Gene Symbol: U2af2
Description: U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2
Alias: 65kDa, splicing factor U2AF 65 kDa subunit, U2 auxiliary factor 65 kDa subunit, U2 small nuclear ribonucleoprotein auxiliary factor (U2AF), 65 kDa, U2 snRNP auxiliary factor large subunit
Zamore P, Patton J, Green M. Cloning and domain structure of the mammalian splicing factor U2AF. Nature. 1992;355:609-14 pubmed
..It contains two functional domains: a sequence-specific RNA-binding region composed of three ribonucleoprotein-consensus sequence domains, and an arginine/serine-rich motif necessary for splicing but not for binding to pre-mRNA. ..
Sailer A, Macdonald N, Weissmann C. Cloning and sequencing of the murine homologue of the human splicing factor U2AF65. Nucleic Acids Res. 1992;20:2374 pubmed
Colwill K, Feng L, Yeakley J, Gish G, Caceres J, Pawson T, et al
. SRPK1 and Clk/Sty protein kinases show distinct substrate specificities for serine/arginine-rich splicing factors. J Biol Chem. 1996;271:24569-75 pubmed
..These results suggest that SRPK1 and Clk/Sty may play different roles in regulating SR splicing factors, and suggest that Clk/Sty has a broader substrate specificity than SRPK1. ..
Prigge J, Iverson S, Siders A, Schmidt E. Interactome for auxiliary splicing factor U2AF(65) suggests diverse roles. Biochim Biophys Acta. 2009;1789:487-92 pubmed publisher
..splicing machinery that is composed of two protein subunits, the 35 kDa U2AF(35) (U2AF1) and the 65 kDa U2AF(65) (U2AF2). U2AF interacts with various splicing factors within this machinery...
Tsoi H, Lau C, Lau K, Chan H. Perturbation of U2AF65/NXF1-mediated RNA nuclear export enhances RNA toxicity in polyQ diseases. Hum Mol Genet. 2011;20:3787-97 pubmed publisher
..We also provide a novel mechanistic explanation to how perturbation of RNA nuclear export would contribute to polyQ degeneration. ..
Lai S, O Callaghan B, Zoghbi H, Orr H. 14-3-3 Binding to ataxin-1(ATXN1) regulates its dephosphorylation at Ser-776 and transport to the nucleus. J Biol Chem. 2011;286:34606-16 pubmed publisher
..In the nucleus, we propose that dephosphorylation of pS776-ATXN1 by PP2A regulates the interaction of ATXN1 with the splicing factors RBM17 and U2AF65. ..
Pedrotti S, Busà R, Compagnucci C, Sette C. The RNA recognition motif protein RBM11 is a novel tissue-specific splicing regulator. Nucleic Acids Res. 2012;40:1021-32 pubmed publisher
..Thus, our findings identify RBM11 as a novel tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. ..
Boeckel J, Guarani V, Koyanagi M, Roexe T, Lengeling A, Schermuly R, et al
. Jumonji domain-containing protein 6 (Jmjd6) is required for angiogenic sprouting and regulates splicing of VEGF-receptor 1. Proc Natl Acad Sci U S A. 2011;108:3276-81 pubmed publisher
..Jmjd6 interacts with the splicing factors U2AF65 that binds to Flt1 mRNA. In conclusion, Jmjd6 regulates the splicing of Flt1, thereby controlling angiogenic sprouting. ..
Manceau V, Kremmer E, Nabel E, Maucuer A. The protein kinase KIS impacts gene expression during development and fear conditioning in adult mice. PLoS ONE. 2012;7:e43946 pubmed publisher
..This difference suggests that disregulation of gene expression due to KIS inactivation affects specific brain functions. ..