Upk3b

Summary

Gene Symbol: Upk3b
Description: uroplakin 3B
Alias: AI447729, AI957187, P35, PMS2L14, UpIIIb, uroplakin-3b, UP3b, uroplakin IIIb
Species: mouse
Products:     Upk3b

Top Publications

  1. Deng F, Liang F, Tu L, Resing K, Hu P, Supino M, et al. Uroplakin IIIb, a urothelial differentiation marker, dimerizes with uroplakin Ib as an early step of urothelial plaque assembly. J Cell Biol. 2002;159:685-94 pubmed
    ..These results indicate that p35 (uroplakin IIIb) is a urothelial differentiation product structurally and functionally related to uroplakin III, and that p35-..
  2. Kuriyama S, Tamiya Y, Tanaka M. Spatiotemporal expression of UPK3B and its promoter activity during embryogenesis and spermatogenesis. Histochem Cell Biol. 2017;147:17-26 pubmed publisher
    Uroplakin (Upk) 3 is one of the main structural components of the urothelium tissue. Although expression of UPK3B is seen in a wider variety of the tissues and organs than UPK3A, tissue-specific expression has not yet been analyzed...
  3. Cheng W, Jacobs W, Zhang J, Moro A, Park J, Kushida M, et al. DeltaNp63 plays an anti-apoptotic role in ventral bladder development. Development. 2006;133:4783-92 pubmed
    ..We conclude that DeltaNp63 plays a crucial anti-apoptotic role in normal bladder development...
  4. Yu Z, Mannik J, Soto A, Lin K, Andersen B. The epidermal differentiation-associated Grainyhead gene Get1/Grhl3 also regulates urothelial differentiation. EMBO J. 2009;28:1890-903 pubmed publisher
    ..These results show a crucial role for Get1 in urothelial differentiation and barrier formation. ..
  5. Drerup J, Hayashi K, Cui H, Mettlach G, Long M, Marvin M, et al. Attention-deficit/hyperactivity phenotype in mice lacking the cyclin-dependent kinase 5 cofactor p35. Biol Psychiatry. 2010;68:1163-71 pubmed publisher
    ..Mice lacking the Cdk5-activating cofactor p35 are deficient in cortical lamination, suggesting altered motor/reward circuitry...
  6. Weiss R, Guo S, Shan A, Shi H, Romano R, Sinha S, et al. Brg1 determines urothelial cell fate during ureter development. J Am Soc Nephrol. 2013;24:618-26 pubmed publisher
  7. Cain J, Islam E, Haxho F, Blake J, Rosenblum N. GLI3 repressor controls functional development of the mouse ureter. J Clin Invest. 2011;121:1199-206 pubmed publisher
    ..Together, these data demonstrate that Hh signaling controls Kit and Hcn3 expression and ureter peristalsis. ..
  8. Pignon J, Grisanzio C, Geng Y, Song J, Shivdasani R, Signoretti S. p63-expressing cells are the stem cells of developing prostate, bladder, and colorectal epithelia. Proc Natl Acad Sci U S A. 2013;110:8105-10 pubmed publisher
    ..Because p63 is a master regulator of stratified epithelial development, this finding provides a unique developmental insight into the cell of origin of squamous cell metaplasia and squamous cell carcinoma of the colon. ..
  9. Rudat C, Grieskamp T, Röhr C, Airik R, Wrede C, Hegermann J, et al. Upk3b is dispensable for development and integrity of urothelium and mesothelium. PLoS ONE. 2014;9:e112112 pubmed publisher
    ..Here, we show that uroplakin 3B (Upk3b), which encodes an integral membrane protein of the tetraspanin superfamily, is specifically expressed ..