Gene Symbol: Tusc2
Description: tumor suppressor candidate 2
Alias: 1190001E22Rik, AA407686, Fus1, Lgcc, PAP, Pdap2, tumor suppressor candidate 2, PDGFA associated protein 2, fus-1 protein, fusion 1 protein, lung cancer candidiate, FUS
Lerman M, Minna J. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium. Cancer Res. 2000;60:6116-33 pubmed
..We found six of the genes to have two or more amino acid sequence-altering mutations including BLU, NPRL2/Gene21, FUS1, HYAL1, FUS2, and SEMA3B...
Ivanova A, Ivanov S, Pascal V, Lumsden J, Ward J, Morris N, et al
. Autoimmunity, spontaneous tumourigenesis, and IL-15 insufficiency in mice with a targeted disruption of the tumour suppressor gene Fus1. J Pathol. 2007;211:591-601 pubmed
The Fus1 gene resides in the critical 3p21.3 human chromosomal region deleted in lung and breast cancers...
Jadin L, Wu X, Ding H, Frost G, Onclinx C, Triggs Raine B, et al
. Skeletal and hematological anomalies in HYAL2-deficient mice: a second type of mucopolysaccharidosis IX?. FASEB J. 2008;22:4316-26 pubmed publisher
..In addition, the viability of HYAL2-deficient mice raises the possibility that a similar defect, defining a new MPS disorder, exists in humans. ..
Hood M, Uzhachenko R, Boyd K, Skaar E, Ivanova A. Loss of mitochondrial protein Fus1 augments host resistance to Acinetobacter baumannii infection. Infect Immun. 2013;81:4461-9 pubmed publisher
b>Fus1 is a tumor suppressor protein with recently described immunoregulatory functions. Although its role in sterile inflammation is being elucidated, its role in regulating immune responses to infectious agents has not been examined...
Uzhachenko R, Issaeva N, Boyd K, Ivanov S, Carbone D, Ivanova A. Tumour suppressor Fus1 provides a molecular link between inflammatory response and mitochondrial homeostasis. J Pathol. 2012;227:456-69 pubmed publisher
b>Fus1, encoded by a 3p21.3 tumour suppressor gene, is down-regulated, mutated or lost in the majority of inflammatory thoracic malignancies...
Uzhachenko R, Ivanov S, Yarbrough W, Shanker A, Medzhitov R, Ivanova A. Fus1/Tusc2 is a novel regulator of mitochondrial calcium handling, Ca2+-coupled mitochondrial processes, and Ca2+-dependent NFAT and NF-?B pathways in CD4+ T cells. Antioxid Redox Signal. 2014;20:1533-47 pubmed publisher
b>Fus1 has been established as mitochondrial tumor suppressor, immunomodulator, and antioxidant protein, but molecular mechanism of these activities remained to be identified...