Gene Symbol: Uqcrc1
Description: ubiquinol-cytochrome c reductase core protein 1
Alias: 1110032G10Rik, cytochrome b-c1 complex subunit 1, mitochondrial, complex III subunit 1, core protein I, ubiquinol-cytochrome-c reductase complex core protein 1
Wittenburg H, Lammert F, Wang D, Churchill G, Li R, Bouchard G, et al
. Interacting QTLs for cholesterol gallstones and gallbladder mucin in AKR and SWR strains of mice. Physiol Genomics. 2002;8:67-77 pubmed
..According to standard nomenclature, the gallstone QTL on chromosome 9 is named Lith5. ..
Schilling B, Murray J, Yoo C, Row R, Cusack M, Capaldi R, et al
. Proteomic analysis of succinate dehydrogenase and ubiquinol-cytochrome c reductase (Complex II and III) isolated by immunoprecipitation from bovine and mouse heart mitochondria. Biochim Biophys Acta. 2006;1762:213-22 pubmed
..The identification of several posttranslational modifications, including the covalent FAD modification of flavoprotein subunit 1 from Complex II, was possible due to high mass spectrometric sequence coverage. ..
Kriaucionis S, Paterson A, Curtis J, Guy J, MacLeod N, Bird A. Gene expression analysis exposes mitochondrial abnormalities in a mouse model of Rett syndrome. Mol Cell Biol. 2006;26:5033-42 pubmed
..mice with neurological symptoms overexpress the nuclear gene for ubiquinol-cytochrome c reductase core protein 1 (Uqcrc1). Chromatin immunoprecipitation demonstrated that MeCP2 interacts with the Uqcrc1 promoter...
Kotarsky H, Tabasum I, Mannisto S, Heikinheimo M, Hansson S, Fellman V. BCS1L is expressed in critical regions for neural development during ontogenesis in mice. Gene Expr Patterns. 2007;7:266-73 pubmed
..The predominant expression of BCS1L in this region, together with its presence in peripheral ganglia from E13 onwards, indicates a role for BCS1L in the development of neural structures. ..
Maynard T, Meechan D, Dudevoir M, Gopalakrishna D, Peters A, Heindel C, et al
. Mitochondrial localization and function of a subset of 22q11 deletion syndrome candidate genes. Mol Cell Neurosci. 2008;39:439-51 pubmed publisher
..Zdhhc8 has an apparent interaction with Uqcrc1, a component of mitochondrial complex III...
Ishihara N, Nomura M, Jofuku A, Kato H, Suzuki S, Masuda K, et al
. Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice. Nat Cell Biol. 2009;11:958-66 pubmed publisher
Ghezzi D, Arzuffi P, Zordan M, Da Re C, Lamperti C, Benna C, et al
. Mutations in TTC19 cause mitochondrial complex III deficiency and neurological impairment in humans and flies. Nat Genet. 2011;43:259-63 pubmed publisher
..TTC19 is a putative cIII assembly factor whose disruption is associated with severe neurological abnormalities in humans and flies. ..