Unc45a

Summary

Gene Symbol: Unc45a
Description: unc-45 myosin chaperone A
Alias: AW538196, protein unc-45 homolog A, SMAP-1, UNC-45A, smooth muscle cell associated protein-1, stromal membrane-associated protein 1, unc-45 homolog A
Species: mouse
Products:     Unc45a

Top Publications

  1. Chen D, Li S, Singh R, Spinette S, Sedlmeier R, Epstein H. Dual function of the UNC-45b chaperone with myosin and GATA4 in cardiac development. J Cell Sci. 2012;125:3893-903 pubmed publisher
    ..These novel results suggest that the heart-specific UNC-45b isoform functions as a molecular chaperone mediating contractile function of the sarcomere and gene expression in cardiac development. ..
  2. Yanai N, Sato Y, Obinata M. A new type-II membrane protein in erythropoietic organs enhances erythropoiesis. Leukemia. 1997;11 Suppl 3:484-5 pubmed
    ..Over expression of its antisense cDNA in a stroma cell line caused a decrease in the erythropoietic supporting activity. Thus, SMAP-1 may play an important role in the erythropoietic stimulatory activity of the stromal cells. ..
  3. Price M, Landsverk M, Barral J, Epstein H. Two mammalian UNC-45 isoforms are related to distinct cytoskeletal and muscle-specific functions. J Cell Sci. 2002;115:4013-23 pubmed
    ..These results suggest that the general cell UNC-45 isoform may have primarily cytoskeletal functions and that the striated muscle UNC-45 isoform may be restricted to roles in muscle-specific differentiation. ..
  4. Liu L, Srikakulam R, Winkelmann D. Unc45 activates Hsp90-dependent folding of the myosin motor domain. J Biol Chem. 2008;283:13185-93 pubmed publisher
    ..Two unc-45 genes are found in vertebrates, a general cell isoform, unc45a, and a striated muscle-specific isoform, unc45b...
  5. Lamberti A, Sanges C, Chambery A, Migliaccio N, Rosso F, Di Maro A, et al. Analysis of interaction partners for eukaryotic translation elongation factor 1A M-domain by functional proteomics. Biochimie. 2011;93:1738-46 pubmed publisher
    ..Interestingly, a co-localization of SORBS2 and eEF1A was evidenced at level of plasma membrane, thus suggesting the involvement of eEF1A1 in novel key signal transduction complexes. ..