaier K, Sasaki T, Jones R, Snapper S, Bouchard D, et al. Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells. Immunity. 2000;13:463-73 pubmed
    ..Introduction of the cbl-b mutation into a vav1-/- background relieved the functional defects of vav1-/- T cells and caused spontaneous autoimmunity...
  14. Ardouin L, Bracke M, Mathiot A, Pagakis S, Norton T, Hogg N, et al. Vav1 transduces TCR signals required for LFA-1 function and cell polarization at the immunological synapse. Eur J Immunol. 2003;33:790-7 pubmed
    ..b>Vav1 is a guanine nucleotide exchange factor for members of the Rho/Rac family of GTPases which is activated following ..
  15. Chang K, Sanchez Aguilera A, Shen S, Sengupta A, Madhu M, Ficker A, et al. Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival. Blood. 2012;120:800-11 pubmed publisher
    ..Compensatory up-regulation of expression and activation of Vav3 in Vav1/Vav2-deficient B-cell progenitors increases the transformation ability of p190-BCR-ABL...
  16. Cowan C, Shao Y, Sahin M, Shamah S, Lin M, Greer P, et al. Vav family GEFs link activated Ephs to endocytosis and axon guidance. Neuron. 2005;46:205-17 pubmed
    ..We find that, during axon guidance, ephrin binding to Ephs triggers Vav-dependent endocytosis of the ligand-receptor complex, thus converting an initially adhesive interaction into a ..
  17. Fischer K, Kong Y, Nishina H, Tedford K, Marengere L, Kozieradzki I, et al. Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor. Curr Biol. 1998;8:554-62 pubmed
    b>Vav is a guanine-nucleotide exchange factor for the Rho-like small GTPases RhoA, Rac1 and Cdc42, which regulate cytoskeletal reorganization and activation of stress-activated protein kinases (SAPK/JNKs)...
  18. Gulbranson Judge A, Tybulewicz V, Walters A, Toellner K, MacLennan I, Turner M. Defective immunoglobulin class switching in Vav-deficient mice is attributable to compromised T cell help. Eur J Immunol. 1999;29:477-87 pubmed
    b>Vav, a guanine nucleotide exchange factor for members of the Rho family of small GTPases, is activated through engagement of B and T lymphocyte antigen receptors...
  19. Dumont C, Corsoni Tadrzak A, Ruf S, de Boer J, Williams A, Turner M, et al. Rac GTPases play critical roles in early T-cell development. Blood. 2009;113:3990-8 pubmed publisher
    ..Furthermore, we found a similar novel phenotype in the absence of Vav1, Vav2, and Vav3, which function as guanine nucleotide exchange factors for Rac1 and Rac2...
  20. Reynolds L, Smyth L, Norton T, Freshney N, Downward J, Kioussis D, et al. Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and -independent pathways. J Exp Med. 2002;195:1103-14 pubmed
    b>Vav1 is a signal transducing protein required for T cell receptor (TCR) signals that drive positive and negative selection in the thymus. Furthermore, Vav1-deficient thymocytes show greatly reduced TCR-induced intracellular calcium flux...
  21. Yu B, Martins I, Li P, Amarasinghe G, Umetani J, Fernandez Zapico M, et al. Structural and energetic mechanisms of cooperative autoinhibition and activation of Vav1. Cell. 2010;140:246-56 pubmed publisher
    ..We report the structure and biophysical and cellular analyses of the five-domain autoinhibitory element of Vav1. The catalytic Dbl homology (DH) domain of Vav1 is controlled by two energetically coupled processes...
  22. Kong Y, Fischer K, Bachmann M, Mariathasan S, Kozieradzki I, Nghiem M, et al. Vav regulates peptide-specific apoptosis in thymocytes. J Exp Med. 1998;188:2099-111 pubmed
    The protooncogene Vav functions as a GDP/GTP exchange factor (GEF) for Rho-like small GTPases involved in cytoskeletal reorganization and cytokine production in T cells...
  23. Shah V, Ozment Skelton T, Williams D, Keshvara L. Vav1 and PI3K are required for phagocytosis of beta-glucan and subsequent superoxide generation by microglia. Mol Immunol. 2009;46:1845-53 pubmed publisher
    ..Here, we report that the guanine nucleotide exchange factor Vav1 as well as phosphoinositide-3 kinase (PI3K) are downstream mediators of what is now recognized as the Dectin-1 ..
  24. Fujikawa K, Miletic A, Alt F, Faccio R, Brown T, Hoog J, et al. Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells. J Exp Med. 2003;198:1595-608 pubmed
    ..Although the expression of Vav1 alone is sufficient for normal lymphocyte development, our data also reveal lineage-specific roles for Vav2 and ..
  25. Faure S, Salazar Fontana L, Semichon M, Tybulewicz V, Bismuth G, Trautmann A, et al. ERM proteins regulate cytoskeleton relaxation promoting T cell-APC conjugation. Nat Immunol. 2004;5:272-9 pubmed
    ..Here we demonstrate that ezrin-radixin-moesin proteins are rapidly inactivated after antigen recognition through a Vav1-Rac1 pathway...
  26. Coppola J, Bryant S, Koda T, Conway D, Barbacid M. Mechanism of activation of the vav protooncogene. Cell Growth Differ. 1991;2:95-105 pubmed
    ..amino acid sequence of p95vav revealed an amino-terminal leucine-rich region not present in the activated vav oncogene. This region consists of an amphipathic helix-loop-helix followed by a leucine zipper, a structure reminiscent ..
  27. Bhavsar P, Vigorito E, Turner M, Ridley A. Vav GEFs regulate macrophage morphology and adhesion-induced Rac and Rho activation. Exp Cell Res. 2009;315:3345-58 pubmed publisher
    The Vav family of proteins have the potential to act as both signalling adapters and GEFs for Rho GTPases. They have therefore been proposed as regulators of the cytoskeleton in various cell types...
  28. Graham D, Akilesh H, Gmyrek G, Piccio L, Gilfillan S, Sim J, et al. ITAM signaling in dendritic cells controls T helper cell priming by regulating MHC class II recycling. Blood. 2010;116:3208-18 pubmed publisher
    ..mediated by the DC immunoreceptor tyrosine-based activation motif (ITAM)-containing adaptors (DAP12 and FcR?) and Vav family guanine nucleotide exchange factors controls the half-life of surface peptide-MHCII (pMHCII) complexes and ..
  29. Turner M, Mee P, Walters A, Quinn M, Mellor A, Zamoyska R, et al. A requirement for the Rho-family GTP exchange factor Vav in positive and negative selection of thymocytes. Immunity. 1997;7:451-60 pubmed
    ..TCR-mediated signals that determine these selection processes are only partly understood. Vav, a GDP-GTP exchange factor for Rho-family proteins, is tyrosine phosphorylated following TCR stimulation, ..
  30. Adams J, Houston H, Allen J, Lints T, Harvey R. The hematopoietically expressed vav proto-oncogene shares homology with the dbl GDP-GTP exchange factor, the bcr gene and a yeast gene (CDC24) involved in cytoskeletal organization. Oncogene. 1992;7:611-8 pubmed
    The vav proto-oncogene encodes a protein of unknown function that is rendered oncogenic by loss of a short N-terminal domain...
  31. Graham D, Stephenson L, Lam S, Brim K, Lee H, Bautista J, et al. An ITAM-signaling pathway controls cross-presentation of particulate but not soluble antigens in dendritic cells. J Exp Med. 2007;204:2889-97 pubmed
    ..by the immunoreceptor tyrosine-based activation motif (ITAM)-containing adaptors DAP12 and FcRgamma utilizes the Vav family of Rho guanine nucleotide exchange factors (GEFs) for processing and cross-presentation of particulate, but ..
  32. Lawson C, Donald S, Anderson K, Patton D, Welch H. P-Rex1 and Vav1 cooperate in the regulation of formyl-methionyl-leucyl-phenylalanine-dependent neutrophil responses. J Immunol. 2011;186:1467-76 pubmed publisher
    ..Surprisingly, fMLF-stimulated ROS formation, adhesion, and chemotaxis were synergistically controlled by P-Rex1 and Vav1. These responses were more severely impaired in neutrophils lacking both P-Rex1 and Vav1 than those lacking the ..
  33. Weber M, Treanor B, Depoil D, Shinohara H, Harwood N, Hikida M, et al. Phospholipase C-gamma2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen. J Exp Med. 2008;205:853-68 pubmed publisher
    ..We identify a key role for phospholipase C-gamma2 (PLCgamma2), Vav, B cell linker, and Bruton's tyrosine kinase in the formation of highly coordinated "microsignalosomes," ..
  34. Li P, Martins I, Amarasinghe G, Rosen M. Internal dynamics control activation and activity of the autoinhibited Vav DH domain. Nat Struct Mol Biol. 2008;15:613-8 pubmed publisher
    ..The Dbl homology (DH) domain of the proto-oncoprotein and guanine nucleotide exchange factor Vav1 is autoinhibited through interactions between its catalytic surface and a helix from an N-terminal acidic region...
  35. Hall A, Gakidis M, Glogauer M, Wilsbacher J, Gao S, Swat W, et al. Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis. Immunity. 2006;24:305-16 pubmed
    ..Rac2 prevents phagocytosis mediated by integrin and Fcgamma receptors (FcgammaR), whereas the genetic deletion of Vav1 and Vav3 only prevents integrin-mediated phagocytosis through the complement receptor alpha(M)beta(2)...
  36. Prisco A, Vanes L, Ruf S, Trigueros C, Tybulewicz V. Lineage-specific requirement for the PH domain of Vav1 in the activation of CD4+ but not CD8+ T cells. Immunity. 2005;23:263-74 pubmed
    b>Vav1 is a guanine nucleotide exchange factor (GEF) for Rho-family GTPases, which is activated by tyrosine phosphorylation following TCR stimulation...
  37. Fischer K, Zmuldzinas A, Gardner S, Barbacid M, Bernstein A, Guidos C. Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+ CD8+ thymocytes. Nature. 1995;374:474-7 pubmed
    ..induces tyrosine phosphorylation of specific SH2- and SH3-domain-containing cytoplasmic proteins, including Vav. Here we show that vav-/- embryonic stem cells generate only limited numbers of immature and mature T and B ..
  38. Han J, Luby Phelps K, Das B, Shu X, Xia Y, Mosteller R, et al. Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav. Science. 1998;279:558-60 pubmed
    ..b>Vav, a guanosine diphosphate (GDP)-guanosine triphosphate (GTP) exchange factor for Rac that stimulates the exchange of ..
  39. Reynolds L, de Bettignies C, Norton T, Beeser A, Chernoff J, Tybulewicz V. Vav1 transduces T cell receptor signals to the activation of the Ras/ERK pathway via LAT, Sos, and RasGRP1. J Biol Chem. 2004;279:18239-46 pubmed
    b>Vav1 is a signaling protein required for both positive and negative selection of CD4(+)CD8(+) double positive thymocytes. Activation of the ERK MAPK pathway is also required for positive selection...
  40. Penninger J, Fischer K, Sasaki T, Kozieradzki I, Le J, Tedford K, et al. The oncogene product Vav is a crucial regulator of primary cytotoxic T cell responses but has no apparent role in CD28-mediated co-stimulation. Eur J Immunol. 1999;29:1709-18 pubmed
    The guanine nucleotide-exchange factor Vav is a regulator of antigen-mediated cytoskeletal reorganization required for receptor clustering, proliferation and thymic selection...
  41. Utomo A, Cullere X, Glogauer M, Swat W, Mayadas T. Vav proteins in neutrophils are required for FcgammaR-mediated signaling to Rac GTPases and nicotinamide adenine dinucleotide phosphate oxidase component p40(phox). J Immunol. 2006;177:6388-97 pubmed
    ..However, studies in cytokine-primed cells revealed a strict requirement for Vav1 and Vav3 and Rac1 and Rac2 in the FcgammaR-mediated oxidative burst...
  42. Pearce A, Senis Y, Billadeau D, Turner M, Watson S, Vigorito E. Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen. J Biol Chem. 2004;279:53955-62 pubmed
    ..b>Vav1, Vav2, and Vav3 play a crucial role in the regulation of phospholipase C gamma (PLC gamma) isoforms by immuno-..
  43. Gakidis M, Cullere X, Olson T, Wilsbacher J, Zhang B, Moores S, et al. Vav GEFs are required for beta2 integrin-dependent functions of neutrophils. J Cell Biol. 2004;166:273-82 pubmed
    ..Using Vav1/Vav3-deficient neutrophils (Vav1/3ko), we show that Vav proteins are required for multiple beta2 integrin-dependent ..
  44. Pires de Miranda M, Alenquer M, Marques S, Rodrigues L, Lopes F, Bustelo X, et al. The Gammaherpesvirus m2 protein manipulates the Fyn/Vav pathway through a multidocking mechanism of assembly. PLoS ONE. 2008;3:e1654 pubmed publisher
    ..One such protein is M2, a murine gammaherpesvirus 68-encoded molecule that activates the Vav1/Rac1 pathway via the formation of trimolecular complexes with Scr family members...
  45. Manetz T, Gonzalez Espinosa C, Arudchandran R, Xirasagar S, Tybulewicz V, Rivera J. Vav1 regulates phospholipase cgamma activation and calcium responses in mast cells. Mol Cell Biol. 2001;21:3763-74 pubmed
    The hematopoietic cell-specific protein Vav1 is a substrate of tyrosine kinases activated following engagement of many receptors, including FcepsilonRI...
  46. Houlard M, Arudchandran R, Regnier Ricard F, Germani A, Gisselbrecht S, Blank U, et al. Vav1 is a component of transcriptionally active complexes. J Exp Med. 2002;195:1115-27 pubmed
    The importance of the hematopoietic protooncogene Vav1 in immune cell function is widely recognized, although its regulatory mechanisms are not completely understood...
  47. Chan G, Hanke T, Fischer K. Vav-1 regulates NK T cell development and NK cell cytotoxicity. Eur J Immunol. 2001;31:2403-10 pubmed
    The hematopoietic-specific Rho-family GTP exchange factor Vav-1 is a regulator of lymphocyte antigen receptor signaling and mediates normal maturation and activation of B and T cells...
  48. Tarakhovsky A, Turner M, Schaal S, Mee P, Duddy L, Rajewsky K, et al. Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav. Nature. 1995;374:467-70 pubmed
    ..of B- or T-cell antigen receptors results in the rapid tyrosine phosphorylation of a number of proteins, including Vav, a protein expressed in cells of the haematopoietic system...
  49. Li X, Utomo A, Cullere X, Choi M, Milner D, Venkatesh D, et al. The ?-glucan receptor Dectin-1 activates the integrin Mac-1 in neutrophils via Vav protein signaling to promote Candida albicans clearance. Cell Host Microbe. 2011;10:603-15 pubmed publisher
    ..Both Mac-1 activation and Dectin-1- and Mac-1-induced neutrophil effector functions require Vav1 and Vav3, exchange factors for RhoGTPases...
  50. Zugaza J, López Lago M, Caloca M, Dosil M, Movilla N, Bustelo X. Structural determinants for the biological activity of Vav proteins. J Biol Chem. 2002;277:45377-92 pubmed
    We have used an extensive mutagenesis approach to study the specific role of the eight structural domains of Vav during both the activation and signaling steps of this Rac1 exchange factor...
  51. Weckbecker G, Bruns C, Fischer K, Heusser C, Li J, Metzler B, et al. Strongly reduced alloreactivity and long-term survival times of cardiac allografts in Vav1- and Vav1/Vav2-knockout mice. Transpl Int. 2007;20:353-64 pubmed
    ..We have studied the role of Vav1 and Vav2 in allogeneic T-cell activation, antibody responses and allograft rejection...
  52. Spurrell D, Luckashenak N, Minney D, Chaplin A, Penninger J, Liwski R, et al. Vav1 regulates the migration and adhesion of dendritic cells. J Immunol. 2009;183:310-8 pubmed publisher
    ..b>Vav1, a guanine nucleotide exchange factor for Rho family GTPases, mediates cytoskeletal rearrangement in hematopoietic ..
  53. Krawczyk C, Oliveira dos Santos A, Sasaki T, Griffiths E, Ohashi P, Snapper S, et al. Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells. Immunity. 2002;16:331-43 pubmed
    ..We show that Vav1 controls integrin-mediated adhesion of thymocytes and T cells to ECM proteins and ICAM1 following TCR stimulation...
  54. Colucci F, Rosmaraki E, Bregenholt S, Samson S, Di Bartolo V, Turner M, et al. Functional dichotomy in natural killer cell signaling: Vav1-dependent and -independent mechanisms. J Exp Med. 2001;193:1413-24 pubmed
    The product of the protooncogene Vav1 participates in multiple signaling pathways and is a critical regulator of antigen-receptor signaling in B and T lymphocytes, but its role during in vivo natural killer (NK) cell differentiation is ..
  55. Sauzeau V, Sevilla M, Montero M, Bustelo X. The Rho/Rac exchange factor Vav2 controls nitric oxide-dependent responses in mouse vascular smooth muscle cells. J Clin Invest. 2010;120:315-30 pubmed publisher
  56. Wulfing C, Bauch A, Crabtree G, Davis M. The vav exchange factor is an essential regulator in actin-dependent receptor translocation to the lymphocyte-antigen-presenting cell interface. Proc Natl Acad Sci U S A. 2000;97:10150-5 pubmed
    ..Here we study the involvement of the guanine nucleotide exchange factor vav in this process. We crossed 129 vav(-/-) mice with B10/BR 5C...
  57. Bachmann M, Nitschke L, Krawczyk C, Tedford K, Ohashi P, Fischer K, et al. The guanine-nucleotide exchange factor Vav is a crucial regulator of B cell receptor activation and B cell responses to nonrepetitive antigens. J Immunol. 1999;163:137-42 pubmed
    The proto-oncogene product Vav is required for receptor clustering, proliferation, and differentiation of T cells, and Vav was identified as a substrate in the TCR and B cell receptor signaling pathway...
  58. Miura Shimura Y, Duan L, Rao N, Reddi A, Shimura H, Rottapel R, et al. Cbl-mediated ubiquitinylation and negative regulation of Vav. J Biol Chem. 2003;278:38495-504 pubmed
    ..Cbl is known to associate with the proto-oncogene product Vav, a hematopoietic-restricted Rac guanine nucleotide exchange factor, but the consequences of this interaction remain ..
  59. Vigorito E, Gambardella L, Colucci F, McAdam S, Turner M. Vav proteins regulate peripheral B-cell survival. Blood. 2005;106:2391-8 pubmed
    Mice lacking all 3 Vav proteins fail to produce significant numbers of recirculating follicular or marginal zone B cells. Those B cells that do mature have shortened lifespans...
  60. Charvet C, Canonigo A, Bécart S, Maurer U, Miletic A, Swat W, et al. Vav1 promotes T cell cycle progression by linking TCR/CD28 costimulation to FOXO1 and p27kip1 expression. J Immunol. 2006;177:5024-31 pubmed
    ..In this study, we investigated the role of Vav in T cell cycle progression. TCR/CD28-stimulated Vav1(-/-) T cells displayed a cell cycle block at the G0-G1 stage, which accounted for their defective proliferation...
  61. Wilkinson B, Koenigsknecht Talboo J, Grommes C, Lee C, Landreth G. Fibrillar beta-amyloid-stimulated intracellular signaling cascades require Vav for induction of respiratory burst and phagocytosis in monocytes and microglia. J Biol Chem. 2006;281:20842-50 pubmed
    ..The Vav guanine nucleotide exchange factor is tyrosine-phosphorylated in response to fAbeta peptides as a result of the ..