Ucp2

Summary

Gene Symbol: Ucp2
Description: uncoupling protein 2 (mitochondrial, proton carrier)
Alias: Slc25a8, UCP 2, UCPH, mitochondrial uncoupling protein 2, solute carrier family 25 member 8, uncoupling protein 2, mitochondrial
Species: mouse
Products:     Ucp2

Top Publications

  1. Horimoto M, Fülöp P, Derdak Z, Wands J, BAFFY G. Uncoupling protein-2 deficiency promotes oxidant stress and delays liver regeneration in mice. Hepatology. 2004;39:386-92 pubmed
    ..We examined how liver regeneration is affected by uncoupling protein-2 (UCP2), an inner mitochondrial membrane carrier that senses and negatively regulates superoxide production...
  2. Zhang C, Baffy G, Perret P, Krauss S, Peroni O, Grujic D, et al. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell. 2001;105:745-55 pubmed
    ..Uncoupling protein-2 (UCP2) mediates mitochondrial proton leak, decreasing ATP production...
  3. Parker N, Vidal Puig A, Azzu V, Brand M. Dysregulation of glucose homeostasis in nicotinamide nucleotide transhydrogenase knockout mice is independent of uncoupling protein 2. Biochim Biophys Acta. 2009;1787:1451-7 pubmed publisher
    ..to increased mitochondrial reactive oxygen species production and subsequent activation of uncoupling protein 2 (UCP2)...
  4. Zhou M, Xu A, Tam P, Lam K, Huang B, Liang Y, et al. Upregulation of UCP2 by adiponectin: the involvement of mitochondrial superoxide and hnRNP K. PLoS ONE. 2012;7:e32349 pubmed publisher
    ..at least in part by stimulating the expression of a mitochondrial inner membrane transporter, uncoupling protein 2 (UCP2)...
  5. Mattiasson G, Shamloo M, Gido G, Mathi K, Tomasevic G, Yi S, et al. Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma. Nat Med. 2003;9:1062-8 pubmed
    ..identify inducible neuroprotective genes, we found that neuronal survival correlates with increased expression of Ucp2. In mice overexpressing human UCP-2, brain damage was diminished after experimental stroke and traumatic brain ..
  6. Yoshitomi H, Yamazaki K, Tanaka I. Mechanism of ubiquitous expression of mouse uncoupling protein 2 mRNA: control by cis-acting DNA element in 5'-flanking region. Biochem J. 1999;340 ( Pt 2):397-404 pubmed
    ..6.2-kb region upstream from the translation-initiation site of the mouse UCP2 gene and analysed its transcription activity using chimaeric mouse UCP2 promoter-placental-alkaline-phosphatase (..
  7. Fülöp P, Derdak Z, Sheets A, Sabo E, Berthiaume E, Resnick M, et al. Lack of UCP2 reduces Fas-mediated liver injury in ob/ob mice and reveals importance of cell-specific UCP2 expression. Hepatology. 2006;44:592-601 pubmed
    ..Lipid-laden hepatocytes highly express uncoupling protein-2 (UCP2), a mitochondrial carrier that competes with adenosine triphosphate (ATP) synthesis by mediating proton leak...
  8. Berardi M, Shih W, Harrison S, Chou J. Mitochondrial uncoupling protein 2 structure determined by NMR molecular fragment searching. Nature. 2011;476:109-13 pubmed publisher
    b>Mitochondrial uncoupling protein 2 (UCP2) is an integral membrane protein in the mitochondrial anion carrier protein family, the members of which facilitate the transport of small molecules across the mitochondrial inner membrane...
  9. Gimeno R, Dembski M, Weng X, Deng N, Shyjan A, Gimeno C, et al. Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis. Diabetes. 1997;46:900-6 pubmed
    ..Unlike the known UCP, which is expressed specifically in brown adipose tissue, the UCP homolog (UCPH) mRNA is expressed in a variety of tissues, with predominant expression in human white adipose tissue and skeletal ..

More Information

Publications66

  1. Joseph J, Koshkin V, Saleh M, Sivitz W, Zhang C, Lowell B, et al. Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression. J Biol Chem. 2004;279:51049-56 pubmed
    Chronic exposure to elevated free fatty acids (lipotoxicity) induces uncoupling protein (UCP2) in the pancreatic beta-cell, and therefore a causal link between UCP2 and beta-cell defects associated with obesity may exist...
  2. Emre Y, Hurtaud C, Nubel T, Criscuolo F, Ricquier D, Cassard Doulcier A. Mitochondria contribute to LPS-induced MAPK activation via uncoupling protein UCP2 in macrophages. Biochem J. 2007;402:271-8 pubmed
    ..More precisely, we have identified the inner mitochondrial membrane UCP2 (uncoupling protein 2) as a physiological brake on ROS signalling...
  3. Andrews Z, Erion D, Beiler R, Liu Z, Abizaid A, Zigman J, et al. Ghrelin promotes and protects nigrostriatal dopamine function via a UCP2-dependent mitochondrial mechanism. J Neurosci. 2009;29:14057-65 pubmed publisher
    ..Ghrelin-induced neuroprotection was dependent on the mitochondrial redox state via uncoupling protein 2 (UCP2)-dependent alterations in mitochondrial respiration, reactive oxygen species production, and biogenesis...
  4. Duval C, Negre Salvayre A, Dogilo A, Salvayre R, Penicaud L, Casteilla L. Increased reactive oxygen species production with antisense oligonucleotides directed against uncoupling protein 2 in murine endothelial cells. Biochem Cell Biol. 2002;80:757-64 pubmed
    ..These data also support the notion that manipulations of UCP-2 at the genetic level could control ROS metabolism at the cellular level. ..
  5. Horvath B, Spies C, Horvath G, Kox W, Miyamoto S, Barry S, et al. Uncoupling protein 2 (UCP2) lowers alcohol sensitivity and pain threshold. Biochem Pharmacol. 2002;64:369-74 pubmed
    ..Uncoupling protein 2 (UCP2) is a mitochondrial protonophore that regulates cellular energy homeostasis...
  6. Bechmann I, Diano S, Warden C, Bartfai T, Nitsch R, Horvath T. Brain mitochondrial uncoupling protein 2 (UCP2): a protective stress signal in neuronal injury. Biochem Pharmacol. 2002;64:363-7 pubmed
    ..One of these proteins, UCP2, is also expressed in neurons of subcortical brain regions of healthy subjects...
  7. Kong D, Vong L, Parton L, Ye C, Tong Q, Hu X, et al. Glucose stimulation of hypothalamic MCH neurons involves K(ATP) channels, is modulated by UCP2, and regulates peripheral glucose homeostasis. Cell Metab. 2010;12:545-52 pubmed publisher
    ..of MCH-expressing neurons in the lateral hypothalamus is mediated by K(ATP) channels and is negatively regulated by UCP2 (a mitochondrial protein that reduces ATP production), and that glucose sensing by MCH neurons plays an important ..
  8. Couplan E, del Mar Gonzalez Barroso M, Alves Guerra M, Ricquier D, Goubern M, Bouillaud F. No evidence for a basal, retinoic, or superoxide-induced uncoupling activity of the uncoupling protein 2 present in spleen or lung mitochondria. J Biol Chem. 2002;277:26268-75 pubmed
    The phenotypes observed in mice whose uncoupling protein (Ucp2) gene had been invalidated by homologous recombination (Ucp2(-/-) mice) are consistent with an increase in mitochondrial membrane potential in macrophages and pancreatic beta ..
  9. Alves Guerra M, Aheng C, Pecqueur C, Masscheleyn S, Tharaux P, Druilhe A, et al. Analysis of uncoupling protein 2-deficient mice upon anaesthesia and sedation revealed a role for UCP2 in locomotion. PLoS ONE. 2012;7:e41846 pubmed publisher
    General anaesthesia is associated with hypothermia, oxidative stress, and immune depression. Uncoupling Protein (UCP2) is a member of the mitochondrial carrier family present in many organs including the spleen, the lung and the brain...
  10. Lee S, Robson Doucette C, Wheeler M. Uncoupling protein 2 regulates reactive oxygen species formation in islets and influences susceptibility to diabetogenic action of streptozotocin. J Endocrinol. 2009;203:33-43 pubmed publisher
    Currently, the physiological function of uncoupling protein-2 (UCP2) in pancreatic islets and its role in the development of diabetes is a matter of great debate...
  11. Dietrich M, Andrews Z, Horvath T. Exercise-induced synaptogenesis in the hippocampus is dependent on UCP2-regulated mitochondrial adaptation. J Neurosci. 2008;28:10766-71 pubmed publisher
    ..Here we show that voluntary exercise induces uncoupling protein 2 (UCP2) mRNA expression and mitochondrial oxygen consumption in coupled as well as uncoupled respiratory states in the ..
  12. Rupprecht A, Bräuer A, Smorodchenko A, Goyn J, Hilse K, Shabalina I, et al. Quantification of uncoupling protein 2 reveals its main expression in immune cells and selective up-regulation during T-cell proliferation. PLoS ONE. 2012;7:e41406 pubmed publisher
    Uncoupling protein 2 (UCP2) is an inner mitochondrial membrane protein. Although the protein was discovered in 1997, its function and even its tissue distribution are still under debate...
  13. Pecqueur C, Bui T, Gelly C, Hauchard J, Barbot C, Bouillaud F, et al. Uncoupling protein-2 controls proliferation by promoting fatty acid oxidation and limiting glycolysis-derived pyruvate utilization. FASEB J. 2008;22:9-18 pubmed
    Uncoupling protein-2 (UCP2) belongs to the mitochondrial carrier family and has been thought to be involved in suppressing mitochondrial ROS production through uncoupling mitochondrial respiration from ATP synthesis...
  14. Derdak Z, Fülöp P, Sabo E, Tavares R, Berthiaume E, Resnick M, et al. Enhanced colon tumor induction in uncoupling protein-2 deficient mice is associated with NF-kappaB activation and oxidative stress. Carcinogenesis. 2006;27:956-61 pubmed
    ..study this process, we induced colon tumors with azoxymethane (AOM) in mice deficient for uncoupling protein-2 (UCP2). UCP2 has recently emerged as a negative regulator of mitochondrial oxidant production...
  15. Segersvard R, Rippe C, Duplantier M, Herrington M, Isaksson B, Adrian T, et al. mRNA for pancreatic uncoupling protein 2 increases in two models of acute experimental pancreatitis in rats and mice. Cell Tissue Res. 2005;320:251-8 pubmed
    Uncoupling-protein 2 (UCP2) is a mitochondrial protein that appears to be involved in cellular oxidant defense and in the regulation of oncotic cell death, both of which are important features of acute pancreatitis...
  16. Bai Y, Onuma H, Bai X, Medvedev A, Misukonis M, Weinberg J, et al. Persistent nuclear factor-kappa B activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production. J Biol Chem. 2005;280:19062-9 pubmed
    One of the phenotypes of mice with targeted disruption of the uncoupling protein-2 gene (Ucp2-/-) is greater macrophage phagocytic activity and free radical production, resulting in a striking resistance to infectious microorganisms...
  17. de Bilbao F, Arsenijevic D, Vallet P, Hjelle O, Ottersen O, Bouras C, et al. Resistance to cerebral ischemic injury in UCP2 knockout mice: evidence for a role of UCP2 as a regulator of mitochondrial glutathione levels. J Neurochem. 2004;89:1283-92 pubmed
    Uncoupling protein 2 (UCP2) is suggested to be a regulator of reactive oxygen species production in mitochondria...
  18. Krauss S, Zhang C, Lowell B. A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2. Proc Natl Acad Sci U S A. 2002;99:118-22 pubmed
    The uncoupling protein homologue UCP2 is expressed in a variety of mammalian cells. It is thought to be an uncoupler of oxidative phosphorylation...
  19. Nishio K, Qiao S, Yamashita H. Characterization of the differential expression of uncoupling protein 2 and ROS production in differentiated mouse macrophage-cells (Mm1) and the progenitor cells (M1). J Mol Histol. 2005;36:35-44 pubmed
    The expression status of mitochondrial uncoupling protein 2 (UCP2) was investigated in undifferentiated mouse myeloid leukemia (M1) and its differentiated macrophage-like cells (Mm1)...
  20. Sun J, Pu Y, Wang P, Chen S, Zhao Y, Liu C, et al. TRPV1-mediated UCP2 upregulation ameliorates hyperglycemia-induced endothelial dysfunction. Cardiovasc Diabetol. 2013;12:69 pubmed publisher
    ..Uncoupling protein 2 (UCP2) is a regulator of mitochondrial reactive oxygen species (ROS) generation and can antagonise oxidative stress, but ..
  21. Pecqueur C, Alves Guerra M, Gelly C, Levi Meyrueis C, Couplan E, Collins S, et al. Uncoupling protein 2, in vivo distribution, induction upon oxidative stress, and evidence for translational regulation. J Biol Chem. 2001;276:8705-12 pubmed
    Uncoupling protein 2 (UCP2) belongs to the mitochondrial anion carrier family and partially uncouples respiration from ATP synthesis when expressed in recombinant yeast mitochondria...
  22. Li L, Chen J, Ni Y, Feng X, Zhao Z, Wang P, et al. TRPV1 activation prevents nonalcoholic fatty liver through UCP2 upregulation in mice. Pflugers Arch. 2012;463:727-32 pubmed publisher
    ..Chronic dietary capsaicin increased the hepatic uncoupling protein 2 (UCP2) expression in WT but not in TRPV1(-/-) mice (P?<?0.01)...
  23. Ma S, Ma L, Yang D, Luo Z, Hao X, Liu D, et al. Uncoupling protein 2 ablation exacerbates high-salt intake-induced vascular dysfunction. Am J Hypertens. 2010;23:822-8 pubmed publisher
    ..Uncoupling protein 2 (UCP2) has been implicated in the vascular protection, specifically by decreasing ROS production...
  24. Tagen M, Elorza A, Kempuraj D, Boucher W, Kepley C, Shirihai O, et al. Mitochondrial uncoupling protein 2 inhibits mast cell activation and reduces histamine content. J Immunol. 2009;183:6313-9 pubmed publisher
    ..Uncoupling protein 2 (UCP2) is a mitochondrial protein that inhibits insulin secretion from beta cells, possibly through down-regulation of ..
  25. Andrews Z, Horvath T. Uncoupling protein-2 regulates lifespan in mice. Am J Physiol Endocrinol Metab. 2009;296:E621-7 pubmed publisher
    The long-term effects of uncoupled mitochondrial respiration by uncoupling protein-2 (UCP2) in mammalian physiology remain controversial...
  26. Fleury C, Neverova M, Collins S, Raimbault S, Champigny O, Levi Meyrueis C, et al. Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nat Genet. 1997;15:269-72 pubmed
    ..We now report the discovery of a gene that codes for a novel uncoupling protein, designated UCP2, which has 59% amino-acid identity to UCP1, and describe properties consistent with a role in diabetes and obesity...
  27. Echtay K, Roussel D, St Pierre J, Jekabsons M, Cadenas S, Stuart J, et al. Superoxide activates mitochondrial uncoupling proteins. Nature. 2002;415:96-9 pubmed
    ..The functions of its homologues, UCP2 and UCP3, in other tissues are debated...
  28. Andrews Z, Liu Z, Walllingford N, Erion D, Borok E, Friedman J, et al. UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals. Nature. 2008;454:846-51 pubmed publisher
    ..robust changes in hypothalamic mitochondrial respiration in mice that are dependent on uncoupling protein 2 (UCP2)...
  29. Elorza A, Hyde B, Mikkola H, Collins S, Shirihai O. UCP2 modulates cell proliferation through the MAPK/ERK pathway during erythropoiesis and has no effect on heme biosynthesis. J Biol Chem. 2008;283:30461-70 pubmed publisher
    b>UCP2, an inner membrane mitochondrial protein, has been implicated in bioenergetics and reactive oxygen species (ROS) modulation...
  30. Moukdar F, Robidoux J, Lyght O, Pi J, Daniel K, Collins S. Reduced antioxidant capacity and diet-induced atherosclerosis in uncoupling protein-2-deficient mice. J Lipid Res. 2009;50:59-70 pubmed publisher
    ..Uncoupling protein-2 (UCP2) is a mitochondrial inner membrane protein shown to be a negative regulator of macrophage ROS production...
  31. Zhou M, Xu A, Tam P, Lam K, Chan L, Hoo R, et al. Mitochondrial dysfunction contributes to the increased vulnerabilities of adiponectin knockout mice to liver injury. Hepatology. 2008;48:1087-96 pubmed publisher
    ..The gene and protein levels of uncoupling protein 2 (UCP2), a mitochondrial membrane transporter, were decreased in ADN-KO mice and could be significantly up-regulated by ..
  32. Affourtit C, Jastroch M, Brand M. Uncoupling protein-2 attenuates glucose-stimulated insulin secretion in INS-1E insulinoma cells by lowering mitochondrial reactive oxygen species. Free Radic Biol Med. 2011;50:609-16 pubmed publisher
    ..Glucose-stimulated insulin secretion (GSIS) by pancreatic ? cells is regulated by mitochondrial uncoupling protein-2 (UCP2), but opposing phenotypes, GSIS improvement and impairment, have been reported for different Ucp2-ablated mouse ..
  33. Kizaki T, Suzuki K, Hitomi Y, Taniguchi N, Saitoh D, Watanabe K, et al. Uncoupling protein 2 plays an important role in nitric oxide production of lipopolysaccharide-stimulated macrophages. Proc Natl Acad Sci U S A. 2002;99:9392-7 pubmed
    The expression of uncoupling protein 2 (UCP2) was reduced in macrophages after stimulation with lipopolysaccharide (LPS)...
  34. Wang Y, Nishi M, Doi A, Shono T, Furukawa Y, Shimada T, et al. Ghrelin inhibits insulin secretion through the AMPK-UCP2 pathway in beta cells. FEBS Lett. 2010;584:1503-8 pubmed publisher
    ..the orexigenic effect of ghrelin is mediated by the AMP-activated protein kinase (AMPK)-uncoupling protein 2 (UCP2) pathway...
  35. Andrews Z, Horvath B, Barnstable C, Elsworth J, Elseworth J, Yang L, et al. Uncoupling protein-2 is critical for nigral dopamine cell survival in a mouse model of Parkinson's disease. J Neurosci. 2005;25:184-91 pubmed
    ..We show that genetic manipulation of uncoupling protein-2 (UCP2) directly affects substantia nigra dopamine cell function...
  36. Kuhla A, Trieglaff C, Vollmar B. Role of age and uncoupling protein-2 in oxidative stress, RAGE/AGE interaction and inflammatory liver injury. Exp Gerontol. 2011;46:868-76 pubmed publisher
    ..further address the role of uncoupling of mitochondrial respiration, mitochondrial uncoupling protein-2 wild-type (UCP2+/+) and knock out (UCP2-/-) mice were used and studied at an age of 8 (young), 38 (adult) and 76 weeks (senescent)...
  37. Hurtaud C, Gelly C, Bouillaud F, Levi Meyrueis C. Translation control of UCP2 synthesis by the upstream open reading frame. Cell Mol Life Sci. 2006;63:1780-9 pubmed
    Uncoupling protein 2 (UCP2) belongs to a family of transporters of the mitochondrial inner membrane...
  38. Alves Guerra M, Rousset S, Pecqueur C, Mallat Z, Blanc J, Tedgui A, et al. Bone marrow transplantation reveals the in vivo expression of the mitochondrial uncoupling protein 2 in immune and nonimmune cells during inflammation. J Biol Chem. 2003;278:42307-12 pubmed
    The mitochondrial uncoupling protein 2 (UCP2) is expressed in spleen, lung, intestine, white adipose tissue, and immune cells...
  39. Hurtaud C, Gelly C, Chen Z, Levi Meyrueis C, Bouillaud F. Glutamine stimulates translation of uncoupling protein 2mRNA. Cell Mol Life Sci. 2007;64:1853-60 pubmed
    Uncoupling protein 2 (UCP2) belongs to a family of transporters/exchangers of the mitochondrial inner membrane...
  40. Arsenijevic D, Onuma H, Pecqueur C, Raimbault S, Manning B, Miroux B, et al. Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat Genet. 2000;26:435-9 pubmed
    The gene Ucp2 is a member of a family of genes found in animals and plants, encoding a protein homologous to the brown fat uncoupling protein Ucp1 (refs 1-3)...
  41. Vogler S, Pahnke J, Rousset S, Ricquier D, Moch H, Miroux B, et al. Uncoupling protein 2 has protective function during experimental autoimmune encephalomyelitis. Am J Pathol. 2006;168:1570-5 pubmed
    Uncoupling protein 2 (UCP2) is a member of the mitochondrial transporter superfamily that is expressed in many tissues, including immune cells. UCP2 prevents oxidative stress by reducing reactive oxygen species...
  42. Parton L, Ye C, Coppari R, Enriori P, Choi B, Zhang C, et al. Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity. Nature. 2007;449:228-32 pubmed
    ..The mechanism for obesity-induced loss of glucose sensing in POMC neurons involves uncoupling protein 2 (UCP2), a mitochondrial protein that impairs glucose-stimulated ATP production...
  43. Nubel T, Emre Y, Rabier D, Chadefaux B, Ricquier D, Bouillaud F. Modified glutamine catabolism in macrophages of Ucp2 knock-out mice. Biochim Biophys Acta. 2008;1777:48-54 pubmed
    Uncoupling protein 2 (UCP2) belongs to a family of transporters of the mitochondrial inner membrane and is reported to uncouple respiration from ATP synthesis...
  44. Tian X, Wong W, Xu A, Lu Y, Zhang Y, Wang L, et al. Uncoupling protein-2 protects endothelial function in diet-induced obese mice. Circ Res. 2012;110:1211-6 pubmed publisher
    Previous studies indicate uncoupling protein-2 (UCP2) as an antioxidant defense against endothelial dysfunction in hypertension. UCP2 also regulates insulin secretion and action...
  45. Simon Areces J, Dietrich M, Hermes G, Garcia Segura L, Arevalo M, Horvath T. UCP2 induced by natural birth regulates neuronal differentiation of the hippocampus and related adult behavior. PLoS ONE. 2012;7:e42911 pubmed publisher
    b>Mitochondrial uncoupling protein 2 (UCP2) is induced by cellular stress and is involved in regulation of fuel utilization, mitochondrial bioenergetics, cell proliferation, neuroprotection and synaptogenesis in the adult brain...
  46. Suski J, Schonfeld P, Bonora M, Shabalina I, Pinton P, Wieckowski M. Guanosine diphosphate exerts a lower effect on superoxide release from mitochondrial matrix in the brains of uncoupling protein-2 knockout mice: new evidence for a putative novel function of uncoupling proteins as superoxide anion transporters. Biochem Biophys Res Commun. 2012;428:234-8 pubmed publisher
    In this report, we show new experimental evidence that, in mouse brain mitochondria, uncoupling protein-2 (UCP2) can be involved in superoxide (O(2)(·-)) removal from the mitochondrial matrix...
  47. Robson Doucette C, Sultan S, Allister E, Wikstrom J, Koshkin V, Bhattacharjee A, et al. Beta-cell uncoupling protein 2 regulates reactive oxygen species production, which influences both insulin and glucagon secretion. Diabetes. 2011;60:2710-9 pubmed publisher
    The role of uncoupling protein 2 (UCP2) in pancreatic ?-cells is highly debated, partly because of the broad tissue distribution of UCP2 and thus limitations of whole-body UCP2 knockout mouse models...
  48. De Souza C, Araujo E, Stoppiglia L, Pauli J, Ropelle E, Rocco S, et al. Inhibition of UCP2 expression reverses diet-induced diabetes mellitus by effects on both insulin secretion and action. FASEB J. 2007;21:1153-63 pubmed
    Recent characterization of the ability of uncoupling protein 2 (UCP2) to reduce ATP production and inhibit insulin secretion by pancreatic beta-cells has placed this mitochondrial protein as a candidate target for therapeutics in diabetes ..
  49. Basu Ball W, Kar S, Mukherjee M, Chande A, Mukhopadhyaya R, Das P. Uncoupling protein 2 negatively regulates mitochondrial reactive oxygen species generation and induces phosphatase-mediated anti-inflammatory response in experimental visceral leishmaniasis. J Immunol. 2011;187:1322-32 pubmed publisher
    ..demonstrated that Leishmania donovani infection is associated with strong upregulation of uncoupling protein 2 (UCP2), a negative regulator of mitochondrial ROS generation located at the inner membrane of mitochondria...
  50. Guzman J, Sanchez Padilla J, Wokosin D, Kondapalli J, Ilijic E, Schumacker P, et al. Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1. Nature. 2010;468:696-700 pubmed publisher
    ..Because drugs approved for human use can antagonize calcium entry through L-type channels, these results point to a novel neuroprotective strategy for both idiopathic and familial forms of Parkinson's disease. ..
  51. Haines B, Mehta S, Pratt S, Warden C, Li P. Deletion of mitochondrial uncoupling protein-2 increases ischemic brain damage after transient focal ischemia by altering gene expression patterns and enhancing inflammatory cytokines. J Cereb Blood Flow Metab. 2010;30:1825-33 pubmed publisher
    ..The role of UCP2 in neuroprotection is still in debate...
  52. Clavel S, Paradis E, Ricquier D, Richard D. Kainic acid upregulates uncoupling protein-2 mRNA expression in the mouse brain. Neuroreport. 2003;14:2015-7 pubmed
    ..of kainic acid (KA) in C57BL/6J and 129T2SvEmsJ mice led to a transient induction of uncoupling protein-2 (Ucp2) mRNA expression in several brain regions, which included the CA1 subfield of the hippocampus, the dorsal ..
  53. Krauss S, Zhang C, Scorrano L, Dalgaard L, St Pierre J, Grey S, et al. Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction. J Clin Invest. 2003;112:1831-42 pubmed
    ..The mechanism for loss of glucose responsiveness is unknown. Uncoupling protein 2 (UCP2), by virtue of its mitochondrial proton leak activity and consequent negative effect on ATP production, impairs ..
  54. Emre Y, Hurtaud C, Karaca M, Nubel T, Zavala F, Ricquier D. Role of uncoupling protein UCP2 in cell-mediated immunity: how macrophage-mediated insulitis is accelerated in a model of autoimmune diabetes. Proc Natl Acad Sci U S A. 2007;104:19085-90 pubmed
    ..Uncoupling protein 2 (UCP2) is a mitochondrial protein expressed in immune cells...
  55. Echtay K, Esteves T, Pakay J, Jekabsons M, Lambert A, Portero Otin M, et al. A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling. EMBO J. 2003;22:4103-10 pubmed
    ..and other 2-alkenals) specifically induce uncoupling of mitochondria through the uncoupling proteins UCP1, UCP2 and UCP3 and the adenine nucleotide translocase (ANT)...
  56. Pi J, Bai Y, Daniel K, Liu D, Lyght O, Edelstein D, et al. Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function. Endocrinology. 2009;150:3040-8 pubmed publisher
    ..Thus, the chronic absence of UCP2 has the potential to promote persistent reactive oxygen species accumulation and an oxidative stress response...
  57. Diao J, Allister E, Koshkin V, Lee S, Bhattacharjee A, Tang C, et al. UCP2 is highly expressed in pancreatic alpha-cells and influences secretion and survival. Proc Natl Acad Sci U S A. 2008;105:12057-62 pubmed publisher
    In pancreatic beta-cells, uncoupling protein 2 (UCP2) influences mitochondrial oxidative phosphorylation and insulin secretion. Here, we show that alpha-cells express significantly higher levels of UCP2 than do beta-cells...