Usp29

Summary

Gene Symbol: Usp29
Description: ubiquitin specific peptidase 29
Alias: Ocat, ubiquitin carboxyl-terminal hydrolase 29, ASL1/Usp29 fusion, deubiquitinating enzyme 29, ossification center-associated transcript, ubiquitin thioesterase 29, ubiquitin thiolesterase 29, ubiquitin-specific-processing protease 29
Species: mouse
Products:     Usp29

Top Publications

  1. Kim J, Noskov V, Lu X, Bergmann A, Ren X, Warth T, et al. Discovery of a novel, paternally expressed ubiquitin-specific processing protease gene through comparative analysis of an imprinted region of mouse chromosome 7 and human chromosome 19q13.4. Genome Res. 2000;10:1138-47 pubmed
    ..4, we have identified a novel mouse gene, Usp29 (ubiquitin-specific processing protease 29), near two known imprinted genes, Peg3 and Zim1...
  2. Szeto I, Li L, Surani M. Ocat, a paternally expressed gene closely linked and transcribed in the opposite direction to Peg3. Genomics. 2000;67:221-7 pubmed
    ..Here, we describe the identification of another novel imprinted transcript, Ocat (ossification center-associated transcript). Ocat encodes a 5...
  3. Michaud E, Culiat C, Klebig M, Barker P, Cain K, Carpenter D, et al. Efficient gene-driven germ-line point mutagenesis of C57BL/6J mice. BMC Genomics. 2005;6:164 pubmed
    ..The ability of ENU to induce mutations that cause various types of changes in proteins will provide additional insights into the functions of mammalian proteins that may not be detectable by knockout mutations. ..
  4. Huang J, Kim J. DNA methylation analysis of the mammalian PEG3 imprinted domain. Gene. 2009;442:18-25 pubmed publisher
    ..methylated regions (DMR): one in the promoter region of mouse Zim3 and another in the promoter region of human USP29. In the cow, the Peg3-CpG island was the only area that showed DMR status...
  5. Yamaguchi S, Shen L, Liu Y, Sendler D, Zhang Y. Role of Tet1 in erasure of genomic imprinting. Nature. 2013;504:460-4 pubmed publisher
    ..Furthermore, we provide evidence supporting the role of Tet1 in the erasure of paternal imprints in the female germ line. Thus, our study establishes a critical function of Tet1 in the erasure of genomic imprinting. ..
  6. Kim J, Bergmann A, Wehri E, Lu X, Stubbs L. Imprinting and evolution of two Kruppel-type zinc-finger genes, ZIM3 and ZNF264, located in the PEG3/USP29 imprinted domain. Genomics. 2001;77:91-8 pubmed
    ..genes, ZIM3 (zinc-finger gene 3 from imprinted domain) and ZNF264, located downstream of human and mouse USP29 genes (encoding ubiquitin-specific processing protease 29)...
  7. Ruf N, Dünzinger U, Brinckmann A, Haaf T, Nurnberg P, Zechner U. Expression profiling of uniparental mouse embryos is inefficient in identifying novel imprinted genes. Genomics. 2006;87:509-19 pubmed
  8. Faisal M, Kim H, Kim J. Sexual differences of imprinted genes' expression levels. Gene. 2014;533:434-8 pubmed publisher
  9. Denizot A, Besson V, Correra R, Mazzola A, Lopes I, Courbard J, et al. A Novel Mutant Allele of Pw1/Peg3 Does Not Affect Maternal Behavior or Nursing Behavior. PLoS Genet. 2016;12:e1006053 pubmed publisher
    ..Consistent with previous reports, we observe a reduction of postnatal growth. These results support a general role for Pw1/Peg3 in the regulation of body growth but not maternal care and lactation. ..

More Information

Publications14

  1. He H, Ye A, Kim J. Transcriptional Truncation of the Long Coding Imprinted Gene Usp29. PLoS ONE. 2016;11:e0158004 pubmed publisher
    b>Usp29 (Ubiquitin-specific protease 29) is a paternally expressed gene located upstream of another imprinted gene Peg3...
  2. Monk D, Smith R, Arnaud P, Preece M, Stanier P, Beechey C, et al. Imprinted methylation profiles for proximal mouse chromosomes 11 and 7 as revealed by methylation-sensitive representational difference analysis. Mamm Genome. 2003;14:805-16 pubmed
    ..No such mutations were found. ..
  3. Szeto I, Barton S, Keverne E, Surani A. Analysis of imprinted murine Peg3 locus in transgenic mice. Mamm Genome. 2004;15:284-95 pubmed
    ..Concerning the expression of the Peg3 transgene, we detected appropriate expression in the adult brain. However, this was not sufficient to rescue the maternal behavior phenotype seen in Peg3 deficient animals. ..
  4. Kim J, Yu S, Choo J, Kim J. Two evolutionarily conserved sequence elements for Peg3/Usp29 transcription. BMC Mol Biol. 2008;9:108 pubmed publisher
    ..CpG island surrounding the bidirectional promoter of two imprinted genes, Peg3 (Paternally expressed gene 3) and Usp29 (Ubiquitin-specific protease 29)...
  5. Kim J, Ekram M, Kim H, Faisal M, Frey W, Huang J, et al. Imprinting control region (ICR) of the Peg3 domain. Hum Mol Genet. 2012;21:2677-87 pubmed publisher
    ..Taken together, deletion of the Peg3-DMR caused global changes in the imprinting and transcription of the Peg3 domain, confirming that the Peg3-DMR is an ICR for this imprinted domain. ..