Vash1

Summary

Gene Symbol: Vash1
Description: vasohibin 1
Alias: AI834978, D930046M13Rik, G630009D10Rik, vasohibin-1
Species: mouse

Top Publications

  1. ncbi Vasohibin as an endothelium-derived negative feedback regulator of angiogenesis
    Kazuhide Watanabe
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
    J Clin Invest 114:898-907. 2004
  2. ncbi Vasohibin-1 expression in endothelium of tumor blood vessels regulates angiogenesis
    Tomoko Hosaka
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Am J Pathol 175:430-9. 2009
  3. ncbi Distinctive localization and opposed roles of vasohibin-1 and vasohibin-2 in the regulation of angiogenesis
    Hiroshi Kimura
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
    Blood 113:4810-8. 2009
  4. ncbi Vasohibin is up-regulated by VEGF in the retina and suppresses VEGF receptor 2 and retinal neovascularization
    Jikui Shen
    The Departments of Ophthalmology and Neuroscience The Johns Hopkins University School of Medicine Baltimore, Maryland 21287 9277, USA
    FASEB J 20:723-5. 2006
  5. ncbi Vasohibin prevents arterial neointimal formation through angiogenesis inhibition
    Hiroshi Yamashita
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
    Biochem Biophys Res Commun 345:919-25. 2006
  6. ncbi Induction and expression of anti-angiogenic vasohibins in the hematopoietic stem/progenitor cell population
    Hisamichi Naito
    Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    J Biochem 145:653-9. 2009
  7. ncbi Isolation and characterization of vasohibin-2 as a homologue of VEGF-inducible endothelium-derived angiogenesis inhibitor vasohibin
    Takumi Shibuya
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai 980 8575, Japan
    Arterioscler Thromb Vasc Biol 26:1051-7. 2006
  8. ncbi Vasohibin inhibits angiogenic sprouting in vitro and supports vascular maturation processes in vivo
    Johann Kern
    Division of Internal Medicine V, Tumor Biology and Angiogenesis Laboratory, Medical University Innsbruck, Innrain 66, A 6020 Innsbruck, Austria
    BMC Cancer 9:284. 2009
  9. ncbi Endogenous angiogenesis inhibitor vasohibin1 exhibits broad-spectrum antilymphangiogenic activity and suppresses lymph node metastasis
    Takahiro Heishi
    Department of Vascular Biology, Institute of Development, Tohoku University, Aoba ku, Sendai 980 8575, Japan
    Am J Pathol 176:1950-8. 2010
  10. ncbi Protein kinase C{delta} deficiency accelerates neointimal lesions of mouse injured artery involving delayed reendothelialization and vasohibin-1 accumulation
    Xue Bai
    Department of Physiology, Peking University Health Science Center, Beijing, China
    Arterioscler Thromb Vasc Biol 30:2467-74. 2010

Scientific Experts

  • Johann Kern
  • Yasufumi Sato
  • Hikaru Sonoda
  • Hideki Ohta
  • Kazuhide Watanabe
  • Hiroki Miyashita
  • Hiroshi Yamashita
  • Takahiro Heishi
  • Tomoko Hosaka
  • Yasuhiro Suzuki
  • Hiroshi Kimura
  • Takuya Moriya
  • Mayumi Abe
  • Kazue Shimizu
  • Daisuke Saito
  • Xue Bai
  • Hisamichi Naito
  • Tooru Shimosegawa
  • Kanji Hojo
  • Jikui Shen
  • Takumi Shibuya
  • Yohei Maeshima
  • Tatsuyo Nasu
  • Katsuyuki Tanabe
  • Hitoshi Sugiyama
  • Hirofumi Makino
  • Hiroko Yamasaki
  • Takashi Takahashi
  • Mitsunobu Matsumoto
  • Chihiro Yamauchi
  • Andriana Margariti
  • Tomoaki Takakura
  • Takumi Nakamura
  • Shingo Arioka
  • Justin C Mason
  • Ouassila Habi
  • Yanhua Hu
  • Lingfang Zeng
  • Qingbo Xu
  • Xian Wang
  • Aleksandar Ivetic
  • Yuichi Oike
  • Yuichi Mitsuda
  • Nobuyuki Takakura
  • Satoshi Suzuki
  • Miho Kobayashi
  • Takashi Kondo
  • Hiroyasu Kidoya
  • Takashi Fujiwara
  • Peter A Campochiaro
  • Wei-Hong Xiao
  • Wei Hong Xiao
  • Xiaoru Yang
  • Susumu Satomi
  • Sean F Hackett
  • Akira Sato
  • Koichi Tabayashi
  • Yasuhiro Hasegawa
  • Keiichi Imagawa
  • Hideo Maki
  • Yuanying Ding

Detail Information

Publications11

  1. ncbi Vasohibin as an endothelium-derived negative feedback regulator of angiogenesis
    Kazuhide Watanabe
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
    J Clin Invest 114:898-907. 2004
    ..We propose vasohibin to be an endothelium-derived negative feedback regulator of angiogenesis...
  2. ncbi Vasohibin-1 expression in endothelium of tumor blood vessels regulates angiogenesis
    Tomoko Hosaka
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Am J Pathol 175:430-9. 2009
    ....
  3. ncbi Distinctive localization and opposed roles of vasohibin-1 and vasohibin-2 in the regulation of angiogenesis
    Hiroshi Kimura
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
    Blood 113:4810-8. 2009
    ..These results indicate that vasohibin-1 is expressed in ECs in the termination zone to halt angiogenesis, whereas vasohibin-2 is expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis...
  4. ncbi Vasohibin is up-regulated by VEGF in the retina and suppresses VEGF receptor 2 and retinal neovascularization
    Jikui Shen
    The Departments of Ophthalmology and Neuroscience The Johns Hopkins University School of Medicine Baltimore, Maryland 21287 9277, USA
    FASEB J 20:723-5. 2006
    ..These data support the hypothesis that vasohibin acts as a negative feedback regulator of neovascularization in the retina and suggest that suppression of VEGF receptor 2 may play some role in mediating its activity...
  5. ncbi Vasohibin prevents arterial neointimal formation through angiogenesis inhibition
    Hiroshi Yamashita
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai, Japan
    Biochem Biophys Res Commun 345:919-25. 2006
    ..Vasohibin exhibited no direct effect on migration and proliferation of smooth muscle cells. Thus, vasohibin has an activity to prevent neointimal formation by inhibiting adventitial angiogenesis...
  6. ncbi Induction and expression of anti-angiogenic vasohibins in the hematopoietic stem/progenitor cell population
    Hisamichi Naito
    Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    J Biochem 145:653-9. 2009
    ..Recently, vasohibin-1 (VASH1), an endothelium-derived negative feedback regulator of angiogenesis, has been isolated and characterized...
  7. ncbi Isolation and characterization of vasohibin-2 as a homologue of VEGF-inducible endothelium-derived angiogenesis inhibitor vasohibin
    Takumi Shibuya
    Department of Vascular Biology, Institute of Development, Aging, and Cancer, Tohoku University, Sendai 980 8575, Japan
    Arterioscler Thromb Vasc Biol 26:1051-7. 2006
    ..We recently isolated vasohibin, a novel vascular endothelial growth factor (VEGF)-inducible endothelium-derived angiogenesis inhibitor. Our aim is to find DNA sequences homologous to vasohibin and determine their expression profile...
  8. ncbi Vasohibin inhibits angiogenic sprouting in vitro and supports vascular maturation processes in vivo
    Johann Kern
    Division of Internal Medicine V, Tumor Biology and Angiogenesis Laboratory, Medical University Innsbruck, Innrain 66, A 6020 Innsbruck, Austria
    BMC Cancer 9:284. 2009
    ..The murine homologue of human vasohibin (mVASH1), a putative antiangiogenic protein, was investigated for its effects on in vitro and in vivo angiogenesis...
  9. ncbi Endogenous angiogenesis inhibitor vasohibin1 exhibits broad-spectrum antilymphangiogenic activity and suppresses lymph node metastasis
    Takahiro Heishi
    Department of Vascular Biology, Institute of Development, Tohoku University, Aoba ku, Sendai 980 8575, Japan
    Am J Pathol 176:1950-8. 2010
    ..These results suggest vasohibin1 to be the first known intrinsic factor having broad-spectrum antilymphangiogenic activity and indicate that it suppresses lymph node metastasis...
  10. ncbi Protein kinase C{delta} deficiency accelerates neointimal lesions of mouse injured artery involving delayed reendothelialization and vasohibin-1 accumulation
    Xue Bai
    Department of Physiology, Peking University Health Science Center, Beijing, China
    Arterioscler Thromb Vasc Biol 30:2467-74. 2010
    ..To use protein kinase C (PKC) δ-knockout mice to investigate the role of PKCδ in lesion development and to understand the underlying mechanism of the vascular disease...
  11. ncbi Amelioration of renal alterations in obese type 2 diabetic mice by vasohibin-1, a negative feedback regulator of angiogenesis
    Daisuke Saito
    Dept of Medicine and Clinical Science, Okayama Univ Graduate School of Medicine and Dentistry, Okayama, 700 8558, Japan
    Am J Physiol Renal Physiol 300:F873-86. 2011
    ....