Gene Symbol: Txlng
Description: taxilin gamma
Alias: 4932441K18Rik, Fiat, Lrp, gamma-taxilin, factor inhibiting activating transcription factor 4 (ATF4)-mediated transcription, lipopolysaccharide-responsive gene protein, lipopolysaccharide-specific response protein 5
Species: mouse
Products:     Txlng

Top Publications

  1. Yu V, Ambartsoumian G, Verlinden L, Moir J, Prud homme J, Gauthier C, et al. FIAT represses ATF4-mediated transcription to regulate bone mass in transgenic mice. J Cell Biol. 2005;169:591-601 pubmed
    We report the characterization of factor inhibiting activating transcription factor 4 (ATF4)-mediated transcription (FIAT), a leucine zipper nuclear protein...
  2. Yu V, El Hoss J, St Arnaud R. FIAT inhibition increases osteoblast activity by modulating Atf4-dependent functions. J Cell Biochem. 2009;106:186-92 pubmed publisher
    ..We have characterized factor-inhibiting ATF4-mediated transcription (FIAT), a leucine zipper protein that dimerizes with ATF4 to form inactive dimers that cannot bind DNA...
  3. Yu V, Akhouayri O, St Arnaud R. FIAT is co-expressed with its dimerization target ATF4 in early osteoblasts, but not in osteocytes. Gene Expr Patterns. 2009;9:335-40 pubmed publisher
    b>FIAT represses osteocalcin gene transcription by heterodimerizing with ATF4 and preventing it from binding to DNA. We report here the expression profiles of FIAT and ATF4 during osteoblastogenesis...
  4. Du K, Chen Y, Dai Z, Bi Y, Cai T, Hou L, et al. Molecular cloning and functional characterization of a mouse gene upregulated by lipopolysaccharide treatment reveals alternative splicing. Biochem Biophys Res Commun. 2010;391:267-71 pubmed publisher
    ..Upregulation of MLrgW and MLrgS may be an important component of the LPS inflammatory pathway and of the host response to infection with GNB. ..
  5. St Arnaud R, Mandic V, Elchaarani B. FIAT, the factor-inhibiting ATF4-mediated transcription, also represses the transcriptional activity of the bZIP factor FRA-1. Ann N Y Acad Sci. 2010;1192:338-43 pubmed publisher
    b>FIAT is a leucine zipper protein whose name was coined for its interaction with ATF4 and subsequent blockage of ATF4-directed osteocalcin gene transcription...
  6. Hekmatnejad B, Gauthier C, St Arnaud R. Control of Fiat (factor inhibiting ATF4-mediated transcription) expression by Sp family transcription factors in osteoblasts. J Cell Biochem. 2013;114:1863-70 pubmed publisher
    b>FIAT (factor inhibiting ATF4-mediated transcription) represses Osteocalcin gene transcription and inhibits osteoblast activity by heterodimerizing with ATF4 to prevent it from binding DNA...
  7. Hekmatnejad B, Akhouayri O, Jafarov T, St Arnaud R. SUMOylated ?NAC potentiates transcriptional repression by FIAT. J Cell Biochem. 2014;115:866-73 pubmed publisher
    ..coregulator ?NAC (Nascent polypeptide associated complex And Coregulator alpha) and the transcriptional repressor FIAT (Factor Inhibiting ATF4-mediated Transcription) interact but the biological relevance of this interaction remains ..
  8. Hekmatnejad B, Mandic V, Yu V, Akhouayri O, Arabian A, St Arnaud R. Altered gene dosage confirms the genetic interaction between FIAT and ?NAC. Gene. 2014;538:328-33 pubmed publisher
    Factor inhibiting ATF4-mediated transcription (FIAT) interacts with Nascent polypeptide associated complex and coregulator alpha (?NAC)...
  9. Hekmatnejad B, Yu V, Addison W, Mandic V, Pellicelli M, Arabian A, et al. FIAT Deletion Increases Bone Mass But Does Not Prevent High-Fat-Diet-Induced Metabolic Complications. Endocrinology. 2017;158:264-276 pubmed publisher
    Factor inhibiting activating transcription factor 4 (ATF4)-mediated transcription (FIAT) interacts with ATF4 to repress its transcriptional activity...