Twist1

Summary

Gene Symbol: Twist1
Description: twist basic helix-loop-helix transcription factor 1
Alias: M-Twist, Pde, Ska10, Ska, Twist, bHLHa38, pdt, twist-related protein 1, Pluridigite, charlie chaplin, polydactyly EMS, twist gene homolog 1, twist homolog 1
Species: mouse
Products:     Twist1

Top Publications

  1. Murray S, Glackin C, Winters K, Gazit D, Kahn A, Murray E. Expression of helix-loop-helix regulatory genes during differentiation of mouse osteoblastic cells. J Bone Miner Res. 1992;7:1131-8 pubmed
    ..The other, mTwi, the murine homolog of the Drosophila twist gene, is a newly cloned mammalian H-L-H gene. Levels of E12 RNA remained unchanged during differentiation...
  2. Reinhold M, Kapadia R, Liao Z, Naski M. The Wnt-inducible transcription factor Twist1 inhibits chondrogenesis. J Biol Chem. 2006;281:1381-8 pubmed
    ..Significantly, we showed that the transcription repressor Twist1 is induced by canonical Wnt signaling...
  3. Chen Y, Akinwunmi P, Deng J, Tam O, Behringer R. Generation of a Twist1 conditional null allele in the mouse. Genesis. 2007;45:588-92 pubmed
    b>Twist1 is the mouse ortholog of TWIST1, the human gene mutated in Saethre-Chotzen syndrome. Previously, a Twist1 null allele was generated by gene targeting in mouse embryonic stem cells...
  4. Wolf C, Thisse C, Stoetzel C, Thisse B, Gerlinger P, Perrin Schmitt F. The M-twist gene of Mus is expressed in subsets of mesodermal cells and is closely related to the Xenopus X-twi and the Drosophila twist genes. Dev Biol. 1991;143:363-73 pubmed
    The twist gene was characterized in Drosophila as being necessary at gastrulation for the establishment of the mesodermal germ layer. It codes for a nuclear DNA-binding protein that is probably a transcription factor...
  5. Horikawa T, Yang J, Kondo S, Yoshizaki T, Joab I, Furukawa M, et al. Twist and epithelial-mesenchymal transition are induced by the EBV oncoprotein latent membrane protein 1 and are associated with metastatic nasopharyngeal carcinoma. Cancer Res. 2007;67:1970-8 pubmed
    ..principal EBV oncoprotein, latent membrane protein 1 (LMP1), induces epithelial-mesenchymal transition (EMT) via Twist, a master transcriptional regulator in embryogenesis and newly implicated in metastasis, which, in turn, are ..
  6. Firulli B, Redick B, Conway S, Firulli A. Mutations within helix I of Twist1 result in distinct limb defects and variation of DNA binding affinities. J Biol Chem. 2007;282:27536-46 pubmed
    b>Twist1 is a basic helix-loop-helix (bHLH) factor that plays an important role in limb development. Haploinsufficiency of Twist1 results in polydactyly via the inability of Twist1 to antagonistically regulate the related factor Hand2...
  7. Paznekas W, Cunningham M, Howard T, Korf B, Lipson M, Grix A, et al. Genetic heterogeneity of Saethre-Chotzen syndrome, due to TWIST and FGFR mutations. Am J Hum Genet. 1998;62:1370-80 pubmed
    ..a common autosomal dominant condition of craniosynostosis and limb anomalies, were screened for mutations in TWIST, FGFR2, and FGFR3. Nine novel and three recurrent TWIST mutations were found in 12 families...
  8. Bildsoe H, Loebel D, Jones V, Chen Y, Behringer R, Tam P. Requirement for Twist1 in frontonasal and skull vault development in the mouse embryo. Dev Biol. 2009;331:176-88 pubmed publisher
    Using a Cre-mediated conditional deletion approach, we have dissected the function of Twist1 in the morphogenesis of the craniofacial skeleton...
  9. Füchtbauer E. Expression of M-twist during postimplantation development of the mouse. Dev Dyn. 1995;204:316-22 pubmed
    The murine homologue of the Drosophila twist gene has been shown to be essential for head mesenchyme formation and to act as an inhibitor of muscle differentiation...

More Information

Publications68

  1. Lu Y, Li Y, Cavender A, Wang S, Mansukhani A, D Souza R. Molecular studies on the roles of Runx2 and Twist1 in regulating FGF signaling. Dev Dyn. 2012;241:1708-15 pubmed publisher
    ..In this study, we assessed the roles of Runx2 and its functional antagonist Twist1 in regulating fibroblast growth factor (FGF) signaling using in vitro biochemical approaches...
  2. Krawchuk D, Weiner S, Chen Y, Lu B, Costantini F, Behringer R, et al. Twist1 activity thresholds define multiple functions in limb development. Dev Biol. 2010;347:133-46 pubmed publisher
    The basic helix-loop-helix transcription factor Twist1 is essential for normal limb development. Twist1(-/-) embryos die at midgestation...
  3. Loebel D, Tsoi B, Wong N, Tam P. A conserved noncoding intronic transcript at the mouse Dnm3 locus. Genomics. 2005;85:782-9 pubmed
    ..has been identified in a screen for genes that may be regulated by the basic helix-loop-helix transcription factor Twist during mouse development...
  4. Yang J, Mani S, Donaher J, Ramaswamy S, Itzykson R, Come C, et al. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell. 2004;117:927-39 pubmed
    ..for key regulators of metastasis in a murine breast tumor model, we have found that the transcription factor Twist, a master regulator of embryonic morphogenesis, plays an essential role in metastasis...
  5. Ishii M, Han J, Yen H, Sucov H, Chai Y, Maxson R. Combined deficiencies of Msx1 and Msx2 cause impaired patterning and survival of the cranial neural crest. Development. 2005;132:4937-50 pubmed
    ..This increase in apoptosis may contribute to the mispatterning of the cranial ganglia and the hypoplasia of the first arch. ..
  6. Sharif M, Sosic D, Rothlin C, Kelly E, Lemke G, Olson E, et al. Twist mediates suppression of inflammation by type I IFNs and Axl. J Exp Med. 2006;203:1891-901 pubmed
    ..was mediated by induction and activation of the Axl receptor tyrosine kinase and downstream induction of Twist transcriptional repressors that bind to E box elements in the TNF promoter and suppress NF-kappaB-dependent ..
  7. Vincentz J, Barnes R, Rodgers R, Firulli B, Conway S, Firulli A. An absence of Twist1 results in aberrant cardiac neural crest morphogenesis. Dev Biol. 2008;320:131-9 pubmed publisher
    The basic helix-loop-helix transcription factor Twist1 plays an essential role in mesenchymal cell populations during embryonic development and in pathological disease...
  8. Niesner U, Albrecht I, Janke M, Doebis C, Loddenkemper C, Lexberg M, et al. Autoregulation of Th1-mediated inflammation by twist1. J Exp Med. 2008;205:1889-901 pubmed publisher
    The basic helix-loop-helix transcriptional repressor twist1, as an antagonist of nuclear factor kappaB (NF-kappaB)-dependent cytokine expression, is involved in the regulation of inflammation-induced immunopathology...
  9. Zhang Z, Sui P, Dong A, Hassell J, Cserjesi P, Chen Y, et al. Preaxial polydactyly: interactions among ETV, TWIST1 and HAND2 control anterior-posterior patterning of the limb. Development. 2010;137:3417-26 pubmed publisher
    ..Here we provide evidence from mouse conditional knockout limb buds that the bHLH family transcription factor gene Twist1 is required to inhibit Shh expression in the anterior limb bud mesenchyme...
  10. Chakraborty S, Wirrig E, Hinton R, Merrill W, Spicer D, Yutzey K. Twist1 promotes heart valve cell proliferation and extracellular matrix gene expression during development in vivo and is expressed in human diseased aortic valves. Dev Biol. 2010;347:167-79 pubmed publisher
    ..b>Twist1, a class II basic-helix-loop-helix (bHLH) transcription factor, is expressed during early EC development and is ..
  11. Vrljicak P, Chang A, Morozova O, Wederell E, Niessen K, Marra M, et al. Genomic analysis distinguishes phases of early development of the mouse atrio-ventricular canal. Physiol Genomics. 2010;40:150-7 pubmed publisher
    ..These results identify molecular signatures that distinguish different phases of early heart valve formation allowing gene expression and function to be further investigated. ..
  12. Hebrok M, Füchtbauer A, Füchtbauer E. Repression of muscle-specific gene activation by the murine Twist protein. Exp Cell Res. 1997;232:295-303 pubmed
    Inhibition of myogenic differentiation can be achieved by various mechanisms. The murine bHLH protein Twist has been shown to inhibit muscle differentiation in mammalian cells...
  13. Dave N, Guaita Esteruelas S, Gutarra S, Frias A, Beltran M, Peiro S, et al. Functional cooperation between Snail1 and twist in the regulation of ZEB1 expression during epithelial to mesenchymal transition. J Biol Chem. 2011;286:12024-32 pubmed publisher
    ..up-regulation by TGF-?, Snail1 is necessary for the rapid increase in Twist protein and later up-regulation of Twist1 mRNA induced by the cytokine...
  14. Bai Y, Wang J, Morikawa Y, Bonilla Claudio M, Klysik E, Martin J. Bmp signaling represses Vegfa to promote outflow tract cushion development. Development. 2013;140:3395-402 pubmed publisher
    ..Our study reveals that Vegfa levels in the OFT are tightly controlled by Smad- and microRNA-dependent pathways to modulate OFT development. ..
  15. Hinoi E, Bialek P, Chen Y, Rached M, Groner Y, Behringer R, et al. Runx2 inhibits chondrocyte proliferation and hypertrophy through its expression in the perichondrium. Genes Dev. 2006;20:2937-42 pubmed
    ..Analyses of loss- and gain-of-function models show that Twist-1, whose expression in cartilage is restricted to perichondrium, favors chondrocyte maturation in a Runx2-..
  16. Mori M, Nakagami H, Koibuchi N, Miura K, Takami Y, Koriyama H, et al. Zyxin mediates actin fiber reorganization in epithelial-mesenchymal transition and contributes to endocardial morphogenesis. Mol Biol Cell. 2009;20:3115-24 pubmed publisher
    ..In addition, TGF-beta1 up-regulated zyxin via a transcription factor, Twist1. Depletion of either zyxin or Twist1 abrogated the TGF-beta1-dependent EMT, including enhanced cell motility and ..
  17. Chen Z, Behringer R. twist is required in head mesenchyme for cranial neural tube morphogenesis. Genes Dev. 1995;9:686-99 pubmed
    To understand the role of twist during mammalian development, we generated twist-null mice. twist-null embryos died at embryonic day 11.5. Their most prominent phenotype was a failure of the cranial neural folds to fuse...
  18. Gitelman I. Twist protein in mouse embryogenesis. Dev Biol. 1997;189:205-14 pubmed
    The genes in the twist family of bHLH transcription factors are essential for embryogenesis of both vertebrates and invertebrates, as demonstrated by the embryonic lethal phenotypes of the Drosophila and mouse twist-null mutants...
  19. Oram K, Gridley T. Mutations in snail family genes enhance craniosynostosis of Twist1 haplo-insufficient mice: implications for Saethre-Chotzen Syndrome. Genetics. 2005;170:971-4 pubmed
    In Drosophila, mutations in the Twist gene interact with mutations in the Snail gene. We show that the mouse Twist1 mutation interacts with Snai1 and Snai2 mutations to enhance aberrant cranial suture fusion, demonstrating that genetic ..
  20. Solloway M, Robertson E. Early embryonic lethality in Bmp5;Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup. Development. 1999;126:1753-68 pubmed
    ..These findings are discussed with respect to potential mechanisms underlying cooperative signaling by multiple members of the TGF-beta superfamily. ..
  21. Rice D, Aberg T, Chan Y, Tang Z, Kettunen P, Pakarinen L, et al. Integration of FGF and TWIST in calvarial bone and suture development. Development. 2000;127:1845-55 pubmed
    Mutations in the FGFR1-FGFR3 and TWIST genes are known to cause craniosynostosis, the former by constitutive activation and the latter by haploinsufficiency...
  22. Qin L, Liu Z, Chen H, Xu J. The steroid receptor coactivator-1 regulates twist expression and promotes breast cancer metastasis. Cancer Res. 2009;69:3819-27 pubmed publisher
    ..Importantly, WT cells expressed Twist, a master regulator of metastasis, at significantly higher levels versus KO cells...
  23. O Rourke M, Soo K, Behringer R, Hui C, Tam P. Twist plays an essential role in FGF and SHH signal transduction during mouse limb development. Dev Biol. 2002;248:143-56 pubmed
    Loss of Twist gene function arrests the growth of the limb bud shortly after its formation. In the Twist(-/-) forelimb bud, Fgf10 expression is reduced, Fgf4 is not expressed, and the domain of Fgf8 and Fgfr2 expression is altered...
  24. Sosic D, Richardson J, Yu K, Ornitz D, Olson E. Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity. Cell. 2003;112:169-80 pubmed
    During Drosophila embryogenesis, the dorsal transcription factor activates the expression of twist, a transcription factor required for mesoderm formation...
  25. Connerney J, Andreeva V, Leshem Y, Muentener C, Mercado M, Spicer D. Twist1 dimer selection regulates cranial suture patterning and fusion. Dev Dyn. 2006;235:1345-57 pubmed
    ..syndrome is associated with haploinsufficiency of the basic-helix-loop-helix (bHLH) transcription factor TWIST1 and is characterized by premature closure of the cranial sutures, termed craniosynostosis; however, the mechanisms ..
  26. Li L, Cserjesi P, Olson E. Dermo-1: a novel twist-related bHLH protein expressed in the developing dermis. Dev Biol. 1995;172:280-92 pubmed
    ..Within its bHLH region, Dermo-1 shares extensive homology with members of the twist family of bHLH proteins, which are expressed in embryonic mesoderm...
  27. Bialek P, Kern B, Yang X, Schrock M, Sosic D, Hong N, et al. A twist code determines the onset of osteoblast differentiation. Dev Cell. 2004;6:423-35 pubmed
    ..Here we show that Twist proteins transiently inhibit Runx2 function during skeletogenesis...
  28. Lee M, Yutzey K. Twist1 directly regulates genes that promote cell proliferation and migration in developing heart valves. PLoS ONE. 2011;6:e29758 pubmed publisher
    b>Twist1, a basic helix-loop-helix transcription factor, is expressed in mesenchymal precursor populations during embryogenesis and in metastatic cancer cells...
  29. Loebel D, Hor A, Bildsoe H, Jones V, Chen Y, Behringer R, et al. Regionalized Twist1 activity in the forelimb bud drives the morphogenesis of the proximal and preaxial skeleton. Dev Biol. 2012;362:132-40 pubmed publisher
    Development of the mouse forelimb bud depends on normal Twist1 activity...
  30. El Ghouzzi V, Le Merrer M, Perrin Schmitt F, Lajeunie E, Benit P, Renier D, et al. Mutations of the TWIST gene in the Saethre-Chotzen syndrome. Nat Genet. 1997;15:42-6 pubmed
    ..ACS III has been mapped to chromosome 7p21-22. Of interest, TWIST, the human counterpart of the murine Twist gene, has been localized on chromosome 7p21 as well...
  31. Tran P, Shroff E, Burns T, Thiyagarajan S, Das S, Zabuawala T, et al. Twist1 suppresses senescence programs and thereby accelerates and maintains mutant Kras-induced lung tumorigenesis. PLoS Genet. 2012;8:e1002650 pubmed publisher
    ..in both a novel transgenic mutant Kras lung cancer mouse model and in human lung tumors that the inhibition of Twist1 restores a senescence program inducing the loss of a neoplastic phenotype...
  32. Bourgeois P, Bolcato Bellemin A, Danse J, Bloch Zupan A, Yoshiba K, Stoetzel C, et al. The variable expressivity and incomplete penetrance of the twist-null heterozygous mouse phenotype resemble those of human Saethre-Chotzen syndrome. Hum Mol Genet. 1998;7:945-57 pubmed
    ..Here we describe parts of the expression pattern of M-twist in the head of developing wild-type mice and present our analysis of the phenotype of heterozygous twist- null ..
  33. Pan D, Fujimoto M, Lopes A, Wang Y. Twist-1 is a PPARdelta-inducible, negative-feedback regulator of PGC-1alpha in brown fat metabolism. Cell. 2009;137:73-86 pubmed publisher
    ..Here, we describe a molecular network important for PGC-1alpha function and brown fat metabolism. We find that twist-1 is selectively expressed in adipose tissue, interacts with PGC-1alpha, and is recruited to the promoters of PGC-..
  34. Firulli B, Krawchuk D, Centonze V, Vargesson N, Virshup D, Conway S, et al. Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities. Nat Genet. 2005;37:373-81 pubmed publisher
    Autosomal dominant mutations in the gene encoding the basic helix-loop-helix transcription factor Twist1 are associated with limb and craniofacial defects in humans with Saethre-Chotzen syndrome...
  35. Yang M, Wu M, Chiou S, Chen P, Chang S, Liu C, et al. Direct regulation of TWIST by HIF-1alpha promotes metastasis. Nat Cell Biol. 2008;10:295-305 pubmed publisher
    ..The transcription factor TWIST is a master regulator of gastrulation and mesoderm-specification and was implicated recently as an essential ..
  36. Laursen K, Mielke E, Iannaccone P, Füchtbauer E. Mechanism of transcriptional activation by the proto-oncogene Twist1. J Biol Chem. 2007;282:34623-33 pubmed
    Mammalian Twist1, a master regulator in development and a key factor in tumorigenesis, is known to repress transcription by several mechanisms and is therefore considered to mediate its function mainly through inhibition...
  37. Connerney J, Andreeva V, Leshem Y, Mercado M, Dowell K, Yang X, et al. Twist1 homodimers enhance FGF responsiveness of the cranial sutures and promote suture closure. Dev Biol. 2008;318:323-34 pubmed publisher
    Haploinsufficiency of the transcription factor TWIST1 is associated with Saethre-Chotzen Syndrome and is manifested by craniosynostosis, which is the premature closure of the calvaria sutures...
  38. Bildsoe H, Loebel D, Jones V, Hor A, Braithwaite A, Chen Y, et al. The mesenchymal architecture of the cranial mesoderm of mouse embryos is disrupted by the loss of Twist1 function. Dev Biol. 2013;374:295-307 pubmed publisher
    The basic helix-loop-helix transcription factor Twist1 is a key regulator of craniofacial development. Twist1-null mouse embryos exhibit failure of cephalic neural tube closure and abnormal head development and die at E11.0...
  39. Chang T, Hung W. Transcriptional repression of TWIST1 gene by Prospero-related homeobox 1 inhibits invasiveness of hepatocellular carcinoma cells. FEBS Lett. 2012;586:3746-52 pubmed publisher
    ..We find that PROX1 expression is inversely correlated with the expression of epithelial-mesenchymal regulator TWIST1 in HCC cell lines and tumor tissues...
  40. Ma L, Lu M, Schwartz R, Martin J. Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning. Development. 2005;132:5601-11 pubmed
    ..During EMT, Bmp2 promotes expression of the basic helix-loop-helix factor Twist1, previously implicated in EMT in cancer metastases, and the homeobox genes Msx1 and Msx2...
  41. Hebrok M, Wertz K, Füchtbauer E. M-twist is an inhibitor of muscle differentiation. Dev Biol. 1994;165:537-44 pubmed
    The twist gene encodes a transcription factor containing a conserved basic helix-loop-helix domain. During development, transcription factors of this type are normally associated with the induction of differentiation...
  42. Carver E, Oram K, Gridley T. Craniosynostosis in Twist heterozygous mice: a model for Saethre-Chotzen syndrome. Anat Rec. 2002;268:90-2 pubmed
    ..Most Saethre-Chotzen syndrome cases are caused by haploinsufficiency for the TWIST gene...
  43. Miraoui H, Severe N, Vaudin P, Pages J, Marie P. Molecular silencing of Twist1 enhances osteogenic differentiation of murine mesenchymal stem cells: implication of FGFR2 signaling. J Cell Biochem. 2010;110:1147-54 pubmed publisher
    ..The role of Twist1, a basic helix-loop-helix (bHLH) transcription factor, in osteogenic differentiation of MSCs remains unclear...
  44. Fu J, Qin L, He T, Qin J, Hong J, Wong J, et al. The TWIST/Mi2/NuRD protein complex and its essential role in cancer metastasis. Cell Res. 2011;21:275-89 pubmed publisher
    ..Although TWIST is a master regulator of EMT and metastasis for breast and other cancers, the mechanisms responsible for TWIST-..
  45. Pozharskaya V, Torres Gonzalez E, Rojas M, Gal A, Amin M, Dollard S, et al. Twist: a regulator of epithelial-mesenchymal transition in lung fibrosis. PLoS ONE. 2009;4:e7559 pubmed publisher
    ..We hypothesize that EMT in this model of virus-induced pulmonary fibrosis is driven by the expression of the transcription factor Twist.
  46. Chakraborty S, Cheek J, Sakthivel B, Aronow B, Yutzey K. Shared gene expression profiles in developing heart valves and osteoblast progenitor cells. Physiol Genomics. 2008;35:75-85 pubmed publisher
    ..Several transcription factors characteristic of mesenchymal and osteoblast precursor cells, including Twist1, are predominant in E12.5 cushion...
  47. Hamamori Y, Wu H, Sartorelli V, Kedes L. The basic domain of myogenic basic helix-loop-helix (bHLH) proteins is the novel target for direct inhibition by another bHLH protein, Twist. Mol Cell Biol. 1997;17:6563-73 pubmed
    In vertebrates, the basic helix-loop-helix (bHLH) protein Twist may be involved in the negative regulation of cellular determination and in the differentiation of several lineages, including myogenesis, osteogenesis, and neurogenesis...
  48. Mattei M, Stoetzel C, Perrin Schmitt F. The B-HLH protein encoding the M-twist gene is located by in situ hybridization on murine chromosome 12. Mamm Genome. 1993;4:127-8 pubmed
  49. Barbera J, Rodriguez T, Greene N, Weninger W, Simeone A, Copp A, et al. Folic acid prevents exencephaly in Cited2 deficient mice. Hum Mol Genet. 2002;11:283-93 pubmed
    ..To our knowledge, the Cited2 mouse represents the first genetic model in which folic acid can prevent a defect in neural tube closure by a mechanism other than the neutralization of a defect in folate homeostasis. ..
  50. Conlon F, Wright C, Robertson E. Effects of the TWis mutation on notochord formation and mesodermal patterning. Mech Dev. 1995;49:201-9 pubmed
    ..defects appear to result in aberrant somitic differentiation as revealed by the distribution of mox-1 protein and twist RNA expression...
  51. Guzzo R, Andreeva V, Spicer D, Drissi M. Persistent expression of Twist1 in chondrocytes causes growth plate abnormalities and dwarfism in mice. Int J Dev Biol. 2011;55:641-7 pubmed publisher
    Evidence from various in vitro gain and loss of function studies indicate that the bHLH transcription factor Twist1 negatively regulates chondrocyte differentiation; however limited information regarding Twist1 function in postnatal ..
  52. Hjiantoniou E, Iseki S, Uney J, Phylactou L. DNazyme-mediated cleavage of Twist transcripts and increase in cellular apoptosis. Biochem Biophys Res Commun. 2003;300:178-81 pubmed
    ..b>Twist is a basic helix-loop-helix transcription factor that is involved in the regulation of cellular differentiation ..
  53. Liu K, Sun B, Zhao X, Wang X, Li Y, Qiu Z, et al. Hypoxia promotes vasculogenic mimicry formation by the Twist1-Bmi1 connection in hepatocellular carcinoma. Int J Mol Med. 2015;36:783-91 pubmed publisher
    ..The present study aimed to investigate the role of the Twist1‑Bmi1 connection in hypoxia‑induced VM formation and the underlying mechanism...
  54. Mammoto T, Muyleart M, Konduri G, Mammoto A. Twist1 in Hypoxia-induced Pulmonary Hypertension through Transforming Growth Factor-β-Smad Signaling. Am J Respir Cell Mol Biol. 2018;58:194-207 pubmed publisher
    ..The expression of the transcription factor, Twist1, increases in the lungs of patients with pulmonary arterial hypertension...
  55. Zohn I, Li Y, Skolnik E, Anderson K, Han J, Niswander L. p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation. Cell. 2006;125:957-69 pubmed
    ..Finally, p38 regulates E-cadherin protein expression downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by Fibroblast Growth Factor (Fgf) signaling and Snail. ..
  56. Mankoo B, Skuntz S, Harrigan I, Grigorieva E, Candia A, Wright C, et al. The concerted action of Meox homeobox genes is required upstream of genetic pathways essential for the formation, patterning and differentiation of somites. Development. 2003;130:4655-64 pubmed
    ..In particular, our studies place Meox gene function upstream of Pax genes in the regulation of chondrogenic and myogenic differentiation of paraxial mesoderm. ..
  57. Takeuchi Y, Molyneaux K, Runyan C, Schaible K, Wylie C. The roles of FGF signaling in germ cell migration in the mouse. Development. 2005;132:5399-409 pubmed
    ..These data show that a major role of FGF signaling through FGFR2-IIIb is to control germ cell numbers. The data do not discriminate between direct and indirect effects of FGF signaling on germ cells, and both may be involved. ..
  58. Tischfield M, Robson C, Gilette N, Chim S, Sofela F, DeLisle M, et al. Cerebral Vein Malformations Result from Loss of Twist1 Expression and BMP Signaling from Skull Progenitor Cells and Dura. Dev Cell. 2017;42:445-461.e5 pubmed publisher
    ..regulate dural CV development in mammals and describe venous malformations in humans with craniosynostosis and TWIST1 mutations that are recapitulated in mouse models...
  59. Firulli B, McConville D, Byers J, Vincentz J, Barnes R, Firulli A. Analysis of a Hand1 hypomorphic allele reveals a critical threshold for embryonic viability. Dev Dyn. 2010;239:2748-60 pubmed publisher
    ..Interestingly, putative bHLH partners, Hand2 and Twist1, show altered expression in both Hand1 null and hypomorphic backgrounds and intercrossing the Hand1 hypomorphic ..