Vash1

Summary

Gene Symbol: Vash1
Description: vasohibin 1
Alias: AI834978, D930046M13Rik, G630009D10Rik, vasohibin-1
Species: mouse

Top Publications

  1. pmc Endogenous angiogenesis inhibitor vasohibin1 exhibits broad-spectrum antilymphangiogenic activity and suppresses lymph node metastasis
    Takahiro Heishi
    Department of Vascular Biology, Institute of Development, Tohoku University, Aoba ku, Sendai 980 8575, Japan
    Am J Pathol 176:1950-8. 2010
  2. doi Protein kinase C{delta} deficiency accelerates neointimal lesions of mouse injured artery involving delayed reendothelialization and vasohibin-1 accumulation
    Xue Bai
    Department of Physiology, Peking University Health Science Center, Beijing, China
    Arterioscler Thromb Vasc Biol 30:2467-74. 2010
  3. doi Amelioration of renal alterations in obese type 2 diabetic mice by vasohibin-1, a negative feedback regulator of angiogenesis
    Daisuke Saito
    Dept of Medicine and Clinical Science, Okayama Univ Graduate School of Medicine and Dentistry, Okayama, 700 8558, Japan
    Am J Physiol Renal Physiol 300:F873-86. 2011
  4. ncbi Vasohibin prevents arterial neointimal formation through angiogenesis inhibition
    Hiroshi Yamashita
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
    Biochem Biophys Res Commun 345:919-25. 2006
  5. pmc Vasohibin as an endothelium-derived negative feedback regulator of angiogenesis
    Kazuhide Watanabe
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
    J Clin Invest 114:898-907. 2004
  6. pmc Vasohibin-1 expression in endothelium of tumor blood vessels regulates angiogenesis
    Tomoko Hosaka
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Am J Pathol 175:430-9. 2009
  7. doi Distinctive localization and opposed roles of vasohibin-1 and vasohibin-2 in the regulation of angiogenesis
    Hiroshi Kimura
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
    Blood 113:4810-8. 2009
  8. ncbi Isolation and characterization of vasohibin-2 as a homologue of VEGF-inducible endothelium-derived angiogenesis inhibitor vasohibin
    Takumi Shibuya
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai 980 8575, Japan
    Arterioscler Thromb Vasc Biol 26:1051-7. 2006
  9. ncbi Vasohibin is up-regulated by VEGF in the retina and suppresses VEGF receptor 2 and retinal neovascularization
    Jikui Shen
    The Departments of Ophthalmology and Neuroscience The Johns Hopkins University School of Medicine Baltimore, Maryland 21287 9277, USA
    FASEB J 20:723-5. 2006
  10. pmc Angiogenesis inhibitor vasohibin-1 enhances stress resistance of endothelial cells via induction of SOD2 and SIRT1
    Hiroki Miyashita
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    PLoS ONE 7:e46459. 2012

Scientific Experts

  • Johann Kern
  • Yasufumi Sato
  • Hikaru Sonoda
  • Hiroki Miyashita
  • Hideki Ohta
  • Yasuhiro Suzuki
  • Kazuhide Watanabe
  • Hiroshi Yamashita
  • Takahiro Heishi
  • Tomoko Hosaka
  • Hiroshi Kimura
  • Takuya Moriya
  • Kazue Shimizu
  • Mayumi Abe
  • Daisuke Saito
  • Takashi Kondo
  • Xue Bai
  • Hisamichi Naito
  • Tooru Shimosegawa
  • Kanji Hojo
  • Jikui Shen
  • Takumi Shibuya
  • Manabu Ono
  • Yoshinori Okada
  • Yasushi Hoshikawa
  • Hideki Hayashi
  • Soichi Ito
  • Takanobu Nakamura
  • Tatsuaki Watanabe
  • Yohei Maeshima
  • Tatsuyo Nasu
  • Katsuyuki Tanabe
  • Hitoshi Sugiyama
  • Hirofumi Makino
  • Hiroko Yamasaki
  • Takashi Takahashi
  • Mitsunobu Matsumoto
  • Chihiro Yamauchi
  • Andriana Margariti
  • Lingfang Zeng
  • Tomoaki Takakura
  • Qingbo Xu
  • Xian Wang
  • Takumi Nakamura
  • Shingo Arioka
  • Aleksandar Ivetic
  • Justin C Mason
  • Yuichi Oike
  • Ouassila Habi
  • Yanhua Hu
  • Yuichi Mitsuda
  • Nobuyuki Takakura
  • Satoshi Suzuki
  • Miho Kobayashi
  • Takashi Fujiwara
  • Hiroyasu Kidoya
  • Peter A Campochiaro
  • Wei Hong Xiao
  • Xiaoru Yang
  • Susumu Satomi
  • Sean F Hackett
  • Akira Sato
  • Koichi Tabayashi
  • Keiichi Imagawa
  • Hideo Maki
  • Yasuhiro Hasegawa
  • Yuanying Ding

Detail Information

Publications12

  1. pmc Endogenous angiogenesis inhibitor vasohibin1 exhibits broad-spectrum antilymphangiogenic activity and suppresses lymph node metastasis
    Takahiro Heishi
    Department of Vascular Biology, Institute of Development, Tohoku University, Aoba ku, Sendai 980 8575, Japan
    Am J Pathol 176:1950-8. 2010
    ..These results suggest vasohibin1 to be the first known intrinsic factor having broad-spectrum antilymphangiogenic activity and indicate that it suppresses lymph node metastasis...
  2. doi Protein kinase C{delta} deficiency accelerates neointimal lesions of mouse injured artery involving delayed reendothelialization and vasohibin-1 accumulation
    Xue Bai
    Department of Physiology, Peking University Health Science Center, Beijing, China
    Arterioscler Thromb Vasc Biol 30:2467-74. 2010
    ..To use protein kinase C (PKC) δ-knockout mice to investigate the role of PKCδ in lesion development and to understand the underlying mechanism of the vascular disease...
  3. doi Amelioration of renal alterations in obese type 2 diabetic mice by vasohibin-1, a negative feedback regulator of angiogenesis
    Daisuke Saito
    Dept of Medicine and Clinical Science, Okayama Univ Graduate School of Medicine and Dentistry, Okayama, 700 8558, Japan
    Am J Physiol Renal Physiol 300:F873-86. 2011
    ....
  4. ncbi Vasohibin prevents arterial neointimal formation through angiogenesis inhibition
    Hiroshi Yamashita
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
    Biochem Biophys Res Commun 345:919-25. 2006
    ..Vasohibin exhibited no direct effect on migration and proliferation of smooth muscle cells. Thus, vasohibin has an activity to prevent neointimal formation by inhibiting adventitial angiogenesis...
  5. pmc Vasohibin as an endothelium-derived negative feedback regulator of angiogenesis
    Kazuhide Watanabe
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
    J Clin Invest 114:898-907. 2004
    ..We propose vasohibin to be an endothelium-derived negative feedback regulator of angiogenesis...
  6. pmc Vasohibin-1 expression in endothelium of tumor blood vessels regulates angiogenesis
    Tomoko Hosaka
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Am J Pathol 175:430-9. 2009
    ....
  7. doi Distinctive localization and opposed roles of vasohibin-1 and vasohibin-2 in the regulation of angiogenesis
    Hiroshi Kimura
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
    Blood 113:4810-8. 2009
    ..These results indicate that vasohibin-1 is expressed in ECs in the termination zone to halt angiogenesis, whereas vasohibin-2 is expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis...
  8. ncbi Isolation and characterization of vasohibin-2 as a homologue of VEGF-inducible endothelium-derived angiogenesis inhibitor vasohibin
    Takumi Shibuya
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai 980 8575, Japan
    Arterioscler Thromb Vasc Biol 26:1051-7. 2006
    ..We recently isolated vasohibin, a novel vascular endothelial growth factor (VEGF)-inducible endothelium-derived angiogenesis inhibitor. Our aim is to find DNA sequences homologous to vasohibin and determine their expression profile...
  9. ncbi Vasohibin is up-regulated by VEGF in the retina and suppresses VEGF receptor 2 and retinal neovascularization
    Jikui Shen
    The Departments of Ophthalmology and Neuroscience The Johns Hopkins University School of Medicine Baltimore, Maryland 21287 9277, USA
    FASEB J 20:723-5. 2006
    ..These data support the hypothesis that vasohibin acts as a negative feedback regulator of neovascularization in the retina and suggest that suppression of VEGF receptor 2 may play some role in mediating its activity...
  10. pmc Angiogenesis inhibitor vasohibin-1 enhances stress resistance of endothelial cells via induction of SOD2 and SIRT1
    Hiroki Miyashita
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    PLoS ONE 7:e46459. 2012
    Vasohibin-1 (VASH1) is isolated as an endothelial cell (EC)-produced angiogenesis inhibitor...
  11. pmc Vasohibin inhibits angiogenic sprouting in vitro and supports vascular maturation processes in vivo
    Johann Kern
    Division of Internal Medicine V, Tumor Biology and Angiogenesis Laboratory, Medical University Innsbruck, Innrain 66, A 6020 Innsbruck, Austria
    BMC Cancer 9:284. 2009
    ..The murine homologue of human vasohibin (mVASH1), a putative antiangiogenic protein, was investigated for its effects on in vitro and in vivo angiogenesis...
  12. doi Induction and expression of anti-angiogenic vasohibins in the hematopoietic stem/progenitor cell population
    Hisamichi Naito
    Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    J Biochem 145:653-9. 2009
    ..Recently, vasohibin-1 (VASH1), an endothelium-derived negative feedback regulator of angiogenesis, has been isolated and characterized...