Ucn

Summary

Gene Symbol: Ucn
Description: urocortin
Alias: Mpv17, Ucn1, urocortin
Species: mouse
Products:     Ucn

Top Publications

  1. Kim Y, Park M, Uhm D, Chung S. Modulation of T-type Ca2+ channels by corticotropin-releasing factor through protein kinase C pathway in MN9D dopaminergic cells. Biochem Biophys Res Commun. 2007;358:796-801 pubmed
    ..The application of CRF-related peptide, urocortin 1, reversibly inhibited T-type Ca(2+) currents, which was a major Ca(2+) channel in the cells...
  2. Vetter D, Li C, Zhao L, Contarino A, Liberman M, Smith G, et al. Urocortin-deficient mice show hearing impairment and increased anxiety-like behavior. Nat Genet. 2002;31:363-9 pubmed
    b>Urocortin is a member of the corticotropin-releasing hormone peptide family and is found in many discrete brain regions...
  3. Giardino W, Pastor R, Anacker A, Spangler E, Cote D, Li J, et al. Dissection of corticotropin-releasing factor system involvement in locomotor sensitivity to methamphetamine. Genes Brain Behav. 2011;10:78-89 pubmed publisher
    ..mice, each deficient for a single component of the CRF system: CRF-R1, CRF-R2, CRF, or the CRF-related peptide Urocortin 1 (Ucn1)...
  4. Fekete E, Zhao Y, Szucs A, Sabino V, Cottone P, Rivier J, et al. Systemic urocortin 2, but not urocortin 1 or stressin 1-A, suppresses feeding via CRF2 receptors without malaise and stress. Br J Pharmacol. 2011;164:1959-75 pubmed publisher
    Infusion of corticotropin-releasing factor (CRF)/urocortin (Ucn) family peptides suppresses feeding in mice. We examined whether rats show peripheral CRF/Ucn-induced anorexia and determined its behavioural and pharmacological bases...
  5. Xu L, Scheenen W, Leshan R, Patterson C, Elias C, Bouwhuis S, et al. Leptin signaling modulates the activity of urocortin 1 neurons in the mouse nonpreganglionic Edinger-Westphal nucleus. Endocrinology. 2011;152:979-88 pubmed publisher
    ..This nucleus hosts the majority of urocortin 1 (Ucn1) neurons in the rodent brain, and because Ucn1 is a potent satiety hormone and electrical lesioning of ..
  6. Neufeld Cohen A, Tsoory M, Evans A, Getselter D, Gil S, Lowry C, et al. A triple urocortin knockout mouse model reveals an essential role for urocortins in stress recovery. Proc Natl Acad Sci U S A. 2010;107:19020-5 pubmed publisher
    ..The urocortin neuropeptides are members of the corticotropin-releasing factor family and are associated with the central ..
  7. Cservenka A, Spangler E, Cote D, Ryabinin A. Postnatal developmental profile of urocortin 1 and cocaine- and amphetamine-regulated transcript in the perioculomotor region of C57BL/6J mice. Brain Res. 2010;1319:33-43 pubmed publisher
    b>Urocortin 1 (Ucn 1) is an endogenous corticotropin releasing factor (CRF)-related peptide...
  8. Pastor R, McKinnon C, Scibelli A, Burkhart Kasch S, Reed C, Ryabinin A, et al. Corticotropin-releasing factor-1 receptor involvement in behavioral neuroadaptation to ethanol: a urocortin1-independent mechanism. Proc Natl Acad Sci U S A. 2008;105:9070-5 pubmed publisher
    ..Because CRF1 receptors are also activated by urocortin-1 (Ucn1), we tested Ucn1 knockout mice for EtOH sensitization and found normal sensitization in this genotype...
  9. Choi J, Pham T, Jang Y, Bui B, Lee B, Joo K, et al. Corticotropin-releasing factor (CRF) and urocortin promote the survival of cultured cerebellar GABAergic neurons through the type 1 CRF receptor. J Korean Med Sci. 2006;21:518-26 pubmed
    ..investigated the trophic role for CRF family of peptides by culturing cerebellar neurons in the presence of CRF, urocortin or urocortin II...

More Information

Publications32

  1. Tao J, Lin M, Sha J, Tan G, Soong T, Li S. Separate locations of urocortin and its receptors in mouse testis: function in male reproduction and the relevant mechanisms. Cell Physiol Biochem. 2007;19:303-12 pubmed
    b>Urocortin (UCN), a newly identified corticotrophin-releasing-factor (CRF) related peptide, has been demonstrated to play important roles in female reproductive system...
  2. Giardino W, Cocking D, Kaur S, Cunningham C, Ryabinin A. Urocortin-1 within the centrally-projecting Edinger-Westphal nucleus is critical for ethanol preference. PLoS ONE. 2011;6:e26997 pubmed publisher
    ..involvement of neurons of the centrally projecting Edinger-Westphal nucleus (EWcp) containing the neuropeptide Urocortin-1 (Ucn1) in excessive ethanol (EtOH) intake and EtOH sensitivity...
  3. Fabre V, Massart R, Rachalski A, Jennings K, Brass A, Sharp T, et al. Differential gene expression in mutant mice overexpressing or deficient in the serotonin transporter: a focus on urocortin 1. Eur Neuropsychopharmacol. 2011;21:33-44 pubmed publisher
    ..Among genes with altered expression, the gene encoding the neuropeptide urocortin 1 was down-regulated in 5-HTT KO and up-regulated in 5-HTT TG mice...
  4. Purser M, Dalvi P, Wang Z, Belsham D. The cytokine ciliary neurotrophic factor (CNTF) activates hypothalamic urocortin-expressing neurons both in vitro and in vivo. PLoS ONE. 2013;8:e61616 pubmed publisher
    ..line that endogenously expresses the CNTF receptor to examine the direct effects of CNTF on mRNA levels of urocortin-1, urocortin-2, agouti-related peptide, brain-derived neurotrophic factor, and neurotensin...
  5. Derks N, Roubos E, Kozicz T. Presence of estrogen receptor beta in urocortin 1-neurons in the mouse non-preganglionic Edinger-Westphal nucleus. Gen Comp Endocrinol. 2007;153:228-34 pubmed
    Adaptation to stress involves the activity of the hypothalamic-pituitary-adrenal (HPA-) axis. Urocortin 1 (Ucn1) coordinates responses to stressors...
  6. Buckinx R, Bagyánszki M, Avula L, Adriaensen D, Van Nassauw L, Timmermans J. Expression of corticotropin-releasing factor and urocortins in the normal and Schistosoma mansoni-infected mouse ileum. Cell Tissue Res. 2015;359:453-463 pubmed publisher
    ..Furthermore, UCN2 and UCN3 were found in the musculature. During acute schistosomiasis, UCN1 showed an increased immunoreactivity in blood vessels and UCN3 was de novo expressed mainly in submucous neurons...
  7. Zalutskaya A, Arai M, Bounoutas G, Abou Samra A. Impaired adaptation to repeated restraint and decreased response to cold in urocortin 1 knockout mice. Am J Physiol Endocrinol Metab. 2007;293:E259-63 pubmed
    b>Urocortin 1 (UCN1) is a corticotropin-releasing factor (CRF)-like peptide whose role in stress is not well characterized...
  8. Tsatsanis C, Androulidaki A, Alissafi T, Charalampopoulos I, Dermitzaki E, Roger T, et al. Corticotropin-releasing factor and the urocortins induce the expression of TLR4 in macrophages via activation of the transcription factors PU.1 and AP-1. J Immunol. 2006;176:1869-77 pubmed
    ..Exposure of peritoneal macrophages and RAW 264.7 cells to CRF, UCN1, or UCN2 up-regulated TLR4 mRNA and protein levels...
  9. Weitemier A, Ryabinin A. Urocortin 1 in the dorsal raphe regulates food and fluid consumption, but not ethanol preference in C57BL/6J mice. Neuroscience. 2006;137:1439-45 pubmed
    The midbrain-localized Edinger-Westphal nucleus is a major site of production of urocortin 1...
  10. Tsatsanis C, Androulidaki A, Dermitzaki E, Charalampopoulos I, Spiess J, Gravanis A, et al. Urocortin 1 and Urocortin 2 induce macrophage apoptosis via CRFR2. FEBS Lett. 2005;579:4259-64 pubmed
    ..In conclusion, our data suggest that endogenous CRFR2 ligands exert an anti-inflammatory effect via induction of macrophage apoptosis. ..
  11. Kozicz T, Korosi A, Korsman C, Tilburg Ouwens D, Groenink L, Veening J, et al. Urocortin expression in the Edinger-Westphal nucleus is down-regulated in transgenic mice over-expressing neuronal corticotropin-releasing factor. Neuroscience. 2004;123:589-94 pubmed
    ..b>Urocortin (Ucn), a recently discovered member of the CRF peptide family may play a role in the pathophysiology of stress-..
  12. Asakawa A, Inui A, Ueno N, Makino S, Fujino M, Kasuga M. Urocortin reduces food intake and gastric emptying in lean and ob/ob obese mice. Gastroenterology. 1999;116:1287-92 pubmed
    ..This study was designed to investigate whether intraperitoneally injected urocortin reduces gastric emptying, feeding, and body weight in lean and ob/ob obese mice...
  13. Giardino W, Rodriguez E, Smith M, Ford M, Galili D, Mitchell S, et al. Control of chronic excessive alcohol drinking by genetic manipulation of the Edinger-Westphal nucleus urocortin-1 neuropeptide system. Transl Psychiatry. 2017;7:e1021 pubmed publisher
    ..with stress-responsive neuropeptide modulators (including the paralog of corticotropin-releasing factor, urocortin-1)...
  14. Vergetaki A, Jeschke U, Vrekoussis T, Taliouri E, Sabatini L, Papakonstanti E, et al. Galectin-1 overexpression in endometriosis and its regulation by neuropeptides (CRH, UCN) indicating its important role in reproduction and inflammation. PLoS ONE. 2014;9:e114229 pubmed publisher
    ..Also, the neuropeptides, corticotropin releasing hormone (CRH) and urocortin (UCN) and their receptors are expressed in eutopic and ectopic endometrium showing a differential expression ..
  15. Derks N, Pinter O, Zuure W, Ledent C, Watanabe M, Molnar C, et al. Cannabinoid modulation of midbrain urocortin 1 neurones during acute and chronic stress. J Neuroendocrinol. 2012;24:1447-61 pubmed publisher
    Neurones in the centrally projecting Edinger-Westphal nucleus (EWcp) are the main site of urocortin 1 (Ucn1) synthesis in the mammalian brain, and are assumed to play a role in the stress response of the animal...
  16. Hasdemir B, Mhaske P, Paruthiyil S, Garnett E, Heyman M, Matloubian M, et al. Sex- and corticotropin-releasing factor receptor 2- dependent actions of urocortin 1 during inflammation. Am J Physiol Regul Integr Comp Physiol. 2016;310:R1244-57 pubmed publisher
    We investigated whether corticotropin-releasing factor receptor 2 (CRF2) and its high-affinity agonist urocortin 1 (Ucn1) mediate sex-specific signaling and immune responses...
  17. Zhao L, Donaldson C, Smith G, Vale W. The structures of the mouse and human urocortin genes (Ucn and UCN). Genomics. 1998;50:23-33 pubmed
    The mouse and human urocortin genes (Ucn and UCN, respectively) have been isolated, characterized, and found to have very similar structures...
  18. Combs C, Fuller K, Kumar H, Albert A, Pirianov G, McCormick J, et al. Urocortin is a novel regulator of osteoclast differentiation and function through inhibition of a canonical transient receptor potential 1-like cation channel. J Endocrinol. 2012;212:187-97 pubmed publisher
    This study investigated the role of urocortin (UCN), a member of the corticotrophin-releasing factor (CRF) family of peptides, in osteoclast maturation and function. We found that 10(-7)?M UCN significantly (P<0...
  19. Okere B, Xu L, Roubos E, Sonetti D, Kozicz T. Restraint stress alters the secretory activity of neurons co-expressing urocortin-1, cocaine- and amphetamine-regulated transcript peptide and nesfatin-1 in the mouse Edinger-Westphal nucleus. Brain Res. 2010;1317:92-9 pubmed publisher
    Central stress regulatory pathways utilize various neuropeptides, such as urocortin-1 (Ucn1) and cocaine- and amphetamine-regulated transcript peptide (CART)...
  20. Ikeda K, Tojo K, Inada Y, Takada Y, Sakamoto M, Lam M, et al. Regulation of urocortin I and its related peptide urocortin II by inflammatory and oxidative stresses in HL-1 cardiomyocytes. J Mol Endocrinol. 2009;42:479-89 pubmed publisher
    Despite our knowledge on the regulation of urocortin (Ucn) I and its related peptides in the heart, the possible involvement of cardiovascular stress substances, such as cytokines or angiotensin II (Ang II), on this regulation remains to ..
  21. Gonzalez Rey E, Chorny A, Varela N, Robledo G, Delgado M. Urocortin and adrenomedullin prevent lethal endotoxemia by down-regulating the inflammatory response. Am J Pathol. 2006;168:1921-30 pubmed
    b>Urocortin 1 (UCN) and adrenomedullin (AM) are two neuropeptides that have emerged as potential endogenous anti-inflammatory factors based on their production by and binding to immune cells...
  22. Wang X, Su H, Copenhagen L, Vaishnav S, Pieri F, Shope C, et al. Urocortin-deficient mice display normal stress-induced anxiety behavior and autonomic control but an impaired acoustic startle response. Mol Cell Biol. 2002;22:6605-10 pubmed
    ..Its actions are mediated through two receptors, Crhr1 and Crhr2. Urocortin (Ucn), a Crh-related neuropeptide and the postulated endogenous ligand for Crhr2, is a potential mediator of ..
  23. Weninger S, Peters L, Majzoub J. Urocortin expression in the Edinger-Westphal nucleus is up-regulated by stress and corticotropin-releasing hormone deficiency. Endocrinology. 2000;141:256-63 pubmed
    b>Urocortin is a 40-amino acid mammalian peptide related to CRH and urotensin. The physiological role of urocortin is unknown, but it has been postulated to serve some of the functions previously attributed to CRH...