Gene Symbol: Usp7
Description: ubiquitin specific peptidase 7
Alias: 2210010O09Rik, AA409944, AA617399, AU019296, AW548146, C80752, Hausp, ubiquitin carboxyl-terminal hydrolase 7, deubiquitinating enzyme 7, herpesvirus-associated ubiquitin-specific protease, mHAUSP, ubiquitin specific protease 7, ubiquitin thioesterase 7, ubiquitin thiolesterase 7, ubiquitin-specific-processing protease 7
Species: mouse
Products:     Usp7

Top Publications

  1. Song M, Salmena L, Carracedo A, Egia A, Lo Coco F, Teruya Feldstein J, et al. The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network. Nature. 2008;455:813-7 pubmed publisher
    ..action of a previously unknown PTEN-deubiquitinylating enzyme, herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7), and that the integrity of this molecular framework is required for PTEN to be able to enter ..
  2. Novellasdemunt L, Foglizzo V, Cuadrado L, Antas P, Kucharska A, Encheva V, et al. USP7 Is a Tumor-Specific WNT Activator for APC-Mutated Colorectal Cancer by Mediating ?-Catenin Deubiquitination. Cell Rep. 2017;21:612-627 pubmed publisher
    ..CID-deleted APC truncation promotes ?-catenin deubiquitination through reverse binding of ?-TrCP and USP7 to the destruction complex...
  3. Yu Y, Hayward G. The ubiquitin E3 ligase RAUL negatively regulates type i interferon through ubiquitination of the transcription factors IRF7 and IRF3. Immunity. 2010;33:863-77 pubmed publisher
  4. Forand A, Koumakis E, Rousseau A, Sassier Y, Journe C, Merlin J, et al. Disruption of the Phosphate Transporter Pit1 in Hepatocytes Improves Glucose Metabolism and Insulin Signaling by Modulating the USP7/IRS1 Interaction. Cell Rep. 2016;16:2736-2748 pubmed publisher
    ..We identified USP7 as a PiT1 binding partner and demonstrated that Pit1 deletion inhibited USP7/IRS1 dissociation upon insulin ..
  5. Liefke R, Karwacki Neisius V, Shi Y. EPOP Interacts with Elongin BC and USP7 to Modulate the Chromatin Landscape. Mol Cell. 2016;64:659-672 pubmed publisher
    ..EPOP interacts with the transcription elongation factor Elongin BC and the H2B deubiquitinase USP7 to modulate transcriptional processes in mESCs similar to MYC...
  6. Qin W, Leonhardt H, Spada F. Usp7 and Uhrf1 control ubiquitination and stability of the maintenance DNA methyltransferase Dnmt1. J Cell Biochem. 2011;112:439-44 pubmed publisher
    ..Here, we show that both Dnmt1 and Uhrf1 coprecipitate with ubiquitin specific peptidase 7 (Usp7), a de-ubiquitinating enzyme...
  7. Colleran A, Collins P, O Carroll C, Ahmed A, Mao X, McManus B, et al. Deubiquitination of NF-?B by Ubiquitin-Specific Protease-7 promotes transcription. Proc Natl Acad Sci U S A. 2013;110:618-23 pubmed publisher
    ..We have identified the deubiquitinase Ubiquitin Specific Protease-7 (USP7) as a regulator of NF-?B transcriptional activity. USP7 deubiquitination of NF-?B leads to increased transcription...
  8. Kon N, Zhong J, Kobayashi Y, Li M, Szabolcs M, Ludwig T, et al. Roles of HAUSP-mediated p53 regulation in central nervous system development. Cell Death Differ. 2011;18:1366-75 pubmed publisher
    The deubiquitinase HAUSP (herpesvirus-associated ubiquitin-specific protease; also called USP7) has a critical role in regulating the p53-Mdm2 (murine double minute 2) pathway...
  9. Luo M, Zhou J, Leu N, Abreu C, Wang J, Anguera M, et al. Polycomb protein SCML2 associates with USP7 and counteracts histone H2A ubiquitination in the XY chromatin during male meiosis. PLoS Genet. 2015;11:e1004954 pubmed publisher
    ..SCML2 interacts with and recruits a deubiquitinase, USP7, to the XY body in spermatocytes...

More Information


  1. Song M, Song S, Kim S, Oh H, Lim D. The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex. EMBO J. 2008;27:1863-74 pubmed publisher
    ..protein (DAXX) in the nucleus, thereby disrupting the interactions between MDM2, DAXX, and the deubiquitinase, HAUSP, and enhancing the self-ubiquitin ligase activity of MDM2...
  2. Vugmeyster Y, Borodovsky A, Maurice M, Maehr R, Furman M, Ploegh H. The ubiquitin-proteasome pathway in thymocyte apoptosis: caspase-dependent processing of the deubiquitinating enzyme USP7 (HAUSP). Mol Immunol. 2002;39:431-41 pubmed
    ..We show that the deubiquitinating enzyme USP7 (HAUSP) is proteolytically processed upon dexamethasone-, gamma-irradiation-, and antigen-induced cell death...
  3. Yuan L, Lv Y, Li H, Gao H, Song S, Zhang Y, et al. Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis. Nat Cell Biol. 2015;17:1169-81 pubmed publisher
    ..These findings demonstrate that OTUD3 is an essential regulator of PTEN and that the OTUD3-PTEN signalling axis plays a critical role in tumour suppression. ..
  4. Kon N, Kobayashi Y, Li M, Brooks C, Ludwig T, Gu W. Inactivation of HAUSP in vivo modulates p53 function. Oncogene. 2010;29:1270-9 pubmed publisher
    b>Hausp is a deubiquitinase that has been shown to regulate the p53-Mdm2 pathway. Cotransfection of p53 and Hausp stabilizes p53 through the removal of ubiquitin moieties from polyubiquitinated p53...
  5. Maertens G, El Messaoudi Aubert S, Elderkin S, Hiom K, Peters G. Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor. EMBO J. 2010;29:2553-65 pubmed publisher
    ..Here, we report that two ubiquitin-specific proteases, USP7 and USP11, co-purify with human PRC1-type complexes through direct interactions with the Psc orthologues MEL18 and ..
  6. Hasegawa K, Sin H, Maezawa S, Broering T, Kartashov A, Alavattam K, et al. SCML2 establishes the male germline epigenome through regulation of histone H2A ubiquitination. Dev Cell. 2015;32:574-88 pubmed publisher
    ..Our results reveal divergent mechanisms involving a shared regulator by which the male germline epigenome is distinguished from that of the soma and progenitor cells. ..
  7. Tavana O, Li D, Dai C, Lopez G, Banerjee D, Kon N, et al. HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma. Nat Med. 2016;22:1180-1186 pubmed publisher
    ..Here we have identified ubiquitin-specific protease 7 (USP7; also known as HAUSP) as a regulator of N-Myc function in neuroblastoma...
  8. Papp S, Huber A, Jordan S, Kriebs A, Nguyen M, Moresco J, et al. DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization. elife. 2015;4: pubmed publisher
    ..stimulates Cry1 phosphorylation and its deubiquitination by Herpes virus associated ubiquitin-specific protease (Hausp, a.k.a Usp7), stabilizing Cry1 and shifting circadian clock time...
  9. Lee K, Cho J, Kim C, Kang A, Kim M, Ahn B, et al. Herpesvirus-associated ubiquitin-specific protease (HAUSP) modulates peroxisome proliferator-activated receptor ? (PPAR?) stability through its deubiquitinating activity. J Biol Chem. 2013;288:32886-96 pubmed publisher
    ..In this study, herpesvirus-associated ubiquitin-specific protease (HAUSP) was isolated as a binding partner of PPAR?...
  10. Hall J, Tabata M, Rodgers J, Puigserver P. USP7 attenuates hepatic gluconeogenesis through modulation of FoxO1 gene promoter occupancy. Mol Endocrinol. 2014;28:912-24 pubmed publisher
    ..ubiquitin-specific protease 7 (USP7; also known as herpesvirus-associated ubiquitin-specific protease, HAUSP), a deubiquitinating enzyme...
  11. Giglio S, Mancini F, Pellegrino M, Di Conza G, Puxeddu E, Sacchi A, et al. Regulation of MDM4 (MDMX) function by p76(MDM2): a new facet in the control of p53 activity. Oncogene. 2010;29:5935-45 pubmed publisher
    ..Moreover, these data suggest an oncosuppressive function for a product of the Mdm2 gene. ..
  12. Yoo K, Lee H, Lee H, Lee K, Lee S, Chung H, et al. Expression and functional analyses of mHAUSP regulating apoptosis of cervical adenocarcinoma cells. Int J Oncol. 2005;27:97-104 pubmed
    ..We previously isolated a mouse orthologue of HAUSP, mHAUSP, encoding 1103 amino acids with a molecular weight of approximately 135 kDa containing highly conserved Cys, Asp (..
  13. Lim S, Shin J, Kim Y, Baek K. Identification and characterization of murine mHAUSP encoding a deubiquitinating enzyme that regulates the status of p53 ubiquitination. Int J Oncol. 2004;24:357-64 pubmed
    ..In this study, we isolated and characterized a mouse orthologue of HAUSP, mHAUSP. The mHAUSP cDNA was cloned from mouse ES cells by RT-PCR...
  14. Jahan A, Lestra M, Swee L, Fan Y, Lamers M, Tafesse F, et al. Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling. Proc Natl Acad Sci U S A. 2016;113:E705-14 pubmed publisher
    ..Our approach benefits from the use of activity-based probes in primary cells without any previous genome modification, and underscores the importance of ubiquitin-mediated regulation to refine signaling cascades. ..
  15. Hong S, Kim S, Ka S, Choi I, Kang S. USP7, a ubiquitin-specific protease, interacts with ataxin-1, the SCA1 gene product. Mol Cell Neurosci. 2002;20:298-306 pubmed
    ..Using the yeast two-hybrid system, we have found that USP7, a ubiquitin-specific protease, binds to ataxin-1...
  16. van Loosdregt J, Fleskens V, Fu J, Brenkman A, Bekker C, Pals C, et al. Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity. Immunity. 2013;39:259-71 pubmed publisher
    ..Expression of the deubiquitinase (DUB) USP7 was found to be upregulated and active in Treg cells, being associated with Foxp3 in the nucleus...
  17. Hirano A, Nakagawa T, Yoshitane H, Oyama M, Kozuka Hata H, Lanjakornsiripan D, et al. USP7 and TDP-43: Pleiotropic Regulation of Cryptochrome Protein Stability Paces the Oscillation of the Mammalian Circadian Clock. PLoS ONE. 2016;11:e0154263 pubmed publisher
    ..We found that ubiquitin-specific protease 7 (USP7 also known as HAUSP) associates with CRY1 and CRY2 and stabilizes CRYs through deubiquitination...
  18. Meng H, Harrison D, Meehan R. MBD4 interacts with and recruits USP7 to heterochromatic foci. J Cell Biochem. 2015;116:476-85 pubmed publisher
    ..We identified UHRF1 and USP7 as two new interaction partners for MBD4...
  19. Zaman M, Nomura T, Takagi T, Okamura T, Jin W, Shinagawa T, et al. Ubiquitination-deubiquitination by the TRIM27-USP7 complex regulates tumor necrosis factor alpha-induced apoptosis. Mol Cell Biol. 2013;33:4971-84 pubmed publisher
    ..TRIM27 forms a complex with and ubiquitinates the ubiquitin-specific protease USP7, which deubiquitinates receptor-interacting protein 1 (RIP1), resulting in the positive regulation of TNF-?-induced ..
  20. Gao Y, Koppen A, Rakhshandehroo M, TaĊŸdelen I, van de Graaf S, van Loosdregt J, et al. Early adipogenesis is regulated through USP7-mediated deubiquitination of the histone acetyltransferase TIP60. Nat Commun. 2013;4:2656 pubmed publisher
    ..b>USP7, a dominant deubiquitinating enzyme in 3T3-L1 adipocytes and mouse adipose tissue, deubiquitinates Tip60 both in ..
  21. Orr S, Gese E, Hood L. A new approach to understanding T cell development: the isolation and characterization of immature CD4-, CD8-, CD3- T cell cDNAs by subtraction cloning. Mol Biol Cell. 1992;3:761-73 pubmed
    ..This approach of employing subtraction coupled with large scale partial cDNA sequence determination can be useful to identify genes that may be involved in early T cell growth, cellular recognition or differentiation. ..
  22. Agathanggelou A, Smith E, Davies N, Kwok M, Zlatanou A, Oldreive C, et al. USP7 inhibition alters homologous recombination repair and targets CLL cells independently of ATM/p53 functional status. Blood. 2017;130:156-166 pubmed publisher
    The role of deubiquitylase ubiquitin-specific protease 7 (USP7) in the regulation of the p53-dependent DNA damage response (DDR) pathway is well established...