Gene Symbol: Ucp1
Description: uncoupling protein 1 (mitochondrial, proton carrier)
Alias: AI385626, Slc25a7, Ucp, mitochondrial brown fat uncoupling protein 1, UCP 1, solute carrier family 25 member 7, thermogenin, uncoupling protein 1, mitochondrial, uncoupling protein, mitochondrial
Species: mouse
Products:     Ucp1

Top Publications

  1. Shabalina I, Petrovic N, de Jong J, Kalinovich A, Cannon B, Nedergaard J. UCP1 in brite/beige adipose tissue mitochondria is functionally thermogenic. Cell Rep. 2013;5:1196-203 pubmed publisher
    ..in which certain white adipose tissue depots significantly increase gene expression for the uncoupling protein UCP1 and thus supposedly acquire thermogenic, fat-burning properties, has attracted considerable attention...
  2. Kiskinis E, Hallberg M, Christian M, Olofsson M, Dilworth S, White R, et al. RIP140 directs histone and DNA methylation to silence Ucp1 expression in white adipocytes. EMBO J. 2007;26:4831-40 pubmed
    ..Here we show by analysis of Ucp1, a gene which is typically expressed in brown but not white adipocytes, that RIP140 is essential for both DNA and ..
  3. Shabalina I, Petrovic N, Kramarova T, Hoeks J, Cannon B, Nedergaard J. UCP1 and defense against oxidative stress. 4-Hydroxy-2-nonenal effects on brown fat mitochondria are uncoupling protein 1-independent. J Biol Chem. 2006;281:13882-93 pubmed
    ..We have investigated here the ability of HNE to activate UCP1. Using brown fat mitochondria from UCP1+/+ and UCP1-/- mice to allow for identification of UCP1-dependent effects, ..
  4. Esteves T, Parker N, Brand M. Synergy of fatty acid and reactive alkenal activation of proton conductance through uncoupling protein 1 in mitochondria. Biochem J. 2006;395:619-28 pubmed
    The kinetics of proton transport through mammalian UCP1 (uncoupling protein 1) expressed in yeast mitochondria were measured. There was little or no UCP1 activity in the absence of added palmitate, but significant activity in its presence...
  5. Inokuma K, Okamatsu Ogura Y, Omachi A, Matsushita Y, Kimura K, Yamashita H, et al. Indispensable role of mitochondrial UCP1 for antiobesity effect of beta3-adrenergic stimulation. Am J Physiol Endocrinol Metab. 2006;290:E1014-21 pubmed
    Mitochondrial uncoupling protein-1 (UCP1) has been thought to be a key molecule for thermogenesis during cold exposure and spontaneous hyperphagia and thereby in the autonomic regulation of energy expenditure and adiposity...
  6. da Rocha S, Charalambous M, Lin S, Gutteridge I, Ito Y, Gray D, et al. Gene dosage effects of the imprinted delta-like homologue 1 (dlk1/pref1) in development: implications for the evolution of imprinting. PLoS Genet. 2009;5:e1000392 pubmed publisher
    ..We propose a negative correlation between gene dosage and survival that fixes an upper limit on growth promotion by Dlk1, and we hypothesize that trade-off between growth and lethality might have driven imprinting at this locus. ..
  7. Echtay K, Esteves T, Pakay J, Jekabsons M, Lambert A, Portero Otin M, et al. A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling. EMBO J. 2003;22:4103-10 pubmed
    ..trans-retinal and other 2-alkenals) specifically induce uncoupling of mitochondria through the uncoupling proteins UCP1, UCP2 and UCP3 and the adenine nucleotide translocase (ANT)...
  8. Enerback S, Jacobsson A, Simpson E, Guerra C, Yamashita H, Harper M, et al. Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature. 1997;387:90-4 pubmed
    The mitochondrial uncoupling protein (UCP) in the mitochondrial inner membrane of mammalian brown adipose tissue generates heat by uncoupling oxidative phosphorylation. This process protects against cold and regulates energy balance...
  9. Keipert S, Klaus S, Heldmaier G, Jastroch M. UCP1 ectopically expressed in murine muscle displays native function and mitigates mitochondrial superoxide production. Biochim Biophys Acta. 2010;1797:324-30 pubmed publisher
    ..physiological effects could be demonstrated in several mouse models ectopically expressing uncoupling protein 1 (UCP1)...

More Information


  1. Okamatsu Ogura Y, Nio Kobayashi J, Iwanaga T, Terao A, Kimura K, Saito M. Possible involvement of uncoupling protein 1 in appetite control by leptin. Exp Biol Med (Maywood). 2011;236:1274-81 pubmed publisher
    ..To clarify whether UCP1 is also involved in the anorexigenic effect of leptin, in this study we examined the effect of leptin on food ..
  2. Petrovic N, Walden T, Shabalina I, Timmons J, Cannon B, Nedergaard J. Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adi. J Biol Chem. 2010;285:7153-64 pubmed publisher
    ..are distinct from white adipocytes has spurred questions concerning the origin and molecular characteristics of the UCP1-expressing cells observed in classic white adipose tissue depots under certain physiological or pharmacological ..
  3. Tseng Y, Kokkotou E, Schulz T, Huang T, Winnay J, Taniguchi C, et al. New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature. 2008;454:1000-4 pubmed publisher
    ..5), increased expression of the brown-fat-defining marker uncoupling protein 1 (UCP1) and adipogenic transcription factors PPARgamma and CCAAT/enhancer-binding proteins (C/EBPs), and induction of ..
  4. Neschen S, Katterle Y, Richter J, Augustin R, Scherneck S, Mirhashemi F, et al. Uncoupling protein 1 expression in murine skeletal muscle increases AMPK activation, glucose turnover, and insulin sensitivity in vivo. Physiol Genomics. 2008;33:333-40 pubmed publisher
    ..b>UCP1-mediated uncoupling of oxidative phosphorylation in skeletal muscle was paralleled by AMPK activation and thereby ..
  5. Fedorenko A, Lishko P, Kirichok Y. Mechanism of fatty-acid-dependent UCP1 uncoupling in brown fat mitochondria. Cell. 2012;151:400-13 pubmed publisher
    Mitochondrial uncoupling protein 1 (UCP1) is responsible for nonshivering thermogenesis in brown adipose tissue (BAT)...
  6. Kopecky J, Clarke G, Enerback S, Spiegelman B, Kozak L. Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity. J Clin Invest. 1995;96:2914-23 pubmed
    The brown fat-specific mitochondrial uncoupling protein (UCP) provides a mechanism for generating heat by uncoupling respiration and oxidative phosphorylation...
  7. Shabalina I, Ost M, Petrovic N, Vrbacky M, Nedergaard J, Cannon B. Uncoupling protein-1 is not leaky. Biochim Biophys Acta. 2010;1797:773-84 pubmed publisher
    The activity of uncoupling protein-1 (UCP1) is rate-limiting for nonshivering thermogenesis and diet-induced thermogenesis...
  8. Tews D, Fischer Posovszky P, Fromme T, Klingenspor M, Fischer J, Ruther U, et al. FTO deficiency induces UCP-1 expression and mitochondrial uncoupling in adipocytes. Endocrinology. 2013;154:3141-51 pubmed publisher
    ..Uncoupling protein 1 (Ucp-1) was significantly higher expressed in both gonadal and inguinal adipose depots of Fto(-/-) compared with Fto(+/+)..
  9. Ringholm S, Grunnet Knudsen J, Leick L, Lundgaard A, Munk Nielsen M, Pilegaard H. PGC-1? is required for exercise- and exercise training-induced UCP1 up-regulation in mouse white adipose tissue. PLoS ONE. 2013;8:e64123 pubmed publisher
    The aim of the present study was to test the hypotheses that 1) a single exercise bout increases UCP1 mRNA in both inguinal (i)WAT and epididymal (e)WAT, 2) UCP1 expression and responsiveness to exercise are different in iWAT and eWAT, 3) ..
  10. Li B, Nolte L, Ju J, Han D, Coleman T, Holloszy J, et al. Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice. Nat Med. 2000;6:1115-20 pubmed
    ..for obesity and type 2 diabetes, we generated transgenic mice expressing the mitochondrial uncoupling protein (Ucp) in skeletal muscle...
  11. Klaus S, Rudolph B, Dohrmann C, Wehr R. Expression of uncoupling protein 1 in skeletal muscle decreases muscle energy efficiency and affects thermoregulation and substrate oxidation. Physiol Genomics. 2005;21:193-200 pubmed
    Skeletal muscle uncoupling by ectopic expression of mitochondrial uncoupling protein 1 (UCP1) has been shown to result in a lean phenotype in mice characterized by increased energy expenditure (EE), resistance to diet-induced obesity, and ..
  12. Kajimura S, Seale P, Kubota K, Lunsford E, Frangioni J, Gygi S, et al. Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Nature. 2009;460:1154-8 pubmed publisher
    ..These data indicate that the PRDM16-C/EBP-beta complex initiates brown fat formation from myoblastic precursors, and may provide opportunities for the development of new therapeutics for obesity and type-2 diabetes. ..
  13. Han D, Nolte L, Ju J, Coleman T, Holloszy J, Semenkovich C. UCP-mediated energy depletion in skeletal muscle increases glucose transport despite lipid accumulation and mitochondrial dysfunction. Am J Physiol Endocrinol Metab. 2004;286:E347-53 pubmed
    ..in insulin resistance, we studied mice with high-level expression of uncoupling protein-1 in skeletal muscle (UCP-H mice)...
  14. Xue Y, Petrovic N, Cao R, Larsson O, Lim S, Chen S, et al. Hypoxia-independent angiogenesis in adipose tissues during cold acclimation. Cell Metab. 2009;9:99-109 pubmed publisher
    ..exposure resulted in elevated expression levels of brown-fat-associated proteins, including uncoupling protein-1 (UCP1) and PGC-1alpha...
  15. Tanaka T, Yoshida N, Kishimoto T, Akira S. Defective adipocyte differentiation in mice lacking the C/EBPbeta and/or C/EBPdelta gene. EMBO J. 1997;16:7432-43 pubmed
  16. Almind K, Manieri M, Sivitz W, Cinti S, Kahn C. Ectopic brown adipose tissue in muscle provides a mechanism for differences in risk of metabolic syndrome in mice. Proc Natl Acad Sci U S A. 2007;104:2366-71 pubmed
    ..At a molecular level, this difference correlates with a marked higher expression of uncoupling protein 1 (UCP1) and a higher degree of uncoupling in vitro in mitochondria isolated from muscle of 129 versus B6 mice...
  17. Echtay K, Roussel D, St Pierre J, Jekabsons M, Cadenas S, Stuart J, et al. Superoxide activates mitochondrial uncoupling proteins. Nature. 2002;415:96-9 pubmed
    Uncoupling protein 1 (UCP1) diverts energy from ATP synthesis to thermogenesis in the mitochondria of brown adipose tissue by catalysing a regulated leak of protons across the inner membrane...
  18. Nedergaard J, Golozoubova V, Matthias A, Asadi A, Jacobsson A, Cannon B. UCP1: the only protein able to mediate adaptive non-shivering thermogenesis and metabolic inefficiency. Biochim Biophys Acta. 2001;1504:82-106 pubmed
    The uniqueness of UCP1 (as compared to UCP2/UCP3) is evident from expression analysis and ablation studies...
  19. Kozak U, Kopecky J, Teisinger J, Enerback S, Boyer B, Kozak L. An upstream enhancer regulating brown-fat-specific expression of the mitochondrial uncoupling protein gene. Mol Cell Biol. 1994;14:59-67 pubmed
    Previous studies on the regulation of a Ucp minigene in transgenic mice demonstrated that the sequences necessary for brown-fat-specific expression and inducibility by norepinephrine were located in the 5' flanking region between 1 and 2...
  20. Seale P, Bjork B, Yang W, Kajimura S, Chin S, Kuang S, et al. PRDM16 controls a brown fat/skeletal muscle switch. Nature. 2008;454:961-7 pubmed publisher
    ..Taken together, these data indicate that PRDM16 specifies the brown fat lineage from a progenitor that expresses myoblast markers and is not involved in white adipogenesis. ..
  21. Feldmann H, Golozoubova V, Cannon B, Nedergaard J. UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab. 2009;9:203-9 pubmed publisher
    As original studies of UCP1-ablated mice failed to demonstrate an obesogenic effect, alternative mechanisms for adaptive adrenergic thermogenesis have been sought...
  22. Dupuis L, Gonzalez de Aguilar J, Echaniz Laguna A, Eschbach J, Rene F, Oudart H, et al. Muscle mitochondrial uncoupling dismantles neuromuscular junction and triggers distal degeneration of motor neurons. PLoS ONE. 2009;4:e5390 pubmed publisher
    ..We studied transgenic mice with muscular overexpression of uncoupling protein 1 (UCP1), a potent mitochondrial uncoupler, as a model of muscle restricted hypermetabolism...
  23. Couplan E, Gelly C, Goubern M, Fleury C, Quesson B, Silberberg M, et al. High level of uncoupling protein 1 expression in muscle of transgenic mice selectively affects muscles at rest and decreases their IIb fiber content. J Biol Chem. 2002;277:43079-88 pubmed
    The mitochondrial uncoupling protein of brown adipose tissue (UCP1) was expressed in skeletal muscle and heart of transgenic mice at levels comparable with the amount found in brown adipose tissue mitochondria...
  24. Robidoux J, Cao W, Quan H, Daniel K, Moukdar F, Bai X, et al. Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes. Mol Cell Biol. 2005;25:5466-79 pubmed
    The sympathetic nervous system regulates the activity and expression of uncoupling protein 1 (UCP1) through the three beta-adrenergic receptor subtypes and their ability to raise intracellular cyclic AMP (cAMP) levels...
  25. Shabalina I, Jacobsson A, Cannon B, Nedergaard J. Native UCP1 displays simple competitive kinetics between the regulators purine nucleotides and fatty acids. J Biol Chem. 2004;279:38236-48 pubmed
    Elucidation of the regulation of uncoupling protein 1 (UCP1) activity in its native environment, i.e...
  26. Wong K, Szeto F, Zhang W, Ye H, Kong J, Zhang Z, et al. Involvement of the vitamin D receptor in energy metabolism: regulation of uncoupling proteins. Am J Physiol Endocrinol Metab. 2009;296:E820-8 pubmed publisher
    ..rate of fatty acid beta-oxidation in the white adipose tissue was higher, and the expression of uncoupling protein (UCP) 1, UCP2 and UCP3 was markedly upregulated in VDR-null mice, suggesting a higher energy expenditure in the mutant ..
  27. Zhang N, Fu Z, Linke S, Chicher J, Gorman J, Visk D, et al. The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism. Cell Metab. 2010;11:364-78 pubmed publisher
    ..These results demonstrate that FIH acts to a significant degree through the nervous system to regulate metabolism. ..
  28. Winn N, Vieira Potter V, Gastecki M, Welly R, Scroggins R, Zidon T, et al. Loss of UCP1 exacerbates Western diet-induced glycemic dysregulation independent of changes in body weight in female mice. Am J Physiol Regul Integr Comp Physiol. 2017;312:R74-R84 pubmed publisher
    We tested the hypothesis that female mice null for uncoupling protein 1 (UCP1) would have increased susceptibility to Western diet-induced "whitening" of brown adipose tissue (AT) and glucose intolerance...
  29. Johnson K, Wiesweg B, Schott M, Ehlers M, Muller M, Minich W, et al. Examination of orbital tissues in murine models of Graves' disease reveals expression of UCP-1 and the TSHR in retrobulbar adipose tissues. Horm Metab Res. 2013;45:401-7 pubmed publisher
    ..antibodies (TSAbs) were evaluated and orbits were stained immunohistochemically for F4/80, uncoupling protein-1 (UCP-1) and the TSHR...
  30. Thoonen R, Ernande L, Cheng J, Nagasaka Y, Yao V, Miranda Bezerra A, et al. Functional brown adipose tissue limits cardiomyocyte injury and adverse remodeling in catecholamine-induced cardiomyopathy. J Mol Cell Cardiol. 2015;84:202-11 pubmed publisher
    Brown adipose tissue (BAT) has well recognized thermogenic properties mediated by uncoupling protein 1 (UCP1); more recently, BAT has been demonstrated to modulate cardiovascular risk factors...
  31. Shabalina I, Vrbacký M, Pecinová A, Kalinovich A, Drahota Z, Houštěk J, et al. ROS production in brown adipose tissue mitochondria: the question of UCP1-dependence. Biochim Biophys Acta. 2014;1837:2017-2030 pubmed publisher
    Whether active UCP1 can reduce ROS production in brown-fat mitochondria is presently not settled...
  32. Wang C, Wei D, Guan M, Xue Y. Triiodothyronine regulates distribution of thyroid hormone receptors by activating AMP-activated protein kinase in 3T3-L1 adipocytes and induces uncoupling protein-1 expression. Mol Cell Biochem. 2014;393:247-54 pubmed publisher
    ..and TR? mRNA levels in the cells, as well as marker genes for brown adipose tissue including uncoupling protein (UCP)-1 and Cidea...
  33. Nøhr M, Bobba N, Richelsen B, Lund S, Pedersen S. Inflammation Downregulates UCP1 Expression in Brown Adipocytes Potentially via SIRT1 and DBC1 Interaction. Int J Mol Sci. 2017;18: pubmed publisher
    ..Uncoupling protein 1 (UCP1) expression has been reported to be under control of the intracellular deacetylase SIRT1...
  34. Newton G, Weremowicz S, Morton C, Copeland N, Gilbert D, Jenkins N, et al. Characterization of human and mouse cartilage oligomeric matrix protein. Genomics. 1994;24:435-9 pubmed
    ..1. These data confirm and extend the known regions of homology between human and mouse chromosomes and establish that COMP, like thrombospondin-1, -2, -3, and -4, is present in the human and mouse genomes. ..
  35. Liu X, Rossmeisl M, McClaine J, Riachi M, Harper M, Kozak L. Paradoxical resistance to diet-induced obesity in UCP1-deficient mice. J Clin Invest. 2003;111:399-407 pubmed
    The availability of mice lacking the mitochondrial uncoupling protein UCP1, has provided an opportunity to analyze the relationship between the capacity for energy expenditure and the development of obesity in response to a high-fat, high-..
  36. Lute B, Jou W, Lateef D, Goldgof M, Xiao C, Piñol R, et al. Biphasic effect of melanocortin agonists on metabolic rate and body temperature. Cell Metab. 2014;20:333-45 pubmed publisher
    ..We propose that the hypometabolism/hypothermia is a regulated response, potentially beneficial during extreme physiologic stress. ..
  37. Shinoda K, Ohyama K, Hasegawa Y, Chang H, Ogura M, Sato A, et al. Phosphoproteomics Identifies CK2 as a Negative Regulator of Beige Adipocyte Thermogenesis and Energy Expenditure. Cell Metab. 2015;22:997-1008 pubmed publisher
    ..These results indicate that CK2 is a plausible target to rewire the β3-adrenenoceptor signaling cascade that promotes thermogenesis in adipocytes. ..
  38. Ohno H, Shinoda K, Ohyama K, Sharp L, Kajimura S. EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex. Nature. 2013;504:163-7 pubmed publisher
    ..These data indicate that EHMT1 is an essential enzymatic switch that controls brown adipose cell fate and energy homeostasis. ..
  39. Ikeda K, Kang Q, Yoneshiro T, Camporez J, Maki H, Homma M, et al. UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis. Nat Med. 2017;23:1454-1465 pubmed publisher
    Uncoupling protein 1 (UCP1) plays a central role in nonshivering thermogenesis in brown fat; however, its role in beige fat remains unclear...
  40. Parker N, Crichton P, Vidal Puig A, Brand M. Uncoupling protein-1 (UCP1) contributes to the basal proton conductance of brown adipose tissue mitochondria. J Bioenerg Biomembr. 2009;41:335-42 pubmed publisher
    ..BAT can express another mitochondrial anion carrier, UCP1, at concentrations similar to ANT...
  41. Suto J, Sekikawa K. Quantitative trait locus analysis of plasma cholesterol and triglyceride levels in KK x RR F2 mice. Biochem Genet. 2003;41:325-41 pubmed
    ..Identification of distinct, but related traits in an identical chromosomal region will facilitate revealing the responsible gene. ..
  42. Mills K, Mathews K, Scherpbier Heddema T, Schelper R, Schmalzel R, Bailey H, et al. Genetic mapping near the myd locus on mouse chromosome 8. Mamm Genome. 1995;6:278-80 pubmed
    ..J. Hered 67, 135, 1976). This portion of Chr 8 contains the genes for a mitochondrial uncoupling protein (Ucp) and kallikrein (Kal3), which map to distal 4q in the human, providing evidence for a segment of homology...
  43. Chen W, Yang Q, Roeder R. Dynamic interactions and cooperative functions of PGC-1alpha and MED1 in TRalpha-mediated activation of the brown-fat-specific UCP-1 gene. Mol Cell. 2009;35:755-68 pubmed publisher
    ..Here, we have employed the PPARgamma- and TRalpha-activated brown adipose tissue-specific UCP-1 enhancer to investigate mechanistic aspects of PGC-1alpha function...
  44. Li F, Wu R, Cui X, Zha L, Yu L, Shi H, et al. Histone Deacetylase 1 (HDAC1) Negatively Regulates Thermogenic Program in Brown Adipocytes via Coordinated Regulation of Histone H3 Lysine 27 (H3K27) Deacetylation and Methylation. J Biol Chem. 2016;291:4523-36 pubmed publisher
    ..adipocytes results in a dissociation of HDAC1 from promoters of BAT-specific genes, including uncoupling protein 1 (Ucp1) and peroxisome proliferator-activated receptor γ co-activator 1α (Pgc1α), leading to increased ..
  45. Tsukita S, Yamada T, Uno K, Takahashi K, Kaneko K, Ishigaki Y, et al. Hepatic glucokinase modulates obesity predisposition by regulating BAT thermogenesis via neural signals. Cell Metab. 2012;16:825-32 pubmed publisher
    ..Thus, this intertissue energy-saving system may contribute to determining obesity predisposition. ..
  46. Chen S, Chen J, Johnson P, Muppala V, Lee Y. C/EBPbeta, when expressed from the C/ebpalpha gene locus, can functionally replace C/EBPalpha in liver but not in adipose tissue. Mol Cell Biol. 2000;20:7292-9 pubmed
    ..Moreover, our studies with the C/ebpalpha(beta/beta) mice provide new insights into the nonredundant functions of C/EBPalpha and C/EBPbeta on gene regulation in WAT. ..
  47. Xue B, Coulter A, Rim J, Koza R, Kozak L. Transcriptional synergy and the regulation of Ucp1 during brown adipocyte induction in white fat depots. Mol Cell Biol. 2005;25:8311-22 pubmed
    ..An 80-fold difference in expression of the mitochondrial uncoupling gene (Ucp1) at the mRNA and protein levels between A/J and C57BL/6J (B6) mice is controlled by allelic interactions among nine ..
  48. Ost M, Keipert S, Klaus S. Targeted mitochondrial uncoupling beyond UCP1 - The fine line between death and metabolic health. Biochimie. 2017;134:77-85 pubmed publisher
    ..the molecular and metabolic consequences of targeted uncoupling, expressing functional uncoupling protein 1 (UCP1) ectopically in white adipose tissue or skeletal muscle...
  49. Sun C, Berry W, Olson L. PDGFR? controls the balance of stromal and adipogenic cells during adipose tissue organogenesis. Development. 2017;144:83-94 pubmed publisher
    ..Our data highlight the importance of balancing stromal versus adipogenic cell expansion during white adipose tissue development, with PDGFR? activity coordinating this crucial process in the embryo. ..
  50. Lehr L, Canola K, Asensio C, Jimenez M, Kuehne F, Giacobino J, et al. The control of UCP1 is dissociated from that of PGC-1alpha or of mitochondriogenesis as revealed by a study using beta-less mouse brown adipocytes in culture. FEBS Lett. 2006;580:4661-6 pubmed
    In rodent brown adipose tissue, the beta-adrenergic signaling is believed, by an action on PGC-1alpha, to control UCP1 expression and mitochondriogenesis...
  51. Wang Y, Kimura K, Inokuma K, Saito M, Kontani Y, Kobayashi Y, et al. Potential contribution of vasoconstriction to suppression of heat loss and homeothermic regulation in UCP1-deficient mice. Pflugers Arch. 2006;452:363-9 pubmed
    To investigate the thermoregulatory mechanism in mice lacking uncoupling protein 1 (UCP1) from the viewpoint of heat loss, we measured oxygen consumptions (VO2), skin-surface temperatures (Tskin, an index of heat release), blood flows in ..
  52. Maurer S, Fromme T, Grossman L, Hüttemann M, Klingenspor M. The brown and brite adipocyte marker Cox7a1 is not required for non-shivering thermogenesis in mice. Sci Rep. 2015;5:17704 pubmed publisher
    ..Body mass gain and glucose tolerance did not differ between wildtype and Cox7a1 knockout mice fed with high fat or control diet. We conclude that brown adipose tissue function in mice does not require the presence of Cox7a1. ..
  53. Lee K, Villena J, Moon Y, Kim K, Lee S, Kang C, et al. Inhibition of adipogenesis and development of glucose intolerance by soluble preadipocyte factor-1 (Pref-1). J Clin Invest. 2003;111:453-61 pubmed
    ..These findings demonstrate the inhibition of adipogenesis by Pref-1 in vivo and the resulting impairment of adipocyte function that leads to the development of metabolic abnormalities. ..
  54. Blanco G, Pritchard C, Underhill P, Breeds S, Townsend K, Greenfield A, et al. Molecular phenotyping of the mouse ky mutant reveals UCP1 upregulation at the neuromuscular junctions of dystrophic soleus muscle. Neuromuscul Disord. 2004;14:217-28 pubmed
    ..Altogether, the data presented suggest that the ky muscular dystrophy develops by a distinctive pathogenic mechanism. ..
  55. Kozak L, Britton J, Kozak U, Wells J. The mitochondrial uncoupling protein gene. Correlation of exon structure to transmembrane domains. J Biol Chem. 1988;263:12274-7 pubmed
    ..The 5'-untranslated region of the mRNA is composed of 231 nucleotides, and the 3'-untranslated region contains 81 nucleotides prior to addition of the poly(A) tail. ..
  56. Nadeau J, Birkenmeier C, Chowdhury K, Crosby J, Lalley P. Zinc finger protein gene complexes on mouse chromosomes 8 and 11. Genomics. 1990;8:469-76 pubmed
    ..Surprisingly, both genes were closely linked to two previously mapped, Krüppel-related zinc finger protein genes, suggesting that they are part of gene complexes. ..
  57. Dalmas E, Lehmann F, Dror E, Wueest S, Thienel C, Borsigova M, et al. Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production. Immunity. 2017;47:928-942.e7 pubmed publisher
    ..Accordingly, IL-33 injections rescued islet function in obese mice. Our findings provide evidence that an immunometabolic crosstalk between islet-derived IL-33, ILC2s, and myeloid cells fosters insulin secretion. ..
  58. Lin J, Martagón A, Cimini S, Gonzalez D, Tinkey D, Biter A, et al. Pharmacological Activation of Thyroid Hormone Receptors Elicits a Functional Conversion of White to Brown Fat. Cell Rep. 2015;13:1528-37 pubmed publisher
    ..These data establish TR agonists as a class of browning agents, implicate the TRs in the browning of WAT, and suggest a profound pharmacological potential of this action. ..
  59. Rodríguez Sánchez L, Rial E. The distinct bioenergetic properties of the human UCP1. Biochimie. 2017;134:51-55 pubmed publisher
    The uncoupling protein UCP1 from brown adipose tissue is a mitochondrial carrier which allows dissipation of metabolic energy as heat...
  60. Long J, Svensson K, Bateman L, Lin H, Kamenecka T, Lokurkar I, et al. The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria. Cell. 2016;166:424-435 pubmed publisher
    Brown and beige adipocytes are specialized cells that express uncoupling protein 1 (UCP1) and dissipate chemical energy as heat. These cells likely possess alternative UCP1-independent thermogenic mechanisms...
  61. Terajima M, Matsui Y, Copeland N, Gilbert D, Jenkins N, Obinata M. Structural organization of the mouse glycophorin A gene. J Biochem. 1994;116:1105-10 pubmed
    ..The upstream regulatory region of the mouse gene consists of multiple motifs for DNA binding factors that may be required for its erythroid-specific expression. ..
  62. Ishizeki K, Takahashi N, Nawa T. Phenotypic characteristics of adipocytes generated from Meckel's chondrocytes in response to chick serum in vitro. Cell Tissue Res. 2002;309:251-60 pubmed
    ..staining of adipocytes with stage-specific antibodies revealed the presence of immunoreactive uncoupling protein (UCP-1) and peroxisome proliferator-activated receptor (PPARgamma) in immature adipocytes, and leptin and glucose ..
  63. Matthias A, Jacobsson A, Cannon B, Nedergaard J. The bioenergetics of brown fat mitochondria from UCP1-ablated mice. Ucp1 is not involved in fatty acid-induced de-energization ("uncoupling"). J Biol Chem. 1999;274:28150-60 pubmed
    The bioenergetics of brown fat mitochondria isolated from UCP1-ablated mice were investigated...
  64. Clarke K, ADAMS A, Manzke L, Pearson T, Borchers C, Porter R. A role for ubiquitinylation and the cytosolic proteasome in turnover of mitochondrial uncoupling protein 1 (UCP1). Biochim Biophys Acta. 2012;1817:1759-67 pubmed publisher
    In this study we show that mitochondrial uncoupling protein 1 (UCP1) in brown adipose tissue (BAT) and thymus mitochondria can be ubiquitinylated and degraded by the cytosolic proteasome...
  65. Bertholet A, Kazak L, Chouchani E, Bogaczyńska M, Paranjpe I, Wainwright G, et al. Mitochondrial Patch Clamp of Beige Adipocytes Reveals UCP1-Positive and UCP1-Negative Cells Both Exhibiting Futile Creatine Cycling. Cell Metab. 2017;25:811-822.e4 pubmed publisher
    ..Similar to brown fat, beige adipocytes are assumed to express mitochondrial uncoupling protein 1 (UCP1) and are thermogenic due to the UCP1-mediated H+ leak across the inner mitochondrial membrane...
  66. Oelkrug R, Kutschke M, Meyer C, Heldmaier G, Jastroch M. Uncoupling protein 1 decreases superoxide production in brown adipose tissue mitochondria. J Biol Chem. 2010;285:21961-8 pubmed publisher
    In thermogenic brown adipose tissue, uncoupling protein 1 (UCP1) catalyzes the dissipation of mitochondrial proton motive force as heat...
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