Gene Symbol: Tubb5
Description: tubulin, beta 5 class I
Alias: AA408537, AI596182, B130022C14Rik, M(beta)5, tubulin beta-5 chain
Species: mouse
Products:     Tubb5

Top Publications

  1. Sullivan K, Cleveland D. Identification of conserved isotype-defining variable region sequences for four vertebrate beta tubulin polypeptide classes. Proc Natl Acad Sci U S A. 1986;83:4327-31 pubmed
  2. Bhattacharya R, Cabral F. A ubiquitous beta-tubulin disrupts microtubule assembly and inhibits cell proliferation. Mol Biol Cell. 2004;15:3123-31 pubmed
    ..The results show that class V beta-tubulin is functionally distinct from other tubulin isotypes and imparts unique properties on the microtubules into which it incorporates. ..
  3. Ngo L, Haas M, Qu Z, Li S, Zenker J, Teng K, et al. TUBB5 and its disease-associated mutations influence the terminal differentiation and dendritic spine densities of cerebral cortical neurons. Hum Mol Genet. 2014;23:5147-58 pubmed publisher
    ..We have previously shown that mutations in the ?-tubulin gene TUBB5 cause microcephaly with structural brain abnormalities in humans...
  4. Guzun R, Karu Varikmaa M, Gonzalez Granillo M, Kuznetsov A, Michel L, Cottet Rousselle C, et al. Mitochondria-cytoskeleton interaction: distribution of ?-tubulins in cardiomyocytes and HL-1 cells. Biochim Biophys Acta. 2011;1807:458-69 pubmed publisher
    ..On the other hand, absence of both ?II-tubulin and MtCK in HL-1 cells can be associated with their more glycolysis-dependent energy metabolism which is typical for cancer cells (Warburg effect). ..
  5. Fourest Lieuvin A, Peris L, Gache V, Garcia Saez I, Juillan Binard C, Lantez V, et al. Microtubule regulation in mitosis: tubulin phosphorylation by the cyclin-dependent kinase Cdk1. Mol Biol Cell. 2006;17:1041-50 pubmed
    ..These data indicate that phosphorylation of tubulin by Cdk1 could be involved in the regulation of microtubule dynamics during mitosis. ..
  6. Fowles L, Bennetts J, Berkman J, Williams E, Koopman P, Teasdale R, et al. Genomic screen for genes involved in mammalian craniofacial development. Genesis. 2003;35:73-87 pubmed
  7. Hembree M, Prasadan K, Manna P, Preuett B, Spilde T, Bhatia A, et al. Semiquantitative polymerase chain reaction in RNase-producing tissues: Analysis of the developing pancreas. J Pediatr Surg. 2001;36:1629-32 pubmed
  8. Lewis S, Lee M, Cowan N. Five mouse tubulin isotypes and their regulated expression during development. J Cell Biol. 1985;101:852-61 pubmed
    ..tubulin cloned cDNAs, two (M alpha 1 and M alpha 2) that encode alpha-tubulin and three (M beta 2, M beta 4, and M beta 5) that encode beta-tubulin. The sequence of these clones reveals that each represents a distinct gene product...
  9. Loebel D, O Rourke M, Steiner K, Banyer J, Tam P. Isolation of differentially expressed genes from wild-type and Twist mutant mouse limb buds. Genesis. 2002;33:103-13 pubmed

More Information


  1. Feng J, Lawson M, Melamed P. A proteomic comparison of immature and mature mouse gonadotrophs reveals novel differentially expressed nuclear proteins that regulate gonadotropin gene transcription and RNA splicing. Biol Reprod. 2008;79:546-61 pubmed publisher
    ..This study has revealed a number of novel factors that alter gonadotropin expression and gonadotroph function, and likely mediate or moderate effects of the regulatory hormones. ..
  2. Gao Y, Vainberg I, Chow R, Cowan N. Two cofactors and cytoplasmic chaperonin are required for the folding of alpha- and beta-tubulin. Mol Cell Biol. 1993;13:2478-85 pubmed
    ..We show that actin and tubulins compete efficiently with one another for association with cytoplasmic chaperonin complexes. These data imply that actin and alpha- and beta-tubulin interact with the same site(s) on chaperonin complexes. ..
  3. Breuss M, Heng J, Poirier K, Tian G, Jaglin X, Qu Z, et al. Mutations in the ?-tubulin gene TUBB5 cause microcephaly with structural brain abnormalities. Cell Rep. 2012;2:1554-62 pubmed publisher
    ..Here, we show that Tubb5 is expressed in neurogenic progenitors in the mouse and that its depletion in vivo perturbs the cell cycle of ..
  4. Lin C, Theodorides M, McDaniel A, Tordoff M, Zhang Q, Li X, et al. QTL analysis of dietary obesity in C57BL/6byj X 129P3/J F2 mice: diet- and sex-dependent effects. PLoS ONE. 2013;8:e68776 pubmed publisher
    ..filtering methods highlighted seven candidate genes within the QTL locus boundaries: Crx, Dmpk, Ahr, Mrpl28, Glo1, Tubb5, and Mut...
  5. Semiz S, Park J, Nicoloro S, Furcinitti P, Zhang C, Chawla A, et al. Conventional kinesin KIF5B mediates insulin-stimulated GLUT4 movements on microtubules. EMBO J. 2003;22:2387-99 pubmed
    ..This insulin signaling pathway regulating KIF5B function appears to be required for GLUT4 translocation to the plasma membrane. ..
  6. Tateossian H, Powles N, Dickinson R, Ficker M, Maconochie M. Determination of downstream targets of FGF signalling using gene trap and cDNA subtractive approaches. Exp Cell Res. 2004;292:101-14 pubmed
  7. Vosseller K, Hansen K, Chalkley R, Trinidad J, Wells L, Hart G, et al. Quantitative analysis of both protein expression and serine / threonine post-translational modifications through stable isotope labeling with dithiothreitol. Proteomics. 2005;5:388-98 pubmed
    ..These results demonstate BEMAD is suitable for large-scale quantitative analysis of both protein expression and serine / threonine post-translational modifications. ..
  8. Wang T, Gu S, Ronni T, Du Y, Chen X. In vivo dual-tagging proteomic approach in studying signaling pathways in immune response. J Proteome Res. 2005;4:941-9 pubmed
    ..This integrated approach provides global information on the functional link between MyD88 and other proteins in transducing the TLR-mediated signal and is generally applicable to in vivo analyses of other signaling pathways. ..
  9. Smith R, Bacos K, Fedele V, Soulet D, Walz H, Obermuller S, et al. Mutant huntingtin interacts with {beta}-tubulin and disrupts vesicular transport and insulin secretion. Hum Mol Genet. 2009;18:3942-54 pubmed publisher
    ..Thus, our findings have revealed a novel pathogenetic process by which mutant huntingtin may disrupt hormone exocytosis from beta-cells and possibly impair vesicular transport in any cell that expresses the pathogenic protein. ..
  10. Niwa S, Takahashi H, Hirokawa N. ?-Tubulin mutations that cause severe neuropathies disrupt axonal transport. EMBO J. 2013;32:1352-64 pubmed publisher
    ..Thus, our data identified the critical region of ?-tubulin required for axonal transport and suggest a molecular mechanism for human neuronal diseases caused by tubulin mutations. ..
  11. Breuss M, Hansen A, Landler L, Keays D. Brain-specific knockin of the pathogenic Tubb5 E401K allele causes defects in motor coordination and prepulse inhibition. Behav Brain Res. 2017;323:47-55 pubmed publisher
    ..We have previously reported that mutations in TUBB5 cause microcephaly that is accompanied by severe intellectual impairment and motor delay...
  12. Breuss M, Fritz T, Gstrein T, Chan K, Ushakova L, Yu N, et al. Mutations in the murine homologue of TUBB5 cause microcephaly by perturbing cell cycle progression and inducing p53-associated apoptosis. Development. 2016;143:1126-33 pubmed publisher
    ..In this study we explore the genetic and cellular mechanisms that cause TUBB5-associated microcephaly by exploiting two new mouse models: a conditional E401K knock-in, and a conditional ..
  13. Wang D, Villasante A, Lewis S, Cowan N. The mammalian beta-tubulin repertoire: hematopoietic expression of a novel, heterologous beta-tubulin isotype. J Cell Biol. 1986;103:1903-10 pubmed
    ..Comparison of M beta 1 and M beta 3 with the completed (M beta 4, M beta 5) or extended (M beta 2) sequence of three previously described beta-tubulin isotypes shows that each includes a ..