Gene Symbol: Ubc
Description: ubiquitin C
Alias: 2700054O04Rik, AI194771, Rps27a, TI-225, Uba52, Ubb, polyubiquitin-C, polyubiquitin C
Species: mouse
Products:     Ubc

Top Publications

  1. Doi H, Adachi H, Katsuno M, Minamiyama M, Matsumoto S, Kondo N, et al. p62/SQSTM1 differentially removes the toxic mutant androgen receptor via autophagy and inclusion formation in a spinal and bulbar muscular atrophy mouse model. J Neurosci. 2013;33:7710-27 pubmed publisher
    ..Our results demonstrate that p62 provides two different therapeutic targets in SBMA pathogenesis: (1) autophagy-dependent degradation and (2) benevolent inclusion formation of the mutant AR. ..
  2. McMahon M, Itoh K, Yamamoto M, Hayes J. Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression. J Biol Chem. 2003;278:21592-600 pubmed
    ..These data suggest that Keap1 negatively regulates Nrf2 by both enhancing its rate of proteasomal degradation and altering its subcellular distribution. ..
  3. Massoumi R, Chmielarska K, Hennecke K, Pfeifer A, Fassler R. Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling. Cell. 2006;125:665-77 pubmed
  4. Cheng J, Kang X, Zhang S, Yeh E. SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia. Cell. 2007;131:584-95 pubmed
    ..These results show that SENP1 plays a key role in the regulation of the hypoxic response through regulation of HIF1alpha stability and that SUMOylation can serve as a direct signal for ubiquitin-dependent degradation. ..
  5. Lim S, Chen X, Lim Y, Hanson D, Vo T, Howerton K, et al. Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation. Mol Cell. 2008;29:9-22 pubmed publisher
    ..These studies define a scaffolding role for nuclear FAK in facilitating cell survival through enhanced p53 degradation under conditions of cellular stress. ..
  6. Eide E, Woolf M, Kang H, Woolf P, Hurst W, Camacho F, et al. Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation. Mol Cell Biol. 2005;25:2795-807 pubmed
    ..Cell culture-based biochemical assays combined with measurement of cell-based rhythm complement genetic studies to elucidate basic mechanisms controlling the mammalian clock. ..
  7. Hao R, Nanduri P, Rao Y, Panichelli R, Ito A, Yoshida M, et al. Proteasomes activate aggresome disassembly and clearance by producing unanchored ubiquitin chains. Mol Cell. 2013;51:819-28 pubmed publisher
    ..Thus, unanchored ubiquitin chains are key signaling molecules that connect and coordinate the proteasome and autophagy to eliminate toxic protein aggregates. ..
  8. Boutet S, Disatnik M, Chan L, Iori K, Rando T. Regulation of Pax3 by proteasomal degradation of monoubiquitinated protein in skeletal muscle progenitors. Cell. 2007;130:349-62 pubmed
    ..These results reveal an important mechanism of Pax3 regulation in muscle progenitors and an unrecognized role of protein monoubiquitination in mediating proteasomal degradation. ..
  9. Zhang J, Stirling B, Temmerman S, Ma C, Fuss I, Derry J, et al. Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice. J Clin Invest. 2006;116:3042-9 pubmed
    ..These results suggest that CYLD limits inflammation and tumorigenesis by regulating ubiquitination in vivo. ..

More Information


  1. Shembade N, Harhaj N, Liebl D, Harhaj E. Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling. EMBO J. 2007;26:3910-22 pubmed
    ..Thus, TAX1BP1 is pivotal for the termination of NF-kappaB and JNK signaling by functioning as an essential regulator of A20. ..
  2. Lu Y, Adegoke O, Nepveu A, Nakayama K, Bedard N, Cheng D, et al. USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1. Mol Cell Biol. 2009;29:547-58 pubmed publisher
  3. Tokunaga F, Sakata S, Saeki Y, Satomi Y, Kirisako T, Kamei K, et al. Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation. Nat Cell Biol. 2009;11:123-32 pubmed publisher
    ..These results indicate that LUBAC is involved in the physiological regulation of the canonical NF-kappaB activation pathway through linear polyubiquitylation of NEMO. ..
  4. Chang M, Jin W, Sun S. Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production. Nat Immunol. 2009;10:1089-95 pubmed publisher
    ..Our findings suggest that Peli1 is a ubiquitin ligase needed for the transmission of TRIF-dependent TLR signals. ..
  5. Nastasi T, Bongiovanni A, Campos Y, Mann L, Toy J, Bostrom J, et al. Ozz-E3, a muscle-specific ubiquitin ligase, regulates beta-catenin degradation during myogenesis. Dev Cell. 2004;6:269-82 pubmed
    ..These findings reveal a novel mechanism of regulation of Mb-beta-catenin and the role of this pool of the protein in myofibrillogenesis, and implicate the Ozz-E3 ligase in the process of myofiber differentiation. ..
  6. Scoma H, Humby M, Yadav G, Zhang Q, Fogerty J, Besharse J. The de-ubiquitinylating enzyme, USP2, is associated with the circadian clockwork and regulates its sensitivity to light. PLoS ONE. 2011;6:e25382 pubmed publisher
    ..Rhythmic expression of USP2 in the SCN and other tissues offers a new level of control of the clock machinery through de-ubiqutinylation and suggests a role for USP2 during circadian adaptation to environmental day length changes. ..
  7. Wright A, Reiley W, Chang M, Jin W, Lee A, Zhang M, et al. Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD. Dev Cell. 2007;13:705-16 pubmed
    ..These findings establish CYLD as a pivotal deubiquitinating enzyme (DUB) that regulates germ cell apoptosis and spermatogenesis and suggest an essential role for CYLD in controlling the RIP1/NF-kappaB signaling axis in testis. ..
  8. Lim S, Miller N, Nam J, Chen X, Lim Y, Schlaepfer D. Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival. J Biol Chem. 2010;285:1743-53 pubmed publisher
    ..Our studies demonstrate that nuclear Pyk2 functions to limit p53 levels, thus facilitating cell growth and survival in a kinase-independent manner. ..
  9. Sun J, Pedersen M, Bengtsson S, Ronnstrand L. Grb2 mediates negative regulation of stem cell factor receptor/c-Kit signaling by recruitment of Cbl. Exp Cell Res. 2007;313:3935-42 pubmed
  10. Tong K, Padmanabhan B, Kobayashi A, Shang C, Hirotsu Y, Yokoyama S, et al. Different electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response. Mol Cell Biol. 2007;27:7511-21 pubmed
    ..Together with the results from calorimetric and functional studies, we conclude that different electrostatic potentials primarily define the ETGE and DLG motifs as a hinge and latch that senses the oxidative/electrophilic stress. ..
  11. Isogai S, Morimoto D, Arita K, Unzai S, Tenno T, Hasegawa J, et al. Crystal structure of the ubiquitin-associated (UBA) domain of p62 and its interaction with ubiquitin. J Biol Chem. 2011;286:31864-74 pubmed publisher
    ..These observations reveal an autoinhibitory mechanism in the p62 UBA domain and suggest that autoinhibition plays a role in the function of p62. ..
  12. Aberle H, Bauer A, Stappert J, Kispert A, Kemler R. beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J. 1997;16:3797-804 pubmed
    ..We show that ubiquitination of beta-catenin is greatly reduced in Wnt-expressing cells, providing the first evidence that the ubiquitin-proteasome degradation pathway may act downstream of GSK3beta in the regulation of beta-catenin. ..
  13. Ryu K, Maehr R, Gilchrist C, Long M, Bouley D, Mueller B, et al. The mouse polyubiquitin gene UbC is essential for fetal liver development, cell-cycle progression and stress tolerance. EMBO J. 2007;26:2693-706 pubmed
    b>UbC is one of two stress-inducible polyubiquitin genes in mammals and is thought to supplement the constitutive UbA genes in maintaining cellular ubiquitin (Ub) levels during episodes of cellular stress...
  14. Shiraishi S, Zhou C, Aoki T, Sato N, Chiba T, Tanaka K, et al. TBP-interacting protein 120B (TIP120B)/cullin-associated and neddylation-dissociated 2 (CAND2) inhibits SCF-dependent ubiquitination of myogenin and accelerates myogenic differentiation. J Biol Chem. 2007;282:9017-28 pubmed
    ..TIP120B is proposed to be a novel regulator for myogenesis. ..
  15. Reiley W, Zhang M, Jin W, Losiewicz M, Donohue K, Norbury C, et al. Regulation of T cell development by the deubiquitinating enzyme CYLD. Nat Immunol. 2006;7:411-7 pubmed
    ..Because of a cell-autonomous defect in T cell development, CYLD-deficient mice had substantially fewer mature CD4(+) and CD8(+) single-positive thymocytes and peripheral T cells. ..
  16. Rada P, Rojo A, Chowdhry S, McMahon M, Hayes J, Cuadrado A. SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner. Mol Cell Biol. 2011;31:1121-33 pubmed publisher
    ..Our results show for the first time that Nrf2 is targeted by GSK-3 for SCF/?-TrCP-dependent degradation. We propose a "dual degradation" model to describe the regulation of Nrf2 under different pathophysiological conditions. ..
  17. Balkhi M, Fitzgerald K, Pitha P. Functional regulation of MyD88-activated interferon regulatory factor 5 by K63-linked polyubiquitination. Mol Cell Biol. 2008;28:7296-308 pubmed publisher
    ..Thus, our findings offer a new mechanistic insight into IRF-5 gene induction program through hitherto unknown processes of IRF-5 ubiquitination. ..
  18. Zhang X, Heckmann B, Xie X, Saarinen A, Liu J. Regulation of FSP27 protein stability by AMPK and HSC70. Am J Physiol Endocrinol Metab. 2014;307:E1047-56 pubmed publisher
    ..Promotion of FSP27 degradation may be an important factor responsible for the beneficial effect of AMPK activators on energy metabolism. ..
  19. Wertz I, Kusam S, Lam C, Okamoto T, Sandoval W, Anderson D, et al. Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7. Nature. 2011;471:110-4 pubmed publisher
    ..Our findings suggest that profiling the FBW7 and MCL1 status of tumours, in terms of protein levels, messenger RNA levels and genetic status, could be useful to predict the response of patients to antitubulin chemotherapeutics. ..
  20. Yang B, Gay D, Macleod M, Cao X, Hala T, Sweezer E, et al. Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells. Nat Immunol. 2008;9:1356-63 pubmed publisher
    ..Our data demonstrate that Nedd4 promotes the conversion of naive T cells into activated T cells. We propose that Nedd4 and Itch ubiquitinate distinct target proteins in vivo. ..
  21. Yan J, Yang X, Kim Y, Joo J, Jetten A. RAP80 interacts with the SUMO-conjugating enzyme UBC9 and is a novel target for sumoylation. Biochem Biophys Res Commun. 2007;362:132-8 pubmed
    ..In addition to SUMO-1, RAP80 was efficiently conjugated to SUMO-3 but was only a weak substrate for SUMO-2 conjugation. These findings suggest that sumoylation plays a role in the regulation of RAP80 functions. ..
  22. Abbott D, Yang Y, Hutti J, Madhavarapu S, Kelliher M, Cantley L. Coordinated regulation of Toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains. Mol Cell Biol. 2007;27:6012-25 pubmed
    ..These findings suggest a biochemical mechanism for the faulty cytokine balance seen in Crohn's disease. ..
  23. Liu J, Han C, Xie B, Wu Y, Liu S, Chen K, et al. Rhbdd3 controls autoimmunity by suppressing the production of IL-6 by dendritic cells via K27-linked ubiquitination of the regulator NEMO. Nat Immunol. 2014;15:612-22 pubmed publisher
    ..Our data identify Rhbdd3 as a critical regulator of DC activation and indicate K27-linked polyubiquitination is a potent ubiquitin-linked pattern involved in the control of autoimmunity. ..
  24. Chen B, Mallampalli R. Masking of a nuclear signal motif by monoubiquitination leads to mislocalization and degradation of the regulatory enzyme cytidylyltransferase. Mol Cell Biol. 2009;29:3062-75 pubmed publisher
    ..These results unravel a unique molecular mechanism whereby monoubiquitination governs the trafficking and life span of a critical regulatory enzyme in vivo. ..
  25. Lu T, Onizawa M, Hammer G, Turer E, Yin Q, Damko E, et al. Dimerization and ubiquitin mediated recruitment of A20, a complex deubiquitinating enzyme. Immunity. 2013;38:896-905 pubmed publisher
    ..This complementation involved homodimerization of A20 proteins, and we have defined an extensive dimerization interface in A20. These studies reveal how A20 proteins collaborate to restrict TNF signaling. ..
  26. Campos Y, Qiu X, Zanoteli E, Moshiach S, Vergani N, Bongiovanni A, et al. Ozz-E3 ubiquitin ligase targets sarcomeric embryonic myosin heavy chain during muscle development. PLoS ONE. 2010;5:e9866 pubmed publisher
    ..Our findings identify Ozz-E3 as the ubiquitin ligase complex that interacts with and regulates myosin within its fully assembled cytoskeletal structure. ..
  27. Jin W, Chang M, Paul E, Babu G, Lee A, Reiley W, et al. Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice. J Clin Invest. 2008;118:1858-66 pubmed publisher
    ..These findings establish CYLD as a crucial negative regulator of osteoclastogenesis and suggest its involvement in the p62/TRAF6 signaling axis. ..
  28. Kajino T, Omori E, Ishii S, Matsumoto K, Ninomiya Tsuji J. TAK1 MAPK kinase kinase mediates transforming growth factor-beta signaling by targeting SnoN oncoprotein for degradation. J Biol Chem. 2007;282:9475-81 pubmed
    ..Inactivation of TAK1 prevented TGF-beta-induced SnoN degradation and impaired induction of the TGF-beta-responsive genes. These data suggest that TAK1 modulates TGF-beta-dependent cellular responses by targeting SnoN for degradation. ..
  29. Farook J, Shields J, Tawfik A, Markand S, Sen T, Smith S, et al. GADD34 induces cell death through inactivation of Akt following traumatic brain injury. Cell Death Dis. 2013;4:e754 pubmed publisher
    ..Finally, in vivo depletion of GADD34 using a lentiviral knockdown approach leads to a rescue of Akt activation and markedly attenuates TBI-induced cell death. ..
  30. Chang L, Kamata H, Solinas G, Luo J, Maeda S, Venuprasad K, et al. The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. Cell. 2006;124:601-13 pubmed
    ..Thus, JNK antagonizes NF-kappaB during TNFalpha signaling by promoting the proteasomal elimination of c-FLIP(L). ..
  31. Mallampalli R, Kaercher L, Snavely C, Pulijala R, Chen B, Coon T, et al. Fbxl12 triggers G1 arrest by mediating degradation of calmodulin kinase I. Cell Signal. 2013;25:2047-59 pubmed publisher
    ..Thus, Fbxl12 may be a previously uncharacterized, functional growth inhibitor regulating cell cycle progression that might be used for mechanism-based therapy. ..
  32. Turer E, Tavares R, Mortier E, Hitotsumatsu O, Advincula R, Lee B, et al. Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20. J Exp Med. 2008;205:451-64 pubmed publisher
    ..These findings provide novel insights into how physiological TLR signals are regulated. ..
  33. Jin H, Yamashita H, Nakamura T, Fukuba H, Takahashi T, Hiji M, et al. Synphilin-1 transgenic mice exhibit mild motor impairments. Neurosci Lett. 2008;445:12-7 pubmed publisher
    ..Synphilin-1 might be involved in motor function, and its accumulation in the central nervous system can cause motor impairments. ..
  34. Hernandez M, Janusonis S. Quantitative mRNA analysis of serotonin 5-HT? and adrenergic ?? receptors in the mouse embryonic telencephalon. Dev Neurosci. 2010;32:278-87 pubmed publisher
    ..These findings suggest that 5-HT?-R splice variants and ??-ARs are differentially regulated in the embryonic telencephalon and that their relative amounts may carry developmentally important information. ..
  35. Suetsugu S, Tezuka T, Morimura T, Hattori M, Mikoshiba K, Yamamoto T, et al. Regulation of actin cytoskeleton by mDab1 through N-WASP and ubiquitination of mDab1. Biochem J. 2004;384:1-8 pubmed
    ..These findings suggest that mDab1 regulates the actin cytoskeleton through N-WASP, which is negatively regulated by phosphorylation-mediated ubiquitination of mDab1. ..
  36. Wang H, Goode T, Iakova P, Albrecht J, Timchenko N. C/EBPalpha triggers proteasome-dependent degradation of cdk4 during growth arrest. EMBO J. 2002;21:930-41 pubmed
    ..Our studies show that C/EBPalpha disrupts the cdk4-cdc37-Hsp90 complex via direct interaction with cdk4 and reduces protein levels of cdk4 by increasing proteasome-dependent degradation of cdk4. ..
  37. Wang X, Morgan S, Loeken M. Pax3 stimulates p53 ubiquitination and degradation independent of transcription. PLoS ONE. 2011;6:e29379 pubmed publisher
    ..These findings further suggest novel explanations for PAX3 functions in human diseases, such as in neural crest-derived cancers and Waardenburg syndrome types 1 and 3. ..
  38. Nakao R, Hirasaka K, Goto J, Ishidoh K, Yamada C, Ohno A, et al. Ubiquitin ligase Cbl-b is a negative regulator for insulin-like growth factor 1 signaling during muscle atrophy caused by unloading. Mol Cell Biol. 2009;29:4798-811 pubmed publisher
    ..The inhibition of Cbl-b-mediated ubiquitination may be a new therapeutic strategy for unloading-mediated muscle atrophy. ..
  39. Wiech M, Olszewski M, Tracz Gaszewska Z, Wawrzynow B, Zylicz M, Zylicz A. Molecular mechanism of mutant p53 stabilization: the role of HSP70 and MDM2. PLoS ONE. 2012;7:e51426 pubmed publisher
    ..Moreover, sequestration of p73 tumour suppressor protein by these nuclear aggregates may lead to gain-of-function phenotypes. ..
  40. Schile A, Garcia Fernandez M, Steller H. Regulation of apoptosis by XIAP ubiquitin-ligase activity. Genes Dev. 2008;22:2256-66 pubmed publisher
    ..This demonstrates a physiological requirement of XIAP ubiquitin-ligase activity for the inhibition of caspases and for tumor suppression in vivo. ..
  41. Hsu T, Hsiao H, Wu P, Liu W, Lai M. Deltex1 promotes protein kinase C? degradation and sustains Casitas B-lineage lymphoma expression. J Immunol. 2014;193:1672-80 pubmed publisher
    ..Our results suggest the coordination between E3 ligases during T cell anergy; DTX1 acts with Cbl-b to assure a more extensive silencing of PKC?, whereas DTX1-mediated PKC? degradation further stabilizes Cbl-b. ..
  42. Rajsbaum R, Versteeg G, Schmid S, Maestre A, Belicha Villanueva A, Martínez Romero C, et al. Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKK? kinase-mediated antiviral response. Immunity. 2014;40:880-95 pubmed publisher
    ..Our work attributes a previously unrecognized activating role of K48-linked unanchored polyubiquitin chains in kinase activation and identifies the UbE2K-TRIM6-ubiquitin axis as critical for IFN signaling and antiviral response. ..
  43. Yang C, Zhou W, Jeon M, Demydenko D, Harada Y, Zhou H, et al. Negative regulation of the E3 ubiquitin ligase itch via Fyn-mediated tyrosine phosphorylation. Mol Cell. 2006;21:135-41 pubmed
    ..Thus, in contrast to the activation pathway mediated by serine/threonine phosphorylation, tyrosine phosphorylation of Itch plays a negative role in modulating Itch-promoted ubiquitination. ..
  44. Usui S, Maejima Y, Pain J, Hong C, Cho J, Park J, et al. Endogenous muscle atrophy F-box mediates pressure overload-induced cardiac hypertrophy through regulation of nuclear factor-kappaB. Circ Res. 2011;109:161-71 pubmed publisher
    ..Taken together, inhibition of MAFbx attenuates pathological hypertrophy, thereby protecting the heart from progression into heart failure. ..
  45. Ki S, Choi M, Lee C, Kim S. Galpha12 specifically regulates COX-2 induction by sphingosine 1-phosphate. Role for JNK-dependent ubiquitination and degradation of IkappaBalpha. J Biol Chem. 2007;282:1938-47 pubmed
  46. Yu L, Korhonen L, Martinez R, Jokitalo E, Chen Y, Arumae U, et al. Regulation of sympathetic neuron and neuroblastoma cell death by XIAP and its association with proteasomes in neural cells. Mol Cell Neurosci. 2003;22:308-18 pubmed
    ..The RING domain was essentially required for the proteasomal association of XIAP and for its ubiquitination. ..
  47. Wang Y, Tang Y, Teng L, Wu Y, Zhao X, Pei G. Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol. 2006;7:139-47 pubmed
    ..Thus, beta-arrestins are essential negative regulators of innate immune activation via TLR-IL-1R signaling. ..
  48. Kase S, He S, Sonoda S, Kitamura M, Spee C, Wawrousek E, et al. alphaB-crystallin regulation of angiogenesis by modulation of VEGF. Blood. 2010;115:3398-406 pubmed publisher
    ..Our studies indicate an important role for alphaB-crystallin as a chaperone for VEGF-A in angiogenesis and its potential as a therapeutic target. ..
  49. Keren Kaplan T, Attali I, Motamedchaboki K, Davis B, Tanner N, Reshef Y, et al. Synthetic biology approach to reconstituting the ubiquitylation cascade in bacteria. EMBO J. 2012;31:378-90 pubmed publisher
    ..Characterization of several ubiquitylated proteins demonstrated the integrity, specificity and fidelity of the system, and revealed new biological findings. ..
  50. Kannan M, Lee S, Schwedhelm Domeyer N, Stegmuller J. The E3 ligase Cdh1-anaphase promoting complex operates upstream of the E3 ligase Smurf1 in the control of axon growth. Development. 2012;139:3600-12 pubmed publisher
    ..Finally, we show that a stabilized form of Smurf1 overrides the inhibition of axon growth by myelin. Taken together, we uncovered a Cdh1-APC/Smurf1/RhoA pathway that mediates axonal growth suppression in the developing mammalian brain. ..
  51. Li X, Zhang S, Blander G, Tse J, Krieger M, Guarente L. SIRT1 deacetylates and positively regulates the nuclear receptor LXR. Mol Cell. 2007;28:91-106 pubmed
    ..Our findings suggest that deacetylation of LXRs by SIRT1 may be a mechanism that affects atherosclerosis and other aging-associated diseases. ..
  52. Leitch V, Agre P, King L. Altered ubiquitination and stability of aquaporin-1 in hypertonic stress. Proc Natl Acad Sci U S A. 2001;98:2894-8 pubmed
    ..Additionally, these studies demonstrate that reduced protein ubiquitination and increased protein stability lead to increased levels of AQP1 expression during hypertonic stress. ..
  53. Okumura F, Yoshida K, Liang F, Hatakeyama S. MDA-9/syntenin interacts with ubiquitin via a novel ubiquitin-binding motif. Mol Cell Biochem. 2011;352:163-72 pubmed publisher
  54. Guo H, Zhang C, Liu Q, Li Q, Lian G, Wu D, et al. The Axin/TNKS complex interacts with KIF3A and is required for insulin-stimulated GLUT4 translocation. Cell Res. 2012;22:1246-57 pubmed publisher
    ..We have thus elucidated a new protein complex that is directly associated with the motor protein kinesin in insulin-stimulated GLUT4 translocation. ..
  55. Ren P, Sheng Z, Wang Y, Yi X, Zhou Q, Zhou J, et al. RNF20 promotes the polyubiquitination and proteasome-dependent degradation of AP-2? protein. Acta Biochim Biophys Sin (Shanghai). 2014;46:136-40 pubmed publisher
    ..These results suggested that RNF20 may play roles in adipocyte differentiation by stimulating ubiquitin-proteasome-dependent degradation of AP-2?. ..
  56. Mikawa T, Maruyama T, Okamoto K, Nakagama H, Lleonart M, Tsusaka T, et al. Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2. J Cell Biol. 2014;204:729-45 pubmed publisher
    ..We propose that Mdm2, a downstream effector of p53, attenuates the Warburg effect via ubiquitination and degradation of PGAM. ..
  57. Ventadour S, Jarzaguet M, Wing S, Chambon C, Combaret L, Bechet D, et al. A new method of purification of proteasome substrates reveals polyubiquitination of 20 S proteasome subunits. J Biol Chem. 2007;282:5302-9 pubmed
    ..Furthermore, the data suggest that proteasome homeostasis involves an autoregulatory mechanism. ..
  58. Hirano S, Suzuki N, Slagsvold T, Kawasaki M, Trambaiolo D, Kato R, et al. Structural basis of ubiquitin recognition by mammalian Eap45 GLUE domain. Nat Struct Mol Biol. 2006;13:1031-2 pubmed
    ..In the Eap45 GLUE-Ub complex structure, Ub binds far from the proposed PI-binding site of Eap45 GLUE, suggesting their independent binding. ..
  59. Naoe H, Araki K, Nagano O, Kobayashi Y, Ishizawa J, Chiyoda T, et al. The anaphase-promoting complex/cyclosome activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation. Mol Cell Biol. 2010;30:3994-4005 pubmed publisher
    ..Our data revealed a novel function for Cdh1 as a regulator of Rho and provided insights into the role of Cdh1 in cell cytoskeleton organization and cell motility. ..
  60. Trempe J, Chen C, Grenier K, Camacho E, Kozlov G, McPherson P, et al. SH3 domains from a subset of BAR proteins define a Ubl-binding domain and implicate parkin in synaptic ubiquitination. Mol Cell. 2009;36:1034-47 pubmed publisher
    ..The findings identify a pathway for the recruitment of synaptic substrates to parkin with the potential to explain the defects in synaptic transmission observed in recessive forms of PD. ..
  61. Shembade N, Harhaj N, Yamamoto M, Akira S, Harhaj E. The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation. J Virol. 2007;81:13735-42 pubmed
    ..Collectively, our results reveal that Ubc13 is essential for Tax ubiquitination, its interaction with NEMO, and Tax-mediated NF-kappaB activation...
  62. He X, Ma Q. NRF2 cysteine residues are critical for oxidant/electrophile-sensing, Kelch-like ECH-associated protein-1-dependent ubiquitination-proteasomal degradation, and transcription activation. Mol Pharmacol. 2009;76:1265-78 pubmed publisher
  63. Lockett A, Goebl M, Harrington M. Transient membrane recruitment of IRAK-1 in response to LPS and IL-1beta requires TNF R1. Am J Physiol Cell Physiol. 2008;295:C313-23 pubmed publisher
    ..In the absence of TNF R1-dependent events, exposure to LPS or IL-1 leads to hyperactivation of the inflammatory response. ..
  64. Cheng P, Lu H, Shelly M, Gao H, Poo M. Phosphorylation of E3 ligase Smurf1 switches its substrate preference in support of axon development. Neuron. 2011;69:231-43 pubmed publisher
    ..Thus, PKA-dependent phosphorylation of the E3 ligase could switch its substrate preference, contributing to selective protein degradation required for localized cellular function. ..
  65. Boyault C, Gilquin B, Zhang Y, Rybin V, Garman E, Meyer Klaucke W, et al. HDAC6-p97/VCP controlled polyubiquitin chain turnover. EMBO J. 2006;25:3357-66 pubmed
  66. Chen Y, Dai X, Haas A, Wen R, Wang D. Proteasome-dependent down-regulation of activated Stat5A in the nucleus. Blood. 2006;108:566-74 pubmed
  67. Ishiguro T, Nakajima M, Naito M, Muto T, Tsuruo T. Identification of genes differentially expressed in B16 murine melanoma sublines with different metastatic potentials. Cancer Res. 1996;56:875-9 pubmed
    ..TI-241 may regulate the expression of various genes as a transcription factor in the complex process of metastasis. ..
  68. Cheng K, Lam K, Wang Y, Wu D, Zhang M, Wang B, et al. TRAF6-mediated ubiquitination of APPL1 enhances hepatic actions of insulin by promoting the membrane translocation of Akt. Biochem J. 2013;455:207-16 pubmed publisher
    ..Thus TRAF6-mediated ubiquitination of APPL1 is a vital step for the hepatic actions of insulin through modulation of membrane trafficking and activity of Akt. ..
  69. Burz D, Dutta K, Cowburn D, Shekhtman A. Mapping structural interactions using in-cell NMR spectroscopy (STINT-NMR). Nat Methods. 2006;3:91-3 pubmed
    ..The resulting spectra provide a complete titration of the interaction and define structural details of the interacting surfaces at atomic resolution. ..
  70. Tanabe C, Maeda T, Zou K, Liu J, Liu S, Nakajima T, et al. The ubiquitin ligase synoviolin up-regulates amyloid ? production by targeting a negative regulator of ?-secretase, Rer1, for degradation. J Biol Chem. 2012;287:44203-11 pubmed publisher
    ..Thus, it is likely that Syvn regulates the assembly of the ?-secretase complex via the degradation of Rer1, which results in the generation of A?. ..
  71. Sun Y, Vashisht A, Tchieu J, Wohlschlegel J, Dreier L. Voltage-dependent anion channels (VDACs) recruit Parkin to defective mitochondria to promote mitochondrial autophagy. J Biol Chem. 2012;287:40652-60 pubmed publisher
    ..We hypothesize that VDACs serve as mitochondrial docking sites to recruit Parkin from the cytosol to defective mitochondria. ..
  72. Corcoran K, Wang X, Lybarger L. Adapter-mediated substrate selection for endoplasmic reticulum-associated degradation. J Biol Chem. 2009;284:17475-87 pubmed publisher
    ..This mechanism of substrate recruitment by adapter proteins may explain the ability of some E3 ligases, including cellular ERAD E3 ligases, to specifically target the ubiquitination of multiple substrates that are unrelated in sequence. ..
  73. Kawabe H, Neeb A, Dimova K, Young S, Takeda M, Katsurabayashi S, et al. Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development. Neuron. 2010;65:358-72 pubmed publisher
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