Gene Symbol: U2af1
Description: U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1
Alias: 2010107D16Rik, splicing factor U2AF 35 kDa subunit, U2 auxiliary factor 35 kDa subunit, U2 snRNP auxiliary factor small subunit
Pereira P, Magnol L, Sahún I, Brault V, Duchon A, Prandini P, et al
. A new mouse model for the trisomy of the Abcg1-U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome. Hum Mol Genet. 2009;18:4756-69 pubmed publisher
..Here we show that the trisomy of the 12 genes, found in the 0.59 Mb (Abcg1-U2af1) Hsa21 sub-telomeric region, in mice (Ts1Yah) produced defects in novel object recognition, open-field and Y-maze ..
Maréchal D, Lopes Pereira P, Duchon A, Herault Y. Dosage of the Abcg1-U2af1 region modifies locomotor and cognitive deficits observed in the Tc1 mouse model of Down syndrome. PLoS ONE. 2015;10:e0115302 pubmed publisher
..report we analyzed the contribution of the genetic dosage of 13 conserved mouse genes located between Abcg1 and U2af1, in the telomeric part of Hsa21...
Shepard J, Reick M, Olson S, Graveley B. Characterization of U2AF(6), a splicing factor related to U2AF(35). Mol Cell Biol. 2002;22:221-30 pubmed
..Based on its sequence and functional similarity to U2AF(35), U2AF(26) may play a role in regulating alternative splicing. ..
Rzymski T, Grzmil P, Meinhardt A, Wolf S, Burfeind P. PHF5A represents a bridge protein between splicing proteins and ATP-dependent helicases and is differentially expressed during mouse spermatogenesis. Cytogenet Genome Res. 2008;121:232-44 pubmed publisher
..both with ATP-dependent helicases EP400 and DDX1 and with arginine-serine (RS)-rich domains of splicing factors U2AF1 and SFRS5 in mouse...
Shirai C, Ley J, White B, Kim S, Tibbitts J, Shao J, et al
. Mutant U2AF1 Expression Alters Hematopoiesis and Pre-mRNA Splicing In Vivo. Cancer Cell. 2015;27:631-43 pubmed publisher
Heterozygous somatic mutations in the spliceosome gene U2AF1 occur in âˆ¼ 11% of patients with myelodysplastic syndromes (MDS), the most common adult myeloid malignancy. It is unclear how these mutations contribute to disease...
Park S, Ou J, Chamberlain L, Simone T, Yang H, Virbasius C, et al
. U2AF35(S34F) Promotes Transformation by Directing Aberrant ATG7 Pre-mRNA 3' End Formation. Mol Cell. 2016;62:479-90 pubmed publisher
..Collectively, our results reveal a basis for U2AF35(S34F) oncogenic activity. ..
Davisson M, Bechtel L, Akeson E, Fortna A, Slavov D, Gardiner K. Evolutionary breakpoints on human chromosome 21. Genomics. 2001;78:99-106 pubmed
..These data suggest that there may be as few as 21 functional genes in the mouse chromosome 17 segment. This information is important for defining existing and constructing more complete mouse models of Down syndrome. ..
Cazalla D, Newton K, Caceres J. A novel SR-related protein is required for the second step of Pre-mRNA splicing. Mol Cell Biol. 2005;25:2969-80 pubmed
..SRrp53 also regulates alternative splicing in a concentration-dependent manner. Taken together, these results suggest that SRrp53 is a novel SR-related protein that has a role both in constitutive and in alternative splicing. ..
Tretyakova I, Zolotukhin A, Tan W, Bear J, Propst F, Ruthel G, et al
. Nuclear export factor family protein participates in cytoplasmic mRNA trafficking. J Biol Chem. 2005;280:31981-90 pubmed
..We propose a model in which MAP1B tethers the NXF-associated mRNA to microtubules and facilitates their translocation along dendrites while Unrip provides a scaffold for the assembly of these transport intermediates. ..