Gene Symbol: Usp46
Description: ubiquitin specific peptidase 46
Alias: 1190009E20Rik, 2410018I08Rik, AI451644, ubiquitin carboxyl-terminal hydrolase 46, deubiquitinating enzyme 46, ubiquitin specific protease 46, ubiquitin thioesterase 46, ubiquitin thiolesterase 46, ubiquitin-specific-processing protease 46
Species: mouse
Products:     Usp46

Top Publications

  1. Tomida S, Mamiya T, Sakamaki H, Miura M, Aosaki T, Masuda M, et al. Usp46 is a quantitative trait gene regulating mouse immobile behavior in the tail suspension and forced swimming tests. Nat Genet. 2009;41:688-95 pubmed publisher
    ..5 Mb using several congenic and subcongenic strains. Ubiquitin-specific peptidase 46 (Usp46) with a lysine codon deletion was located in this region...
  2. Zhang W, Tian Q, Li Q, Wang J, Wang C, Liu T, et al. Lysine 92 amino acid residue of USP46, a gene associated with 'behavioral despair' in mice, influences the deubiquitinating enzyme activity. PLoS ONE. 2011;6:e26297 pubmed publisher
    ..Ubiquitin-Specific Protease 46 (USP46) has recently been identified as a quantitative trait gene responsible for immobility in the tail suspension test ..
  3. Imai S, Mamiya T, Tsukada A, Sakai Y, Mouri A, Nabeshima T, et al. Ubiquitin-specific peptidase 46 (Usp46) regulates mouse immobile behavior in the tail suspension test through the GABAergic system. PLoS ONE. 2012;7:e39084 pubmed publisher
    ..We have previously identified ubiquitin-specific peptidase 46 (Usp46) as a quantitative trait gene responsible for decreasing immobility time in the TST in mice...
  4. Imai S, Kano M, Nonoyama K, Ebihara S. Behavioral characteristics of ubiquitin-specific peptidase 46-deficient mice. PLoS ONE. 2013;8:e58566 pubmed publisher
    We have previously identified Usp46, which encodes for ubiquitin-specific peptidase 46, as a quantitative trait gene affecting the immobility time of mice in the tail suspension test (TST) and forced swimming test...
  5. Umemura S, Imai S, Mimura A, Fujiwara M, Ebihara S. Impaired Maternal Behavior in Usp46 Mutant Mice: A Model for Trans-Generational Transmission of Maternal Care. PLoS ONE. 2015;10:e0136016 pubmed publisher
    b>Usp46 mutant mice (congenic strain on a B6 genetic background; MT mice) have a low weaning rate and display poor maternal behavior compared to C57BL/6J mice (B6 mice)...
  6. Jahan A, Lestra M, Swee L, Fan Y, Lamers M, Tafesse F, et al. Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling. Proc Natl Acad Sci U S A. 2016;113:E705-14 pubmed publisher
    ..We identified ubiquitin-specific peptidase (Usp) 12 and Usp46, which had not been previously described in this pathway...