Uchl1

Summary

Gene Symbol: Uchl1
Description: ubiquitin carboxy-terminal hydrolase L1
Alias: AW822034, C88048, PGP9.5, R75593, gad, PGP 9.5, UCH-L1, gracile axonal dystrophy, neuron cytoplasmic protein 9.5, protein gene product 9.5, ubiquitin carboxyl-terminal hydrolase isozyme L1, ubiquitin thioesterase L1
Species: mouse

Publications

  1. Role of the homeodomain transcription factor Bapx1 in mouse distal stomach development
    Michael P Verzi
    Department of Medical Oncology, Dana Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    Gastroenterology 136:1701-10
  2. COUP-TFII is essential for radial and anteroposterior patterning of the stomach
    Norio Takamoto
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Development 132:2179-89
  3. Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart
    Volker Haufe
    Friedrich Schiller University, Institute of Physiology II, Teichgraben 8, 07740 Jena, Germany
    J Physiol 564:683-96
  4. Identification of Sox8 as a modifier gene in a mouse model of Hirschsprung disease reveals underlying molecular defect
    Marzena Maka
    Institut für Biochemie, Universität Erlangen Nürnberg, D 91054 Erlangen, Germany
    Dev Biol 277:155-69
  5. Cranial sensory neuron development in the absence of brain-derived neurotrophic factor in BDNF/Bax double null mice
    David Hellard
    Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Dev Biol 275:34-43
  6. Microarray expression analysis of gad mice implicates involvement of Parkinson's disease associated UCH-L1 in multiple metabolic pathways
    M Bonin
    Department of Medical Genetics, University of Tübingen, Calwerstrasse 7, 72076 Tübingen, Germany
    Brain Res Mol Brain Res 126:88-97
  7. The role of Hoxa3 gene in parathyroid gland organogenesis of the mouse
    Yoko Kameda
    Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    J Histochem Cytochem 52:641-51
  8. Developmental regulation of ubiquitin C-terminal hydrolase isozyme expression during spermatogenesis in mice
    Jungkee Kwon
    Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Biol Reprod 71:515-21
  9. Endothelin-1 regulates cardiac sympathetic innervation in the rodent heart by controlling nerve growth factor expression
    Masaki Ieda
    Cardiopulmonary Division, Department of Internal Medicine, Keio University School of Medicine, Tookyo, Japan
    J Clin Invest 113:876-84
  10. Sema3A regulates the timing of target contact by cranial sensory axons
    Thomas E Dillon
    Department of Biology, Loyola University Chicago, Chicago, Illinois 60626, USA
    J Comp Neurol 470:13-24

Scientific Experts

  • Yoko Kameda
  • Y Suzuki
  • Michael D Bates
  • J Li
  • Gorji Marzban
  • Jenny Tollet
  • Anthony J Lombardino
  • Tadashi Okubo
  • Shigeyoshi Aoi
  • H M Young
  • Xiuqian Mu
  • J Aruga
  • J M Hall
  • S G Gong
  • T Ito
  • S Wakisaka
  • Carlo Zancanaro
  • Yasuhiro Kon
  • L Guembe
  • J O Hiltunen
  • Jungkee Kwon
  • Keiji Wada
  • Yasuhiro Yoshikawa
  • Satoshi Sekiguchi
  • Mikako Sakurai
  • Shigeru Kyuwa
  • Yoshiyuki Ishii
  • Rieko Setsuie
  • Michael P Verzi
  • Adel Maklad
  • Sehwan Shim
  • Yu Ichiro Koma
  • Warren E Zimmer
  • Brianna Flynn
  • Robert J Schwartz
  • Elyanne M Ratcliffe
  • Norio Takamoto
  • Marzena Maka
  • Volker Haufe
  • Michael D Gershon
  • K Wada
  • Thomas E Dillon
  • M Bonin
  • Masaki Ieda
  • David Hellard
  • Yu Lai Wang
  • Yae Sato
  • Mami Noda
  • Yu-Lai Wang
  • Fumiko Harada
  • Hitoshi Osaka
  • T Kikuchi
  • Yan Jiang
  • Frank L Rice
  • Joy M Greer
  • C Le Moine
  • Katharine M Cronk
  • Eva M J Peters
  • Suwanna Jitpukdeebodintra
  • M Vlaskovska
  • H C Chou
  • L J Kurihara
  • D Wolpowitz
  • F A White
  • Ramesh A Shivdasani
  • Yan Zhang
  • Byeong Moo Kim
  • Monique N Stanfel
  • Kyle J Bichsel
  • Kelvin A Moses
  • Jodi R Nicolai
  • Laura A Hansen
  • David W Threadgill
  • Tang Cheng Lee
  • Jackie E Evenson
  • Satoshi Nagamine
  • Masayuki Sekiguchi
  • Mari Masuda
  • Young-Bae Kwon
  • Man Hagiyama
  • Mamoru Nakanishi
  • Akihiko Ito
  • Kazuyuki Yamada
  • Kazuyuki Hamaguchi
  • Tomohiro Kabuta
  • Young Bae Kwon
  • Yu-ichiro Koma
  • Ko Zushida
  • Seiichi Hirota
  • Hiroshi Yokozaki

Detail Information

Publications62

  1. Role of the homeodomain transcription factor Bapx1 in mouse distal stomach development
    Michael P Verzi
    Department of Medical Oncology, Dana Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    Gastroenterology 136:1701-10
    ....
  2. COUP-TFII is essential for radial and anteroposterior patterning of the stomach
    Norio Takamoto
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Development 132:2179-89
    ..Our results are consistent with a functional link between hedgehog proteins and COUP-TFII, factors that are vital for epithelial-mesenchymal interactions...
  3. Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart
    Volker Haufe
    Friedrich Schiller University, Institute of Physiology II, Teichgraben 8, 07740 Jena, Germany
    J Physiol 564:683-96
    ..Our data suggest that neuronal and skeletal muscle Na(+) channels contribute to the action potential of cardiomyocytes in the adult mammalian heart...
  4. Identification of Sox8 as a modifier gene in a mouse model of Hirschsprung disease reveals underlying molecular defect
    Marzena Maka
    Institut für Biochemie, Universität Erlangen Nürnberg, D 91054 Erlangen, Germany
    Dev Biol 277:155-69
    ..Our study suggests that Sox8 and Sox10 are jointly required for the maintenance of these vagal neural crest stem cells...
  5. Cranial sensory neuron development in the absence of brain-derived neurotrophic factor in BDNF/Bax double null mice
    David Hellard
    Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Dev Biol 275:34-43
    ....
  6. Microarray expression analysis of gad mice implicates involvement of Parkinson's disease associated UCH-L1 in multiple metabolic pathways
    M Bonin
    Department of Medical Genetics, University of Tübingen, Calwerstrasse 7, 72076 Tübingen, Germany
    Brain Res Mol Brain Res 126:88-97
    ..Here, we investigated the gene expression pattern of the brain of 3-month-old Uch-l1-deficient gracile axonal dystrophy (gad) mice by microarray analysis. A total of 146 genes were differentially regulated by at least a 1...
  7. The role of Hoxa3 gene in parathyroid gland organogenesis of the mouse
    Yoko Kameda
    Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    J Histochem Cytochem 52:641-51
    ..These results indicate that lack of the Hoxa3 gene affects the intrinsic ability of the third pharyngeal pouch to form the parathyroid rudiment and has no detectable effect on the migration of neural crest cells...
  8. Developmental regulation of ubiquitin C-terminal hydrolase isozyme expression during spermatogenesis in mice
    Jungkee Kwon
    Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Biol Reprod 71:515-21
    ..Our previous work demonstrated that UCH-L1-deficient gracile axonal dystrophy (gad) mice exhibit progressively decreasing spermatogonial stem cell proliferation, suggesting that UCH ..
  9. Endothelin-1 regulates cardiac sympathetic innervation in the rodent heart by controlling nerve growth factor expression
    Masaki Ieda
    Cardiopulmonary Division, Department of Internal Medicine, Keio University School of Medicine, Tookyo, Japan
    J Clin Invest 113:876-84
    ..These findings indicate that endothelin-1 regulates NGF expression in cardiomyocytes and plays a critical role in sympathetic innervation of the heart...
  10. Sema3A regulates the timing of target contact by cranial sensory axons
    Thomas E Dillon
    Department of Biology, Loyola University Chicago, Chicago, Illinois 60626, USA
    J Comp Neurol 470:13-24
    ..Contact of the epithelium occurs prematurely in Sema3A-/minus; mice, but not penetration. Taken together, our data imply that Sema3A acts as a short-range repellent that regulates the timing of target contact by trigeminal axons...
  11. Immunohistochemical analysis of protein gene product 9.5, a ubiquitin carboxyl-terminal hydrolase, during placental and embryonic development in the mouse
    Satoshi Sekiguchi
    Department of Veterinary Pathology, Nippon Veterinary and Animal Science University, Kyounan cho, Musashino, Tokyo 180 8602, Japan
    Exp Anim 52:365-9
    ..These findings suggest that the protein may play a significant role in implantation and placental development, and differentiation of embryonic ectoderm...
  12. Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron
    Hitoshi Osaka
    Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, 187 8502, Japan
    Hum Mol Genet 12:1945-58
    ..Mutations in UCH L1 are linked to Parkinson's disease as well as gracile axonal dystrophy (gad) in mice...
  13. The involvement of brain-derived neurotrophic factor (BDNF) in the regeneration of periodontal Ruffini endings following transection of the inferior alveolar nerve
    Fumiko Harada
    Division of Oral Anatomy, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Arch Histol Cytol 66:183-94
    ..These data showing that a reduced expression of BDNF causes delayed regeneration of the periodontal Ruffini endings suggest the involvement of BDNF in the regeneration process of these mechanoreceptors...
  14. Mash1 is required for glomus cell formation in the mouse carotid body
    Yoko Kameda
    Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Kanagawa 228 8555, Japan
    Dev Biol 283:128-39
    ..Many cells immunoreactive for the S-100 protein, a sustentacular cell marker, appear in the mutant carotid body during fetal development. The Mash1 gene is thus required for the genesis of glomus cells but not for sustentacular cells...
  15. Replaceable neurons and neurodegenerative disease share depressed UCHL1 levels
    Anthony J Lombardino
    Laboratory of Animal Behavior, The Rockefeller University, Box 137, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:8036-41
    ..showed a consistent and robust underexpression of the deubiquitination gene ubiquitin carboxyl-terminal hydrolase (UCHL1) that is involved with protein degradation...
  16. Impaired expression of myogenic regulatory molecules in the pelvic floor muscles of murine embryos with anorectal malformations
    Shigeyoshi Aoi
    Division of Surgery, Children s Research Hospital, Kyoto Prefectural University of Medicine, Kyoto 602 0841, Japan
    J Pediatr Surg 40:805-9
    ..These results suggest that myogenic stem cells, available from bone marrow contents, may be used for postnatal muscle regeneration to reinforce the pelvic floor muscle function in children with ARM...
  17. The EGFR is required for proper innervation to the skin
    Adel Maklad
    Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    J Invest Dermatol 129:690-8
    ..These data demonstrate that EGFR is required for proper cutaneous innervation during development and suggest that it limits axonal outgrowth and branching in a DRG-autonomous manner...
  18. Ubiquitin C-terminal hydrolase L1 deficiency decreases bone mineralization
    Sehwan Shim
    Department of Laboratory Animal Medicine, College of Veterinary Medicine, Chonbuk National University, Jeonju, Korea
    J Vet Med Sci 70:649-51
    ..involvement of UCH-L1 in the regulation of bone mineralization, we evaluated the bone mineral density (BMD) rate of gad mice, using the Latheta computed tomography system...
  19. Cell adhesion molecule 1 is a novel pancreatic-islet cell adhesion molecule that mediates nerve-islet cell interactions
    Yu Ichiro Koma
    Division of Pathology, Kobe University Graduate School of Medicine, Kobe, Japan
    Gastroenterology 134:1544-54
    ..The strong correlation between CADM1 expression and hormonally functional phenotypes suggests that CADM1 is involved in hormone secretion from ICTs...
  20. Gene regulation logic in retinal ganglion cell development: Isl1 defines a critical branch distinct from but overlapping with Pou4f2
    Xiuqian Mu
    Department of Biochemistry and Molecular Biology, M D Anderson Cancer Center and Graduate Training Program in Genes and Development, Graduate School of Biomedical Sciences, University of Texas, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 105:6942-7
    ..They also reveal that identical RGC expression patterns are achieved by different combinations of divergent inputs from upstream transcription factors...
  21. Reduction in memory in passive avoidance learning, exploratory behaviour and synaptic plasticity in mice with a spontaneous deletion in the ubiquitin C-terminal hydrolase L1 gene
    Mikako Sakurai
    Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Eur J Neurosci 27:691-701
    ..In the present study, we investigated the role of UCH-L1 in the brain by utilizing gracile axonal dystrophy (gad) mice with a spontaneous deletion in the gene Uch-l1 as a loss-of-function model...
  22. FRS2 alpha 2F/2F mice lack carotid body and exhibit abnormalities of the superior cervical sympathetic ganglion and carotid sinus nerve
    Yoko Kameda
    Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Kanagawa 228 8555, Japan
    Dev Biol 314:236-47
    ..We propose that the sympathetic ganglion provides glomus cell precursors into the third arch artery derivative in the presence of sensory fibers of the glossopharyngeal nerve...
  23. Effect of Gdnf haploinsufficiency on rate of migration and number of enteric neural crest-derived cells
    Brianna Flynn
    Department of Anatomy and Cell Biology, University of Melbourne, Vic, Australia
    Dev Dyn 236:134-41
    ..Gdnf haploinsufficiency did not cause any detectable change in the rate of neuronal differentiation of ENCs...
  24. Localization of ubiquitin C-terminal hydrolase L1 in mouse ova and its function in the plasma membrane to block polyspermy
    Satoshi Sekiguchi
    Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1 1 1 Yayoi, Tokyo 113 8657, Japan
    Am J Pathol 169:1722-9
    ..the functional role of UCH-L1 in mouse eggs, we analyzed the fertilization rate of UCH-L1-deficient ova of gad female mice...
  25. Expression of glial progenitor markers p75NTR and S100 protein in the developing mouse parathyroid gland
    Yoko Kameda
    Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Kanagawa 228 8555, Japan
    Cell Tissue Res 327:15-23
    ..The neural progenitor markers, neurofilament 160 and TuJ1, are also absent from the parathyroid. Taken together, we suggest that Gcm2 supplies only some glial progenitor characteristics to the parathyroid rudiment...
  26. Sox2 is required for development of taste bud sensory cells
    Tadashi Okubo
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genes Dev 20:2654-9
    ....
  27. Netrin/DCC-mediated attraction of vagal sensory axons to the fetal mouse gut
    Elyanne M Ratcliffe
    Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Columbia University, New York, New York 10032, USA
    J Comp Neurol 498:567-80
    ..005); antibodies to DCC again blocked this preferential outgrowth (P < 0.05). These data suggest that netrins, which are expressed in the bowel, attract DCC-expressing vagal sensory axons...
  28. The Hlx homeobox transcription factor is required early in enteric nervous system development
    Michael D Bates
    Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    BMC Dev Biol 6:33
    ..5-16.5. CONCLUSION: The Hlx homeobox transcription factor is required for early aspects of ENS development...
  29. Netrins and DCC in the guidance of migrating neural crest-derived cells in the developing bowel and pancreas
    Yan Jiang
    Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Dev Biol 258:364-84
    ..Netrins also promoted the survival/development of enteric crest-derived cells. The formation of submucosal and pancreatic ganglia thus involves the attraction of DCC-expressing crest-derived cells by netrins...
  30. Characterization of the testis in congenitally ubiquitin carboxy-terminal hydrolase-1 (Uch-L1) defective (gad) mice
    Jungkee Kwon
    Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Exp Anim 52:1-9
    The gracile axonal dystrophy (gad) mice are known to have a deletion within the gene encoding ubiquitin carboxy-terminal hydrolase-1 (Uch-L1) and show hereditary sensory deterioration and motor paresis...
  31. The development and subsequent elimination of aberrant peripheral axon projections in Semaphorin3A null mutant mice
    F A White
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, 06510, USA
    Dev Biol 225:79-86
    ..In conclusion, these findings suggest the existence of correction mechanisms that eliminate most sensory axon pathfinding errors early in development...
  32. Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium
    T Ito
    Department of Pathology, Yokohama City University School of Medicine, Yokohama, Japan
    Development 127:3913-21
    ..Thus, the neuroendocrine differentiation depends on basic helix-loop-helix factors, and Notch/Notch-ligand pathways may be involved in determining the cell differentiation fate in fetal airway epithelium...
  33. Cysteine-rich domain isoforms of the neuregulin-1 gene are required for maintenance of peripheral synapses
    D Wolpowitz
    Columbia University, College of Physicians and Surgeons, Program in Neurobiology and Behavior, New York, New York 10032, USA
    Neuron 25:79-91
    ....
  34. Expression of sonic hedgehog, patched, and Gli1 in developing taste papillae of the mouse
    J M Hall
    Department of Cellular and Structural Biology, University of Colorado Health Sciences Center, Denver 80262, USA
    J Comp Neurol 406:143-55
    ....
  35. Histochemical demonstration of neuronal nitric oxide synthase during development of mouse respiratory tract
    L Guembe
    Department of Cytology and Histology, University of Navarra, Pamplona
    Am J Respir Cell Mol Biol 20:342-51
    ..However, because no perinatal increase in the number or intensity of staining of nNOS-positive nerve structures was seen, no apparent relation between neural NO and vasodilation can be established at birth...
  36. Prenatal differentiation of mouse vomeronasal neurones
    G Tarozzo
    Department of Animal and Human Biology, University of Turin, Italy
    Eur J Neurosci 10:392-6
    ....
  37. GFRalpha1 is an essential receptor component for GDNF in the developing nervous system and kidney
    G Cacalano
    Department of Molecular Biology, Genentech, Incorporated, South San Francisco, California 94080, USA
    Neuron 21:53-62
    ....
  38. Fine structural changes of muscle spindles in the gracile axonal dystrophy mutant mouse
    A Takagi
    Department of Pathology, Hiroshima University School of Medicine, Japan
    Virchows Arch 428:289-96
    Fine structural changes of muscle spindles in the extensor digitorum longus of the gracile axonal dystrophy mutant mouse were studied from 20 to 120 postnatal days...
  39. Progressive degeneration of motor nerve terminals in GAD mutant mouse with hereditary sensory axonopathy
    H Miura
    Division of Degenerative Disease, National Institute of Neuroscience, NCNP, Tokyo, Japan
    Neuropathol Appl Neurobiol 19:41-51
    The evolution of motor nerve degeneration was examined in gracile axonal dystrophy (GAD) mutant mice, which develop initial sensory ataxia and subsequent motor paresis...
  40. Breeding of the gad-mdx mouse: influence of genetically induced denervation on dystrophic muscle fibers
    J G Suh
    Laboratory of Animal Genetics, School of Agriculture, Nagoya University, Japan
    Lab Anim Sci 44:42-6
    A new double mutant mouse strain, gad-mdx, was established...
  41. Developmental changes of nerve growth factor levels in the gracile axonal dystrophy mouse
    K Matsui
    National Institute of Neuroscience, Tokyo, Japan
    Neurosci Lett 177:116-8
    Nerve growth factor (NGF) levels were measured in various tissues of the gracile axonal dystrophy (GAD) mouse...
  42. Stimulus induced repetitive muscle potentials in the gracile axonal dystrophy (GAD) mouse
    A P Chandran
    National Institute of Neuroscience, NCNP, Tokyo, Japan
    Electromyogr Clin Neurophysiol 35:225-30
    b>Gracile axonal dystrophy (GAD) is an inherited neurodegenerative disease in the mouse with progressive sensory ataxia and motor paresis...
  43. GDNF family receptors in the embryonic and postnatal rat heart and reduced cholinergic innervation in mice hearts lacking ret or GFRalpha2
    J O Hiltunen
    Program of Molecular Neurobiology, Institute of Biotechnology, University of Helsinki, Finland
    Dev Dyn 219:28-39
    ..These findings indicate that GFRalpha2/Ret signaling is required for normal cholinergic innervation of heart...
  44. P2X3 knock-out mice reveal a major sensory role for urothelially released ATP
    M Vlaskovska
    Autonomic Neuroscience Institute, Royal Free and University College Medical School, London NW3 2PF, United Kingdom
    J Neurosci 21:5670-7
    ..These data strongly suggest a major sensory role for urothelially released ATP acting via P2X(3) receptors on a subpopulation of pelvic afferent fibers...
  45. Loss of Uch-L1 and Uch-L3 leads to neurodegeneration, posterior paralysis and dysphagia
    L J Kurihara
    Howard Hughes Medical Institute and Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Hum Mol Genet 10:1963-70
    ..For example, gracile axonal dystrophy (gad) mutant mice, which harbor a deletion within the gene encoding ubiquitin C-terminal hydrolase L1 (..
  46. Acquisition of neuronal and glial markers by neural crest-derived cells in the mouse intestine
    Heather M Young
    Department of Anatomy and Cell Biology, University of Melbourne, 3010, Victoria, Australia
    J Comp Neurol 456:1-11
    ..5(+) nor S100b(+). Because some classes of neurons are not present in significant numbers until after birth, the expression of PGP9.5 by developing enteric neurons appeared to precede the expression of neuron type-specific markers...
  47. Developmental patterning of the circumvallate papilla
    Suwanna Jitpukdeebodintra
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles 90033, USA
    Int J Dev Biol 46:755-63
    ....
  48. Diverse dependencies of developing Merkel innervation on the trkA and both full-length and truncated isoforms of trkC
    Katharine M Cronk
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, NY 12208, USA
    Development 129:3739-50
    ..Therefore, truncated trkC plays a more important role in the development of this innervation than kinase forms of trkA or trkC or of NT3, the only known ligand for trkC receptors...
  49. Homeobox gene hoxa3 is essential for the formation of the carotid body in the mouse embryos
    Yoko Kameda
    Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Kanagawa 228 8555, Japan
    Dev Biol 247:197-209
    ..The superior cervical ganglion rather showed hypertrophic features in Hoxa3 homozygous mutants lacking the carotid body...
  50. Opioid receptor gene expression in dopamine transporter knock-out mice in adult and during development
    C Le Moine
    UMR CNRS 5541, Laboratoire d Histologie Embryologie, Université Victor Segalen Bordeaux 2, Bordeaux, France
    Neuroscience 112:131-9
    ....
  51. Developmental timing of hair follicle and dorsal skin innervation in mice
    Eva M J Peters
    Department of Dermatology, University Hospital Eppendorf, University of Hamburg, Hamburg D 20246, Germany
    J Comp Neurol 448:28-52
    ..This sequence of developing innervation consistently correlates with hair follicle development, indicating a close interdependence of neuronal and epithelial morphogenesis...
  52. Hoxb8 is required for normal grooming behavior in mice
    Joy M Greer
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Neuron 33:23-34
    ..The aberrant behavior observed in Hoxb8 mutants is not unlike that of humans suffering from the OC-spectrum disorder, trichotillomania. Interestingly, Hoxb8 is expressed in regions of the CNS known as the "OCD-circuit."..
  53. Characterization of olfactory nerve abnormalities in Twirler mice
    S G Gong
    Department of Orthodontics and Pediatric Dentistry, School of Dentistry, University of Michigan, Ann Arbor 48109 1078, USA
    Differentiation 69:58-65
    ..The defects in the Twirler may prove to be a valuable system to analyze problems in olfactory pathfinding and maturation...
  54. The distribution of PGP9. 5, BDNF and NGF in the vallate papilla of adult and developing mice
    H C Chou
    Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei
    Anat Embryol (Berl) 204:161-9
    ..We also suggest that neurotrophins in the early developing vallate papillae might act as local tropic factors for the embryonic growth of nerve fibers to induce differentiation of the taste buds...
  55. Neuropathology of gracile axonal dystrophy (GAD) mouse. An animal model of central distal axonopathy in primary sensory neurons
    M Mukoyama
    Chubu National Hospital, Aichi, Japan
    Acta Neuropathol 79:294-9
    A new neurological mutant mouse shows a gracile axonal dystrophy (GAD). The degenerative lesion develops by postnatal day 80, first appearing in the most rostral portion of the gracile fascicles...